Kauffmann, Philipp

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical Case Reports"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Geisenhainer, Katharina"],["dc.contributor.author","Klenke, Daniela"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Kurbad, Oliver"],["dc.contributor.author","Bremmer, Felix"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Schliephake, H."],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.date.accessioned","2022-02-01T10:32:02Z"],["dc.date.available","2022-02-01T10:32:02Z"],["dc.date.issued","2022"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.1002/ccr3.5268"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/99006"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-517"],["dc.relation.eissn","2050-0904"],["dc.relation.issn","2050-0904"],["dc.rights","CC BY 4.0"],["dc.rights.uri","http://creativecommons.org/licenses/by-nc/4.0/"],["dc.title","Desmoid fibromatosis in the pharyngeal wall: A case report and literature review"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","jbm.a.37411"],["dc.bibliographiccitation.firstpage","1599"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Biomedical Materials Research Part A"],["dc.bibliographiccitation.lastpage","1615"],["dc.bibliographiccitation.volume","110"],["dc.contributor.affiliation","Behrens, Christina; 1\r\nDepartment of Oral and Maxillofacial Surgery\r\nGeorge‐Augusta‐University\r\nGöttingen Germany"],["dc.contributor.affiliation","Kauffmann, Philipp; 1\r\nDepartment of Oral and Maxillofacial Surgery\r\nGeorge‐Augusta‐University\r\nGöttingen Germany"],["dc.contributor.affiliation","von Hahn, Nikolaus; 1\r\nDepartment of Oral and Maxillofacial Surgery\r\nGeorge‐Augusta‐University\r\nGöttingen Germany"],["dc.contributor.affiliation","Giesecke, Ariane; 1\r\nDepartment of Oral and Maxillofacial Surgery\r\nGeorge‐Augusta‐University\r\nGöttingen Germany"],["dc.contributor.affiliation","Schirmer, Uwe; 2\r\nInstitute for Bioprocessing and Analytical Measurement Techniques\r\nHeiligenstadt Germany"],["dc.contributor.affiliation","Liefeith, Klaus; 2\r\nInstitute for Bioprocessing and Analytical Measurement Techniques\r\nHeiligenstadt Germany"],["dc.contributor.author","Behrens, Christina"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Hahn, Nikolaus"],["dc.contributor.author","Giesecke, Ariane"],["dc.contributor.author","Schirmer, Uwe"],["dc.contributor.author","Liefeith, Klaus"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2022-06-01T09:39:01Z"],["dc.date.available","2022-06-01T09:39:01Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-11T13:14:12Z"],["dc.description.abstract","Abstract\r\nThe aim of the present study was to establish a modular platform of poly‐L‐lysine‐heparin (PLL‐Hep) polyelectrolyte multilayer (PEM) coatings on titanium surfaces for dual growth factor delivery of recombinant human bone morphogenic protein 2 (rhBMP2) and recombinant human vascular endothelial growth factor 165 (rhVEGF165) in clinically relevant quantities. Release characteristics for both growth factors differed significantly depending on film architecture. rhBMP2 induced activation of alkaline phosphatase in C2C12 cells and proliferation of human mesenchymal stem cells (hMSCs). rhVEGF mediated induction of von Willebrand factor (vWF) in hMSCs and proliferation of human umbilical vein endothelial cells. Osteogenic and angiogenic effects were modified by variation in cross‐linking and architecture of the PEMs. By creating multilayer films with distinct zones, release characteristics and proportion of both growth factor delivery could be tuned and surface‐activity modified to enhance angiogenic or osteogenic function in various ways. In summary, the system provides a modular platform for growth factor delivery that allows for individual composition and accentuation of angiogenic and osteogenic surface properties."],["dc.description.sponsorship","German Research Foundation (DFG)"],["dc.identifier.doi","10.1002/jbm.a.37411"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108367"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-572"],["dc.publisher","John Wiley & Sons, Inc."],["dc.relation.eissn","1552-4965"],["dc.relation.issn","1549-3296"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made."],["dc.rights.uri","http://creativecommons.org/licenses/by-nc-nd/4.0/"],["dc.title","Development