Rödiger, Matthias

[["dc.bibliographiccitation.firstpage","177"],["dc.bibliographiccitation.issue","2-3"],["dc.bibliographiccitation.journal","Journal of Molecular Histology"],["dc.bibliographiccitation.lastpage","184"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Roediger, Matthias"],["dc.contributor.author","Miosge, Nicolai"],["dc.contributor.author","Gersdorff, Nikolaus"],["dc.date.accessioned","2018-08-20T11:49:34Z"],["dc.date.available","2018-08-20T11:49:34Z"],["dc.date.issued","2010"],["dc.description.abstract","Laminins are the major glycoproteins present in all basement membranes. Previously, we showed that perlecan is present during human development. Although an overview of mRNA-expression of the laminin beta1 and beta2 chains in various developing fetal organs is already available, a systematic localization of the laminin beta1 and beta2 chains on the protein level during embryonic and fetal human development is missing. Therefore, we studied the immunohistochemical expression and tissue distribution of the laminin beta1 and beta2 chains in various developing embryonic and fetal human organs between gestational weeks 8 and 12. The laminin beta1 chain was ubiquitously expressed in the basement membrane zones of the brain, ganglia, blood vessels, liver, kidney, skin, pancreas, intestine, heart and skeletal system. Furthermore, the laminin beta2 chain was present in the basement membrane zones of the brain, ganglia, skin, heart and skeletal system. The findings of this study support and expand upon the theory that these two laminin chains are important during human development."],["dc.identifier.doi","10.1007/s10735-010-9275-5"],["dc.identifier.pmid","20552257"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5016"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15420"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1567-2387"],["dc.relation.eissn","1567-2379"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Tissue distribution of the laminin β1 and β2 chain during embryonic and fetal human development"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1999"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Clinical Oral Investigations"],["dc.bibliographiccitation.lastpage","2006"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Rinke, Sven"],["dc.contributor.author","Lange, Katharina"],["dc.contributor.author","Roediger, Matthias"],["dc.contributor.author","Gersdorff, Nikolaus"],["dc.date.accessioned","2018-11-07T09:49:53Z"],["dc.date.available","2018-11-07T09:49:53Z"],["dc.date.issued","2015"],["dc.description.abstract","Objectives This practice-based study evaluated the clinical performance and risk factors for biological and technical complications with conventionally luted zirconia crowns. Materials and methods Sixty-eight patients (39 female) with a total of 323 restorations placed on 219 vital teeth, 69 endodontically treated teeth (ETT), and 41 implants (incisors, 96; premolars, 89; molars, 138; observational period, 79.7 +/- 14.2 months) underwent a clinical follow-up examination and were included in the study. Time-dependent survival (in situ), success (event free), and veneering ceramic fracture (VCF) rates were calculated and analyzed relative to the following risk factors: smoking status, location of the crown, and type of abutment. Results Fifty-three complete failures were recorded. A significant influence of the abutment type on survival could be detected (p = 0.033): ETT demonstrated a significantly (p = 0.029) lower 7-year survival rate (73.8 %, 95 % confidence interval [95 % CI] 0.600-0.876) than crowns placed on implants (90.0 %, 95 % CI 0.814-0.990). The success rate of the crowns was significantly influenced by the location of the restoration (p = 0.0058). A total of 75.6 % (95 % CI 0.648-0.864) of the anterior crowns remained event free, compared to 50.4 % (95 % CI 0.388-0.621) of the molar crowns. Furthermore, the location of the crowns affected the VCF rate (p = 0.018, event-free anterior teeth 95.2 % (95 % CI 0.880-1), event-free molars 80.9 % (95 % CI 0.706-0.913)). Conclusions Survival and success rates were significantly influenced by the type of abutment and the location of the restoration."],["dc.description.sponsorship","DeguDent GmbH, Hanau, Germany"],["dc.identifier.doi","10.1007/s00784-015-1410-y"],["dc.identifier.isi","000362283100030"],["dc.identifier.pmid","25663382"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35593"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1436-3771"],["dc.relation.issn","1432-6981"],["dc.title","Risk factors for technical and biological complications with zirconia single crowns"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","164"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","The International Journal of Prosthodontics"],["dc.bibliographiccitation.lastpage","171"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Rinke, Sven"],["dc.contributor.author","Gersdorff, Nikolaus"],["dc.contributor.author","Lange, Katharina"],["dc.contributor.author","Roediger, Matthias"],["dc.date.accessioned","2018-11-07T09:27:29Z"],["dc.date.available","2018-11-07T09:27:29Z"],["dc.date.issued","2013"],["dc.description.abstract","Purpose: