Müller, Gerhard Anton

[["dc.bibliographiccitation.firstpage","115"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Transplantation Proceedings"],["dc.bibliographiccitation.lastpage","116"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Braun, F."],["dc.contributor.author","Canelo, R."],["dc.contributor.author","Lorf, Thomas"],["dc.contributor.author","Schutz, Ekkehard"],["dc.contributor.author","Grupp, Clemens"],["dc.contributor.author","Mueller, Gerhard A."],["dc.contributor.author","Ringe, B."],["dc.date.accessioned","2018-11-07T10:57:10Z"],["dc.date.available","2018-11-07T10:57:10Z"],["dc.date.issued","2000"],["dc.identifier.doi","10.1016/S0041-1345(99)00903-3"],["dc.identifier.isi","000085416700048"],["dc.identifier.pmid","10700989"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50181"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.conference","5th Congress of the International-Society-of-Organ-Sharing (ISOS)"],["dc.relation.eventlocation","MAASTRICHT, NETHERLANDS"],["dc.relation.issn","0041-1345"],["dc.title","Living-related versus living-unrelated kidney transplantation using tacrolimus initial immunosuppression"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0222102"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Grupp, Clemens"],["dc.contributor.author","Troche-Polzien, Ilka"],["dc.contributor.author","Stock, Johanna"],["dc.contributor.author","Bramlage, Carsten"],["dc.contributor.author","Müller, Gerhard A."],["dc.contributor.author","Koziolek, Michael"],["dc.contributor.editor","Gonzalez Suarez, Maria Lourdes"],["dc.date.accessioned","2020-12-10T18:42:10Z"],["dc.date.available","2020-12-10T18:42:10Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1371/journal.pone.0222102"],["dc.identifier.eissn","1932-6203"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16604"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77833"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Thrombophilic risk factors in hemodialysis: Association with early vascular access occlusion and patient survival in long-term follow-up"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2939"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Clinical Rheumatology"],["dc.bibliographiccitation.lastpage","2946"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Bramlage, Carsten Paul"],["dc.contributor.author","Froelich, Britta"],["dc.contributor.author","Wallbach, Manuel"],["dc.contributor.author","Minguet, Joan"],["dc.contributor.author","Grupp, Clemens"],["dc.contributor.author","Deutsch, Cornelia"],["dc.contributor.author","Bramlage, Peter"],["dc.contributor.author","Koziolek, Michael"],["dc.contributor.author","Mueller, Gerhard Anton"],["dc.date.accessioned","2018-11-07T10:05:16Z"],["dc.date.available","2018-11-07T10:05:16Z"],["dc.date.issued","2016"],["dc.description.abstract","In patients with rheumatic diseases, reliable markers for determining disease activity are scarce. One potential parameter is the level of immunoglobulin free light chains (FLCs), which is known to be elevated in the blood of patients with certain rheumatic diseases. Few studies have quantified FLCs in urine, a convenient source of test sample, in patients with different rheumatic diseases. We carried out a retrospective analysis of patients with rheumatic disease attending the University hospital of Goettingen, Germany. Subjects were included if they had urine levels of both kappa and lambda FLCs available and did not have myeloma. Data regarding systemic inflammation and kidney function were recorded, and FLC levels were correlated with inflammatory markers. Of the 382 patients with rheumatic disease, 40.1 % had chronic polyarthritis, 21.2 % connective tissue disease, 18.6 % spondyloarthritis and 15.7 % vasculitis. Elevated levels of kappa FLCs were found for 84 % of patients and elevated lambda for 52.7 %. For the patients with rheumatoid arthritis, FLCs correlated with C-reactive protein (kappa, r = 0.368, p < 0.001; lambda, r = 0.398, p < 0.001) and erythrocyte sedimentation rate (kappa, r = 0.692, p < 0.001; lambda, r = 0.612, p < 0.001). Patients being treated with rituximab displayed FLC levels similar to those of the reference group. There were clear elevations in both kappa and lambda FLCs in patients with rheumatic disease, but not in kappa/lambda ratio. The correlation between FLCs and inflammatory markers in patients with rheumatoid arthritis demonstrates their potential for predicting disease activity."],["dc.identifier.doi","10.1007/s10067-016-3437-0"],["dc.identifier.isi","000388826200010"],["dc.identifier.pmid","27734231"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38865"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","London"],["dc.relation.issn","1434-9949"],["dc.relation.issn","0770-3198"],["dc.title","The