of a system of heparin multilayers on titanium surfaces for dual growth factor release"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","41"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","International Journal of Implant Dentistry"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Stünkel, Robert"],["dc.contributor.author","Zeller, Alexander-Nicolai"],["dc.contributor.author","Bohne, Thomas"],["dc.contributor.author","Böhrnsen, Florian"],["dc.contributor.author","Wedi, Edris"],["dc.contributor.author","Raschke, David"],["dc.contributor.author","Kauffmann, Philipp"],["dc.date.accessioned","2022-10-10T06:18:06Z"],["dc.date.available","2022-10-10T06:18:06Z"],["dc.date.issued","2022-10-06"],["dc.date.updated","2022-10-09T03:11:11Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Nowadays, 3D planning and static for dynamic aids play an increasing role in oral rehabilitation of the masticatory apparatus with dental implants. The aim of this study is to compare the accuracy of implant placement using a 3D-printed drilling guide and an intraoral real-time dynamic navigation system.\r\n \r\n \r\n Methods\r\n A total of 60 implants were placed on 12 partially edentulous lower jaw models. 30 were placed with pilot drilling guides, the other half with dynamic navigation (DENACAM®). In addition, implant placement in interdental gaps and free-end situations were investigated. Accuracy was assessed by cone-beam computed tomography (CBCT).\r\n \r\n \r\n Results\r\n Both systems achieved clinically acceptable results, yet more accurate results regarding the offset of implant base and tip in several spatial dimensions were achieved using drilling guides (each p < 0.05). With regard to angulation, real-time navigation was more precise (p = 0.0016). Its inaccuracy was 3°; the template-guided systems was 4.6°. Median horizontal deviation was 0.52 mm at base and 0.75 mm at tip using DENACAM®. When using the pilot drill guide, horizontal deviation was 0.34 mm in the median and at the tip by 0.59 mm. Regarding angulation, it was found that the closer the drill hole was to the system's marker, the better navigation performed. The template did not show this trend (p = 0.0043; and p = 0.0022).\r\n \r\n \r\n Conclusion\r\n Considering the limitations of an in vitro study, dynamic navigation can be used be a tool for reliable and accurate implantation. However, further clinical studies need to follow in order to provide an evidence-based recommendation for use in vivo."],["dc.identifier.citation","International Journal of Implant Dentistry. 2022 Oct 06;8(1):41"],["dc.identifier.doi","10.1186/s40729-022-00430-6"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/116164"],["dc.language.iso","en"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","Dental implants"],["dc.subject","Guided surgery"],["dc.subject","Stereotactic surgery"],["dc.subject","Referencing"],["dc.subject","Intraoral real-time navigation"],["dc.subject","Static templates"],["dc.subject","Implant accuracy"],["dc.title","Accuracy of intraoral real-time navigation versus static, CAD/CAM-manufactured pilot drilling guides in dental implant surgery: an in vitro study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","clr.13820"],["dc.bibliographiccitation.firstpage","1228"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Clinical Oral Implants Research"],["dc.bibliographiccitation.lastpage","1240"],["dc.bibliographiccitation.volume","32"],["dc.contributor.affiliation","Raschke, David; 1Department for Oral & Maxillofacial Surgery Universitätsmedizin Goettingen Goettingen Germany"],["dc.contributor.affiliation","Tröltzsch, Markus; 2Private Office Ansbach Germany & Department for Oral & Maxillofacial Surgery Universitätsmedizin Goettingen Goettingen Germany"],["dc.contributor.affiliation","Santander, Petra; 3Department of Orthodontics Universitätsmedizin Göttingen Goettingen Germany"],["dc.contributor.affiliation","Brockmeyer, Phillip; 1Department for Oral & Maxillofacial Surgery Universitätsmedizin Goettingen Goettingen Germany"],["dc.contributor.affiliation","Schliephake, Henning; 1Department for Oral & Maxillofacial Surgery Universitätsmedizin Goettingen Goettingen