Müller, Gerhard Anton

[["dc.bibliographiccitation.firstpage","595"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Annals of the Rheumatic Diseases"],["dc.bibliographiccitation.lastpage","600"],["dc.bibliographiccitation.volume","65"],["dc.contributor.author","Scheel, Alexander Konrad"],["dc.contributor.author","Hermann, Kay Geert A."],["dc.contributor.author","Ohrndorf, S."],["dc.contributor.author","Werner, C."],["dc.contributor.author","Schirmer, Claudia"],["dc.contributor.author","Detert, J."],["dc.contributor.author","Bollow, M."],["dc.contributor.author","Hamm, Bernd"],["dc.contributor.author","Mueller, Gerhard A."],["dc.contributor.author","Burmester, Gerd-Ruediger"],["dc.contributor.author","Backhaus, M."],["dc.date.accessioned","2018-11-07T09:50:42Z"],["dc.date.available","2018-11-07T09:50:42Z"],["dc.date.issued","2006"],["dc.description.abstract","Objective: To perform a prospective long term follow up study comparing conventional radiography (CR), ultrasonography ( US), and magnetic resonance imaging (MRI) in the detection of bone erosions and synovitis in rheumatoid arthritis ( RA) finger joints. Methods: The metacarpophalangeal and proximal interphalangeal joints II - V ( 128 joints) of the clinically dominant hand of 16 patients with RA were included. Follow up joint by joint comparisons for erosions and synovitis were made. Results: At baseline, CR detected erosions in 5/128 (4%) of all joints, US in 12/128 (9%), and MRI in 34/ 128 (27%). Seven years later, an increase of joints with erosions was found with CR (26%), US (49%) ( p< 0.001 each), and MRI (32%, NS). In contrast, joint swelling and tenderness assessed by clinical examination were decreased at follow up ( p = 0.2, p< 0.001). A significant reduction in synovitis with US and MRI ( p< 0.001 each) was seen. In CR, 12 patients did not have any erosions at baseline, while in 10/ 12 patients erosions were detected in 25/96 ( 26%) joints after 7 years. US initially detected erosions in 9 joints, of which two of these joints with erosions were seen by CR at follow up. MRI initially found 34 erosions, of which 14 (41%) were then detected by CR. Conclusion: After 7 years, an increase of bone erosions was detected by all imaging modalities. In contrast, clinical improvement and regression of synovitis were seen only with US and MRI. More than one third of erosions previously detected by MRI were seen by CR 7 years later."],["dc.identifier.doi","10.1136/ard.2005.041814"],["dc.identifier.isi","000236764900007"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35757"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","B M J Publishing Group"],["dc.relation.issn","0003-4967"],["dc.title","Prospective 7 year follow up imaging study comparing radiography, ultrasonography, and magnetic resonance imaging in rheumatoid arthritis finger joints"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","375"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","IEEE Transactions on Biomedical Engineering"],["dc.bibliographiccitation.lastpage","382"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Schwaighofer, A."],["dc.contributor.author","Tresp, V."],["dc.contributor.author","Mayer, P."],["dc.contributor.author","Krause, A."],["dc.contributor.author","Beuthan, Juergen"],["dc.contributor.author","Rost, H."],["dc.contributor.author","Metzger, G."],["dc.contributor.author","Mueller, Gerhard A."],["dc.contributor.author","Scheel, Alexander Konrad"],["dc.date.accessioned","2018-11-07T10:40:24Z"],["dc.date.available","2018-11-07T10:40:24Z"],["dc.date.issued","2003"],["dc.description.abstract","We describe a classification system for a novel imaging method for arthritic ringer joints. The basis of this system is a laser imaging technique which is sensitive to the optical characteristics of ringer joint tissue. From the laser images acquired at baseline and follow-up, finger joints can automatically be classified according to whether the inflammatory status has improved or worsened. To perform the classification task, various linear and kernel-based systems were implemented and their performances were compared. Based on the results presented in this paper, we conclude that the laser-based imaging permits a reliable classification of pathological finger joints, making it a sensitive method for detecting arthritic changes."],["dc.identifier.doi","10.1109/TBME.2003.808827"],["dc.identifier.isi","000181609400011"],["dc.identifier.pmid","12669994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46294"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Ieee-inst Electrical Electronics Engineers Inc"],["dc.relation.issn","0018-9294"],["dc.title","Classification of rheumatoid joint inflammation based on laser imaging"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","239"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Annals of the