The clinical performance of three-and four-unit fixed partial dentures (FPDs) with frameworks made of yttria partially stabilized zirconia was determined after a mean observational period of 84 months. Materials and Methods: Seventy-five patients were treated with 99 posterior FPDs. Fifty-one specimens were veneered with an experimental ceramic suitable for titanium and zirconia frameworks; 48 restorations were veneered with a commercially available low-fusing ceramic optimized for zirconia frameworks. All restorations were luted with zinc-phosphate cement. Statistical analysis was performed according to Kaplan-Meier; potential risk factors were analyzed using the Cox regression analysis. Results: Nineteen restorations failed completely: 12 due to technical complications, 6 due to biologic complications, and 1 for unknown reasons. The overall survival rate after 84 months was 83.4%. Thirty-two events required clinical intervention for restoration maintenance, resulting in a time-dependent success rate of 57.9% after 84 months. Nineteen dropouts occurred during the follow-up time. None of the evaluated factors showed an association with survival or success of the restorations. Conclusions: After a mean observational period of 7 years, the survival and success rates of zirconia-based posterior FPDs were inferior to those published for metal-ceramic FPDs. The majority of failures were caused by technical complications (material fractures). The main reasons for clinical intervention to maintain function were fractures of the veneering ceramic and decementations. Int J Prosthodont 2013;26:164-171. doi: 10.11607/ijp.3229"],["dc.description.sponsorship","DeguDent"],["dc.identifier.doi","10.11607/ijp.3229"],["dc.identifier.isi","000316180400011"],["dc.identifier.pmid","23476912"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30549"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Quintessence Publishing Co Inc"],["dc.relation.issn","0893-2174"],["dc.title","Prospective Evaluation of Zirconia Posterior Fixed Partial Dentures: 7-Year Clinical Results"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","141"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Canadian Journal of Physiology and Pharmacology"],["dc.bibliographiccitation.lastpage","146"],["dc.bibliographiccitation.volume","88"],["dc.contributor.author","Roediger, Matthias"],["dc.contributor.author","Zhang, X."],["dc.contributor.author","Ugele, Bernhard"],["dc.contributor.author","Gersdorff, Nikolaus"],["dc.contributor.author","Wright, Stephen H."],["dc.contributor.author","Burckhardt, Gerhard"],["dc.contributor.author","Bahn, Andrew"],["dc.date.accessioned","2018-11-07T08:46:04Z"],["dc.date.available","2018-11-07T08:46:04Z"],["dc.date.issued","2010"],["dc.description.abstract","Recent investigations involving intact rabbit renal proximal tubules indicated that organic anion transporter 3 (OAT3) may be involved in the transport of 2,3-dimercapto-1-propanesulfonic acid (DMPS). Therefore, we evaluated the interaction of OAT3 with DMPS to determine the effect of OAT3 on basolateral DMPS uptake. We used stably transfected HEK293 cells expressing human and rabbit orthologs of the exchanger OAT1 and OAT3. Using 6-carboxyfluorescein (6-CF) as a substrate, the IC(50) determinations for reduced DMPS (DMPSH) revealed a stronger interaction with OAT1 than with OAT3 (rbOAT1, 123.3 +/- 13.7: hOAT1, 85.1 +/- 8.8; rbOAT3, 171.7 +/- 22.3: and hOAT3, 172.2 +/- 36.4 mu mol/L). However, inhibition of 6-CF uptake by the oxidized form of DMPS (DMPSS), the main form of DMPS in the blood, showed a greater affinity for OAT3 (rbOAT1, 237.4 +/- 23; hOAT1, 104.6 +/- 13.1: rbOAT3, 52.4 +/- 7.6: and hOAT3, 31.6 +/- 6.6 mu mol/L). To determine whether DMPSH and DMPSS are substrates for OAT3, we performed efflux studies with [(14)C]glutarate and inwardly directed gradients of glutarate. The inhibitors trans-stimulated the efflux of [(14)C]glutarate, suggesting that OAT3 may be able to transport both forms of DMPS. On the basis of the substantial interaction of OAT3 with DMPSS, we conclude that OAT3 represents the dominant basolateral player in renal detoxification processes resulting from use of DMPS."],["dc.description.sponsorship","NIH [DK074022]"],["dc.identifier.doi","10.1139/Y09-123"],["dc.identifier.isi","000276484000008"],["dc.identifier.pmid","20237588"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20598"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Research Council Canada-n R C Research Press"],["dc.relation.issn","0008-4212"],["dc.title","Organic anion transporter 3 (OAT3) and renal transport of the metal chelator 2,3-dimercapto-1-propanesulfonic acid (DMPS)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1077"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","HISTOLOGY AND HISTOPATHOLOGY"],["dc.bibliographiccitation.lastpage","1084"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Gersdorff, Nikolaus"],["dc.contributor.author","Otto, S."],["dc.contributor.author","Roediger, Matthias"],["dc.contributor.author","Kruegel, Jenny"],["dc.contributor.author","Miosge, Nicolai"],["dc.date.accessioned","2018-11-07T10:58:06Z"],["dc.date.available","2018-11-07T10:58:06Z"],["dc.date.issued","2007"],["dc.description.abstract","Nidogen- 