Giese, Alf

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Giese, Alf"],["dc.contributor.author","Lankenau, Eva"],["dc.contributor.author","Kantelhardt, Sven Rainer"],["dc.contributor.author","Huettmann, Gereon"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2018-11-07T11:21:41Z"],["dc.date.available","2018-11-07T11:21:41Z"],["dc.date.issued","2009"],["dc.format.extent","881"],["dc.identifier.isi","000272974100053"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55832"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","3rd Quadrennial Meeting of the World-Federation-of-Neuro-Oncoloyg/6th Meeting of the Asian-Society-for-Neuro-Oncology"],["dc.relation.eventlocation","Yokohama, JAPAN"],["dc.relation.issn","1522-8517"],["dc.title","OPTICAL COHERENCE TOMOGRAPHY FOR INTRAOPERATIVE ANALYSIS OF GLIOMA TISSUE MICROSTRUCTURE AND LIGHT ATTENUATION AS A NOVEL TECHNIQUE TO CONTROL THE EXTENT OF RESECTION"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","611"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Neurosurgery"],["dc.bibliographiccitation.lastpage","615"],["dc.bibliographiccitation.volume","66"],["dc.contributor.author","Giese, Alf"],["dc.contributor.author","Winkler, Peter A."],["dc.contributor.author","Schichor, Christian"],["dc.contributor.author","Kantelhardt, Sven Rainer"],["dc.contributor.author","Boeckh-Behrens, Tobias"],["dc.contributor.author","Tonn, Joerg-Christian"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2018-11-07T08:45:40Z"],["dc.date.available","2018-11-07T08:45:40Z"],["dc.date.issued","2010"],["dc.description.abstract","OBJECTIVE: A spinal perimedullary arteriovenous fistula (PMAVF) is a direct fistula of one or more spinal arteries into the perimedullary venous network with reversed venous flow and subsequent venous congestion of the spinal cord. The therapeutic goal of surgery is to normalize the venous drainage by obliterating the fistula. Strictly ventral lesions typically require an anterior approach to ensure adequate exposure of the fistula as well and the preservation of the physiological blood supply to the spinal cord. CLINICAL PRESENTATION: We present a case of a ventral PMAVF at the level of T10 with feeders from the anterior spinal artery, caudally draining veins on the ventral spinal cord, and a dilated transmedullary vein filling cranially draining veins on the dorsal aspect of the spinal cord. TECHNIQUE: The dilated transmedullary vein was approached by a laminectomy. The vein was coagulated, and the gliotic channel was used to approach the ventral fistula site from the dorsal surface of the spinal cord. Complete obliteration of the fistula was achieved, and the preoperative neurological deficit improved. CONCLUSION: We conclude that transmedullarly draining veins offers a possible dorsal approach for the occlusion of some ventral PMAVFs, thus avoiding more complex anterior approaches to the ventral spinal cord."],["dc.identifier.doi","10.1227/01.NEU.0000365365.10977.48"],["dc.identifier.isi","000274795800044"],["dc.identifier.pmid","20173556"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20501"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0148-396X"],["dc.title","A Transmedullary Approach to Occlusion of a Ventral Perimedullary Arteriovenous Fistula of the Thoracic Spinal Cord"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Kim, Ella L."],["dc.contributor.author","Richter, Christoph"],["dc.contributor.author","Pilzak, Agatha A."],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Gunawan, Bastian"],["dc.contributor.author","Schmitz-Salue, Christoph"],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T11:21:41Z"],["dc.date.available","2018-11-07T11:21:41Z"],["dc.date.issued","2009"],["dc.format.extent","918"],["dc.identifier.isi","000272974100197"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55834"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","3rd Quadrennial Meeting of the World-Federation-of-Neuro-Oncoloyg/6th Meeting of the Asian-Society-for-Neuro-Oncology"],["dc.relation.eventlocation","Yokohama, JAPAN"],["dc.relation.issn","1522-8517"],["dc.title","ESTABLISHMENT AND CHARACTERIZATION OF AN EXPERIMENTAL MODEL OF INVASIVE GLIOMA WITH HIGHLY RADIORESISTANT PHENOTYPE"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","11"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Biochemical Pharmacology"],["dc.bibliographiccitation.lastpage","20"],["dc.bibliographiccitation.volume","77"],["dc.contributor.author","Kim, Ella L."],["dc.contributor.author","Giese, Alf"],["dc.contributor.author","Deppert, Wolfgang