Rödiger, Matthias

[["dc.bibliographiccitation.firstpage","31"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Oral Biosciences"],["dc.bibliographiccitation.lastpage","45"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Roediger, Matthias"],["dc.contributor.author","Miró, Xavier"],["dc.contributor.author","Geffers, Robert"],["dc.contributor.author","Irmer, Malte"],["dc.contributor.author","Huels, Alfons"],["dc.contributor.author","Miosge, Nicolai"],["dc.contributor.author","Gersdorff, Nikolaus"],["dc.date.accessioned","2019-07-09T11:52:27Z"],["dc.date.available","2019-07-09T11:52:27Z"],["dc.date.issued","2009"],["dc.description.abstract","The purpose of this study was to compare gene expression profiles of peri-implantitis and periodontitis to elucidate potential differences at the molecular level. With the help of microarray analysis, genome-wide gene expression of inflamed peri-implant granulation tissue, inflamed and healthy periodontal tissues (n=48 patients) were compared and the data were validated by real-time reverse transcription polymerase chain reaction. After highlighting different gene classes, we focused on the extracellular matrix-receptor interaction pathway and gene expression of extracellular matrix molecules, their receptors and matrix degrading enzymes. Only genes of non-fibril-forming collagens (types IV, VI, VII, and Q) were increased in peri-implantitis compared to periodontitis, whereas the expressions of two fibril-forming collagens (types III and K) were decreased in peri-implantitis, which suggested that peri-implant tissue re-models faster than periodontal tissue in vivo. Furthermore, cathepsin D and cathepsin S seem to participate in the destruction of peri-implant connective tissue. Despite their clinical similarities, the present investigation demonstrated that peri-implantitis and periodontitis are two different disease entities at least at the messanger ribonucleic acid level. The data provide insight for future studies aimed at dissecting the pathogenesis of peri-implant inflammation."],["dc.identifier.doi","10.2330/joralbiosci.51.31"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4310"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60194"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Profiling of Differentially Expressed Genes in Peri-implantitis and Periodontitis in vivo by Microarray Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","141"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","The International journal of prosthodontics"],["dc.bibliographiccitation.lastpage","8"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Roediger, Matthias"],["dc.contributor.author","Gersdorff, Nikolaus"],["dc.contributor.author","Huels, Alfons"],["dc.contributor.author","Rinke, Sven"],["dc.date.accessioned","2019-07-10T08:13:30Z"],["dc.date.available","2019-07-10T08:13:30Z"],["dc.date.issued","2010"],["dc.description.abstract","PURPOSE: In this prospective clinical study, the performance of three- and four-unit fixed partial dentures (FPDs) with frameworks fabricated of yttria partially stabilized zirconia was determined after a mean observation period of 50 months. The study focused on the survival of the restoration (in situ criterion) and the success of the ceramic veneers (no defect). MATERIALS AND METHODS: Seventy-five patients with a maximum of two missing teeth and an antagonistic dentition were treated at the Department of Prosthodontics, University of Goettigen, with 99 posterior FPDs. Fifty-one specimens (experimental group) were veneered with an experimental ceramic suitable for titanium and zirconia frameworks (thermal expansion coefficient [TEC]: 8.5 microm/m K); 48 restorations (Ceram-S group) were veneered with a commercially available low-fusing ceramic optimized for zirconia frameworks (TEC: 9.5 microm/m K). All restorations were luted with zinc-phosphate cement. Statistical analysis was performed according to the Kaplan-Meier method; time-dependent success rates of the different types of ceramic veneers were analyzed using the log-rank test. RESULTS: Seven restorations were lost: 4 due to technical complications and 3 due to biologic complications. The overall survival rate after 48 months was 94% (Kaplan-Meier analysis). Twenty-three events required clinical intervention for restoration maintenance: 13 ceramic veneer chippings (polishing), 6 losses of retention (recementation), 3 caries lesions (filling therapy), and 1 loss of vitality (endodontic treatment). Between the two groups of veneering materials, no significant difference in the probability for success was determined (log-rank test, P=.81). CONCLUSIONS: Within a mean observation period of 4 years, sufficient survival rates for zirconia-based posterior FPDs could be verified. The main complications included fracture of the ceramic veneering material and decementation, which occurred mainly in the mandible."],["dc.identifier.pmid","20305852"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6042"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61265"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","0893-2174"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.subject.ddc","610"],["dc.subject.mesh","Adult"],["dc.subject.mesh","Aged"],["dc.subject.mesh","Dental Restoration Failure"],["dc.subject.mesh","Denture Design"],["dc.subject.mesh","Denture, Partial, Fixed"],["dc.subject.mesh","Female"],["dc.subject.mesh","Follow-Up Studies"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Male"],["dc.subject.mesh","Middle Aged"],["dc.subject.mesh","Prospective Studies"],["dc.subject.mesh","Survival Analysis"],["dc.subject.mesh","Tooth, Artificial"],["dc.subject.mesh","Treatment Outcome"],["dc.subject.mesh","Zirconium"],["dc.title","Prospective evaluation of zirconia posterior fixed partial dentures: four-year clinical results."