Kauffmann, Philipp

[["dc.bibliographiccitation.artnumber","189"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Molecular and Clinical Oncology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Hoene, Georg"],["dc.contributor.author","Gruber, Rudolf"],["dc.contributor.author","Leonhard, Johanna"],["dc.contributor.author","Wiechens, Bernhard"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.date.accessioned","2021-08-12T07:46:07Z"],["dc.date.available","2021-08-12T07:46:07Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.3892/mco.2021.2351"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88623"],["dc.notes.intern","DOI Import GROB-448"],["dc.relation.eissn","2049-9469"],["dc.relation.issn","2049-9450"],["dc.title","Combined quality of life and posttraumatic growth evaluation during follow‑up care of patients suffering from oral squamous cell carcinoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1095"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Cranio-Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","1103"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.contributor.author","Krohn, Sebastian"],["dc.contributor.author","Thiemann, Charlotte"],["dc.contributor.author","Schulz, Xenia"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Schlottig, Falk"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Gruber, Rudolf Matthias"],["dc.date.accessioned","2018-11-07T10:11:07Z"],["dc.date.available","2018-11-07T10:11:07Z"],["dc.date.issued","2016"],["dc.description.abstract","The present study aimed to evaluate primary stability (PS) and osseointegration of dental implants in polylactide [70/30 poly(L-lactide-co-o, L-lactide); (PLDLA)1 modified bone in 30 Goettingen minipigs. Each animal received three implants per jaw quadrant. In a split -mouth design, one side of the maxilla and mandible was randomly allocated to the experimental treatment (PLDLA applied into the drill hole before implantation), while the contralateral sides served as intraindividual controls (no PLDLA applied). The required insertion torque and the implant stability quotient (ISQ) were measured during implantation. ISQ volume density (VD) of new bone formation (NBF), and the bone -implant contact (BIC) were evaluated at the end of the observation period (1, 3, 6, 12, and 24 months, respectively) in six animals each. Across all study groups, the PLDLA treatment resulted in a) a comparable insertion torque, b) an equivalent ISQ c) a reduced BIC, and d) a reduced VD of NBF, as opposed to the untreated controls. In conclusion, the PLDLA treatment did not affect the PS, but rather led to an impaired osseointegration, which was particularly strong in the compact mandibular bone, and decreased in the spongious maxillary bone. PLDLA induced anchoring in spongious bone should be evaluated in further investigations. (C) 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved."],["dc.description.sponsorship","Thommen Medical AG, Grenchen, Switzerland"],["dc.identifier.doi","10.1016/j.jcms.2016.05.025"],["dc.identifier.isi","000381322200029"],["dc.identifier.pmid","27346283"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39987"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Churchill Livingstone"],["dc.relation.issn","1878-4119"],["dc.relation.issn","1010-5182"],["dc.title","Primary stability and osseointegration of dental implants in polylactide modified bone - A pilot study in Goettingen minipigs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1223"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Clinical Oral Investigations"],["dc.bibliographiccitation.lastpage","1234"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Goldstein, Jan"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Epple, Matthias"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2018-06-25T07:45:51Z"],["dc.date.available","2018-06-25T07:45:51Z"],["dc.date.issued","2018-04"],["dc.description.abstract","(1) Objectives: The aim of the present study was to test the hypothesis that the ratio of angiogenic and osteogenic signaling affects ectopic bone formation when delivered in different amounts. (2) Materials and methods: Porous composite PDLLA/CaCO3 scaffolds were loaded with rhBMP2 and rhVEGF in different dosage combinations and implanted into the gluteal muscles of 120 adult male Wistar rats. Bone formation and expression of alkaline phosphatase and Runx2 were quantified by histomorphometry. Spatial distribution across the scaffolds was assessed by using a grid that discriminated between the periphery and center of the scaffolds. (3) Results: The evaluation showed that the combined delivery of bone morphogenetic protein BMP2 and VEGF in different dosage combinations did not enhance the overall quantity of ectopic bone formation compared to the delivery of BMP2 alone. The addition of VEGF generally upregulated Runx2 after 4 weeks, which may have retarded terminal osteogenic differentiation. However, slow combined delivery of 1.5–2.0 μg BMP2 combined with 50 ng VEGF165 over a period of 5 weeks supported a more even distribution of bone