Haubrock, Martin

[["dc.bibliographiccitation.firstpage","I509"],["dc.bibliographiccitation.issue","18"],["dc.bibliographiccitation.journal","Bioinformatics"],["dc.bibliographiccitation.lastpage","I514"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Li, Jie"],["dc.contributor.author","Hua, X. U."],["dc.contributor.author","Haubrock, Martin"],["dc.contributor.author","Wang, J."],["dc.contributor.author","Wingender, Edgar"],["dc.date.accessioned","2018-11-07T09:05:52Z"],["dc.date.available","2018-11-07T09:05:52Z"],["dc.date.issued","2012"],["dc.description.abstract","The great variety of human cell types in morphology and function is due to the diverse gene expression profiles that are governed by the distinctive regulatory networks in different cell types. It is still a challenging task to explain how the regulatory networks achieve the diversity of different cell types. Here, we report on our studies of the design principles of the tissue regulatory system by constructing the regulatory networks of eight human tissues, which subsume the regulatory interactions between transcription factors (TFs), microRNAs (miRNAs) and non-TF target genes. The results show that there are in-/out-hubs of high in-/out-degrees in tissue networks. Some hubs (strong hubs) maintain the hub status in all the tissues where they are expressed, whereas others (weak hubs), in spite of their ubiquitous expression, are hubs only in some tissues. The network motifs are mostly feed-forward loops. Some of them having no miRNAs are the common motifs shared by all tissues, whereas the others containing miRNAs are the tissue-specific ones owned by one or several tissues, indicating that the transcriptional regulation is more conserved across tissues than the post-transcriptional regulation. In particular, a common bow-tie framework was found that underlies the motif instances and shows diverse patterns in different tissues. Such bow-tie framework reflects the utilization efficiency of the regulatory system as well as its high variability in different tissues, and could serve as the model to further understand the structural adaptation of the regulatory system to the specific requirements of different cell functions."],["dc.identifier.doi","10.1093/bioinformatics/bts387"],["dc.identifier.isi","000308532300030"],["dc.identifier.pmid","22962474"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25421"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.conference","11th European Conference on Computational Biology (ECCB) / Conference of the Intelligent Systems in Molecular Biology (ISMB)"],["dc.relation.eventlocation","Basel, SWITZERLAND"],["dc.relation.issn","1367-4803"],["dc.title","The architecture of the gene regulatory networks of different tissues"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","115"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Pharmacogenomics"],["dc.bibliographiccitation.lastpage","127"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Dalila, Nawar"],["dc.contributor.author","Brockmoeller, Juergen"],["dc.contributor.author","Tzvetkov, Mladen Vassilev"],["dc.contributor.author","Schirmer, Markus"],["dc.contributor.author","Haubrock, Martin"],["dc.contributor.author","Vormfelde, Stefan Viktor"],["dc.date.accessioned","2018-11-07T10:03:50Z"],["dc.date.available","2018-11-07T10:03:50Z"],["dc.date.issued","2015"],["dc.description.abstract","Aim: Polymorphisms in the mineralocorticoid receptor may affect urinary sodium and potassium excretion. We investigated polymorphisms in the MR gene in relation to urinary electrolyte excretion in two separate studies. Patients & methods: The genotype-phenotype association was studied in healthy volunteers after single doses of bumetanide, furosemide, torsemide, hydrochlorothiazide, triamterene and after NaCl restriction. Results: High potassium excretion under all conditions except torsemide, and high NaCl excretion after bumetanide and furosemide were associated with the A allele of the intron-3 polymorphism (rs3857080). This polymorphism explained 5-10% of the functional variation and in vitro, rs3857080 affected DNA binding of the transcription factor LHX4. Conclusion: rs3857080 may be a promising new candidate for research in cardiac and renal disorders and on antialdosteronergic drugs like spironolactone. Original submitted 23 June 2014; Revision submitted 5 November 2014"],["dc.identifier.doi","10.2217/pgs.14.163"],["dc.identifier.isi","000348455400003"],["dc.identifier.pmid","25616098"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38561"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Future Medicine Ltd"],["dc.relation.issn","1744-8042"],["dc.relation.issn","1462-2416"],["dc.title","Impact of mineralocorticoid receptor polymorphisms on urinary electrolyte excretion with and without diuretic drugs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","124"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Bioinformatics"],["dc.bibliographiccitation.lastpage","129"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Goesmann, A."],["dc.contributor.author","Haubrock, M."],["dc.contributor.author","Meyer, F."],["dc.contributor.author","Kalinowski, J."],["dc.contributor.author","Giegerich, R."],["dc.date.accessioned","2022-06-08T07:59:05Z"],["dc.date.available","2022-06-08T07:59:05Z"],["dc.date.issued","2002"],["dc.identifier.doi","10.1093/bioinformatics/18.1.124"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110627"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.relation.eissn","1460-2059"],["dc.relation.issn","1367-4803"],["dc.title","PathFinder: reconstruction and dynamic visualization of metabolic pathways"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1011"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Cancers"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","De Oliveira, Tiago"],["dc.contributor.author","Goldhardt, Tina"],["dc.contributor.author","Edelmann, Marcus"],["dc.contributor.author","Rogge, Torben"],["dc.contributor.author","Rauch, Karsten"],["dc.contributor.author","Kyuchukov, Nikola Dobrinov"],["dc.contributor.author","Menck, Kerstin"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Kalucka, Joanna"],["dc.contributor.author","Khan, Shawez"],["dc.contributor.author","Gaedcke, Jochen"],["dc.contributor.author","Haubrock, Martin"],["dc.contributor.author","Beissbarth, Tim"],["dc.contributor.author","Bohnenberger, Hanibal"],["dc.contributor.author","Planque, Mélanie"],["dc.contributor.author","Fendt, Sarah-Maria"],["dc.contributor.author","Ackermann, Lutz"],["dc.contributor.author","Ghadimi, Michael"],["dc.contributor.author","Conradi, Lena-Christin"],["dc.date.accessioned","2021-04-14T08:27:56Z"],["dc.date.available","2021-04-14T08:27:56Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.3390/cancers13051011"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82456"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2072-6694"],["dc.title","Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","148"],["dc.bibliographiccitation.issue","03"],["dc.bibliographiccitation.journal","Sprache · Stimme · Gehör"],["dc.bibliographiccitation.lastpage","153"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Hansen, H."],["dc.contributor.author","Haubrock, Martin"],["dc.date.accessioned","2022-06-08T07:58:49Z"],["dc.date.available","2022-06-08T07:58:49Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1055/s-0033-1345156"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110534"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-575"],["dc.relation.eissn","1439-1260"],["dc.relation.issn","0342-0477"],["dc.title","Sprachtherapeutische Ressourcen und Verteilungsgerechtigkeit - Eine Analyse aus gesundheitsökonomischer Perspektive"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]