Kim, Soya

[["dc.bibliographiccitation.firstpage","667"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.lastpage","672"],["dc.bibliographiccitation.volume","179"],["dc.contributor.author","Schmidberger, Heinz"],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Kim, S."],["dc.contributor.author","Hille, Andrea"],["dc.contributor.author","Pradier, Olivier"],["dc.contributor.author","Hess, C. F."],["dc.date.accessioned","2018-11-07T10:36:01Z"],["dc.date.available","2018-11-07T10:36:01Z"],["dc.date.issued","2003"],["dc.description.abstract","Background: Chemotherapy-induced mucositis can be related to a decrease in oral neutrophils. We tested the relationship between radiation-induced mucositis and oral neutrophil counts. Patients and Methods: Oral neutrophil counts were obtained for ten patients with head and neck cancer who received radiotherapy of the pharynx and oral cavity. Four patients received additional chemotherapy (5-FU, Mitomycin). Counts were obtained before and during treatment; four healthy volunteers were included in the study as well. For evaluation, a quantitative mouth rinse assay, including neutrophil-staining with acridin-orange, was applied. Results: We observed large inter-individual variations with respect to neutrophil counts for patients and control persons (Table 1). During treatment (irradiation or chemoirradiation), large intra-individual variations were seen additionally (Figure 1). We found a correlation between neutrophil counts and clinical reaction grade. Neutrophil counts increased with increasing mucositis (Figure 2). This increase was more pronounced for patients treated with chemoirradiation compared to radiation alone. Treatment breaks at weekends had no clear influence on neutrophil counts. Conclusions: We observed a weak correlation between neutrophil counts and clinical reaction grade. However, the variations in neutrophil counts are too large to utilize this parameter as a surrogate for clinical mucositis grading. The assumption that a decrease in oral neutrophils is associated with radiation-induced mucositis was clearly negated."],["dc.identifier.doi","10.1007/s00066-003-1121-1"],["dc.identifier.isi","000185950700002"],["dc.identifier.pmid","14566474"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45227"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.relation.issn","0179-7158"],["dc.title","Radiation-induced mucositis and neutrophil granulocytes in oral mucosa"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","421"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Neuroendocrinology"],["dc.bibliographiccitation.lastpage","429"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Kang, S. S."],["dc.contributor.author","Kim, S. R."],["dc.contributor.author","Leonhardt, S."],["dc.contributor.author","Jarry, H."],["dc.contributor.author","Wuttke, W."],["dc.contributor.author","Kim, K."],["dc.date.accessioned","2021-12-08T12:27:33Z"],["dc.date.available","2021-12-08T12:27:33Z"],["dc.date.issued","2001"],["dc.identifier.doi","10.1046/j.1365-2826.2000.00466.x"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95386"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1365-2826"],["dc.relation.issn","0953-8194"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","Effect of Interleukin-1β on Gonadotropin-Releasing Hormone (GnRH) and GnRH Receptor Gene Expression in Castrated Male Rats"],["dc.title.alternative","Effect of IL-1β on GnRH and its receptor gene expression"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","47"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Immunology Letters"],["dc.bibliographiccitation.lastpage","52"],["dc.bibliographiccitation.volume","88"],["dc.contributor.author","Soruri, Afsaneh"],["dc.contributor.author","Kim, S."],["dc.contributor.author","Kiafard, Z."],["dc.contributor.author","Zwirner, Joerg"],["dc.date.accessioned","2018-11-07T10:37:43Z"],["dc.date.available","2018-11-07T10:37:43Z"],["dc.date.issued","2003"],["dc.description.abstract","The anaphylatoxin C5a is a potent proinflammatory stimulus with immunomodulatory activities. Expression of its receptor C5aR (CD88) has been detected on cells of myeloid origin such as granulocytes and monocytes/macrophages. However, controversial results exist on the expression of C5aR on T and B lymphocytes as well as on mature dendritic cells (DC). The aim of the present study was to characterize expression of C5aR protein on myeloid and lymphoid cells in the mouse. For this purpose, rat monoclonal antibodies with specificity against the murine C5aR were generated. Using these reagents a distinct amount of C5aR antigen was observed on neutrophils and macrophages. In contrast, C5aR protein was not detectable on resting or stimulated murine T or B lymphocytes. Furthermore, no C5aR protein could be observed on splenic CD11c positive DC which have been classified in the literature as relatively mature. Taken together, our results suggest that in the mouse expression of C5aR protein may be restricted to leukocytes of myeloid origin whereas previous evidence for C5aR expression on lymphoid cells may be reevaluated. (C) 2003 Elsevier Science B.V. All rights reserved."],["dc.identifier.doi","10.1016/S0165-2478(03)00052-X"],["dc.identifier.isi","000184327800008"],["dc.identifier.pmid","12853161"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45637"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0165-2478"],["dc.title","Characterization of C5aR expression on murine myeloid and lymphoid cells by the use of a novel monoclonal antibody"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3759"],["dc.bibliographiccitation.issue","20"],["dc.bibliographiccitation.journal","Journal of Cell Science"],["dc.bibliographiccitation.lastpage","3771"],["dc.bibliographiccitation.volume","122"],["dc.contributor.author","Kim, Soya"],["dc.contributor.author","Gailite, Ieva"],["dc.contributor.author","Moussian, Bernard"],["dc.contributor.author","Luschnig, Stefan"],["dc.contributor.author","Goette, Maik"],["dc.contributor.author","Fricke, Karen"],["dc.contributor.author","Honemann-Capito, Mona"],["dc.contributor.author","Grubmüller, Helmut"],["dc.contributor.author","Wodarz, Andreas"],["dc.date.accessioned","2017-09-07T11:46:47Z"],["dc.date.available","2017-09-07T11:46:47Z"],["dc.date.issued","2009"],["dc.description.abstract","Polarity of many cell types is controlled by a protein complex consisting of Bazooka/PAR-3 (Baz), PAR-6 and atypical protein kinase C (aPKC). In Drosophila, the Baz-PAR-6-aPKC complex is required for the control of cell polarity in the follicular epithelium, in ectodermal epithelia and neuroblasts. aPKC is the main signaling component of this complex that functions by phosphorylating downstream targets, while the PDZ domain proteins Baz and PAR-6 control the subcellular localization and kinase activity of aPKC. We compared the mutant phenotypes of an aPKC null allele with those of four novel aPKC alleles harboring point mutations that abolish the kinase activity or the binding of aPKC to PAR-6. We show that these point alleles retain full functionality in the control of follicle cell polarity, but produce strong loss-of-function phenotypes in embryonic epithelia and neuroblasts. Our data, combined with molecular dynamics simulations, show that the kinase activity of aPKC and its ability to bind PAR-6 are only required for a subset of its functions during development, revealing tissue-specific differences in the way that aPKC controls cell polarity."],["dc.identifier.doi","10.1242/jcs.052514"],["dc.identifier.gro","3143041"],["dc.identifier.isi","000270570800019"],["dc.identifier.pmid","19789180"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/511"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0021-9533"],["dc.title","Kinase-activity-independent functions of atypical protein kinase C in Drosophila"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]