Schmidt-Samoa, Carsten

[["dc.bibliographiccitation.firstpage","630"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","636"],["dc.bibliographiccitation.volume","259"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Lange, Peter"],["dc.contributor.author","Spreer, Annette"],["dc.contributor.author","Neubieser, Katja"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Nau, Roland"],["dc.contributor.author","Schmidt, Holger"],["dc.date.accessioned","2018-11-07T09:11:41Z"],["dc.date.available","2018-11-07T09:11:41Z"],["dc.date.issued","2012"],["dc.description.abstract","Presence of BB-specific antibodies in the cerebrospinal fluid (CSF) with evidence of their intrathecal production in conjunction with the white cell count in the CSF and typical clinical symptoms is the traditional diagnostic gold standard of Lyme neuroborreliosis (LNB). Few data are available on the CSF lactate concentration in European adults with the diagnosis of acute LNB. The objective of the study was to investigate the CSF changes during acute LNB. Routine CSF parameters [leukocyte count, protein, lactate and albumin concentrations, CSF/serum quotients of albumin (Q(Alb)), IgG, IgA and IgM, and oligoclonal IgG bands] and the Borrelia burgdorferi (BB)-specific antibody index were retrospectively studied in relation to the clinical presentation in patients diagnosed with acute LNB. A total of 118 patients with LNB were categorized into the following groups according to their symptoms at presentation; group 1: polyradiculoneuritis (Bannwarth's syndrome), group 2: isolated facial palsy and group 3: predominantly meningitic course of the disease. In addition to the CSF of patients with acute LNB, CSF of 19 patients with viral meningitis (VM) and 3 with neurolues (NL) were analyzed. There were 97 patients classified with definite LNB, and 21 as probable LNB. Neck stiffness and fever were reported by 15.3% of patients. Most of these patients were younger than 50 years. Polyradiculoneuritis was frequently found in patients older than 50 years. Lymphopleocytosis was found in all patients. Only 5 patients had a CSF lactate >= 3.5 mmol/l, and the mean CSF lactate level was not elevated (2.1 +/- A 0.6 mmol/l). The patients with definite LNB had significantly higher lactate levels than patients with probable LNB. Elevated lactate levels were accompanied by fever and headache. In the Reiber nomograms, intrathecal immunoglobulin synthesis was found for IgM in 70.2% followed by IgG in 19.5%. Isoelectric focussing detected an intrathecal IgG synthesis in 83 patients (70.3%). Elevated BB AIs in the CSF were found in 97 patients (82.2%). Patients with VM showed lower CSF protein concentration and CSF/serum quotients of albumin than LNB patients. In acute LNB, all patients had elevated cerebrospinal fluid (CSF) leukocyte counts. In contrast to infections by other bacteria, CSF lactate was lower than 3.5 mmol/l in all but 5 patients. The CSF findings did not differ between polyradiculoneuritis, facial palsy, and meningitis. The CSF in LNB patients strongly differed from CSF in VM patients with respect to protein concentration and the CSF/serum albumin quotient."],["dc.identifier.doi","10.1007/s00415-011-6221-8"],["dc.identifier.isi","000302489400004"],["dc.identifier.pmid","21898139"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8098"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26777"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","0340-5354"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Cerebrospinal fluid findings in adults with acute Lyme neuroborreliosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","94"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","121"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Cabral-Calderin, Yuranny"],["dc.contributor.author","Weinrich, Christiane Anne"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Poland, Eva"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Wilke, Melanie"],["dc.date.accessioned","2017-09-07T11:54:45Z"],["dc.date.available","2017-09-07T11:54:45Z"],["dc.date.issued","2016"],["dc.description.abstract","Transcranial alternating current stimulation (tACS) has emerged as a promising tool for manipulating ongoing brain oscillations. While previous studies demonstrated frequency-specific effects of tACS on diverse cognitive functions, its effect on neural activity remains poorly understood. Here we asked how tACS modulates regional fMRI blood oxygenation level dependent (BOLD) signal as a function of frequency, current strength, and task condition. TACS was applied over the posterior cortex of healthy human subjects while the BOLD signal was measured during rest or task conditions (visual perception, passive video viewing and motor task). TACS was applied in a blockwise manner at different frequencies (10, 16, 60 and 80 Hz). The strongest tACS effects on BOLD activity were observed with stimulation at alpha (10 Hz) and beta (16 Hz) frequency bands, while effects of tACS at the gamma range were rather