Böhrnsen, Florian

[["dc.bibliographiccitation.firstpage","1853-1857"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Oncology Letters"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Böhrnsen, Florian"],["dc.contributor.author","Enders, Christina"],["dc.contributor.author","Ludwig, Hans-Christoph"],["dc.contributor.author","Brück, Wolfgang"],["dc.contributor.author","Füzesi, Laszlo"],["dc.contributor.author","Gutenberg, Angelika"],["dc.date.accessioned","2018-06-26T08:12:45Z"],["dc.date.available","2018-06-26T08:12:45Z"],["dc.date.issued","2015-09"],["dc.description.abstract","Tumors of the pineal region (PR) are rare and can be subdivided into four main histomorphological groups: Pineal-parenchymal tumors (PPT), germ cell tumors (GCT), glial tumors and miscellaneous tumors. The appropriate pathological classification and grading of these malignancies is essential for determining the clinical management and prognosis. However, an early diagnosis is often delayed due to unspecific clinical symptoms, and histological support is not always decisive to identify the diversity of tumors of the PR. The present study aimed to characterize 18 tumors of the PR using comparative genomic hybridization. All the tumors were primarily surgically resected without any previous irradiation or chemotherapy. In addition to chromosomal aberrations in PPT and different GCTs of the PR, the present study described, for the first time, the chromosomal changes in a few rare entities (solitary-fibrous and neuroendocrine tumors) of the PR. The tumors in the study, regardless of histology and World Health Organization grade, were characterized by frequent gains at 7, 9q, 12q, 16p, 17 and 22q, and losses at 13q. While the detection of chromosomal aberrations in these tumors appears not to be indicative enough of histological entities and their grade of malignancy, the present data may be of use to select genes of interest for higher resolution genomic analyses."],["dc.identifier.doi","10.3892/ol.2015.3383"],["dc.identifier.pmid","26622764"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15149"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.title","Common molecularcytogenetic alterations in tumors originating from the pineal region"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","41"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","International Journal of Implant Dentistry"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Stünkel, Robert"],["dc.contributor.author","Zeller, Alexander-Nicolai"],["dc.contributor.author","Bohne, Thomas"],["dc.contributor.author","Böhrnsen, Florian"],["dc.contributor.author","Wedi, Edris"],["dc.contributor.author","Raschke, David"],["dc.contributor.author","Kauffmann, Philipp"],["dc.date.accessioned","2022-10-10T06:18:06Z"],["dc.date.available","2022-10-10T06:18:06Z"],["dc.date.issued","2022-10-06"],["dc.date.updated","2022-10-09T03:11:11Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Nowadays, 3D planning and static for dynamic aids play an increasing role in oral rehabilitation of the masticatory apparatus with dental implants. The aim of this study is to compare the accuracy of implant placement using a 3D-printed drilling guide and an intraoral real-time dynamic navigation system.\r\n \r\n \r\n Methods\r\n A total of 60 implants were placed on 12 partially edentulous lower jaw models. 30 were placed with pilot drilling guides, the other half with dynamic navigation (DENACAM®). In addition, implant placement in interdental gaps and free-end situations were investigated. Accuracy was assessed by cone-beam computed tomography (CBCT).\r\n \r\n \r\n Results\r\n Both systems achieved clinically acceptable results, yet more accurate results regarding the offset of implant base and tip in several spatial dimensions were achieved using drilling guides (each p < 0.05). With regard to angulation, real-time navigation was more precise (p = 0.0016). Its inaccuracy was 3°; the template-guided systems was 4.6°. Median horizontal deviation was 0.52 mm at base and 0.75 mm at tip using DENACAM®. When using the pilot drill guide, horizontal deviation was 0.34 mm in the median and at the tip by 0.59 mm. Regarding angulation, it was found that the closer the drill hole was to the system's marker, the better navigation performed. The template did not show this trend (p = 0.0043; and p = 0.0022).\r\n \r\n \r\n Conclusion\r\n Considering the limitations of an in vitro study, dynamic navigation can be used be a tool for reliable and accurate implantation. However, further clinical studies need to follow in order to provide an evidence-based recommendation for use in vivo."],["dc.identifier.citation","International Journal of Implant Dentistry. 