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","625"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","QUINTESSENCE INTERNATIONAL"],["dc.bibliographiccitation.lastpage","633"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Rinke, Sven"],["dc.contributor.author","Tsigaras, Athanasios"],["dc.contributor.author","Huels, Alfons"],["dc.contributor.author","Roediger, Matthias"],["dc.date.accessioned","2018-11-07T08:52:08Z"],["dc.date.available","2018-11-07T08:52:08Z"],["dc.date.issued","2011"],["dc.description.abstract","Objective: To evaluate the long-term performance of conventionally luted In-Ceram crowns with a maximum follow-up period of 18.6 years. Method and Materials: Eighty patients (39 females and 41 males) were treated at the University of Gottingen with a total of 272 In-Ceram restorations (163 anterior and 109 posterior). All participated in a clinical follow-up examination (mean observational period, 13.5 +/- 3.6 years). Time-dependent crown survival (in situ criteria) and success rates (event-free restorations) were calculated according to Kaplan-Meier and analyzed in relation to the crown position (anterior vs posterior crowns) using a Cox regression model. Results: Forty-three complete failures (overall survival, 80.5%) were recorded; 73.4% remained event-free after 15 years. Of the 163 anterior restorations, 18 crowns failed (9 fractures and 9 biologic reasons), resulting in a survival rate of 87.5% after 15 years (success rate, 82.7%). The remaining complete failures (10 fractures, 8 biologic reasons, and 7 changes of treatment plan) were recorded for posterior crowns (survival rate, 68.3%; success rate, 56.9%). Cox regression revealed a significant difference in survival (P = .00523) and success rates (P = .000297) of anterior and posterior crowns. Conclusion: The survival and success rates of anterior In-Ceram crowns at 15 years are comparable to those published for metal-ceramic crowns. Significantly lower survival rates and an increased rate of complications should be expected if In-Ceram crowns are placed on premolars and molars. Chipping of the veneering material was the most frequent technical complication in the posterior area. (Quintessence Int 2011;42:625-633)"],["dc.identifier.isi","000295786400003"],["dc.identifier.pmid","21842002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22095"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Quintessence Publishing Co Inc"],["dc.relation.issn","0033-6572"],["dc.title","An 18-year retrospective evaluation of glass-infiltrated alumina crowns"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Dental Research Journal"],["dc.bibliographiccitation.lastpage","11"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Gersdorff, Nikolaus"],["dc.contributor.author","Miró, Xavier"],["dc.contributor.author","Roediger, Matthias"],["dc.contributor.author","Geffers, Robert"],["dc.contributor.author","Huels, Alfons"],["dc.contributor.author","Miosge, Nicolai"],["dc.contributor.author","Toepfer, Tanja"],["dc.date.accessioned","2019-07-10T08:12:53Z"],["dc.date.available","2019-07-10T08:12:53Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: In the periodontium, the functions of the cell populations regarding the host-mediated tissue destruction in health and disease are not well understood. The purpose of this study was to measure the expression of genes differentially expressed in chronically inflamed periodontal ligament (PDL) cells compared to healthy PDL cells. Methods: We compared the genome-wide gene expressions of chronically inflamed and healthy PDL cells by microarray analysis, and validated the data by real-time RT-PCR to identify the genes that might play distinct roles in chronic periodontal disease in vivo. Results: The expression rates of 14,239 genes were investigated and 3,165 of them were found differentially expressed by at least two-fold; the expression rates of 1,515 genes were significantly upregulated and the expression rates of 1,650 genes were significantly downregulated in inflamed PDL cells. Conclusion: We focused on mainly structural components, for example, laminins and integrins, as well as degrading enzymes, for example, MMPs and cathepsins. The molecular composition of the laminin network varies in chronically inflamed compared to healthy PDL cells in vivo. Furthermore, integrin alpha6beta4, together with laminin-332, might be involved in chronic periodontal inflammation. Diverse keratins were upregulated, indicating that the epithelial cell rests of Malassez might also be involved in chronic periodontitis. The microarray analysis has identified a profile of genes potentially involved in chronic periodontal inflammation in vivo."],["dc.identifier.fs","432816"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4309"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61070"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Gene Expression Analysis of Chronically Inflamed and Healthy Human Periodontal Ligament Cells in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]