modest. Specifically, we found that tACS at 16 Hz induced BOLD activity increase in fronto-parietal areas. Overall, tACS effects varied as a function of frequency and task, and were predominantly seen in regions that were not activated by the task. Also, the modulated regions were poorly predicted by current density modeling studies. Taken together, our results suggest that tACS does not necessarily exert its strongest effects in regions below the electrodes and that region specificity might be achieved with tACS due to varying susceptibility of brain regions to entrain to a given frequency. (C) 2015 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/hbm.23016"],["dc.identifier.fs","618728"],["dc.identifier.gro","3141752"],["dc.identifier.isi","000369150500007"],["dc.identifier.pmid","26503692"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14044"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/680"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: Hermann and Lilly Schilling Foundation"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1097-0193"],["dc.relation.issn","1065-9471"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Transcranial Alternating Current Stimulation Affects the BOLD Signal in a Frequency and Task-dependent Manner"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","153"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","NeuroImage. Clinical"],["dc.bibliographiccitation.lastpage","163"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Siemerkus, Jakob"],["dc.contributor.author","Irle, Eva"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Weniger, Godehard"],["dc.date.accessioned","2019-07-09T11:40:00Z"],["dc.date.available","2019-07-09T11:40:00Z"],["dc.date.issued","2012"],["dc.description.abstract","Psychotic symptoms in schizophrenia are related to disturbed self-recognition and to disturbed experience of agency. Possibly, these impairments contribute to first-person large-scale egocentric learning deficits. Sixteen inpatients with schizophrenia and 16 matched healthy comparison subjects underwent functional magnetic resonance imaging (fMRI) while finding their way in a virtual maze. The virtual maze presented a first-person view, lacked any topographical landmarks and afforded egocentric navigation strategies. The participants with schizophrenia showed impaired performance in the virtual maze when compared with controls, and showed a similar but weaker pattern of activity changes during egocentric learning when compared with controls. Especially the activity of task-relevant brain regions (precuneus and posterior cingulate and retrosplenial cortex) differed from that of controls across all trials of the task. Activity increase within the right-sided precuneus was related to worse virtual maze performance and to stronger positive symptoms in participants with schizophrenia. We suggest that psychotic symptoms in schizophrenia are related to aberrant neural activity within the precuneus. Possibly, first-person large-scale egocentric navigation and learning designs may be a feasible tool for the assessment and treatment of cognitive deficits related to self-recognition in patients with schizophrenia."],["dc.identifier.doi","10.1016/j.nicl.2012.10.004"],["dc.identifier.fs","590989"],["dc.identifier.pmid","24179748"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10588"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58074"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2213-1582"],["dc.rights","CC BY-NC-ND 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/3.0"],["dc.title","Egocentric spatial learning in schizophrenia investigated with functional magnetic resonance imaging."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1647"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Social cognitive and affective neuroscience"],["dc.bibliographiccitation.lastpage","1657"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Barke, Antonia"],["dc.contributor.author","Bode, Stefan"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Van Heer, Christina"],["dc.contributor.author","Stahl, Jutta"],["dc.date.accessioned","2019-07-09T11:44:44Z"],["dc.date.available","2019-07-09T11:44:44Z"],["dc.date.issued","2017"],["dc.description.abstract","The attitude towards one's own imperfection strongly varies between individuals. Here, we investigated variations in error-related activity depending on two sub-traits of perfectionism, Personal Standard Perfectionism (PSP) and Evaluative Concern Perfectionism (ECP) in a large scale functional magnetic resonance imaging study (N = 75) using a digit-flanker task. Participants with higher PSP scores showed both more post-error slowing and more neural activity in the medial-frontal gyrus including anterior cingulate cortex after errors. Interestingly, high-EC perfectionists with low PSP showed no post-error slowing and the highest activity in the middle frontal gyrus, whereas high-EC perfectionists with high PSP showed the lowest activity in this brain area and more post-error