significance and predictive value of free light chains in the urine of patients with chronic inflammatory rheumatic disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","199"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Nephrology"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Delistefani, Fani"],["dc.contributor.author","Wallbach, Manuel"],["dc.contributor.author","Müller, Gerhard A"],["dc.contributor.author","Koziolek, Michael J"],["dc.contributor.author","Grupp, Clemens"],["dc.date.accessioned","2019-07-09T11:51:45Z"],["dc.date.available","2019-07-09T11:51:45Z"],["dc.date.issued","2019"],["dc.description.abstract","Abstract Background Due to rising vascular comorbidities of patients undergoing dialysis, the prevalence of permanent hemodialysis catheters as hemodialysis access is increasing. However, infection is a major complication of these catheters. Therefore, identification of potential predicting risk factors leading to early infection related complications is valuable, in particular the significance the CRP (C-reactive protein)-value is of interest. Methods In this retrospective study 151 permanent hemodialysis catheters implanted in 130 patients were examined. The following data were collected at the time of catheter implantation: CRP-value, history of catheter-related infection, microbiological status, immunosuppression and diabetes mellitus. The primary outcomes were recorded over the 3 months following the implantation: catheter-related infection, days of hospital stay and death. Catheter removal or revision, rehospitalization and use of antibiotics were identified as secondary outcomes. Results We identified a total of 27 (17.9%) infections (systemic infection: 2.26 episodes/ 1000 catheter days, local infection: 0.6 episodes/ 1000 catheter days). The development of an infection was independent of the CRP-value (p = 0.66) as well as the presence of diabetes mellitus (p = 0.64) or immunosuppression (p = 0.71). Univariate analysis revealed that infection was more frequent in patients with MRSA-carriage (p < 0.001), in case of previous catheter-related infection (p < 0.05) and of bacteremia or bacteriuria in the period of 3 months before catheter implantation (p < 0.001). Catheter removal or revision (p = 0.002), rehospitalization (p = 0.001) and use of antibiotics (p = 0.02) were also more often observed in patients with MRSA-carriage. Conclusions The CRP-value at the time of implantation of a permanent hemodialysis catheter is not associated with the development of early catheter related infections, but an individual history of catheter-related infection, MRSA-carriage and bacteremia or bacteriuria in the period of 3 months prior to catheter implantation are significant risk factors."],["dc.identifier.doi","10.1186/s12882-019-1392-0"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16186"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60004"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Risk factors for catheter-related infections in patients receiving permanent dialysis catheter"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","PII S0041-1345(02)03053-1"],["dc.bibliographiccitation.firstpage","1751"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Transplantation Proceedings"],["dc.bibliographiccitation.lastpage","1752"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Grupp, Clemens"],["dc.contributor.author","Hemprich, U."],["dc.contributor.author","John, H."],["dc.contributor.author","Braun, F."],["dc.contributor.author","Lorf, Thomas"],["dc.contributor.author","Armstrong, Victor William"],["dc.contributor.author","Ringe, B."],["dc.contributor.author","Mueller, Gerhard A."],["dc.date.accessioned","2018-11-07T10:18:22Z"],["dc.date.available","2018-11-07T10:18:22Z"],["dc.date.issued","2002"],["dc.identifier.doi","10.1016/S0041-1345(02)03053-1"],["dc.identifier.isi","000177369700163"],["dc.identifier.pmid","12176562"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.conference","2nd International Congress on Immunosuppression"],["dc.relation.eventlocation","SAN DIEGO, CALIFORNIA"],["dc.relation.issn","0041-1345"],["dc.title","Lectin staining for urine cytologic monitoring after kidney transplantation"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","582"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Clinical Hypertension"],["dc.bibliographiccitation.lastpage","588"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Grupp, Clemens"],["dc.contributor.author","Koziolek, Michael J."],["dc.contributor.author","Wallbach, Manuel"],["dc.contributor.author","Hoxhold, Kerstin"],["dc.contributor.author","Müller, Gerhard