Saiepour, Nasrin

[["dc.bibliographiccitation.firstpage","E400"],["dc.bibliographiccitation.journal","Glia"],["dc.bibliographiccitation.lastpage","E401"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Yin, Z."],["dc.contributor.author","Raj, D."],["dc.contributor.author","Saiepour, Nasrin"],["dc.contributor.author","van Dam, D."],["dc.contributor.author","Brouwer, Nieske"],["dc.contributor.author","Eggen, Bart J. L."],["dc.contributor.author","Hanisch, U.-K."],["dc.contributor.author","Hol, E."],["dc.contributor.author","Kamphuis, W."],["dc.contributor.author","Bayer, T."],["dc.contributor.author","De Deyn, P. P."],["dc.contributor.author","Boddeke, Erik"],["dc.date.accessioned","2018-11-07T09:54:20Z"],["dc.date.available","2018-11-07T09:54:20Z"],["dc.date.issued","2015"],["dc.identifier.isi","000356386700671"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36516"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","12th European Meeting on Glial Cell Function in Health and Disease"],["dc.relation.eventlocation","Bilbao, SPAIN"],["dc.relation.issn","1098-1136"],["dc.relation.issn","0894-1491"],["dc.title","beta-amyloid plaque-associated microglia priming in transgenic mouse models of Alzheimer's disease"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","205"],["dc.bibliographiccitation.journal","Brain Behavior and Immunity"],["dc.bibliographiccitation.lastpage","221"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Schaafsma, W."],["dc.contributor.author","Zhang, X."],["dc.contributor.author","van Zomeren, K. C."],["dc.contributor.author","Jacobs, S."],["dc.contributor.author","Georgieva, Petya B."],["dc.contributor.author","Wolf, S. A."],["dc.contributor.author","Kettenmann, Helmut"],["dc.contributor.author","Janova, Hana"],["dc.contributor.author","Saiepour, Nasrin"],["dc.contributor.author","Hanisch, U.-K."],["dc.contributor.author","Meerlo, Peter"],["dc.contributor.author","van den Elsen, Peter J."],["dc.contributor.author","Brouwer, Nieske"],["dc.contributor.author","Boddeke, Hendrikus W. G. M."],["dc.contributor.author","Eggen, Bart J. L."],["dc.date.accessioned","2018-11-07T09:53:59Z"],["dc.date.available","2018-11-07T09:53:59Z"],["dc.date.issued","2015"],["dc.description.abstract","Microglia, the innate immune cells of the central nervous system (CNS), react to endotoxins like bacterial lipopolysaccharides (LPS) with a pronounced inflammatory response. To avoid excess damage to the CNS, the microglia inflammatory response needs to be tightly regulated. Here we report that a single LPS challenge results in a prolonged blunted pro-inflammatory response to a subsequent LPS stimulation, both in primary microglia cultures (100 ng/ml) and in vivo after intraperitoneal (0.25 and 1 mg/kg) or intracere-broventricular (5 mu g) LPS administration. Chromatin immunoprecipitation (ChIP) experiments with primary microglia and microglia acutely isolated from mice showed that LPS preconditioning was accompanied by a reduction in active histone modifications AcH3 and H3K4me3 in the promoters of the IL-10 and TNF-alpha genes. Furthermore, LPS preconditioning resulted in an increase in the amount of repressive histone modification H3K9me2 in the IL-1 beta promoter. ChIP and knock-down experiments showed that NF-kappa B subunit RelB was bound to the IL-1 beta promoter in preconditioned microglia and that RelB is required for the attenuated LPS response. In addition to a suppressed pro-inflammatory response, preconditioned primary microglia displayed enhanced phagocytic activity, increased outward potassium currents and nitric oxide production in response to a second LPS challenge. In vivo, a single i.p. LPS injection resulted in reduced performance in a spatial learning task 4 weeks later, indicating that a single inflammatory episode affected memory formation in these mice. Summarizing, we show that LPS-preconditioned microglia acquire an epigenetically regulated, immune-suppressed phenotype, possibly to prevent excessive damage to the central nervous system in case of recurrent (peripheral) inflammation. (C) 2015 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.bbi.2015.03.013"],["dc.identifier.isi","000358460700023"],["dc.identifier.pmid","25843371"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36442"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1090-2139"],["dc.relation.issn","0889-1591"],["dc.title","Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","115"],["dc.bibliographiccitation.journal","Neurobiology of Aging"],["dc.bibliographiccitation.lastpage","122"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Yin, Zhuoran"],["dc.contributor.author","Raj, Divya"],["dc.contributor.author","Saiepour, Nasrin"],["dc.contributor.author","Van Dam, Debby"],["dc.contributor.author","Brouwer, Nieske"],["dc.contributor.author","Holtman, Inge R."],["dc.contributor.author","Eggen, Bart J.L."],["dc.contributor.author","Möller, Thomas"],["dc.contributor.author","Tamm, Joseph A."],["dc.contributor.author","Abdourahman, Aicha"],["dc.contributor.author","Hol, Elly M."],["dc.contributor.author","Kamphuis, Willem"],["dc.contributor.author","Bayer, Thomas A."],["dc.contributor.author","De Deyn, Peter P."],["dc.contributor.author","Boddeke, Erik"],["dc.date.accessioned","2020-12-10T15:20:27Z"],["dc.date.available","2020-12-10T15:20:27Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.neurobiolaging.2017.03.021"],["dc.identifier.issn","0197-4580"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72674"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]