Tammer, Roland

[["dc.bibliographiccitation.firstpage","2678"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","2688"],["dc.bibliographiccitation.volume","59"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Escher, Angelika"],["dc.contributor.author","Dallenga, Tobias"],["dc.contributor.author","Wrzos, Claudia"],["dc.contributor.author","Tammer, Roland"],["dc.contributor.author","Brück, Wolfgang"],["dc.contributor.author","Nessler, Stefan"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Stadelmann, Christine"],["dc.date.accessioned","2017-09-07T11:44:51Z"],["dc.date.available","2017-09-07T11:44:51Z"],["dc.date.issued","2011"],["dc.description.abstract","Magnetic resonance imaging (MRI) is the gold standard for the detection of multiple sclerosis (MS) lesions. However, current MRI techniques provide little information about the structural features of a brain lesion with inflammatory cell infiltration, demyelination, gliosis, acute axonal damage and axonal loss. To identify methods for a differentiation of demyelination, inflammation, and axonal damage we developed a novel mouse model combining cuprizone-induced demyelination and experimental autoimmune encephalomyelitis. MS-like brain lesions were assessed by T1-weighted, T2-weighted, and magnetization transfer MRI as well as by diffusion tensor imaging (DTI). T2-weighted MRI differentiated control and diseased mice, while T1-weighted MRI better reflected the extent of inflammation and axonal damage. In DTI, axonal damage and cellular infiltration led to a reduction of the axial diffusivity, whereas primary demyelination after cuprizone treatment was reflected by changes in radial but not axial diffusivity. Importantly, alterations in radial diffusivity were less pronounced in mice with demyelination, inflammation, and acute axonal damage, indicating that radial diffusivity may underestimate demyelination in acute MS lesions. In conclusion, the combined information from different DTI parameters allows for a more precise identification of solely demyelinated lesions versus demyelinated and acutely inflamed lesions. These findings are of relevance for offering individualized, stage-adapted therapies for MS patients."],["dc.identifier.doi","10.1016/j.neuroimage.2011.08.051"],["dc.identifier.gro","3150360"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7115"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","1053-8119"],["dc.title","Assessment of lesion pathology in a new animal model of MS by multiparametric MRI and DTI"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Translational Psychiatry"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Mitjans, M."],["dc.contributor.author","Begemann, M."],["dc.contributor.author","Ju, A."],["dc.contributor.author","Dere, E."],["dc.contributor.author","Wüstefeld, L."],["dc.contributor.author","Hofer, S."],["dc.contributor.author","Hassouna, I."],["dc.contributor.author","Balkenhol, J."],["dc.contributor.author","Oliveira, B."],["dc.contributor.author","van der Auwera, S."],["dc.contributor.author","Tammer, R."],["dc.contributor.author","Hammerschmidt, K."],["dc.contributor.author","Völzke, H."],["dc.contributor.author","Homuth, G."],["dc.contributor.author","Cecconi, F."],["dc.contributor.author","Chowdhury, K."],["dc.contributor.author","Grabe, H."],["dc.contributor.author","Frahm, J."],["dc.contributor.author","Boretius, S."],["dc.contributor.author","Dandekar, T."],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.date.accessioned","2018-03-08T09:22:12Z"],["dc.date.available","2018-03-08T09:22:12Z"],["dc.date.issued","2017"],["dc.description.abstract","Ambra1 is linked to autophagy and neurodevelopment. Heterozygous Ambra1 deficiency induces autism-like behavior in a sexually dimorphic manner. Extraordinarily, autistic features are seen in female mice only, combined with stronger Ambra1 protein reduction in brain compared to males. However, significance of AMBRA1 for autistic phenotypes in humans and, apart from behavior, for other autism-typical features, namely early brain enlargement or increased seizure propensity, has remained unexplored. Here we show in two independent human samples that a single normal AMBRA1 genotype, the intronic SNP rs3802890-AA, is associated with autistic features in women, who also display lower AMBRA1 mRNA expression in peripheral blood mononuclear cells relative to female GG carriers. Located within a non-coding RNA, likely relevant for mRNA and protein interaction, rs3802890 (A versus G allele) may affect its stability through modification of folding, as predicted by in silico analysis. Searching