R."],["dc.date.accessioned","2018-11-07T08:33:53Z"],["dc.date.available","2018-11-07T08:33:53Z"],["dc.date.issued","2009"],["dc.description.abstract","The tumor suppressor p53 controls a broad range of cellular responses. Induction of a transient (cell cycle arrest) or a permanent (senescence) block of cell proliferation, or the activation of cell death pathways in response to genotoxic stress comprise the major arms of the survival-death axis governed by p53. Due to these biological properties, inactivation of p53 is a crucial step in tumor development and progression, reflected by the high incidence of TP53 mutations in different types of human cancers. The remarkable potency of p53 in suppressing tumorigenic outgrowth has promoted the expectation that tumor cells expressing wild-type p53 (wtp53) should be more prone to elimination by cytotoxic treatments than tumor cells expressing mutant p53 (mutp53) with defunct wtp53 activities. However, recent findings yielded somewhat unexpected insights concerning the preponderance of the survival-promoting effects of wtp53 in cancer cells, a rather undesired property from the therapeutic point of view. In this commentary we will discuss the possibility that the developmentally established distinct patterns of wtp53 mediated responses in different tissues are an important factor in determining the ultimate outcome of cellular responses mediated by wtp53 in different types of tumor cells, with a particular focus on the divergent impact of wtp53 in malignant tumors of the central nervous system. We infer that a selective gain of pro-survival functions of wtp53 in cancer cells will confer a survival advantage that counteracts tumor therapy. (C) 2008 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.bcp.2008.08.030"],["dc.identifier.isi","261779500002"],["dc.identifier.pmid","18812169"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17697"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0006-2952"],["dc.title","Wild-type p53 in cancer cells: When a guardian turns into a blackguard"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Richter, Christoph"],["dc.contributor.author","Kim, Ella L."],["dc.contributor.author","Pilzak, Agatha A."],["dc.contributor.author","Schmitz-Salue, Christoph"],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T11:10:44Z"],["dc.date.available","2018-11-07T11:10:44Z"],["dc.date.issued","2008"],["dc.format.extent","905"],["dc.identifier.isi","000259854500533"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53272"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","13th Annual Meeting of the Society-for-Neuro-Oncology (SNO)"],["dc.relation.eventlocation","Las Vegas, NV"],["dc.relation.issn","1522-8517"],["dc.title","BRAIN TUMOUR-INITIATING STEM-LIKE CELLS IN ESTABLISHED GLIOMA CELL LINES"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","273"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Lasers in Surgery and Medicine"],["dc.bibliographiccitation.lastpage","281"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Kantelhardt, Sven Rainer"],["dc.contributor.author","Diddens, Heike"],["dc.contributor.author","Leppert, Jan"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Huettmann, Gereon"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T11:16:43Z"],["dc.date.available","2018-11-07T11:16:43Z"],["dc.date.issued","2008"],["dc.description.abstract","Background and Objective: The clinical usefulness of 5-ALA guided detection of tumor tissue has been demonstrated for a number of malignancies. However, current techniques of intraoperative detection of protoporphyrin IX fluorescence in situ do not offer subcellular resolution. Therefore, discrimination of non-specific 5-ALA induced fluorescence remains difficult. Materials and Methods: In this study we have used an orthotopic glioma model to analyze PpIX fluorescence in tumor tissue and normal brain by multiphoton excitation microscopy after intraperitoneal administration of 5-ALA. A DermaInspect in vivo imaging system was used for autofluorescence measurements at 750 nm excitation and detection in the green channel of a standard photomultiplier module. For detection of PpIX fluorescence at different excitation wavelengths a red sensitive version of the photomultiplier and a filter combination of short pass filters and a color glass long pass filter was used restricting the sensitivity in the red channel to a range of 580-700 nm. Results: Multiphoton microscopy allowed a higher structural definition of tumor tissue based on the excitation of 5-ALA induced PpTX fluorescence compared to autofluorescence imaging. The high