Kuo, Min-Fang

[["dc.bibliographiccitation.firstpage","718"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Pharmaceutics"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Fresnoza, Shane M."],["dc.contributor.author","Batsikadze, Giorgi"],["dc.contributor.author","Müller, Lynn Elena"],["dc.contributor.author","Rost, Constanze"],["dc.contributor.author","Chamoun, Michael"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2021-07-05T15:00:48Z"],["dc.date.available","2021-07-05T15:00:48Z"],["dc.date.issued","2021"],["dc.description.abstract","Dopamine is crucial for neuroplasticity, which is considered to be the neurophysiological foundation of learning and memory. The specific effect of dopamine on plasticity such as long-term potentiation (LTP) and long-term depression (LTD) is determined by receptor subtype specificity, concentration level, and the kind of plasticity induction technique. In healthy human subjects, the dopamine precursor levodopa (L-DOPA) exerts a dosage-dependent non-linear effect on motor cortex plasticity. Low and high dosage L-DOPA impaired or abolished plasticity, while medium-dose preserved and reversed plasticity in previous studies. Similar dosage-dependent effects were also observed for selective D1-like and D2-like receptor activation that favor excitatory and inhibitory plasticity, respectively. However, such a dosage-dependent effect has not been explored for a nonselective dopamine agonist such as apomorphine in humans. To this aim, nonfocal and focal motor cortex plasticity induction using paired associative stimulation (PAS) and transcranial direct current stimulation (tDCS) were performed respectively in healthy participants under 0.1, 0.2, 0.3 mg apomorphine or placebo drug. Transcranial magnetic stimulation-elicited motor-evoked potentials were used to monitor motor cortical excitability alterations. We hypothesized that, similar to L-DOPA, apomorphine will affect motor cortex plasticity. The results showed that apomorphine with the applied dosages has an inhibitory effect for focal and nonfocal LTP-like and LTD-like plasticity, which was either abolished, diminished or reversed. The detrimental effect on plasticity induction under all dosages of apomorphine suggests a predominantly presynaptic mechanism of action of these dosages."],["dc.identifier.doi","10.3390/pharmaceutics13050718"],["dc.identifier.pii","pharmaceutics13050718"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87908"],["dc.language.iso","en"],["dc.notes.intern","DOI Import DOI-Import GROB-441"],["dc.publisher","MDPI"],["dc.relation.eissn","1999-4923"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Inhibitory Effect of Apomorphine on Focal and Nonfocal Plasticity in the Human Motor Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","503"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Biological Psychiatry"],["dc.bibliographiccitation.lastpage","508"],["dc.bibliographiccitation.volume","66"],["dc.contributor.author","Nitsche, Michael A."],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Karrasch, Ralf"],["dc.contributor.author","Waechter, Bettina"],["dc.contributor.author","Liebetanz, David"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T11:24:33Z"],["dc.date.available","2018-11-07T11:24:33Z"],["dc.date.issued","2009"],["dc.description.abstract","Background: Modulation of the serotonergic system affects long-term potentiation (LTP) and long-term depression (LTD), the likely neurophysiologic derivates of learning and memory formation, in animals and slice preparations. Serotonin-dependent modulation of plasticity has been proposed as an underlying mechanism for depression. However, direct knowledge about the impact of serotonin on neuroplasticity in humans is missing. Here we explore the impact of the serotonin reuptake blocker citalopram on plasticity induced by transcranial direct current stimulation (tDCS) in humans in a single-blinded, placebo-controlled, randomized crossover study. Methods: In 12 healthy subjects, anodal excitability-enhancing or cathodal excitability-diminishing tDCS was applied to the motor cortex under a single dose of 20-mg citalopram or placebo medication. Motor cortex excitability was monitored by single-pulse transcranial magnetic stimulation (TMS). Results: Under placebo medication, anodal tDCS enhanced, and cathodal tDCS reduced, excitability for about 60-120 min. Citalopram enhanced and prolonged the facilitation induced by anodal tDCS, whereas it turned cathodal tDCS-induced inhibition into facilitation. Conclusions: Serotonin has a prominent impact on neuroplasticity in humans, which is in favor for facilitatory plasticity. Taking into account serotonergic hypoactivity in depression, this might explain deficits of learning and memory formation. Moreover, the results suggest that for therapeutic brain stimulation in depression and other neuropsychiatric diseases (e.g., in neurorehabilitation), serotonergic reinforcement may enhance facilitatory aftereffects and thereby increase the efficacy of these tools."],["dc.identifier.doi","10.1016/j.biopsych.2009.03.022"],["dc.identifier.isi","000269330900013"],["dc.identifier.pmid","19427633"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6237"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56434"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","0006-3223"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Serotonin Affects Transcranial Direct Current-Induced Neuroplasticity in Humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","634"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","The International Journal of Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","643"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Kuo, Hsiao-I."],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Batsikadze, Giorgi"],["dc.contributor.author","Jamil, Asif"],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2019-07-09T11:43:50Z"],["dc.date.available","2019-07-09T11:43:50Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1093/ijnp/pyx026"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14694"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58979"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nd/4.0"],["dc.title","Acute and Chronic Noradrenergic Effects on Cortical Excitability in Healthy Humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1387"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Batsikadze, Giorgi"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Hasan, Alkomiet"],["dc.contributor.author","Grundey, Jessica"],["dc.contributor.author","Kuo, M.-F."],["dc.contributor.author","Nitsche, M. A."],["dc.date.accessioned","2018-11-07T10:23:55Z"],["dc.date.available","2018-11-07T10:23:55Z"],["dc.date.issued","2017"],["dc.description.abstract","Nicotine modulates neuroplasticity and improves cognitive functions in animals and humans. In the brain of smoking individuals, calcium-dependent plasticity induced by non-invasive brain stimulation methods such as transcranial direct current stimulation (tDCS) and paired associative stimulation (PAS) is impaired by nicotine withdrawal, but partially re-established after nicotine re-administration. In order to investigate the underlying mechanism further, we tested the impact of the alpha(4)beta(2)-nicotinic receptor partial agonist varenicline on focal and non-focal plasticity in smokers during nicotine withdrawal, induced by PAS and tDCS, respectively. We administered low (0.3 mg) and high (1.0 mg) single doses of varenicline or placebo medication before stimulation over the left motor cortex of 20 healthy smokers under nicotine withdrawal. Motor cortex excitability was monitored by single-pulse transcranial magnetic stimulation-induced motor evoked potential amplitudes for 36 hours after plasticity induction. Stimulation-induced plasticity was absent under placebo medication, whereas it was present in all conditions under high dose. Low dose restituted only tDCS-induced non-focal plasticity, producing no significant impact on focal plasticity. High dose varenicline also prolonged inhibitory plasticity. These results are comparable to the impact of nicotine on withdrawal-related impaired plasticity in smokers and suggest that alpha(4)beta(2) nicotinic receptors are relevantly involved in plasticity deficits and restitution in smokers."],["dc.description.sponsorship","DFG grant [NI 683/4-2]; Open Access Fund of the Leibniz Association"],["dc.identifier.doi","10.1038/s41598-017-01428-6"],["dc.identifier.isi","000400490600012"],["dc.identifier.pmid","28469204"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14777"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42556"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Compromised neuroplasticity in cigarette smokers under nicotine withdrawal is restituted by the nicotinic alpha(4)beta(2)-receptor partial agonist varenicline"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]