Marquardt, Till

[["dc.bibliographiccitation.firstpage","2008"],["dc.bibliographiccitation.issue","18"],["dc.bibliographiccitation.journal","The EMBO Journal"],["dc.bibliographiccitation.lastpage","2025"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Vingill, Siv"],["dc.contributor.author","Brockelt, David"],["dc.contributor.author","Lancelin, Camille"],["dc.contributor.author","Tatenhorst, Lars"],["dc.contributor.author","Dontcheva, Guergana"],["dc.contributor.author","Preisinger, Christian"],["dc.contributor.author","Schwedhelm-Domeyer, Nicola"],["dc.contributor.author","Joseph, Sabitha"],["dc.contributor.author","Mitkovski, Miso"],["dc.contributor.author","Goebbels, Sandra"],["dc.contributor.author","Nave, Klaus-Armin"],["dc.contributor.author","Schulz, Joerg B."],["dc.contributor.author","Marquardt, Till"],["dc.contributor.author","Lingor, Paul"],["dc.contributor.author","Stegmueller, Judith"],["dc.date.accessioned","2018-11-07T10:08:31Z"],["dc.date.available","2018-11-07T10:08:31Z"],["dc.date.issued","2016"],["dc.description.abstract","Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism termed parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. FBXO7 (F-box protein only 7) is a subunit of the SCF (SKP1/cullin-1/F-box protein) E3 ubiquitin ligase complex, but its relevance and function in neurons remain to be elucidated. Here, we report that the E3 ligase FBXO7-SCF binds to and ubiquitinates the proteasomal subunit PSMA2. In addition, we show that FBXO7 is a proteasome-associated protein involved in proteasome assembly. In FBXO7 knockout mice, we find reduced proteasome activity and early-onset motor deficits together with premature death. In addition, we demonstrate that NEX (neuronal helix-loop-helix protein-1)-Cre-induced deletion of the FBXO7 gene in forebrain neurons or the loss of FBXO7 in tyrosine hydroxylase (TH)-positive neurons results in motor defects, reminiscent of the phenotype in PARK15 patients. Taken together, our study establishes a vital role for FBXO7 in neurons, which is required for proper motor control and accentuates the importance of FBXO7 in proteasome function."],["dc.identifier.doi","10.15252/embj.201593585"],["dc.identifier.isi","000384084900006"],["dc.identifier.pmid","27497298"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39477"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1460-2075"],["dc.relation.issn","0261-4189"],["dc.title","Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","514"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Translational Psychiatry"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Goldberg, Maria"],["dc.contributor.author","Islam, Md Rezaul"],["dc.contributor.author","Kerimoglu, Cemil"],["dc.contributor.author","Lancelin, Camille"],["dc.contributor.author","Gisa, Verena"],["dc.contributor.author","Burkhardt, Susanne"],["dc.contributor.author","Krüger, Dennis M."],["dc.contributor.author","Marquardt, Till"],["dc.contributor.author","Malchow, Berend"],["dc.contributor.author","Schmitt, Andrea"],["dc.contributor.author","Fischer, André"],["dc.date.accessioned","2021-12-01T09:23:16Z"],["dc.date.available","2021-12-01T09:23:16Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract MicroRNAs have been linked to synaptic plasticity and memory function and are emerging as potential biomarkers and therapeutic targets for cognitive diseases. Most of these data stem from the analysis of model systems or postmortem tissue from patients which mainly represents an advanced stage of pathology. Due to the in-accessibility of human brain tissue upon experimental manipulation, it is still challenging to identify microRNAs relevant to human cognition, which is however a key step for future translational studies. Here, we employ exercise as an experimental model for memory enhancement in healthy humans with the aim to identify microRNAs linked to memory function. By analyzing the circulating smallRNAome we find a cluster of 18 microRNAs that are highly correlated to cognition. MicroRNA-409-5p and microRNA-501-3p were the most significantly regulated candidates. Functional analysis revealed that the two microRNAs are important for neuronal integrity, synaptic plasticity, and morphology. In conclusion, we provide a novel approach to identify microRNAs linked to human memory function."],["dc.identifier.doi","10.1038/s41398-021-01627-w"],["dc.identifier.pii","1627"],["dc.identifier.pmid","34625536"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94605"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/350"],["dc.identifier.url","https://sfb1286.uni-goettingen.de/literature/publications/137"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation","SFB 1286: Quantitative Synaptologie"],["dc.relation","SFB 1286 | B06: Die Rolle von RNA in Synapsenphysiologie und Neurodegeneration"],["dc.relation.eissn","2158-3188"],["dc.relation.workinggroup","RG A. Fischer (Epigenetics and Systems Medicine in Neurodegenerative Diseases)"],["dc.rights","CC BY 4.0"],["dc.title","Exercise as a model to identify microRNAs linked to human cognition: a role for microRNA-409 and microRNA-501"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]