for further autism-relevant characteristics in Ambra1+/− mice, we observe reduced interest of female but not male mutants regarding pheromone signals of the respective other gender in the social intellicage set-up. Moreover, altered pentylentetrazol-induced seizure propensity, an in vivo readout of neuronal excitation–inhibition dysbalance, becomes obvious exclusively in female mutants. Magnetic resonance imaging reveals mild prepubertal brain enlargement in both genders, uncoupling enhanced brain dimensions from the primarily female expression of all other autistic phenotypes investigated here. These data support a role of AMBRA1/Ambra1 partial loss-of-function genotypes for female autistic traits. Moreover, they suggest Ambra1 heterozygous mice as a novel multifaceted and construct-valid genetic mouse model for female autism."],["dc.identifier.doi","10.1038/tp.2017.213"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14806"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/12914"],["dc.language.iso","en"],["dc.notes.intern","GRO-Li-Import"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.doi","10.1038/tp.2017.213"],["dc.relation.issn","2158-3188"],["dc.relation.issn","2158-3188"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Sexual dimorphism of AMBRA1-related autistic features in human and mouse"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","213"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Medical Primatology"],["dc.bibliographiccitation.lastpage","218"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Abaei, A."],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Tammer, Roland"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Schlumbohm, C."],["dc.contributor.author","Fuchs, E."],["dc.date.accessioned","2017-09-07T11:45:28Z"],["dc.date.available","2017-09-07T11:45:28Z"],["dc.date.issued","2009"],["dc.description.abstract","BACKGROUND: Animal models of human brain disorders often have to rely on non-human primates because of their immunological, physiological, and cognitive similarities to humans. METHODS: Localized proton magnetic resonance spectroscopy was performed to assess cerebral metabolite profiles of male common marmoset monkeys in vivo and to determine putative alterations of adult brain metabolism in response to intrauterine hyperexposure to the synthetic glucocorticoid hormone dexamethasone. RESULTS: Excellent spectral quality allowed for absolute quantification of the concentrations of major metabolites in predominantly white matter, gray matter, and thalamus. Marmoset monkeys intrauterinely hyperexposed to dexamethasone revealed normal neurochemical profiles at adulthood. CONCLUSIONS: Prenatally applied dexamethasone does not lead to persistent metabolic alterations affecting adult brain integrity."],["dc.identifier.doi","10.1111/j.1600-0684.2009.00342.x"],["dc.identifier.gro","3150368"],["dc.identifier.pmid","19374665"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7125"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0047-2565"],["dc.subject","Brain metabolism; Callithrix jacchus; glucocorticoids; prenatal; preterm birth; proton magnetic resonance spectroscopy"],["dc.title","Intrauterine hyperexposure to dexamethasone of the common marmoset monkey revealed normal cerebral metabolite concentrations in adulthood as assessed by quantitative proton magnetic resonance spectroscopy in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","244"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","255"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Tammer, Roland"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Brockmöller, Jürgen"],["dc.contributor.author","Frahm, Jens"],["dc.date.accessioned","2017-09-07T11:44:52Z"],["dc.date.available","2017-09-07T11:44:52Z"],["dc.date.issued","2012"],["dc.description.abstract","Halogenated volatile anesthetics (HVA) are widely used in medicine and research but their effects on brain metabolism in intact organisms are still largely unknown. Here, localized proton magnetic resonance spectroscopy (MRS) of anesthetized mice was applied to evaluate HVA effects on cerebral metabolites in vivo. Experimental protocols combined different concentrations of isoflurane, halothane, sevoflurane, and desflurane with known modulators of adrenergic, GABAergic, and glutamatergic neurotransmission. As a most striking finding, brain lactate increased in individual mice from 1.0 ± 0.6 mM (awake state) to 6.2 ± 1.5 mM (1.75% isoflurane). In addition, relative to total creatine, there were significant isoflurane-induced increases of alanine by 111%, GABA by 