Germany"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Raschke, David"],["dc.contributor.author","Tröltzsch, Markus"],["dc.contributor.author","Santander, Petra"],["dc.contributor.author","Brockmeyer, Phillip"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2021-09-01T06:42:53Z"],["dc.date.available","2021-09-01T06:42:53Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-21T09:20:33Z"],["dc.description.abstract","Abstract Aim To test the hypothesis that the use of rhBMP2 in established defects requires additional growth factors such as rhVEGF to accomplish effective bone repair. Materials and Methods Horizontal/vertical defects of 2 cm length and 1 cm height were created bilaterally in the alveolar crest of the maxillae of 18 minipigs together with the extraction of all premolar teeth and one molar tooth on both sides. After 3 months of healing, defects were augmented with 0.5 g particulate PDLLA/CaCO3 composite loaded with 400 µg rhBMP2/50 µg rhVEGF165 on one side and 800 µg rhBMP2 on the other in 12 test animals, whereas defects in six control animals were sham operated and left unfilled on one side and augmented with blank carriers on the other. After 4 and 13 weeks, the animals were evaluated each for area of new bone formation (mm²) and bone density (area %). Results Augmentations with carriers loaded with 800 g µrhBMP2 failed to induce significantly more bone than in the augmentations with unloaded carrier after 4 and 13 weeks (p = .1000, p = .381). Augmentations with carriers loaded with 400 µg rhBMP2 and 50 µg erhVEGF165 resulted in significantly increased bone formation after 13 weeks (p = .024) compared to blank carriers. Soft tissue in augmentations with combined rhBMP2/rhVEGF165 loading exhibited numerous microvessels compared to soft tissue in augmentations with rhBMP2. Conclusions It is concluded that effective bone regeneration in augmentations of established alveolar ridge defects may require the application of rhVEGF additionally to rhBMP2."],["dc.description.sponsorship","KLS MARTIN"],["dc.identifier.doi","10.1111/clr.13820"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89167"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-455"],["dc.relation.eissn","1600-0501"],["dc.relation.issn","0905-7161"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."],["dc.title","The use of rhBMP2 for augmentation of established horizontal/vertical defects may require additional use of rhVEGF to achieve significant bone regeneration: An in vivo experimental study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","33"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The Journal of Pathology: Clinical Research"],["dc.bibliographiccitation.lastpage","47"],["dc.bibliographiccitation.volume","8"],["dc.contributor.affiliation","Fichtner, Alexander; 1\r\nInstitute of Pathology\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Joost, Jasmin; 1\r\nInstitute of Pathology\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Brockmeyer, Philipp; 2\r\nDepartment of Oral and Maxillofacial Surgery\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Kauffmann, Philipp; 2\r\nDepartment of Oral and Maxillofacial Surgery\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Schliephake, Henning; 2\r\nDepartment of Oral and Maxillofacial Surgery\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Hammerstein‐Equord, Alexander; 3\r\nDepartment of Thoracic and Cardiovascular Surgery\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Kueffer, Stefan; 1\r\nInstitute of Pathology\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Urlaub, Henning; 4\r\nBioanalytical Mass Spectrometry Group\r\nMax Planck Institute for Biophysical Chemistry\r\nGöttingen Germany"],["dc.contributor.affiliation","Oellerich, Thomas; 6\r\nDepartment of Medicine II, Haematology/Oncology\r\nGoethe University\r\nFrankfurt Germany"],["dc.contributor.affiliation","Ströbel, Philipp; 1\r\nInstitute of Pathology\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Bohnenberger, Hanibal; 1\r\nInstitute of Pathology\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Bremmer, Felix; 1\r\nInstitute of Pathology\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.author","Richter, Annika"],["dc.contributor.author","Fichtner, Alexander"],["dc.contributor.author","Joost, Jasmin"],["dc.contributor.author","Brockmeyer, Philipp"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Hammerstein‐Equord, Alexander"],["dc.contributor.author","Kueffer, Stefan"],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Oellerich, Thomas"],["dc.contributor.author","Bremmer, Felix"],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Bohnenberger, Hanibal"],["dc.date.accessioned","2021-12-01T09:23:20Z"],["dc.date.available","2021-12-01T09:23:20Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-20T23:05:20Z"],["dc.description.abstract","Abstract