formation across the implanted scaffolds whereas higher amounts of VEGF did not elicit this effect. (4) Conclusions: The findings suggest that structural organization rather than the quantity of ectopic bone formation is affected by the dosage and the ratio of BMP2 and VEGF levels at the observed intervals. Clinical relevance The development of carriers for dual growth factor delivery has to take into account the necessity to carefully balance the ratio of growth release."],["dc.identifier.doi","10.1007/s00784-017-2202-3"],["dc.identifier.pmid","28936783"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15134"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1436-3771"],["dc.title","Experimental variation of the level and the ratio of angiogenic and osteogenic signaling affects the spatiotemporal expression of bone-specific markers and organization of bone formation in ectopic sites"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","194760352096706"],["dc.bibliographiccitation.journal","CARTILAGE"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Schubert, Andrea"],["dc.contributor.author","Altherr, Manuel"],["dc.contributor.author","Gelis, Thomas"],["dc.contributor.author","Miosge, Nicolai"],["dc.date.accessioned","2021-04-14T08:31:21Z"],["dc.date.available","2021-04-14T08:31:21Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1177/1947603520967069"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83568"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1947-6043"],["dc.relation.issn","1947-6035"],["dc.title","SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1618"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery"],["dc.bibliographiccitation.lastpage","1629"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Troeltzsch, Matthias"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Gruber, Rudolph"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Rau, Anna"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2018-06-25T07:48:54Z"],["dc.date.available","2018-06-25T07:48:54Z"],["dc.date.issued","2016-10"],["dc.description.abstract","To evaluate the efficacy of grafting materials in lateral and vertical ridge augmentations."],["dc.identifier.doi","10.1016/j.jcms.2016.07.028"],["dc.identifier.pmid","27622971"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15135"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1878-4119"],["dc.title","Clinical efficacy of grafting materials in alveolar ridge augmentation: A systematic review"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","11"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"],["dc.bibliographiccitation.lastpage","15"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Cordesmeyer, Robert"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Tröltzsch, Markus"],["dc.contributor.author","Sömmer, Christian"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Bremmer, Felix"],["dc.contributor.author","Laskawi, Rainer"],["dc.date.accessioned","2018-10-10T09:37:57Z"],["dc.date.available","2018-10-10T09:37:57Z"],["dc.date.issued","2017-07"],["dc.description.abstract","Deep neck infections are among the most dangerous acute diseases in the head and neck region. This analysis gives an overview of the bacterial and histopathologic findings of deep neck infections."],["dc.identifier.doi","10.1016/j.oooo.2017.02.003"],["dc.identifier.gro","631840"],["dc.identifier.pmid","28411005"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15934"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","2212-4411"],["dc.title","Bacterial and histopathological findings in deep head and neck infections: a retrospective analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","453"],["dc.bibliographiccitation.issue","3-4"],["dc.bibliographiccitation.journal","Clinical Hemorheology and Microcirculation"],["dc.bibliographiccitation.lastpage","457"],["dc.bibliographiccitation.volume","67"],["dc.contributor.author","Kauffmann, P."],["dc.contributor.author","Troeltzsch, M."],["dc.contributor.author","Cordesmeyer, R."],["dc.contributor.author","Heidekrueger, P.I."],["dc.contributor.author","Schliephake, H."],["dc.contributor.author","Canis, M."],["dc.contributor.author","Wolff, H.A."],["dc.contributor.author","Rave-Fraenk, M."],["dc.contributor.author","Stroebel, P."],["dc.contributor.author","Kehrer, A."],["dc.contributor.author","Prantl, L."],["dc.contributor.author","Aung, T."],["dc.contributor.editor","Jünger, M."],["dc.contributor.editor","Krüger-Genge, A."],["dc.contributor.editor","Jung, F."],["dc.date.accessioned","2020-12-10T18:44:09Z"],["dc.date.available","2020-12-10T18:44:09Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.3233/CH-179226"],["dc.identifier.eissn","1875-8622"],["dc.identifier.issn","1386-0291"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78345"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Presentation of a variation of the chorioallantoic membrane set up as a potential model for individual therapy for squamous cell carcinoma of the oropharynx"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","20"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Oral