2022 Oct 06;8(1):41"],["dc.identifier.doi","10.1186/s40729-022-00430-6"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/116164"],["dc.language.iso","en"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","Dental implants"],["dc.subject","Guided surgery"],["dc.subject","Stereotactic surgery"],["dc.subject","Referencing"],["dc.subject","Intraoral real-time navigation"],["dc.subject","Static templates"],["dc.subject","Implant accuracy"],["dc.title","Accuracy of intraoral real-time navigation versus static, CAD/CAM-manufactured pilot drilling guides in dental implant surgery: an in vitro study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","127"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Regenerative Medicine"],["dc.bibliographiccitation.lastpage","138"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Naujokat, Hendrik"],["dc.contributor.author","Lipp, Maximilian"],["dc.contributor.author","Açil, Yahya"],["dc.contributor.author","Wieker, Henning"],["dc.contributor.author","Birkenfeld, Falk"],["dc.contributor.author","Sengebusch, Andre"],["dc.contributor.author","Böhrnsen, Florian"],["dc.contributor.author","Wiltfang, Jörg"],["dc.date.accessioned","2020-12-10T18:43:40Z"],["dc.date.available","2020-12-10T18:43:40Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.2217/rme-2018-0031"],["dc.identifier.eissn","1746-076X"],["dc.identifier.issn","1746-0751"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78207"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Bone tissue engineering in the greater omentum is enhanced by a periosteal transplant in a miniature pig model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","035001"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Biomedical Materials"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Florian, Böhrnsen"],["dc.contributor.author","Michel, Krier"],["dc.contributor.author","Steffi, Grohmann"],["dc.contributor.author","Nicole, Hauptmann"],["dc.contributor.author","Frant, Marion"],["dc.contributor.author","Klaus, Liefeith"],["dc.contributor.author","Henning, Schliephake"],["dc.date.accessioned","2020-12-10T18:15:58Z"],["dc.date.available","2020-12-10T18:15:58Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1088/1748-605X/ab0362"],["dc.identifier.eissn","1748-605X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75008"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","MSC differentiation on two-photon polymerized, stiffness and BMP2 modified biological copolymers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2561"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","European Archives of Oto-Rhino-Laryngology"],["dc.bibliographiccitation.lastpage","2570"],["dc.bibliographiccitation.volume","269"],["dc.contributor.author","Böhrnsen, Florian"],["dc.contributor.author","Rotter, Nicole"],["dc.contributor.author","Lindner, Ulrich"],["dc.contributor.author","Meier, Markus"],["dc.contributor.author","Wollenberg, Barbara"],["dc.contributor.author","Rohwedel, Jürgen"],["dc.contributor.author","Kramer, Jan"],["dc.date.accessioned","2018-06-26T08:20:14Z"],["dc.date.available","2018-06-26T08:20:14Z"],["dc.date.issued","2012"],["dc.description.abstract","Mesenchymal stromal cells (MSC) have been introduced into the field of tissue-engineered airway transplantation. Since patients with extensive tracheal defects often require an open tracheotomy, this study investigated if MSC could be obtained from the adipose tissue of the neck during this procedure. Cells were isolated by plastic adherence from the adipose tissue of 8 patients. Cell isolates were analyzed for (i) proliferation, (ii) the expression of CD marker molecules and (iii) multilineage differentiation. The isolated spindle-shaped cells showed a high proliferation capacity and the flow cytometric analysis revealed a distinct population meeting the criteria for MSC. Using classical MSC cultivation protocols the characterized cells showed adipogenic, chondrogenic and osteogenic differentiation for all analyzed cell isolates. This study was able to demonstrate that sufficient amounts of stem/progenitor cells can be easily isolated from adipose tissue of the neck obtained during open tracheotomy. These cells may be a source for future tracheal replacement therapies."],["dc.identifier.doi","10.1007/s00405-012-1943-5"],["dc.identifier.pmid","22310837"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15150"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1434-4726"],["dc.title","Human mesenchymal stromal cells from adipose tissue of the neck"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","238"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Cranio-Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","245"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Böhrnsen, Florian"],["dc.contributor.author","Melsheimer, Petra"],["dc.contributor.author","Natorp, Mareike"],["dc.contributor.author","Rolf, Hans"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Wolfer, Susanne"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2021-04-14T08:28:56Z"],["dc.date.available","2021-04-14T08:28:56Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1016/j.jcms.2020.03.001"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82745"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","1010-5182"],["dc.title","Cotransplantation of mesenchymal stromal cells and endothelial cells on calcium carbonate and hydroxylapatite scaffolds in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","668"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Oral Oncology"],["dc.bibliographiccitation.lastpage","673"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Kramer, Franz-Josef"],["dc.contributor.author","Böhrnsen, Florian"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2018-06-26T06:55:52Z"],["dc.date.available","2018-06-26T06:55:52Z"],["dc.date.issued","2015"],["dc.description.abstract","The