The differentiation between a pulmonary metastasis and a newly developed squamous cell carcinoma of the lung in patients with prior head and neck squamous cell carcinoma (HNSCC) is difficult due to a lack of biomarkers but is crucially important for the prognosis and therapy of the affected patient. By using high‐resolution mass spectrometry in combination with stable isotope labelling by amino acids in cell culture, we identified 379 proteins that are differentially expressed in squamous cell carcinomas of the lung and the head and neck. Of those, CAV1, CAV2, LGALS1, LGALS7, CK19, and UGDH were tested by immunohistochemistry on 194 tissue samples (98 lung and 96 HNSCCs). The combination of CAV1 and LGALS7 was able to distinguish the origin of the squamous cell carcinoma with high accuracy (area under the curve 0.876). This biomarker panel was tested on a cohort of 12 clinically classified lung tumours of unknown origin after HNSCC. Nine of those tumours were immunohistochemically classifiable."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1002/cjp2.244"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94624"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","2056-4538"],["dc.rights","CC BY-NC-ND 4.0"],["dc.title","Quantitative proteomics identifies biomarkers to distinguish pulmonary from head and neck squamous cell carcinomas by immunohistochemistry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","162"],["dc.bibliographiccitation.journal","European Cells and Materials"],["dc.bibliographiccitation.lastpage","179"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Moser, N"],["dc.contributor.author","Lohse, N"],["dc.contributor.author","Goldstein, J"],["dc.contributor.author","Kauffmann, P"],["dc.contributor.author","Sven, B"],["dc.contributor.author","Epple, M"],["dc.contributor.author","Schliephake, H"],["dc.contributor.authorgroup","Department of Oral and Maxillofacial Surgery, George-Augusta-University, Robert-Koch-Str. 40, 37075 Göttingen, Germany"],["dc.date.accessioned","2021-06-01T10:48:39Z"],["dc.date.available","2021-06-01T10:48:39Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.22203/eCM.v034a11"],["dc.identifier.pmid","28980278"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17007"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86006"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.intern","Merged from goescholar"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Do we need retarded delivery of bone growth factors in facial bone repair? An experimental study in rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","7803"],["dc.bibliographiccitation.issue","14"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.volume","23"],["dc.contributor.affiliation","Behrens, Christina; 1Department of Oral and Maxillofacial Surgery, George-Augusta-University, 37075 Göttingen, Germany; cbehren@gwdg.de (C.B.); philipp.kauffmann@med.uni-goettingen.de (P.K.); nikolaus.von-hahn@med.uni-goettingen.de (N.v.H.)"],["dc.contributor.affiliation","Kauffmann, Philipp; 1Department of Oral and Maxillofacial Surgery, George-Augusta-University, 37075 Göttingen, Germany; cbehren@gwdg.de (C.B.); philipp.kauffmann@med.uni-goettingen.de (P.K.); nikolaus.von-hahn@med.uni-goettingen.de (N.v.H.)"],["dc.contributor.affiliation","von Hahn, Nikolaus; 1Department of Oral and Maxillofacial Surgery, George-Augusta-University, 37075 Göttingen, Germany; cbehren@gwdg.de (C.B.); philipp.kauffmann@med.uni-goettingen.de (P.K.); nikolaus.von-hahn@med.uni-goettingen.de (N.v.H.)"],["dc.contributor.affiliation","Schirmer, Uwe; 2Institute for Bioprocessing and Analytical Measurement Techniques, 37308 Heiligenstadt, Germany; uwe.schirmer@iba-heiligenstadt.de (U.S.); klaus.liefeith@iba-heiligenstadt.de (K.L.)"],["dc.contributor.affiliation","Liefeith, Klaus; 2Institute for Bioprocessing and Analytical Measurement Techniques, 37308 Heiligenstadt, Germany; uwe.schirmer@iba-heiligenstadt.de (U.S.); klaus.liefeith@iba-heiligenstadt.de (K.L.)"],["dc.contributor.affiliation","Schliephake, Henning; 