Rheumatic Diseases"],["dc.bibliographiccitation.lastpage","245"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Scheel, Alexander Konrad"],["dc.contributor.author","Backhaus, M."],["dc.contributor.author","Klose, Alexander D."],["dc.contributor.author","Moa-Anderson, B."],["dc.contributor.author","Netz, U. J."],["dc.contributor.author","Hermann, Kay Geert A."],["dc.contributor.author","Beuthan, Juergen"],["dc.contributor.author","Mueller, Gerhard A."],["dc.contributor.author","Burmester, Gerd-Ruediger"],["dc.contributor.author","Hielscher, Andreas H."],["dc.date.accessioned","2018-11-07T11:24:38Z"],["dc.date.available","2018-11-07T11:24:38Z"],["dc.date.issued","2005"],["dc.description.abstract","Objective: To identify classifiers in images obtained with sagittal laser optical tomography ( SLOT) that can be used to distinguish between joints affected and not affected by synovitis. Methods: 78 SLOT images of proximal interphalangeal joints II-IV from 13 patients with rheumatoid arthritis were compared with ultrasound ( US) images and clinical examination (CE). SLOT images showing the spatial distribution of scattering and absorption coefficients within the joint cavity were generated. The means and standard errors for seven different classifiers ( operator score and six quantitative measurements) were determined from SLOT images using CE and US as diagnostic references. For classifiers showing significant differences between affected and non-affected joints, sensitivities and specificities for various cut off parameters were obtained by receiver operating characteristic (ROC) analysis. Results: For five classifiers used to characterise SLOT images the mean between affected and unaffected joints was statistically significant using US as diagnostic reference, but statistically significant for only one classifier with CE as reference. In general, high absorption and scattering coefficients in and around the joint cavity are indicative of synovitis. ROC analysis showed that the minimal absorption classifier yields the largest area under the curve (0.777; sensitivity and specificity 0.705 each) with US as diagnostic reference. Conclusion: Classifiers in SLOT images have been identified that show statistically significant differences between joints with and without synovitis. It is possible to classify a joint as inflamed with SLOT, without the need for a reference measurement. Furthermore, SLOT based diagnosis of synovitis agrees better with US diagnosis than CE."],["dc.description.sponsorship","NIAMS NIH HHS [R01 AR 46255-03]"],["dc.identifier.doi","10.1136/ard.2004.024224"],["dc.identifier.isi","000226279200016"],["dc.identifier.pmid","15297282"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56448"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","B M J Publishing Group"],["dc.relation.issn","0003-4967"],["dc.title","First clinical evaluation of sagittal laser optical tomography for detection of synovitis in arthritic finger joints"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S202"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Arthritis & Rheumatism"],["dc.bibliographiccitation.lastpage","S203"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Scheel, Alexander Konrad"],["dc.contributor.author","Meller, J."],["dc.contributor.author","Vosshenrich, R."],["dc.contributor.author","Kohlhoff, E."],["dc.contributor.author","Mueller, Gerhard A."],["dc.contributor.author","Strutz, Frank M."],["dc.date.accessioned","2018-11-07T10:36:17Z"],["dc.date.available","2018-11-07T10:36:17Z"],["dc.date.issued","2003"],["dc.identifier.isi","000185432800481"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45289"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.publisher.place","New york"],["dc.relation.conference","67th Annual Scientific Meeting of the American-College-of-Rheumatology/38th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals"],["dc.relation.eventlocation","ORLANDO, FLORIDA"],["dc.relation.issn","0004-3591"],["dc.title","Early aortitis in the elderly: Diagnosis and follow-up"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Arthritis & Rheumatism"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Scheel, Alexander Konrad"],["dc.contributor.author","Hermann, Kay Geert A."],["dc.contributor.author","Pasewaldt, D."],["dc.contributor.author","Schirmer, Claudia"],["dc.contributor.author","Althoff, Christian E."],["dc.contributor.author","Mueller, Gerhard A."],["dc.contributor.author","Burmester, Gerd-Ruediger"],["dc.contributor.author","Backhaus, M."],["dc.date.accessioned","2018-11-07T10:45:45Z"],["dc.date.available","2018-11-07T10:45:45Z"],["dc.date.issued","2004"],["dc.format.extent","S397"],["dc.identifier.isi","000223799001049"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47578"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.publisher.place","Hoboken"],["dc.relation.conference","68th Annual Scientific Meeting of the American-College-of-Rheumatology/39th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals"],["dc.relation.eventlocation","San Antonio, TX"],["dc.relation.issn","0004-3591"],["dc.title","Reduction of finger joint synovitis detected by low-field magnetic resonance imaging and ultrasound in patients with active rheumatoid arthritis receiving adalimumab (HUMIRA (R))."