submental island flap has become increasingly popular in the treatment of intraoral defects following tumor ablation. However, there was concern that the elevation of the pedicled flap might interfere with the efficiency of level I-lymph node dissection and decrease the oncologic prognosis of the patients."],["dc.identifier.doi","10.1016/j.oraloncology.2015.03.011"],["dc.identifier.pmid","25962940"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15147"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1879-0593"],["dc.title","The submental island flap for the treatment of intraoral tumor-related defects: No effect on recurrence rates"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1121"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Clinical Oral Investigations"],["dc.bibliographiccitation.lastpage","1128"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Böhrnsen, F."],["dc.contributor.author","Fricke, M."],["dc.contributor.author","Sander, C."],["dc.contributor.author","Leha, A."],["dc.contributor.author","Schliephake, H."],["dc.contributor.author","Kramer, F. J."],["dc.date.accessioned","2018-06-26T08:09:06Z"],["dc.date.available","2018-06-26T08:09:06Z"],["dc.date.issued","2015"],["dc.description.abstract","Cancer progression is influenced by tumor microenvironment and communication of stromal cells and tumor cells. Interactions may enhance epithelial-mesenchymal transition (EMT) of tumor cells through signaling proteins such as Wnt/beta-catenin and matrix metalloproteinases (MMP), as well as loss of cellular integrity, which affects invasion, progression, and metastasis of head and neck squamous cell carcinoma (HNSCC). In this study, we are testing the hypothesis that interactions of human mesenchymal stromal cells (MSCs) with HNSCC might influence the expression of markers of EMT and tumor progression by co-culturing human MSC with the PCI-13 HNSCC line."],["dc.identifier.doi","10.1007/s00784-014-1338-7"],["dc.identifier.pmid","25346374"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15148"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1436-3771"],["dc.title","Interactions of human MSC with head and neck squamous cell carcinoma cell line PCI-13 reduce markers of epithelia-mesenchymal transition"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","135"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","International Journal of Oral and Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","142"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Naujokat, H."],["dc.contributor.author","Açil, Y."],["dc.contributor.author","Harder, S."],["dc.contributor.author","Lipp, M."],["dc.contributor.author","Böhrnsen, F."],["dc.contributor.author","Wiltfang, J."],["dc.date.accessioned","2020-12-10T14:24:38Z"],["dc.date.available","2020-12-10T14:24:38Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.ijom.2019.04.005"],["dc.identifier.issn","0901-5027"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72309"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Osseointegration of dental implants in ectopic engineered bone in three different scaffold materials"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Tofangchi, Schahin"],["dc.contributor.author","Hanelt, Andre"],["dc.contributor.author","Böhrnsen, Florian"],["dc.date.accessioned","2018-06-26T08:37:40Z"],["dc.date.available","2018-06-26T08:37:40Z"],["dc.date.issued","2018"],["dc.description.abstract","Although researchers have uncovered potential positive impacts of digital technologies in healthcare and medical centers have been increasingly making use of technology to digitally store their data, the use of healthcare analytics in clinical practice remains limited. In particular, the application of machine learning (ML) approaches, although holding the potential of providing valuable insights, is mainly restricted to descriptive ML, due to the approximate nature of ML, the impact of inaccuracies, and the perceived potential additional efforts in clinical workflows. Taking into account these barriers to healthcare analytics adoption, in this multidisciplinary study, we obtained and jointly analyzed cancer data on 799 cases of cranio-maxillofacial and oral-maxillofacial surgery. We developed a real-time decision support system that predicts optimal treatments and communicates its prediction confidence along with patient attributes that are significant to decision making, thereby providing potentials simultaneously for improving quality of care and for increasing process efficiency for physicians."],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15151"],["dc.language.iso","en"],["dc.notes.preprint","yes"],["dc.notes.status","zu prüfen"],["dc.publisher","AIS Electronic Library"],["dc.relation.conference","ICIS 2017: Transforming Society with Digital Innovation"],["dc.relation.eventend","2017-12-13"],["dc.relation.eventlocation","Seoul"],["dc.relation.eventstart","2017-12-09"],["dc.relation.iserratumof","yes"],["dc.title","Distributed Cognitive Expert Systems in Cancer Data Analytics: A Decision Support System for Oral and Maxillofacial Surgery"],["dc.type","conference_paper"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]