slowing. Our findings are in line with the hypothesis that perfectionists with high concerns but low standards avoid performance monitoring to avoid the worry-inducing nature of detecting personal failure and the anticipation of poor evaluation by others. However, the stronger goal-oriented performance motivation of perfectionists with high concerns and high standards may have led to less avoidance of error processing and a more intense involvement with the imperfect behaviour, which is essential for improving future performance."],["dc.identifier.doi","10.1093/scan/nsx082"],["dc.identifier.pmid","28655179"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14883"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59081"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1749-5024"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.subject.ddc","570"],["dc.title","To err is (perfectly) human: behavioural and neural correlates of error processing and perfectionism."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","139"],["dc.bibliographiccitation.journal","BMC Neurology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Schmidt, Holger"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Holzgraefe, Manfred"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","von Steinbuechel, Nicole"],["dc.contributor.author","Blocher, Joachim"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.date.accessioned","2018-11-07T09:53:13Z"],["dc.date.available","2018-11-07T09:53:13Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: Patients often report neurocognitive difficulties after neuroborreliosis (NB). The frequency and extent of cognitive problems in European patients have been studied incompletely. Methods: Sixty patients received a neurological and neuropsychological work-up 6 months or longer after treatment for proven NB. Quality of life, psychiatric symptom load, and brain atrophy were measured. All results were compared with a group of 30 healthy control persons adapted for age, gender and education being serologically negative for Borrelia burgdorferi senso latu. A cognitive sum score and a global sum score including cognitive, psychological results and quality of life data was calculated for both groups. Results: Patients after NB showed a lower (i.e. more impaired) score on the Scripps Neurological rating scale (SNRS), but the observed neurological deficits were generally mild (mean +/- SD: 97.1 +/- 4.7 vs. 99.1 +/- 2.4, p = 0.02). The mean neuropsychological domain results of the NB group were all within the normal range. However, a lower performance was found for the frontal executive function z-values (mean +/- SD-0.29 +/- 0.60 vs. 0.09 +/- 0.60; p = 0.0059) of NB patients. Comparing the global sum score (mean +/- SD 11.3 +/- 4.2(NB) vs. 14.3 +/- 2.9(control), p = 0.001) and the cognitive sum score of the NB group with those of the control group (mean +/- SD -0.15 +/- 0.42(NB) vs. 0.08 +/- 0.31(control), p = 0.0079), both differences were statistically different. The frequencies of impaired global sum scores and those of the pathological cognitive sum scores (p = 0.07) did not differ statistically. No significant differences were found for health-related quality of life (hrQoL), sleep, psychiatric symptom load, or brain atrophy. Conclusion: The mean cognitive functions of patients after proven NB were in the normal range. However, we were able to demonstrate a lower performance for the domain of frontal executive functions, for the mean cognitive sum score and the global sum score as a sign of subtle but measurable sequelae of neuroborreliosis. Brain atrophy is not a common consequence of neuroborreliosis."],["dc.identifier.doi","10.1186/s12883-015-0386-1"],["dc.identifier.isi","000361446200001"],["dc.identifier.pmid","26286440"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12505"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36286"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2377"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Neurocognitive functions and brain atrophy after proven neuroborreliosis: a case-control study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","102076"],["dc.bibliographiccitation.journal","NeuroImage: Clinical"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Miloserdov, Kristina"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Williams, Kathleen"],["dc.contributor.author","Weinrich, Christiane Anne"],["dc.contributor.author","Kagan, Igor"],["dc.contributor.author","Bürk, Katrin"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Wilke, Melanie"],["dc.date.accessioned","2020-12-10T15:20:31Z"],["dc.date.available","2020-12-10T15:20:31Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.nicl.2019.102076"],["dc.identifier.issn","2213-1582"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16784"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72695"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Aberrant functional connectivity of resting state networks related to misperceptions