Tammer, Roland

[["dc.bibliographiccitation.firstpage","221"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neuroscience Methods"],["dc.bibliographiccitation.lastpage","229"],["dc.bibliographiccitation.volume","153"],["dc.contributor.author","Tammer, Roland"],["dc.contributor.author","Ehrenreich, L."],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Michaelis, Thomas"],["dc.date.accessioned","2017-09-07T11:45:31Z"],["dc.date.available","2017-09-07T11:45:31Z"],["dc.date.issued","2005"],["dc.description.abstract","Knowledge of the precise position of recording microelectrodes within the brain of a non-human primate is essential for a reliable exploration of very small anatomic structures. This work demonstrates the compatibility of a newly developed glass-guided microelectrode design and microfeed equipment with high-resolution 3D magnetic resonance imaging (MRI). T1- and T2-weighted images allow for the non-invasive visualization of chronically implanted microelectrodes within the brain stem of squirrel monkeys in vivo. Neural extracellular multi-unit recordings proved the functionality of the microelectrode before and after the use of 3D MRI suggesting the preservation of normal brain tissue at the tip of the electrode. Because histology confirmed the absence of lesions attributable to MRI, the approach offers an interactive monitoring during the course of neuroethological experiments. Consequently, MRI may become an in vivo alternative to common histological post mortem verifications of electrode tracks and hence may avoid the early sacrificing of primates after only a small number of experiments."],["dc.identifier.doi","10.1016/j.jneumeth.2005.10.018"],["dc.identifier.gro","3150378"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7136"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","0165-0270"],["dc.title","Compatibility of glass-guided recording microelectrodes in the brain stem of squirrel monkeys with high-resolution 3D MRI"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","41"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","NMR in Biomedicine"],["dc.bibliographiccitation.lastpage","49"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Schmelting, Barthel"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Merkler, Doron"],["dc.contributor.author","Tammer, Roland"],["dc.contributor.author","Czéh, Boldizsár"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2017-09-07T11:45:33Z"],["dc.date.available","2017-09-07T11:45:33Z"],["dc.date.issued","2006-02"],["dc.description.abstract","Experimental autoimmune encephalomyelitis (EAE) induced by myelin–oligodendrocyte glycoprotein (MOG) in common marmosets (Callithrix jacchus) is a model for multiple sclerosis. Here, EAE was induced in four common marmosets by 250–300 µg recombinant rat MOG. In addition to a detailed disability scoring, T2- and T1-weighted high-resolution 3D MRI was performed to assess the onset and development of cerebral lesions. The findings were confirmed by histopathology in all animals. Although the animals exhibited a large heterogeneity with regard to onset and localization of lesions and also to disease duration and severity of disability signs, none of the animals revealed any evidence of recovery. A specification of the disability scoring system to account for different aspects of the disease led to a good concurrence of the first MRI-detectable lesion and the onset of central nervous system (CNS) symptoms. The results suggest that MRI monitoring of white matter lesions in conjunction with disability scores that focus on CNS symptoms may be a suitable method to evaluate novel therapeutic interventions even in the presence of pronounced interindividual heterogeneity."],["dc.identifier.doi","10.1002/nbm.999"],["dc.identifier.gro","3150390"],["dc.identifier.pmid","16408325"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7149"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0952-3480"],["dc.subject","magnetic resonance imaging; experimental autoimmune encephalitis; common marmoset; Callithrix jacchus"],["dc.title","Monitoring of EAE onset and progression in the common marmoset monkey by sequential high-resolution 3D MRI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","339"],["dc.bibliographiccitation.issue","3-6"],["dc.bibliographiccitation.journal","Magnetic Resonance Materials in Physics, Biology and Medicine"],["dc.bibliographiccitation.lastpage","347"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Boretius, S."],["dc.contributor.author","Natt, O."],["dc.contributor.author","Watanabe, T."],["dc.contributor.author","Tammer, R."],["dc.contributor.author","Ehrenreich, L."],["dc.contributor.author","Frahm, J."],["dc.contributor.author","Michaelis, T."],["dc.date.accessioned","2017-09-07T11:45:31Z"],["dc.date.available","2017-09-07T11:45:31Z"],["dc.date.issued","2004"],["dc.description.abstract","The purpose was to assess the potential of half Fourier diffusion-weighted single-shot STEAM MRI for diffusion tensor mapping of animal brain in vivo. A STEAM sequence with image acquisition times of about 500 ms was implemented at 2.35 T using six gradient orientations and b values of 200, 700, and 1200 s mm(-2). The use of half Fourier phase-encoding increased the signal-to-noise ratio by 45% relative to full Fourier acquisitions. Moreover, STEAM-derived maps of the relative anisotropy and main diffusion direction were completely free of susceptibility-induced signal losses and geometric distortions. Within measuring times of 3 h, the achieved resolution varied from 600x700x1000 microm3 for squirrel monkeys to 140x280x720 microm3 for mice. While in monkeys the accessible white matter fiber connections were comparable to those reported for humans, detectable fiber structures in mice focused on the corpus callosum, anterior commissure, and hippocampal fimbria. In conclusion diffusion-weighted single-shot STEAM MRI allows for in vivo diffusion tensor mapping of the brain of squirrel monkeys, rats, and mice without motion artifacts and susceptibility distortions."],["dc.identifier.doi","10.1007/s10334-004-0069-1"],["dc.identifier.gro","3150383"],["dc.identifier.pmid","15580374"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7141"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0968-5243"],["dc.subject","Magnetic resonance imaging; Diffusion-weighted imaging; Anisotropy; White matter; Animal brain"],["dc.title","In vivo diffusion tensor mapping of the brain of squirrel monkey, rat, and mouse using single-shot STEAM MRI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Magnetic Resonance in Medicine"],["dc.bibliographiccitation.lastpage","6"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Tammer, Roland"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Michaelis, Thomas"],["dc.date.accessioned","2017-09-07T11:45:26Z"],["dc.date.available","2017-09-07T11:45:26Z"],["dc.date.issued","2006"],["dc.description.abstract","This work demonstrates that intraventricular microinjections of a low dose of potassium dichromate (0.4 μL of 10 mM solution) yield a specific contrast enhancement of white matter (WM) tracts in T1-weighted 3D MRI of mouse brain in vivo. Pronounced and persistent signal increases (40–100% at 24 hr after injection) were observed in the corpus callosum, anterior commissure, fornix, and stria medullaris, as well as in the mammillothalamic tract and fasciculus retroflexus. These results suggest that the extracellular diffusion of diamagnetic chromium(VI) (Cr(VI)) after injection is followed by a tissue-specific reduction to paramagnetic Cr(V) and (III), which relies predominantly on the oxidation of myelin lipids. Because Cr(VI)-induced contrast leads to only a mild unspecific enhancement (10–20%) of gray matter (GM) structures, such as the hippocampal formation, the method reveals novel information that differs from that obtainable using other paramagnetic ions, such as manganese."],["dc.identifier.doi","10.1002/mrm.20930"],["dc.identifier.gro","3150375"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7133"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","0740-3194"],["dc.title","Chromium(VI) as a novel MRI contrast agent for cerebral white matter: Preliminary results in mouse brain in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]