surgery, oral medicine, oral pathology and oral radiology"],["dc.bibliographiccitation.lastpage","28"],["dc.bibliographiccitation.volume","123"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Hahn, Wolfram"],["dc.contributor.author","Sievers, Niklas"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Hohloch, Karin"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.contributor.author","Cordesmeyer, Robert"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Gruber, Rudolf Matthias"],["dc.date.accessioned","2018-06-25T07:43:01Z"],["dc.date.available","2018-06-25T07:43:01Z"],["dc.date.issued","2017-01"],["dc.description.abstract","We compared the intraindividual effects of increasing zoledronic acid (ZA) concentrations on osteoblast-like cells with different embryologic origins."],["dc.fs.pkfprnr","2489"],["dc.identifier.doi","10.1016/j.oooo.2016.08.010"],["dc.identifier.fs","626267"],["dc.identifier.pmid","27720655"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15133"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","2212-4411"],["dc.title","Osteoblast-like cells with different embryologic origins behave differently in increasing zoledronic acid concentrations: a pilot study in pigs"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1065"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Clinical Oral Investigations"],["dc.bibliographiccitation.lastpage","1070"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Cordesmeyer, Robert"],["dc.contributor.author","Winterhoff, Jan"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Laskawi, Rainer"],["dc.date.accessioned","2018-11-07T10:13:42Z"],["dc.date.available","2018-11-07T10:13:42Z"],["dc.date.issued","2016"],["dc.description.abstract","The diagnosis and therapy of obstructive inflammatory disorders of the salivary glands have changed in the past decades following the introduction of sialoendoscopy. The aims of the present study were to analyze the relevance of sialoendoscopy using our own data and to compare the results to those of other studies. A retrospective analysis of 70 patients was performed, who were treated for obstructive disorders of the parotid and/or submandibular gland in whom sialoendoscopy was indicated. Two categories of interventions were considered: diagnostic interventional sialoendoscopy and endoscope-assisted interventions. Interventional sialoendoscopy procedures requiring extirpation of the gland were included in the analysis, as were abnormal intraductal processes that were detected during endoscopy. Treatment was successful in 58 of 67 (86.6 %) procedures (sialoendoscopy without surgical intervention n = 59; endoscope-assisted surgical intervention n = 8). Based on the underlying disease, the success rate was 88.6 % (n = 39) in patients with obstructive sialadenitis without sialolithiasis and 86.6 % (n = 19) in patients with sialolithiasis. It was not possible to draw definitive conclusions on the underlying disease from the observed pathological intraductal changes. Sialoendoscopy is an effective and safe diagnostic and therapeutic option with low complication rate. However, limiting factors such as the size or the position of potentially removable obstacles must be taken into consideration. The rate of gland extirpations can be reduced using sialoendoscopy."],["dc.identifier.doi","10.1007/s00784-015-1588-z"],["dc.identifier.isi","000376403200020"],["dc.identifier.pmid","26362777"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40487"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1436-3771"],["dc.relation.issn","1432-6981"],["dc.title","Sialoendoscopy as a diagnostic and therapeutic option for obstructive diseases of the large salivary glands-a retrospective analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1784"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of Cranio-Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","1787"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Cordesmeyer, Robert"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Tröltzsch, Markus"],["dc.contributor.author","Laskawi, Rainer"],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Bremmer, Felix"],["dc.date.accessioned","2018-10-10T09:31:29Z"],["dc.date.available","2018-10-10T09:31:29Z"],["dc.date.issued","2017-11"],["dc.description.abstract","Adenoid cystic carcinomas are rare malignant tumors of the salivary glands. They are characterized by a high rate of local recurrence, late distant metastasis and a poor disease-free survival. In this study, we analyzed a series of 61 patients who were all treated at the University of Göttingen over a period of 21.0 years."],["dc.identifier.doi","10.1016/j.jcms.2017.08.004"],["dc.identifier.gro","631841"],["dc.identifier.pmid","28935487"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15932"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1878-4119"],["dc.title","Clinical prognostic factors of salivary adenoid cystic carcinoma: A single-center analysis of 61 patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]