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Annals of the Rheumatic Diseases"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Scheel, Alexander Konrad"],["dc.contributor.author","Hermann, Kay Geert A."],["dc.contributor.author","Kahler, Elke"],["dc.contributor.author","Pasewaldt, D."],["dc.contributor.author","Brunner, E."],["dc.contributor.author","Mueller, Gerhard A."],["dc.contributor.author","Burmester, Gerd-Ruediger"],["dc.contributor.author","Backhaus, M."],["dc.date.accessioned","2018-11-07T10:47:27Z"],["dc.date.available","2018-11-07T10:47:27Z"],["dc.date.issued","2004"],["dc.format.extent","471"],["dc.identifier.isi","000224551501600"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47967"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","B M J Publishing Group"],["dc.publisher.place","London"],["dc.relation.conference","Annual European Congress of Rheumatology (EULAR 2004)"],["dc.relation.eventlocation","Berlin, GERMANY"],["dc.relation.issn","0003-4967"],["dc.title","A novel ultrasonographic synovitis score suitable for analyzing rheumatoid arthritis finger joint inflammation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","25"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","DMW - Deutsche Medizinische Wochenschrift"],["dc.bibliographiccitation.lastpage","28"],["dc.bibliographiccitation.volume","130"],["dc.contributor.author","Koziolek, Michael Johann"],["dc.contributor.author","Kunze, Ekkehard"],["dc.contributor.author","Mueller, A."],["dc.contributor.author","Thiem, V."],["dc.contributor.author","Scheel, Alexander Konrad"],["dc.contributor.author","Mueller, Gerhard A."],["dc.contributor.author","Strutz, Frank M."],["dc.date.accessioned","2018-11-07T08:32:40Z"],["dc.date.available","2018-11-07T08:32:40Z"],["dc.date.issued","2005"],["dc.description.abstract","History and clinical findings: A 55-year-old female was admitted complaining of musculoskeletal pain and weakness of both lower extremities for a number of years. Due to a hypothalamic mass of unknown aetiology a diabetes insipidus, a gonadotrophic, somatotrophic and a partially corticotrophic insufficiency had developed. Investigations: Laboratory investigations yielded elevated levels of several inflammatory parameters (C-reactive protein, blood sedimentation rate, fibrinogen and thrombocytes). Serological parameters indicating a systemic rheumatic disorder were absent. X-ray examination revealed combined osteolytic and osteoblastic lesions within the distal parts of both femora and within the proximal portions of both tibiae. MRI showed signal alterations and (99m)Technetium bone scan exhibited a considerably increased uptake. Histopathologically, a biopsy of the left tibia showed multifocal small infiltrates of foamy histiocytes indicating Erdheim-Chester disease (ECD). Treatment and course: Under treatment with glucocorticosteroids musculoskeletal complaints improved, but re-appeared following dose reduction. A therapeutic trial using methotrexat did not affect the complaints. Conclusion: The Erdheim-Chester syndrome is considered to belong to diseases with a proliferation of the monocytic-histiocytic and dendritic cellular system. In the presence of symmetric musculoskeletal symptoms associated with osteosclerotic and osteolytic lesions particularly occurring in the long bones of the lower extremities and concomitant with elevated serum markers of inflammation, the Erdheim-Chester disease should be taken into account. To date, no validated therapy exists."],["dc.identifier.doi","10.1055/s-2005-837370"],["dc.identifier.isi","000226597800006"],["dc.identifier.pmid","15619170"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17392"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0012-0472"],["dc.title","Erdheim-Chester disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1177"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Arthritis & Rheumatism"],["dc.bibliographiccitation.lastpage","1184"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Scheel, Alexander Konrad"],["dc.contributor.author","Krause, A."],["dc.contributor.author","Mesecke-von Rheinbaben, I."],["dc.contributor.author","Metzger, G."],["dc.contributor.author","Rost, H."],["dc.contributor.author","Tresp, V."],["dc.contributor.author","Mayer, P."],["dc.contributor.author","Reuss-Borst, M. A."],["dc.contributor.author","Mueller, Gerhard