A."],["dc.contributor.author","Bramlage, Carsten"],["dc.date.accessioned","2020-12-10T18:28:56Z"],["dc.date.available","2020-12-10T18:28:56Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1111/jch.13212"],["dc.identifier.issn","1524-6175"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76465"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Difference between renal and splenic resistive index as a novel criterion in Doppler evaluation of renal artery stenosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of the American Society of Nephrology"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Grupp, Clemens"],["dc.contributor.author","Troche-Polzien, I."],["dc.contributor.author","Noding, C."],["dc.contributor.author","Mueller, C. A."],["dc.contributor.author","Mueller, Gerhard A."],["dc.date.accessioned","2018-11-07T10:07:08Z"],["dc.date.available","2018-11-07T10:07:08Z"],["dc.date.issued","2002"],["dc.format.extent","462A"],["dc.identifier.isi","000177757502259"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39227"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.issn","1046-6673"],["dc.title","Impaired immune defense in hemodialysis patients: Role of alpha-defensins?"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","84"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","American Journal of Kidney Diseases"],["dc.bibliographiccitation.lastpage","93"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Grupp, Clemens"],["dc.contributor.author","John, H."],["dc.contributor.author","Hemprich, U."],["dc.contributor.author","Singer, A."],["dc.contributor.author","Munzel, U."],["dc.contributor.author","Mueller, Gerhard A."],["dc.date.accessioned","2018-11-07T09:27:45Z"],["dc.date.available","2018-11-07T09:27:45Z"],["dc.date.issued","2001"],["dc.description.abstract","Microscopic examination of urinary sediment is an integral component in the evaluation of nephropathies, However, identification and differentiation of the nucleated nonsquamous cells in urine is often difficult using such conventional techniques as phase contrast or bright field microscopy, even after Papanicolaou staining, and requires a lot of experience. We now report a method to differentiate urinary cell types using lectin staining. Twenty-five lectins were examined with respect to their binding pattern on cryosections of the human kidney and urinary tract, as well as binding to blood cells. The specificity of lectin binding to a cell type both in situ and in urine was confirmed by double labeling with specific antibodies directed against various sections of the nephron or nucleated blood cells. For urine cytologic examinations, acetone-fixed cytopreparations of urinary sediments were incubated with a combination of a fluorescein isothiocyanate (FITC)-coupled and a rhodamine-coupled lectin, followed by staining of the nuclei with 4',6-diamidino-2-phenylindole. Specimens were examined in triple immunofluorescence (FITC/rhodamine/UV). Cell types could be identified by their characteristic lectin-binding pattern. For example, the lectin combination of Sophora japonica agglutinin (aggl; SJA) and Erythrina cristagalli aggl (ECA) permitted a differentiation between cells of the proximal tubules (SJA positive [SJA+], ECA+), distal tubules (SJA negative [SJA-], ECA+), collecting ducts (SJA+, ECA-), and lymphocytes (SJA-, ECA-). In preliminary studies, examination Of urinary sediment in various chronic nephropathies by this technique Showed differences in their cellular excretion pattern. In summary, staining urinary sediments with combinations of lectins provides a rapid and relatively inexpensive method for a facilitated and reliable differentiation of the various nucleated cell types in urine, (C) 2001 by the National Kidney Foundation, Inc."],["dc.identifier.doi","10.1053/ajkd.2001.20592"],["dc.identifier.isi","000166422400012"],["dc.identifier.pmid","11136172"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30611"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co"],["dc.relation.issn","0272-6386"],["dc.title","Identification of nucleated cells in urine using lectin staining"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1491"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Nephrology Dialysis Transplantation"],["dc.bibliographiccitation.lastpage","1496"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Grupp, Clemens"],["dc.contributor.author","Hemprich, U."],["dc.contributor.author","John, H."],["dc.contributor.author","Braun, F."],["dc.contributor.author","Lorf, Thomas"],["dc.contributor.author","Armstrong, Victor William"],["dc.contributor.author","Sattler, B."],["dc.contributor.author","Ringe, B."],["dc.contributor.author","Mueller, Gerhard