Feist, Maren Ida

[["dc.bibliographiccitation.firstpage","1105"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Proteome Research"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Schwarzfischer, Philipp"],["dc.contributor.author","Reinders, Joerg"],["dc.contributor.author","Dettmer, Katja"],["dc.contributor.author","Kleo, Karsten"],["dc.contributor.author","Dimitrova, Lora"],["dc.contributor.author","Hummel, Michael"],["dc.contributor.author","Feist, Maren"],["dc.contributor.author","Kube, Dieter"],["dc.contributor.author","Szczepanowski, Monika"],["dc.contributor.author","Klapper, Wolfram"],["dc.contributor.author","Taruttis, Franziska"],["dc.contributor.author","Engelmann, Julia C."],["dc.contributor.author","Spang, Rainer"],["dc.contributor.author","Gronwald, Wolfram"],["dc.contributor.author","Oefner, Peter J."],["dc.date.accessioned","2018-11-07T10:26:44Z"],["dc.date.available","2018-11-07T10:26:44Z"],["dc.date.issued","2017"],["dc.description.abstract","Burkitt's lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) are pathologically and clinically distinct subtypes of aggressive non-Hodgkin B-cell lymphoma. To learn more about their biology, we employed metabolomic and proteomic methods to study both established cell lines as well as cryopreserved and formalin-fixed paraffin-embedded (FFPE) tissue sections of BL and DLBCL. Strikingly, NMR analyses revealed DLBCL cell lines to produce and secrete significantly (P-adj = 1.72 X 10(-22)) more pyruvic acid than BL cell lines. This finding could be reproduced by targeted GC/MS analyses of cryopreserved tissue sections of BL and DLBCL cases. Enrichment analysis of an overlapping set of N = 2315 proteins, that had been quantified by nanoLC-SWATH-MS in BL and DLBCL cultured cells and cryosections, supported the observed difference in pyruvic acid content, as glycolysis and pyruvate metabolism were downregulated, while one-carbon metabolism was upregulated in BL compared to DLBCL. Furthermore, 92.1% of the overlapping significant proteins showed the same direction of regulation in cryopreserved and FFPE material. Proteome data are available via ProteomeXchange with identifier PXD004936."],["dc.identifier.doi","10.1021/acs.jproteome.6b00164"],["dc.identifier.isi","000395726200001"],["dc.identifier.pmid","28161958"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43107"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Amer Chemical Soc"],["dc.relation.issn","1535-3907"],["dc.relation.issn","1535-3893"],["dc.title","Comprehensive Metaboproteomics of Burkitt's and Diffuse Large B-Cell Lymphoma Cell Lines and Primary Tumor Tissues Reveals Distinct Differences in Pyruvate Content and Metabolism"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]