1 and nidogen- 2 are major components of all basement membranes and are considered to function as link molecules between laminin and collagen type IV networks. Surprisingly, the knockout of one or both nidogens does not cause defects in all tissues or in all basement membranes. In this study, we have elucidated the appearance of the major basement membrane components in adult murine kidney lacking nidogen- 1, nidogen- 2, or both nidogens. To this end, we localized laminin- 111, perlecan, and collagen type IV in knockout mice, heterozygous (+/-) or homozygous (-/-) for the nidogen- 1 gene, the nidogen- 2 gene, or both nidogen genes with the help of light microscopic immunostaining. We also performed immunogold histochemistry to determine the occurrence of these molecules in the murine kidney at the ultrastructural level. The renal basement membranes of single knockout mice contained a similar distribution of laminin- 111, perlecan, and collagen type IV compared to heterozygous mice. In nidogen double- knockout animals, the basement membrane underlying the tubular epithelium was sometimes altered, giving a diffuse and thickened pattern, or was totally absent. The normal or thickened basement membrane of double- knockout mice also showed a similar distribution of laminin- 111, perlecan, and collagen type IV. The results indicate that the lack of nidogen- 1, nidogen- 2, or both nidogens, plays no crucial role in the occurrence and localization of laminin- 111, collagen type IV, and perlecan in murine tubular renal basement membranes."],["dc.identifier.isi","000247757300003"],["dc.identifier.pmid","17616934"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50403"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","F Hernandez"],["dc.relation.issn","0213-3911"],["dc.title","The absence of one or both nidogens does not alter basement membrane composition in adult murine kidney"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","31"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Oral Biosciences"],["dc.bibliographiccitation.lastpage","45"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Roediger, Matthias"],["dc.contributor.author","Miró, Xavier"],["dc.contributor.author","Geffers, Robert"],["dc.contributor.author","Irmer, Malte"],["dc.contributor.author","Huels, Alfons"],["dc.contributor.author","Miosge, Nicolai"],["dc.contributor.author","Gersdorff, Nikolaus"],["dc.date.accessioned","2019-07-09T11:52:27Z"],["dc.date.available","2019-07-09T11:52:27Z"],["dc.date.issued","2009"],["dc.description.abstract","The purpose of this study was to compare gene expression profiles of peri-implantitis and periodontitis to elucidate potential differences at the molecular level. With the help of microarray analysis, genome-wide gene expression of inflamed peri-implant granulation tissue, inflamed and healthy periodontal tissues (n=48 patients) were compared and the data were validated by real-time reverse transcription polymerase chain reaction. After highlighting different gene classes, we focused on the extracellular matrix-receptor interaction pathway and gene expression of extracellular matrix molecules, their receptors and matrix degrading enzymes. Only genes of non-fibril-forming collagens (types IV, VI, VII, and Q) were increased in peri-implantitis compared to periodontitis, whereas the expressions of two fibril-forming collagens (types III and K) were decreased in peri-implantitis, which suggested that peri-implant tissue re-models faster than periodontal tissue in vivo. Furthermore, cathepsin D and cathepsin S seem to participate in the destruction of peri-implant connective tissue. Despite their clinical similarities, the present investigation demonstrated that peri-implantitis and periodontitis are two different disease entities at least at the messanger ribonucleic acid level. The data provide insight for future studies aimed at dissecting the pathogenesis of peri-implant inflammation."],["dc.identifier.doi","10.2330/joralbiosci.51.31"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4310"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60194"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Profiling of Differentially Expressed Genes in Peri-implantitis and Periodontitis in vivo by Microarray Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","228"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Oral Rehabilitation"],["dc.bibliographiccitation.lastpage","237"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Rinke, Sven"],["dc.contributor.author","Schäfer, S."],["dc.contributor.author","Lange, K."],["dc.contributor.author","Gersdorff, Nikolaus"],["dc.contributor.author","Roediger, Matthias"],["dc.date.accessioned","2018-11-07T09:27:57Z"],["dc.date.available","2018-11-07T09:27:57Z"],["dc.date.issued","2013"],["dc.description.abstract","This practice-based study evaluates the clinical performance of conventionally luted metalceramic and zirconia molar crowns fabricated with pronounced anatomical core design and a prolonged cooling period of the veneering porcelain. Fifty-three patients were treated from 07/2008 until 07/2009 with either metalceramic crowns (MCC) (high-noble alloy+low-fusing porcelain) or zirconia crowns (Cercon System, DeguDent, Germany). Forty-nine patients (30 women/19 men) with 100 restorations (metalceramic: 48/zirconia: 52, mean observational period: 36 center dot 5 +/- 6months) participated in a clinical follow-up examination and were included in the study. Time-dependent survival (in situ criteria), success (event-free restorations) and chipping rates (defects of the veneering ceramics) were calculated according to the KaplanMeier method and analysed in relation to the crown fabrication technique, using a Cox regression model (P<0 center dot 05). Three complete failures (metalceramic: 1, zirconia: 2) were recorded (survival rate after 3years: metalceramic: 97 center dot 6%, zirconia: 95 center dot 2%). Of the metalceramic restorations, 90 center dot 9% remained event-free (two ceramic fractures, one endodontic treatment), whereas the success rate for the zirconia was 86 center dot 8% (two ceramic fractures, one endodontic treatment, one secondary caries). No significant differences in survival (P=0 center dot 53), success (P=0 center dot 49) and ceramic fracture rates (P=0 center dot 57) were detected. The combination of a pronounced anatomical core design and a modified firing of the veneering porcelain for the fabrication of zirconia molar crowns resulted in a 3-year survival, success and chipping rate comparable to MCC."],["dc.description.sponsorship","DeguDent GmbH; Dentsply DeTrey"],["dc.identifier.doi","10.1111/joor.12018"],["dc.identifier.isi","000314470100010"],["dc.identifier.pmid","23211063"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30657"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0305-182X"],["dc.title","Practice-based clinical evaluation of metalceramic and zirconia molar crowns: 3-year results"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","141"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","The International journal of prosthodontics"],["dc.bibliographiccitation.lastpage","8"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Roediger, Matthias"],["dc.contributor.author","Gersdorff, Nikolaus"],["dc.contributor.author","Huels, Alfons"],["dc.contributor.author","Rinke, Sven"],["dc.date.accessioned","2019-07-10T08:13:30Z"],["dc.date.available","2019-07-10T08:13:30Z"],["dc.date.issued","2010"],["dc.description.abstract","PURPOSE: In this prospective clinical study, the performance of three- and four-unit fixed partial dentures (FPDs) with frameworks fabricated of yttria partially stabilized zirconia was determined after a mean observation period of 50 months. The study focused on the survival of the restoration (in situ criterion) and the success of the ceramic veneers (no defect). MATERIALS AND METHODS: Seventy-five patients with a maximum of two missing teeth and an antagonistic dentition were treated at the Department of Prosthodontics, University of Goettigen, with 99 posterior FPDs. Fifty-one specimens (experimental group) were veneered with an experimental ceramic suitable for titanium and zirconia frameworks (thermal expansion coefficient [TEC]: 8.5 microm/m K); 48 restorations (Ceram-S group) were veneered with a commercially available low-fusing ceramic optimized for zirconia frameworks (TEC: 9.5 microm/m K). All restorations were luted with zinc-phosphate cement. Statistical analysis was performed according to the Kaplan-Meier method; time-dependent success rates of the different types of ceramic veneers were analyzed using the log-rank test. RESULTS: Seven restorations were lost: 4 due to technical complications and 3 due to biologic complications. The overall survival rate after 48 months was 94% (Kaplan-Meier analysis). Twenty-three events required clinical intervention for restoration maintenance: 13 ceramic veneer chippings (polishing), 6 losses of retention (recementation), 3 caries lesions (filling therapy), and 1 loss of vitality (endodontic treatment). Between the two groups of veneering materials, no significant difference in the probability for success was determined (log-rank test, P=.81). CONCLUSIONS: Within a mean observation period of 4 years, sufficient survival rates for zirconia-based posterior FPDs could be verified. The main complications included fracture of the ceramic veneering material and decementation, which occurred mainly in the mandible."],["dc.identifier.pmid","20305852"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6042"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61265"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","0893-2174"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.subject.ddc","610"],["dc.subject.mesh","Adult"],["dc.subject.mesh","Aged"],["dc.subject.mesh","Dental Restoration Failure"],["dc.subject.mesh","Denture Design"],["dc.subject.mesh","Denture, Partial, Fixed"],["dc.subject.mesh","Female"],["dc.subject.mesh","Follow-Up Studies"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Male"],["dc.subject.mesh","Middle Aged"],["dc.subject.mesh","Prospective Studies"],["dc.subject.mesh","Survival Analysis"],["dc.subject.mesh","Tooth, Artificial"],["dc.subject.mesh","Treatment Outcome"],["dc.subject.mesh","Zirconium"],["dc.title","Prospective evaluation of zirconia posterior fixed partial dentures: four-year clinical results."