A."],["dc.date.accessioned","2018-11-07T10:17:06Z"],["dc.date.available","2018-11-07T10:17:06Z"],["dc.date.issued","2002"],["dc.description.abstract","Background. Urine cytology, although considered a valuable diagnostic tool in the monitoring of kidney graft function, is hampered by difficulty in differentiating the nucleated non-squamous cells in urine using conventional techniques. We have now developed a method for the simple identification of urinary cell types by lectin staining. Methods. Acetone-fixed cytopreparations of urinary sediments were incubated with the lectin combination Sophora Japonica agglutinin (SJA; rhodamine-labelled) and Erythrina cristagalli agglutinin (ECA; fluorescein isothiocyanate (FITC)-labelled) for 15 min, followed by staining of the nuclei with 4',6-diamidino-2-phenylindole (DAPI). The courses of 38 patients were serially monitored after kidney transplantation during the period in hospital. Results. Nucleated urinary cell types could be easily identified from one specimen by their characteristic lectin-binding pattern using triple-immunofluorescence microscopy (FITC/rhodamine/ultra violet), permitting a differentiation between proximal (SJA+/ECA+) and distal tubules (SJA-/ECA+), collecting ducts (SJA+/ECA-) and lymphocytes (SJA-/ECA-). Stable graft function was characterized by low numbers of lymphocytes, tubular cells and urothelia. During rejection episodes, but not graft dysfunction unrelated to rejection, urinary excretion of lymphocytes as well as of distal tubular cells (from 1.0 to 6.0 and from 1.4 to 4.0 per 10 high-power fields, respectively) increased significantly up to 3 days prior to clinical diagnosis. Conclusions. Lectin staining facilitates unambiguous differentiation of the urinary cell types, in particular the various tubular epithelial cells, which are otherwise difficult to identify. This technique provides a rapid and easily applicable tool to evaluate the significance of the respective cell types in the monitoring of kidney graft function."],["dc.identifier.doi","10.1093/ndt/17.8.1491"],["dc.identifier.isi","000177372900024"],["dc.identifier.pmid","12147800"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41167"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0931-0509"],["dc.title","Lectin staining for urine cytologic monitoring after kidney transplantation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2255"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Nephrology Dialysis Transplantation"],["dc.bibliographiccitation.lastpage","2261"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Steffgen, J."],["dc.contributor.author","Kampfer, K."],["dc.contributor.author","Grupp, Clemens"],["dc.contributor.author","Langenberg, C."],["dc.contributor.author","Mueller, Gerhard A."],["dc.contributor.author","Grunewald, Rolf W."],["dc.date.accessioned","2018-11-07T10:35:12Z"],["dc.date.available","2018-11-07T10:35:12Z"],["dc.date.issued","2003"],["dc.description.abstract","Background. Little is known about sorbitol metabolism in renal papillary interstitial cells. For characterization we studied regulation of sorbitol synthesis by aldose reductase (AR) and degradation by sorbitol dehydrogenase (SDH) in papillary interstitial cells. Methods. Interstitial cells were isolated from rat renal inner medulla to a pure cell fraction. mRNA was isolated from cultivated cells and sorbitol, AR and SDH activity were determined enzymatically in homogenates. Results. Sorbitol concentration in these cells at 300 mosmol/l was 4.4 +/- 0.3 vs 78 +/- 3.6 mumol/g protein at 600 mosmol/l. At steady-state conditions at 300 mosmol/l, AR activity was nearly the same as SDH activity (15.1 +/- 1.6 vs 16.6 +/- 2.0 U/g protein). At 600 mosmol/l, AR activity increased to 82.5 +/- 11.4 U/g protein and SDH activity to 31.5 +/- 6.0 U/g protein. Studying the time course of enzyme activity after changing osmolarity from 300 to 600 mosmol/l, we found half maximal stimulation after 2-3 (AR) or 3 (SDH) days. The amount of AR-mRNA preceded the rise of enzyme activity, whereas SDH-mRNA was not significantly influenced. Lowering osmolarity from 600 to 300 mosmol/l, enzyme activity decreased to less than half within 2 (AR) or I (SDH) day(s). Conclusions. The results suggest that sorbitol metabolism contributes to handling of osmotic stress in rat renal papillary interstitial cells."],["dc.identifier.doi","10.1093/ndt/gfg397"],["dc.identifier.isi","000186173800010"],["dc.identifier.pmid","14551351"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45037"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0931-0509"],["dc.title","Osmoregulation of aldose reductase and sorbitol dehydrogenase in cultivated interstitial cells of rat renal inner medulla"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]