A."],["dc.date.accessioned","2018-11-07T10:30:02Z"],["dc.date.available","2018-11-07T10:30:02Z"],["dc.date.issued","2002"],["dc.description.abstract","Objective. To evaluate a newly developed laser-based imaging technique for the study of soft tissue changes and acute inflammatory processes of the proximal interphalangeal (PIP) joints in patients with rheumatoid arthritis (RA). Methods. A novel imaging device was developed which allows the trans illumination of PIP joints using laser light in the near-infrared wavelength range. In a first clinical followup study, a total of 72 PIP joints of 22 patients with RA and 64 PIP joints of 8 healthy controls were examined both clinically and with the new laser device. At baseline and at followup, after a mean of 6 weeks, clinical signs of synovitis, the joint circumference, and the degree of pain were assessed for each joint in order to determine the clinical degree of inflammation. Different features were extracted from the laser images and evaluated by a neural network. Results. At baseline, 72 PIP joints in the RA patients showed clinical signs of inflammation. At followup, 45 PIP joints showed clinical improvement, 13 showed steady active inflammation, and 14 showed deterioration compared with the first visit. None of the 64 PIP joints in the healthy individuals showed any signs of synovitis. The inflammatory status of 60 of the 72 RA joints examined was classified correctly by laser examination and joint circumference determination, giving a sensitivity of 80%, a specificity of 89%, and an accuracy of 83% in detecting inflammatory changes in affected joints. Laser data and joint circumference determination of healthy joints at followup resulted in an accuracy of 85% in reproducing the image. Conclusion. The new laser-based imaging technique allows the transillumination of PIP joints and gives information about the inflammatory status of the joint after processing through a neural network. Our data indicate that laser imaging may provide additional information in the early diagnosis of an inflammatory joint process and may prove particularly useful in assessing acute joint inflammation at followup."],["dc.identifier.doi","10.1002/art.10226"],["dc.identifier.isi","000175646000009"],["dc.identifier.pmid","12115221"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43770"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","0004-3591"],["dc.title","Assessment of proximal finger joint inflammation in patients with rheumatoid arthritis, using a novel laser-based Imaging technique"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3693"],["dc.bibliographiccitation.issue","7-8"],["dc.bibliographiccitation.journal","Transplantation Proceedings"],["dc.bibliographiccitation.lastpage","3694"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Scheel, Alexander Konrad"],["dc.contributor.author","Blaschke, S."],["dc.contributor.author","Schettler, Volker"],["dc.contributor.author","Mayer, C."],["dc.contributor.author","Mueller, Gerhard A."],["dc.contributor.author","Bittermann, H. J."],["dc.contributor.author","Grunewald, Rolf W."],["dc.date.accessioned","2018-11-07T08:31:07Z"],["dc.date.available","2018-11-07T08:31:07Z"],["dc.date.issued","2001"],["dc.identifier.doi","10.1016/S0041-1345(01)02506-4"],["dc.identifier.isi","000173143600266"],["dc.identifier.pmid","11750573"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17048"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.conference","2001: A Transplant Odyssey Congress"],["dc.relation.eventlocation","ISTANBUL, TURKEY"],["dc.relation.issn","0041-1345"],["dc.title","Severe neurotoxicity of tacrolimus (FK506) after renal transplantation: Two case reports"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Annals of the Rheumatic Diseases"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Scheel, Alexander Konrad"],["dc.contributor.author","Hermann, Kay Geert A."],["dc.contributor.author","Schirmer, Claudia"],["dc.contributor.author","Althoff, Christian E."],["dc.contributor.author","Mueller, Gerhard A."],["dc.contributor.author","Hamm, Bernd"],["dc.contributor.author","Burmester, Gerd-Ruediger"],["dc.contributor.author","Backhaus, M."],["dc.date.accessioned","2018-11-07T10:47:27Z"],["dc.date.available","2018-11-07T10:47:27Z"],["dc.date.issued","2004"],["dc.format.extent","469"],["dc.identifier.isi","000224551501592"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47966"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","B M J Publishing Group"],["dc.publisher.place","London"],["dc.relation.conference","Annual European Congress of Rheumatology (EULAR 2004)"],["dc.relation.eventlocation","Berlin, GERMANY"],["dc.relation.issn","0003-4967"],["dc.title","Low-field magnetic resonance imaging for follow-up analysis of finger joint inflammation in patients with active RA receiving adalimumab (humira((R)))"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]