20%, choline-containing compounds by 20%, and myo-inositol by 10% which were accompanied by significant decreases of glucose by 51% and phosphocreatine by 9%. The elevation of lactate was most pronounced in the striatum. The HVA effects correlated with the respective minimal alveolar concentrations and were mostly reversible within minutes. The observed alterations are best explained by an HVA-induced stimulation of adrenergic pathways in conjunction with an inhibition of the respiratory chain. Apart from casting new light on cerebral energy metabolism, the present results challenge brain studies of HVA-anesthetized animals."],["dc.identifier.doi","10.1016/j.neuroimage.2012.12.020"],["dc.identifier.gro","3150358"],["dc.identifier.pmid","23266699"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7113"],["dc.language.iso","en"],["dc.notes.status","public"],["dc.relation.issn","1053-8119"],["dc.title","Halogenated volatile anesthetics alter brain metabolism as revealed by proton magnetic resonance spectroscopy of mice in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1252"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","1260"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Kasper, Lars"],["dc.contributor.author","Tammer, Roland"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Frahm, Jens"],["dc.date.accessioned","2017-09-07T11:45:25Z"],["dc.date.available","2017-09-07T11:45:25Z"],["dc.date.issued","2009"],["dc.description.abstract","Noninvasive imaging of the brain of animal models demands the detection of increasingly smaller structures by in vivo MRI. The purpose of this work was to elucidate the spatial resolution and structural contrast that can be obtained for studying the brain of C57BL/6J mice by optimized T2-weighted fast spin-echo MRI at 9.4 T. As a prerequisite for high-resolution imaging in vivo, motion artifacts were abolished by combining volatile anesthetics and positive pressure ventilation with a specially designed animal bed for fixation. Multiple substructures in the cortex, olfactory bulb, hippocampus, and cerebellum were resolved at 30 to 40 μm in-plane resolution and 200 to 300 μm section thickness as well as for relatively long echo times of 65 to 82 ms. In particular, the approach resulted in the differentiation of up to five cortical layers. In the olfactory bulb the images unraveled the mitral cell layer which has a thickness of mostly single cells. In the hippocampus at least five substructures could be separated. The molecular layer, Purkinje layer, and granular layer of the cerebellum could be clearly differentiated from the white matter. In conclusion, even without the use of a contrast agent, suitable adjustments of a widely available T2-weighted MRI sequence at high field allow for structural MRI of living mice at near single-cell layer resolution."],["dc.identifier.doi","10.1016/j.neuroimage.2009.05.095"],["dc.identifier.gro","3150366"],["dc.identifier.pmid","19520174"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7123"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","1053-8119"],["dc.title","MRI of cellular layers in mouse brain in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2838"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.bibliographiccitation.lastpage","2847"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Tammer, Roland"],["dc.contributor.author","Ashery-Padan, Ruth"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Stoykova, Anastassia"],["dc.date.accessioned","2017-09-07T11:45:28Z"],["dc.date.available","2017-09-07T11:45:28Z"],["dc.date.issued","2009"],["dc.description.abstract","The impact of developmental ablation of Pax6 function on morphology and functional connectivity of the adult cerebrum was studied in cortex-specific Pax6 knockout mice (Pax6cKO) using structural magnetic resonance imaging (MRI), manganese-enhanced MRI, and diffusion tensor MRI in conjunction with fiber tractography. Mutants presented with decreased volumes of total brain and olfactory bulb, reduced cortical thickness, and altered layering of the piriform cortex. Tracking of major neuronal fiber bundles revealed a disorganization of callosal fibers with an almost complete lack of interhemispheric connectivity. In Pax6cKO mice intrahemispheric callosal fibers as well as intracortical fibers were predominantly directed along a rostrocaudal orientation instead of a left-right and dorsoventral orientation found in controls. Fiber disorganization also involved the septohippocampal connection targeting mostly the lateral septal nucleus. The hippocampus was rostrally extended and its volume was