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","591"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Acta Odontologica Scandinavica"],["dc.bibliographiccitation.lastpage","596"],["dc.bibliographiccitation.volume","72"],["dc.contributor.author","Raue, Lars"],["dc.contributor.author","Hartmann, Christiane D."],["dc.contributor.author","Roediger, Matthias"],["dc.contributor.author","Buergers, Ralf"],["dc.contributor.author","Gersdorff, Nikolaus"],["dc.date.accessioned","2018-11-07T09:33:06Z"],["dc.date.available","2018-11-07T09:33:06Z"],["dc.date.issued","2014"],["dc.description.abstract","Objective. A major aspect in evaluating the quality of dental materials is their physical properties. Their properties should be a best fit of the ones of dental hard tissues. Manufacturers give data sheets for each material. The properties listed are characterized by a specific value. This assumes (but does not prove) that there is no direction dependence of the properties. However, dental enamel has direction-dependent properties which additionally vary with location in the tooth. The aim of this paper is to show the local direction dependence of physical properties like the elastic modulus or the thermal expansion in dental hard tissues. With this knowledge the 'perfect filling/dental material' could be characterized. Materials and method. Enamel sections of similar to 400-500 mu m thickness have been cut with a diamond saw from labial/buccal to palatal/lingual (canine, premolar and molar) and parallel to labial (incisor). Crystallite arrangements have been measured in over 400 data points on all types of teeth with x-ray scattering techniques, known from materials science. Results. X-ray scattering measurements show impressively that dental enamel has a strong direction dependence of its physical properties which also varies with location within the tooth. Dental materials possess only little or no property direction dependence. Therefore, a mismatch was found between enamel and dental materials properties. Conclusion. Since dental materials should possess equal (direction depending) properties, worthwhile properties could be characterized by transferring the directional properties of enamel into a property 'wish list' which future dental materials should fulfil. Hereby the 'perfect dental material' can be characterized."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft (DFG)"],["dc.identifier.doi","10.3109/00016357.2013.878391"],["dc.identifier.isi","000344330400005"],["dc.identifier.pmid","24460030"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31894"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.relation.issn","1502-3850"],["dc.relation.issn","0001-6357"],["dc.title","Anisotropic local physical properties of human dental enamel in comparison to properties of some common dental filling materials"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","859"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","HISTOLOGY AND HISTOPATHOLOGY"],["dc.bibliographiccitation.lastpage","868"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Roediger, Matthias"],["dc.contributor.author","Kruegel, Jenny"],["dc.contributor.author","Miosge, Nicolai"],["dc.contributor.author","Gersdorff, Nikolaus"],["dc.date.accessioned","2018-11-07T08:28:11Z"],["dc.date.available","2018-11-07T08:28:11Z"],["dc.date.issued","2009"],["dc.description.abstract","A major component of basement membranes (BMs) is perlecan, a five-domain heparan sulphate proteoglycan. During murine embryogenesis, nearly all BMs of mesenchymal origin express perlecan, and it is believed to participate in the supramolecular assembly of BMs. However, the distribution of perlecan in human embryonic and fetal tissues is widely unknown, except for cartilage anlagen of developing extremities and the fetal spine. Clinical syndromes, caused by perlecan-associated mutations or gene-defects, suggest its multifunctional involvement during human development. Here we reveal the immunohistochemistry of perlecan domains III and V during human development from gestational weeks (gw) 6 to 12 in basement membrane zones (BMZs) of the developing brain, nervous system, blood vessels, skin, lung, heart, kidney, liver, intestine and skeletal system. Interestingly, a difference in the distribution of the two perlecan domains was found in the endoneurium of ganglia. Domain III is strongly present from gw 6 onwards, while domain V shows attenuated expression at this stage and has been detected abundantly only from gw 8 onwards, possibly indicating vascularization of the endoneurium during this early stage. We found perlecan to be present particularly at those stages of human development where epithelial-mesenchymal interactions occur."],["dc.identifier.isi","000266407500007"],["dc.identifier.pmid","19475532"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16364"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","F Hernandez"],["dc.relation.issn","0213-3911"],["dc.title","Tissue distribution of perlecan domains III and V during embryonic and fetal human development"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]