resolution of multiphoton microscopy allowed discrimination of fluorescence from the cytoplasm of tumor cells and 5-ALA induced PpIX fluorescence of normal brain parenchyma adjacent to tumor. Fluorescence lifetime imaging showed significantly longer fluorescence lifetimes of 5-ALA induced PpIX fluorescence in tumor tissue compared to normal brain. This allowed definition and visualization of the tumor/brain interface based on this parameter alone. Conclusion: Multiphoton microscopy of 5-ALA induced PpIX fluorescence in brain tumor tissue conceptually provides a high resolution diagnostic tool, which in addition to structural information may also provide photochemical/functional information."],["dc.identifier.doi","10.1002/lsm.20623"],["dc.identifier.isi","000255515000008"],["dc.identifier.pmid","18412229"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54657"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1096-9101"],["dc.relation.issn","0196-8092"],["dc.title","Multiphoton excitation fluorescence microscopy of 5-aminolevulinic acid induced fluorescence in experimental gliomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","317"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Neurosurgical Anesthesiology"],["dc.bibliographiccitation.lastpage","323"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Keric, Naureen"],["dc.contributor.author","Kantelhardt, Sven Rainer"],["dc.contributor.author","Neulen, Axel"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Henning, Antonia"],["dc.contributor.author","Vollmer, Fritz C."],["dc.contributor.author","Thiemann, Ingmar"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T09:22:51Z"],["dc.date.available","2018-11-07T09:22:51Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: Although the skull limits applicability of sonography, bedside intracranial endosonography might be an alternative to computed tomography scans to detect adverse events in sedated patients. However, the usefulness of intracranial endosonography for potential clinical application has not been evaluated. The present study was designed to investigate the suitability of an image-guided intracranial endosonography (IGIE) catheter for intracranial ultrasound imaging in an ex vivo phantom model and in a large animal model.Materials and Methods: IGIE was evaluated in a cranial phantom and a porcine intracranial hemorrhage (ICH) model. Two anesthetized animals underwent an initial magnetic resonance imaging (MRI) scan, followed by placement of an endosonography catheter in the frontal lobe. After anatomic imaging, an experimental ICH was placed in the contralateral hemisphere. B-scan imaging, duplex, Doppler sonography, and a second MRI were performed. A standard image-guiding device tracked the ultrasound catheter.Results: Endosonography provided high-definition imaging of intracranial structures. Image guidance allowed direction of the catheter to and intuitive identification of anatomic structures. Doppler imaging allowed analysis of blood flow in intracranial vessels. Ultrasound imaging was used to monitor evolution of ICH and the resulting brain edema in real time. Coregistration of ultrasound and MRI images acquired after ICH placement demonstrated the high accuracy of the spatial resolution of IGIE (largest mismatch <5 mm).Conclusions: IGIE provides high-definition images of intracranial structures, Doppler analysis of blood flow, and real-time monitoring of intracranial structural lesions. We suggest that IGIE might prove a valuable tool for intracranial monitoring of sedated patients over extended time periods."],["dc.identifier.doi","10.1097/ANA.0b013e31828cb27e"],["dc.identifier.isi","000323217100015"],["dc.identifier.pmid","23552276"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29441"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0898-4921"],["dc.title","Image-guided Intracranial Endosonography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Kim, Ella L."],["dc.contributor.author","Warneke, Gabi"],["dc.contributor.author","Schmitz-Salue, Christoph"],["dc.contributor.author","Depperr, Wolfgang"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T11:10:43Z"],["dc.date.available","2018-11-07T11:10:43Z"],["dc.date.issued","2008"],["dc.format.extent","772"],["dc.identifier.isi","000259854500061"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53269"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","13th Annual Meeting of the Society-for-Neuro-Oncology (SNO)"],["dc.relation.eventlocation","Las Vegas, NV"],["dc.relation.issn","1522-8517"],["dc.title","CHLOROQUINE INDUCES DEATH