increased relative to that of the forebrain and midbrain. Manganese-induced MRI signal enhancement in the CA3 region suggested a normal function of hippocampal pyramidal cells. Noteworthy, several morphologic disturbances in gray and white matter of Pax6cKO mice were similar to observations in human aniridia patients. The present findings indicate an important role of Pax6 in the development of both the cortex and cerebral fiber connectivity."],["dc.identifier.doi","10.1093/cercor/bhp057"],["dc.identifier.gro","3150369"],["dc.identifier.pmid","19329571"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7126"],["dc.language.iso","en"],["dc.notes.status","public"],["dc.relation.issn","1460-2199"],["dc.subject","cortex development; diffusion tensor imaging; fiber tracking; magnetic resonance imaging; neurologic mutants"],["dc.title","In Vivo MRI of Altered Brain Anatomy and Fiber Connectivity in Adult Pax6 Deficient Mice"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","221"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neuroscience Methods"],["dc.bibliographiccitation.lastpage","229"],["dc.bibliographiccitation.volume","153"],["dc.contributor.author","Tammer, Roland"],["dc.contributor.author","Ehrenreich, L."],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Michaelis, Thomas"],["dc.date.accessioned","2017-09-07T11:45:31Z"],["dc.date.available","2017-09-07T11:45:31Z"],["dc.date.issued","2005"],["dc.description.abstract","Knowledge of the precise position of recording microelectrodes within the brain of a non-human primate is essential for a reliable exploration of very small anatomic structures. This work demonstrates the compatibility of a newly developed glass-guided microelectrode design and microfeed equipment with high-resolution 3D magnetic resonance imaging (MRI). T1- and T2-weighted images allow for the non-invasive visualization of chronically implanted microelectrodes within the brain stem of squirrel monkeys in vivo. Neural extracellular multi-unit recordings proved the functionality of the microelectrode before and after the use of 3D MRI suggesting the preservation of normal brain tissue at the tip of the electrode. Because histology confirmed the absence of lesions attributable to MRI, the approach offers an interactive monitoring during the course of neuroethological experiments. Consequently, MRI may become an in vivo alternative to common histological post mortem verifications of electrode tracks and hence may avoid the early sacrificing of primates after only a small number of experiments."],["dc.identifier.doi","10.1016/j.jneumeth.2005.10.018"],["dc.identifier.gro","3150378"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7136"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","0165-0270"],["dc.title","Compatibility of glass-guided recording microelectrodes in the brain stem of squirrel monkeys with high-resolution 3D MRI"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","41"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","NMR in Biomedicine"],["dc.bibliographiccitation.lastpage","49"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Schmelting, Barthel"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Merkler, Doron"],["dc.contributor.author","Tammer, Roland"],["dc.contributor.author","Czéh, Boldizsár"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2017-09-07T11:45:33Z"],["dc.date.available","2017-09-07T11:45:33Z"],["dc.date.issued","2006-02"],["dc.description.abstract","Experimental autoimmune encephalomyelitis (EAE) induced by myelin–oligodendrocyte glycoprotein (MOG) in common marmosets (Callithrix jacchus) is a model for multiple sclerosis. Here, EAE was induced in four common marmosets by 250–300 µg recombinant rat MOG. In addition to a detailed disability scoring, T2- and T1-weighted high-resolution 3D MRI was performed to assess the onset and development of cerebral lesions. The findings were confirmed by histopathology in all animals. Although the animals exhibited a large heterogeneity with regard to onset and localization of lesions and also to disease duration and severity of disability signs, none of the animals revealed any evidence of recovery. A specification of the disability scoring system to account for different aspects of the disease led to a good concurrence of the first MRI-detectable lesion and the onset of central nervous system (CNS) symptoms. The results suggest that MRI monitoring of white matter lesions in conjunction with disability scores that focus on CNS symptoms may be a suitable method to evaluate novel therapeutic interventions even in the presence of