and intra-individual variability in Parkinson‘s disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","10"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Ear, Nose and Throat Disorders"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Golm, Dennis"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Kröner-Herwig, Birgit"],["dc.date.accessioned","2019-07-09T11:42:50Z"],["dc.date.available","2019-07-09T11:42:50Z"],["dc.date.issued","2016"],["dc.description.abstract","Abstract Background Chronic tinnitus affects 5 % of the population, 17 % suffer under the condition. This distress seems mainly to be dependent on negative cognitive-emotional evaluation of the tinnitus and selective attention to the tinnitus. A well-established paradigm to examine selective attention and emotional processing is the Emotional Stroop Task (EST). Recent models of tinnitus distress propose limbic, frontal and parietal regions to be more active in highly distressed tinnitus patients. Only a few studies have compared high and low distressed tinnitus patients. Thus, this study aimed to explore neural correlates of tinnitus-related distress. Methods Highly distressed tinnitus patients (HDT, n = 16), low distressed tinnitus patients (LDT, n = 16) and healthy controls (HC, n = 16) underwent functional magnetic resonance imaging (fMRI) during an EST, that used tinnitus-related words and neutral words as stimuli. A random effects analysis of the fMRI data was conducted on the basis of the general linear model. Furthermore correlational analyses between the blood oxygen level dependent response and tinnitus distress, loudness, depression, anxiety, vocabulary and hypersensitivity to sound were performed. Results Contradictory to the hypothesis, highly distressed patients showed no Stroop effect in their reaction times. As hypothesized HDT and LDT differed in the activation of the right insula and the orbitofrontal cortex. There were no hypothesized differences between HDT and HC. Activation of the orbitofrontal cortex and the right insula were found to correlate with tinnitus distress. Conclusions The results are partially supported by earlier resting-state studies and corroborate the role of the insula and the orbitofrontal cortex in tinnitus distress."],["dc.identifier.doi","10.1186/s12901-016-0029-1"],["dc.identifier.pmid","27499700"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13859"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58762"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Tinnitus- related distress: evidence from fMRI of an emotional stroop task"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","338"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Cephalalgia"],["dc.bibliographiccitation.lastpage","345"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Polania, Rafael"],["dc.contributor.author","Saller, Katharina"],["dc.contributor.author","Morawetz, Carmen"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Baudewig, Juergen"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Dechent, Peter"],["dc.date.accessioned","2018-11-07T08:59:44Z"],["dc.date.available","2018-11-07T08:59:44Z"],["dc.date.issued","2011"],["dc.description.abstract","Objective: Differences between people with and without migraine on various measures of visual perception have been attributed to abnormal cortical processing due to the disease. The aim of the present study was to explore the dynamics of the basic interictal state with regard to the extrastriate, motion-responsive middle temporal area (MT-complex) with functional magnetic resonance imaging (fMRI) at 3 tesla using coherent/incoherent moving dot stimuli. Method: Twenty-four migraine patients (12 with aura [MwA], 12 without aura [MwoA]) and 12 healthy subjects participated in the study. The individual cortical folding pattern was accounted for by using a cortical matching approach. Results: In the inferior-posterior portion of the MT-complex, most likely representing MT, control subjects showed stronger bilateral activation compared to MwA and MwoA patients. Compared with healthy controls MwoA and MwA patients showed significantly stronger activation mainly at the left side in response to visual stimulation in the superior-anterior portion of the MT-complex, representing the medial-superior temporal area (MST). Conclusion: Our findings strengthen the hypothesis that hyperresponsiveness of the visual cortex in migraine goes beyond early visual areas, even in the interictal period."],["dc.identifier.doi","10.1177/0333102410379889"],["dc.identifier.isi","000288874700011"],["dc.identifier.pmid","20693230"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13044"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23975"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Sage Publications Ltd"],["dc.relation.issn","0333-1024"],["dc.title","Differential activation of the middle-temporal complex to visual stimulation in migraineurs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0201277"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","PLOS