1Department of Oral and Maxillofacial Surgery, George-Augusta-University, 37075 Göttingen, Germany; cbehren@gwdg.de (C.B.); philipp.kauffmann@med.uni-goettingen.de (P.K.); nikolaus.von-hahn@med.uni-goettingen.de (N.v.H.)"],["dc.contributor.author","Behrens, Christina"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","von Hahn, Nikolaus"],["dc.contributor.author","Schirmer, Uwe"],["dc.contributor.author","Liefeith, Klaus"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2022-09-01T09:51:11Z"],["dc.date.available","2022-09-01T09:51:11Z"],["dc.date.issued","2022"],["dc.date.updated","2022-09-04T01:30:20Z"],["dc.description.abstract","The aim of the present study was to develop a collagen/heparin-based multilayer coating on titanium surfaces for retarded release of recombinant human bone morphogenic protein 2 (rhBMP2) to enhance the osteogenic activity of implant surfaces. Polyelectrolyte multilayer (PEM) coatings were constructed on sandblasted/acid-etched surfaces of titanium discs using heparin and collagen. PEM films of ten double layers were produced and overlayed with 200 µL of a rhBMP2 solution containing 15 µg rhBMP2. Subsequently, cross-linking of heparin molecules was performed using EDC/NHS chemistry to immobilize the incorporated rhBMP2. Release characteristics for 3 weeks, induction of Alkaline Phosphatase (ALP) in C2C12 cells and proliferation of human mesenchymal stem cells (hMSCs) were evaluated to analyze the osteogenic capacity of the surface. The coating incorporated 10.5 µg rhBMP2 on average per disc and did not change the surface morphology. The release profile showed a delivery of 14.5% of the incorporated growth factor during the first 24 h with a decline towards the end of the observation period with a total release of 31.3%. Cross-linking reduced the release with an almost complete suppression at 100% cross-linking. Alkaline Phosphatase was significantly increased on day 1 and day 21, indicating that the growth factor bound in the coating remains active and available after 3 weeks. Proliferation of hMSCs was significantly enhanced by the non-cross-linked PEM coating. Nanocoating using collagen/heparin-based PEMs can incorporate clinically relevant amounts of rhBMP2 on titanium surfaces with a retarded release and a sustained enhancement of osteogenic activity without changing the surface morphology."],["dc.description.sponsorship","German Research Foundation (DFG)"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3390/ijms23147803"],["dc.identifier.pii","ijms23147803"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113903"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","1422-0067"],["dc.rights","CC BY 4.0"],["dc.title","Collagen-Based Osteogenic Nanocoating of Microrough Titanium Surfaces"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Case Reports in Dentistry"],["dc.bibliographiccitation.lastpage","8"],["dc.bibliographiccitation.volume","2018"],["dc.contributor.author","Santander, P."],["dc.contributor.author","Schwaibold, E. M. C."],["dc.contributor.author","Bremmer, F."],["dc.contributor.author","Batschkus, S."],["dc.contributor.author","Kauffmann, P."],["dc.date.accessioned","2019-07-09T11:45:55Z"],["dc.date.available","2019-07-09T11:45:55Z"],["dc.date.issued","2018"],["dc.description.abstract","We report a case of multiple keratocysts first diagnosed in an 8-year-old boy. Case report. The incidental radiographic finding of a cystic lesion in an 8-year-old boy led to the surgical enucleation and further diagnosis of a keratocyst associated with a tooth crown. In the course of dental maturation from deciduous to permanent teeth, the boy presented new lesions, always associated with the crowns of teeth. Gorlin-Goltz (nevoid basal-cell carcinoma) syndrome was suspected, and the genetic analysis detected a previously undescribed germline variant in the PTCH1 gene. Treatment. This included a surgical removal of the cystic lesions, as well as the affected teeth. Follow-up. Due to the high recurrence rate of the keratocysts, frequent radiological checks were performed over a 5-year period."],["dc.identifier.doi","10.1155/2018/7594840"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15343"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59336"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2090-6455"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Multiple, Multiloculated, and