RESPONSE IN GLIOMA CELLS BY P53-DEPENDENT AND P53-INDEPENDENT MECHANISMS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","55"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Neurosurgical Anesthesiology"],["dc.bibliographiccitation.lastpage","61"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Greke, Christian"],["dc.contributor.author","Neulen, Axel"],["dc.contributor.author","Kantelhardt, Sven R."],["dc.contributor.author","Birkenmayer, Achim"],["dc.contributor.author","Vollmer, Fritz C."],["dc.contributor.author","Thiemann, Ingmar"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2021-06-01T10:46:56Z"],["dc.date.available","2021-06-01T10:46:56Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1097/ANA.0b013e31826b3d55"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85427"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0898-4921"],["dc.title","Image-guided Transcranial Doppler Sonography for Monitoring of Defined Segments of Intracranial Arteries"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","577"],["dc.bibliographiccitation.issue","7131"],["dc.bibliographiccitation.journal","BMJ"],["dc.bibliographiccitation.lastpage","582"],["dc.bibliographiccitation.volume","316"],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Schütz, Ekkehard"],["dc.contributor.author","Zerr, Inga"],["dc.contributor.author","Otto, A."],["dc.contributor.author","Pfahlberg, A."],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Uhr, Manfred"],["dc.contributor.author","Giese, A."],["dc.contributor.author","Weber, Thomas"],["dc.contributor.author","Kretzschmar, Hans A."],["dc.contributor.author","Poser, Sigrid"],["dc.date.accessioned","2017-09-07T11:44:30Z"],["dc.date.available","2017-09-07T11:44:30Z"],["dc.date.issued","2011"],["dc.description.abstract","Objective: To analyse serum concentrations of brain specific S100 protein in patients with Creutzfeldt-Jakob disease and in controls.Design: Prospective case-control study.Setting: National Creutzfeldt-Jakob disease surveillance unit.Subjects: 224 patients referred to the surveillance unit with suspected Creutzfeldt-Jakob disease and 35 control patients without dementia.Main outcome measure: Serum concentration of S100 protein in patients with Creutzfeldt-Jakob disease, in patients with other diseases causing dementia, and in the control group.Results: Of the 224 patients with suspected Creutzfeldt-Jakob disease, 65 were classed as definitely having the disease after neuropathological verification, an additional 6 were classed as definitely having the disease as a result of a genetic mutation, 43 as probably having the disease, 36 as possibly having the disease, and 74 patients were classed as having other disease. In the 108 patients classed as definitely or probably having Creutzfeldt-Jakob disease the median serum concentration of S100 was 395 pg/ml (SD 387 pg/ml). This was significantly higher than concentrations found in the 74 patients classed as having other diseases (median 109 pg/ml; SD 177 pg/ml; P=0.0001). At a cut off point of 213 pg/ml sensitivity for the diagnosis of the disease was 77.8% (95% confidence interval 68.8% to 85.2%) and specificity was 81.1% (70.3% to 89.3%). There was a significant difference in survival at different concentrations of S100 in Kaplan-Meier curves (P=0.023).Conclusion: Measurement of serum concentrations of S100 is a valuable tool which can be used more easily than tests on cerebrospinal fluid in the differential diagnosis of Creutzfeldt-Jakob disease. More studies are needed to determine whether serial testing of serum S100 improves diagnostic accuracy.Key messages Creutzfeldt-Jakob disease is a rare, fatal neurodegenerative disease. Diagnosis is made clinically and neuropathologically There is no serum test which allows the diagnosis to be made while the patient is alive In this study raised serum concentrations of S100 protein were found in patients with Creutzfeldt-Jakob disease Serum concentrations of S100 could be used with a sensitivity of 77.8% and a specificity of 81.1% to confirm Creutzfeldt-Jakob disease in the differential diagnosis of diseases that cause dementia Serial measurement of S100 concentrations will enhance diagnostic accuracy"],["dc.identifier.doi","10.1136/bmj.316.7131.577"],["dc.identifier.gro","3151673"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8491"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","chake"],["dc.relation.issn","0959-8138"],["dc.title","Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum: prospective case-control study"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]