Wodarz, Andreas

[["dc.bibliographiccitation.firstpage","535"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Cell Science"],["dc.bibliographiccitation.lastpage","545"],["dc.bibliographiccitation.volume","122"],["dc.contributor.author","Zhang, G."],["dc.contributor.author","Breuer, Manuel"],["dc.contributor.author","Foerster, Ankathrin"],["dc.contributor.author","Egger-Adam, Diane"],["dc.contributor.author","Wodarz, Andreas"],["dc.date.accessioned","2018-11-07T08:32:44Z"],["dc.date.available","2018-11-07T08:32:44Z"],["dc.date.issued","2009"],["dc.description.abstract","The formation of the mitotic spindle is controlled by the microtubule organizing activity of the centrosomes and by the effects of chromatin-associated Ran-GTP on the activities of spindle assembly factors. In this study we show that Mars, a Drosophila protein with sequence similarity to vertebrate hepatoma upregulated protein (HURP), is required for the attachment of the centrosome to the mitotic spindle. More than 80% of embryos derived from mars mutant females do not develop properly due to severe mitotic defects during the rapid nuclear divisions in early embryogenesis. Centrosomes frequently detach from spindles and from the nuclear envelope and nucleate astral microtubules in ectopic positions. Consistent with its function in spindle organization, Mars localizes to nuclei in interphase and associates with the mitotic spindle, in particular with the spindle poles, during mitosis. We propose that Mars is an important linker between the spindle and the centrosomes that is required for proper spindle organization during the rapid mitotic cycles in early embryogenesis."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [SFB 590, TP A2, WO 584/4-1, 42]"],["dc.identifier.doi","10.1242/jcs.040352"],["dc.identifier.isi","000263071700012"],["dc.identifier.pmid","19174464"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17407"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Company Of Biologists Ltd"],["dc.relation.issn","0021-9533"],["dc.title","Mars, a Drosophila protein related to vertebrate HURP, is required for the attachment of centrosomes to the mitotic spindle during syncytial nuclear divisions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Journal of Cell Biology"],["dc.bibliographiccitation.volume","87"],["dc.contributor.author","Gailite, I."],["dc.contributor.author","Egger-Adam, Diane"],["dc.contributor.author","Wodarz, Andreas"],["dc.date.accessioned","2018-11-07T11:17:30Z"],["dc.date.available","2018-11-07T11:17:30Z"],["dc.date.issued","2008"],["dc.format.extent","51"],["dc.identifier.isi","000255316100130"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54821"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","31st Annual Meeting of the German-Society-for-Cell-Biology"],["dc.relation.eventlocation","Marburg, GERMANY"],["dc.relation.issn","0171-9335"],["dc.title","Analysis of CG14782, a new interaction partner of Bazooka, in Drosophila development"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","901"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Developmental Cell"],["dc.bibliographiccitation.lastpage","908"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Krahn, Michael P."],["dc.contributor.author","Egger-Adam, Diane"],["dc.contributor.author","Wodarz, Andreas"],["dc.date.accessioned","2018-11-07T08:28:42Z"],["dc.date.available","2018-11-07T08:28:42Z"],["dc.date.issued","2009"],["dc.description.abstract","Bazooka/Par-3 (Baz) is a key regulator of cell polarity in epithelial cells and neuroblasts (NBs). Phosphorylation of Baz by PAR-1 and aPKC is required for its function in epithelia, but little is known about the dephosphorylation mechanisms that antagonize the activities of these kinases or about the relevance of Baz phosphorylation for NB polarity. We found that protein phosphatase 2A (PP2A) binds to Baz via its structural A subunit. By using phospho-specific antibodies, we show that PP2A dephosphorylates; Baz at the conserved serine residue 1085 and thereby antagonizes the kinase activity of PAR-1. Loss of PP2A function leads to complete reversal of polarity in NBs, giving rise to an \"upside-down\" polarity phenotype. Overexpression of PAR-1 or Baz, or mutation of 14-3-3 proteins that bind phosphorylated Baz, causes essentially the same phenotype, indicating that the balance of PAR-1 and PP2A effects on Baz phosphorylation determines NIB polarity."],["dc.description.sponsorship","Deutsche Forschungsgemenschaft [SFB 590, TP A2, WO 584/4-1, 4-2]"],["dc.identifier.doi","10.1016/j.devcel.2009.04.011"],["dc.identifier.isi","000267203700016"],["dc.identifier.pmid","19531360"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16484"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","1534-5807"],["dc.title","PP2A Antagonizes Phosphorylation of Bazooka by PAR-1 to Control Apical-Basal Polarity in Dividing Embryonic Neuroblasts"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]