Recurrent Keratocysts of the Mandible and Maxilla in Association with Gorlin-Goltz (Nevoid Basal-Cell Carcinoma) Syndrome: A Pediatric Case Report and Follow-up over 5 Years"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","18"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Maxillofacial Plastic and Reconstructive Surgery"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Cordesmeyer, Robert"],["dc.contributor.author","Fouellefack, Giséle Awondzeko"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Wiese, Karl-Günther"],["dc.date.accessioned","2019-07-09T11:45:43Z"],["dc.date.available","2019-07-09T11:45:43Z"],["dc.date.issued","2018"],["dc.description.abstract","Background: Clefts in newborns are associated with severe morphological and functional impairment. Especially the lip is of importance as if the treatment result is unsatisfactory, it can lead to psychological changes in the patient. Different operative procedures have been developed over the last decades. The aim of the presented study was the comparison of the surgical techniques according to Millard and Pfeifer regarding the temporal development of the postoperative symmetry of the lip height and mouth width. Methods: Digitized photographs of patients from the department of oral and maxillofacial surgery at the University of Göttingen were evaluated from 1979 to 1996. With a video analysis program, the lip height and mouth width were analyzed regarding the symmetry. We demonstrated the symmetry values over a period of 8 years in order to show the influence of growth on postoperative results. Results: The development of the vertical symmetry of the Philtrum and the lip vermillion on the cleft side in comparison to the healthy side behaves differently depending on Pfeifer and Millard. The lip height of the cleft lip was shorter in both techniques than on the healthy side, but Pfeifer's difference was significantly more pronounced. The lip vermillion height on the cleft side was slightly shorter in the Millard group and markedly larger in the Pfeifer group. Both techniques can achieve good symmetry results for the vertical dimension of the lip. According to Pfeifer, the development of the horizontal dimension on the cleft side is bigger within the first 4 years than on the healthy side; according to the Millard technique, the horizontal development is smaller. These differences are greater within the first 6 years and approach between the 6th and 8th year. Conclusions: The Millard technique demonstrates better results concerning the philtrum and vermillion symmetry during growth within the first 6 years. Over the whole study period, growth corrects the philtrum and vermillion symmetry within the Pfeifer group."],["dc.identifier.doi","10.1186/s40902-018-0157-1"],["dc.identifier.pmid","30105221"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15255"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59294"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/15294 but duplicate"],["dc.relation.issn","2288-8101"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)."],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Postoperative long-term results for the comparison of the symmetry of the upper lip during lip closure according to Millard and Pfeifer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Gastroenterology"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Sportes, A."],["dc.contributor.author","CFM, Jung"],["dc.contributor.author","Gromski, M. A."],["dc.contributor.author","Koehler, P."],["dc.contributor.author","Seif Amir Hosseini, A."],["dc.contributor.author","Kauffmann, P."],["dc.contributor.author","Ellenrieder, V."],["dc.contributor.author","Wedi, E."],["dc.date.accessioned","2021-04-14T08:25:16Z"],["dc.date.available","2021-04-14T08:25:16Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1186/s12876-020-01344-6"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17395"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81573"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1471-230X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Novel modified endoscopic mucosal resection of large GI lesions (> 20 mm) using an external additional working channel (AWC) may improve R0 resection rate: initial clinical experience"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]