pronounced interindividual heterogeneity."],["dc.identifier.doi","10.1002/nbm.999"],["dc.identifier.gro","3150390"],["dc.identifier.pmid","16408325"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7149"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0952-3480"],["dc.subject","magnetic resonance imaging; experimental autoimmune encephalitis; common marmoset; Callithrix jacchus"],["dc.title","Monitoring of EAE onset and progression in the common marmoset monkey by sequential high-resolution 3D MRI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","339"],["dc.bibliographiccitation.issue","3-6"],["dc.bibliographiccitation.journal","Magnetic Resonance Materials in Physics, Biology and Medicine"],["dc.bibliographiccitation.lastpage","347"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Boretius, S."],["dc.contributor.author","Natt, O."],["dc.contributor.author","Watanabe, T."],["dc.contributor.author","Tammer, R."],["dc.contributor.author","Ehrenreich, L."],["dc.contributor.author","Frahm, J."],["dc.contributor.author","Michaelis, T."],["dc.date.accessioned","2017-09-07T11:45:31Z"],["dc.date.available","2017-09-07T11:45:31Z"],["dc.date.issued","2004"],["dc.description.abstract","The purpose was to assess the potential of half Fourier diffusion-weighted single-shot STEAM MRI for diffusion tensor mapping of animal brain in vivo. A STEAM sequence with image acquisition times of about 500 ms was implemented at 2.35 T using six gradient orientations and b values of 200, 700, and 1200 s mm(-2). The use of half Fourier phase-encoding increased the signal-to-noise ratio by 45% relative to full Fourier acquisitions. Moreover, STEAM-derived maps of the relative anisotropy and main diffusion direction were completely free of susceptibility-induced signal losses and geometric distortions. Within measuring times of 3 h, the achieved resolution varied from 600x700x1000 microm3 for squirrel monkeys to 140x280x720 microm3 for mice. While in monkeys the accessible white matter fiber connections were comparable to those reported for humans, detectable fiber structures in mice focused on the corpus callosum, anterior commissure, and hippocampal fimbria. In conclusion diffusion-weighted single-shot STEAM MRI allows for in vivo diffusion tensor mapping of the brain of squirrel monkeys, rats, and mice without motion artifacts and susceptibility distortions."],["dc.identifier.doi","10.1007/s10334-004-0069-1"],["dc.identifier.gro","3150383"],["dc.identifier.pmid","15580374"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7141"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0968-5243"],["dc.subject","Magnetic resonance imaging; Diffusion-weighted imaging; Anisotropy; White matter; Animal brain"],["dc.title","In vivo diffusion tensor mapping of the brain of squirrel monkey, rat, and mouse using single-shot STEAM MRI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Magnetic Resonance in Medicine"],["dc.bibliographiccitation.lastpage","6"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Tammer, Roland"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Michaelis, Thomas"],["dc.date.accessioned","2017-09-07T11:45:26Z"],["dc.date.available","2017-09-07T11:45:26Z"],["dc.date.issued","2006"],["dc.description.abstract","This work demonstrates that intraventricular microinjections of a low dose of potassium dichromate (0.4 μL of 10 mM solution) yield a specific contrast enhancement of white matter (WM) tracts in T1-weighted 3D MRI of mouse brain in vivo. Pronounced and persistent signal increases (40–100% at 24 hr after injection) were observed in the corpus callosum, anterior commissure, fornix, and stria medullaris, as well as in the mammillothalamic tract and fasciculus retroflexus. These results suggest that the extracellular diffusion of diamagnetic chromium(VI) (Cr(VI)) after injection is followed by a tissue-specific reduction to paramagnetic Cr(V) and (III), which relies predominantly on the oxidation of myelin lipids. Because Cr(VI)-induced contrast leads to only a mild unspecific enhancement (10–20%) of gray matter (GM) structures, such as the hippocampal formation, the method reveals novel information that differs from that obtainable using other paramagnetic ions, such as manganese."],["dc.identifier.doi","10.1002/mrm.20930"],["dc.identifier.gro","3150375"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7133"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","0740-3194"],["dc.title","Chromium(VI) as a novel MRI contrast agent for cerebral white matter: Preliminary results in mouse brain in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]