ONE"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Meincke, Jonna"],["dc.contributor.author","Hewitt, Manuel"],["dc.contributor.author","Reischl, Markus"],["dc.contributor.author","Rupp, Rüdiger"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Liebetanz, David"],["dc.date.accessioned","2019-07-09T11:45:46Z"],["dc.date.available","2019-07-09T11:45:46Z"],["dc.date.issued","2018"],["dc.description.abstract","BACKGROUND: Most humans have the ability to activate the auricular muscles. Although (intentional) control suggests an involvement of higher cortical centers underlying posterior auricular muscle (PAM) activation, the cortical representation of the auricular muscles is still unknown. METHODS: With the purpose of identifying a possible cortical representation area we performed automated robotic and image-guided transcranial magnetic stimulation (TMS) mapping (n = 8) and functional magnetic resonance imaging (fMRI) (n = 13). For topographical comparison, a similar experimental protocol was applied for the first dorsal interosseus muscle (FDI) of the hand. RESULTS: The calculated centers of gravity (COGs) of both muscles were located on the precentral gyrus with the PAM COGs located more laterally compared to the FDI. The distance between the mean PAM and mean FDI COG was 26.3 mm. The TMS mapping results were confirmed by fMRI, which showed a dominance of cortical activation within the precentral gyrus during the corresponding motor tasks. The correspondence of TMS and fMRI results was high. CONCLUSION: The involvement of the primary motor cortex in PAM activation might point to an evolved function of the auricular muscles in humans and/or the ability of intentional (and selective) muscle activation."],["dc.identifier.doi","10.1371/journal.pone.0201277"],["dc.identifier.pmid","30052653"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15316"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59310"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Cortical representation of auricular muscles in humans: A robot-controlled TMS mapping and fMRI study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0137056"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Preis, Mira A."],["dc.contributor.author","Kroener-Herwig, Birgit"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Barke, Antonia"],["dc.date.accessioned","2018-11-07T09:53:06Z"],["dc.date.available","2018-11-07T09:53:06Z"],["dc.date.issued","2015"],["dc.description.abstract","Background Neuroimaging studies have demonstrated that the actual experience of pain and the perception of another person in pain share common neural substrates, including the bilateral anterior insular cortex and the anterior midcingulate cortex. As many fMRI studies include the exposure of participants to repeated, similar stimuli, we examined whether empathic neural responses were affected by habituation and whether the participants' prior pain experience influenced these habituation effects. Method In 128 trials (four runs), 62 participants (31 women, 23.0 +/- 4.2 years) were shown pictures of hands exposed to painful pressure (pain pictures) and unexposed (neutral pictures). After each trial, the participants rated the pain of the model. Prior to the experiment, participants were either exposed to the same pain stimulus (pain exposure group) or not (touch exposure group). In order to assess possible habituation effects, linear changes in the strength of the BOLD response to the pain pictures (relative to the neutral pictures) and in the ratings of the model's pain were evaluated across the four runs. Results Although the ratings of the model's pain remained constant over time, we found neural habituation in the bilateral anterior/midinsular cortex, the posterior midcingulate extending to dorsal posterior cingulate cortex, the supplementary motor area, the cerebellum, the right inferior parietal lobule, and the left superior frontal gyrus, stretching to the pregenual anterior cingulate cortex. The participant's prior pain experience did neither affect their ratings of the model's pain nor their maintenance of BOLD activity in areas associated with empathy. Interestingly, participants with high trait personal distress and fantasy tended to show less habituation in the anterior insula. Conclusion Neural structures showed a decrease of the BOLD signal, indicating habituation over the course of 45 minutes. This can be interpreted as a neuronal mechanism responding to the repeated exposure to pain depictions, which may be regarded as functional in a range of contexts."],["dc.identifier.doi","10.1371/journal.pone.0137056"],["dc.identifier.isi","000360299100200"],["dc.identifier.pmid","26317858"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12086"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36260"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Neural Correlates of Empathy with Pain Show Habituation Effects. An fMRI Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]