Krüger, Ullrich

[["dc.bibliographiccitation.firstpage","1085"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Carcinogenesis"],["dc.bibliographiccitation.lastpage","1090"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Blankenburg, S."],["dc.contributor.author","Konig, I. R."],["dc.contributor.author","Moessner, R."],["dc.contributor.author","Laspe, Petra"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Krueger, Ulrich"],["dc.contributor.author","Khan, Sajjad"],["dc.contributor.author","Westphal, G."],["dc.contributor.author","Berking, Carola"],["dc.contributor.author","Volkenandt, Matthias"],["dc.contributor.author","Reich, Kristian"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Ziegler, Andreas"],["dc.contributor.author","Kraemer, Kenneth H."],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T10:29:15Z"],["dc.date.available","2018-11-07T10:29:15Z"],["dc.date.issued","2005"],["dc.description.abstract","Individuals with the rare DNA repair deficiency syndrome xeroderma pigmentosum (XP) are sensitive to the sun and exhibit a 1000-fold increased risk for developing skin cancers, including cutaneous melanoma. Inherited polymorphisms of XP genes may contribute to subtle variations in DNA repair capacity and genetic susceptibility to melanoma. We investigated the role of three polymorphic alleles of the DNA repair gene XPC in a hospital-based case-control study of 294 Caucasian patients from Germany who had cutaneous melanoma and 375 healthy cancer-free sex-matched Caucasian control subjects from the same area. We confirmed that the XPC intron 9 PAT+, intron 11 -6A, and the exon 15 2920C polymorphisms are in a linkage disequilibrium. Only 1.6% of the 669 donors genotyped were discordant for these three polymorphisms. The allele frequencies (cases: controls) were for intron 9 PAT+ 41.7%:36.9%, for intron 11 -6A 41.8%:37.0% and for exon 15 2920C 41.3%:37.3%. Using multivariate logistic regression analyses to control for age, skin type and number of nevi, the three polymorphisms were significantly associated with increased risks of melanoma: OR 1.87 (95% CI: 1.10-3.19; P = 0.022), OR 1.83 (95% CI: 1.07-3.11; P = 0.026), and OR 1.82 (95% CI: 1.07-3.08; P = 0.026), respectively. Exploratory multivariate analyses of distinct subgroups revealed that these polymorphisms were associated with increased risks for the development of multiple primary melanomas (n = 28). The results of our case-control study support the hypothesis that the intron 9 PAT+, intron 11 -6A and exon 15 2920C haplotype may contribute to the risk of developing cutaneous melanoma by increasing the rate of an alternatively spliced XPC mRNA isoform that skips exon 12 and leads to reduced DNA repair. Our results should be validated in independent samples in order to guard against false positive findings."],["dc.description.sponsorship","Intramural NIH HHS [Z01 BC004517-31]"],["dc.identifier.doi","10.1093/carcin/bgi055"],["dc.identifier.isi","000229700100008"],["dc.identifier.pmid","15731165"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43601"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0143-3334"],["dc.title","Assessment of 3 xeroderma pigmentosum group C gene polymorphisms and risk of cutaneous melanoma: a case-control study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Mossner, Rotraut"],["dc.contributor.author","Anders, N."],["dc.contributor.author","Konig, I. R."],["dc.contributor.author","Kruger, Ullrich"],["dc.contributor.author","Schmidt, D."],["dc.contributor.author","Berking, Carola"],["dc.contributor.author","Ziegler, Andreas"],["dc.contributor.author","Brockmoeller, Juergen"],["dc.contributor.author","Volkenandt, Matthias"],["dc.contributor.author","Kaiser, R."],["dc.contributor.author","Westphal, G."],["dc.contributor.author","Reich, Kristian"],["dc.date.accessioned","2018-11-07T10:12:01Z"],["dc.date.available","2018-11-07T10:12:01Z"],["dc.date.issued","2006"],["dc.format.extent","198"],["dc.identifier.isi","000235370600041"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40158"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.publisher.place","Oxford"],["dc.relation.conference","33rd Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF)"],["dc.relation.eventlocation","Aachen, GERMANY"],["dc.relation.issn","0906-6705"],["dc.title","Variations of the MC1R and the GSTM1 and T1 genes in cutaneous malignant melanoma"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Archives of Dermatological Research"],["dc.bibliographiccitation.lastpage","5"],["dc.bibliographiccitation.volume","296"],["dc.contributor.author","Mossner, Rotraut"],["dc.contributor.author","Kaiser, R."],["dc.contributor.author","Matern, P."],["dc.contributor.author","Kruger, Ullrich"],["dc.contributor.author","Westphal, Goetz Alexander"],["dc.contributor.author","Brockmoeller, Juergen"],["dc.contributor.author","Ziegler, Andreas"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Konig, I. R."],["dc.contributor.author","Reich, Kristian"],["dc.date.accessioned","2018-11-07T10:48:15Z"],["dc.date.available","2018-11-07T10:48:15Z"],["dc.date.issued","2004"],["dc.description.abstract","The three peroxisome proliferator-activated receptor (PPAR) subtypes alpha, delta (beta), and gamma belong to the group of nuclear receptors that act as ligand-activated transcription factors. Recently, expression of PPARalpha and gamma in keratinocytes has been demonstrated, and ligands of PPARalpha and gamma have been found to enhance epidermal maturation and protect against cutaneous inflammation. There is evidence for a possible role of PPARs in psoriasis, as the expression of PPARalpha and gamma is decreased in lesional skin and treatment with PPARgamma agonists improves psoriatic keratinocyte pathology in vitro and in vivo. We performed a case-control study to search for possible associations between variations in the genes encoding PPARalpha and gamma and psoriasis. Seven variations in these genes were analyzed in 192 patients with chronic plaque-type psoriasis and 330 healthy controls by PCR-based methods. No association between any of the investigated PPAR variants and psoriasis was found. Our findings argue against a significant contribution of the investigated PPAR variations to the genetic basis of psoriasis."],["dc.identifier.doi","10.1007/s00403-004-0463-6"],["dc.identifier.isi","000222059400001"],["dc.identifier.pmid","15083308"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48146"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-3696"],["dc.title","Variations in the genes encoding the peroxisome proliferator-activated receptors alpha and gamma in psoriasis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","586"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Genes and Immunity"],["dc.bibliographiccitation.lastpage","590"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Schoof, Nils"],["dc.contributor.author","von Bonin, Frederike"],["dc.contributor.author","Koenig, Inke R."],["dc.contributor.author","Moessner, R."],["dc.contributor.author","Krueger, Ulrich"],["dc.contributor.author","Reich, Kristian"],["dc.contributor.author","Berking, Carola"],["dc.contributor.author","Volkenandt, Matthias"],["dc.contributor.author","Ziegler, Andreas"],["dc.contributor.author","Boeckmann, L."],["dc.contributor.author","Kuschal, Christiane"],["dc.contributor.author","Thoms, K-M"],["dc.contributor.author","Kube, Dieter"],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T11:24:52Z"],["dc.date.available","2018-11-07T11:24:52Z"],["dc.date.issued","2009"],["dc.description.abstract","Inherited promoter polymorphisms of the interleukin (IL)-10 gene resulting in altered IL-10 production may contribute to a genetic susceptibility for melanoma. We investigated the role of a haplotype from distal as well as proximal polymorphic sites [-7400InDel, -6752AT (rs6676671), -3538AT (rs1800890), -1087AG (rs1800896), -597AC (rs1800872)] of the IL-10 5'-flanking region in a hospital-based case-control study of 165 Caucasian patients with cutaneous melanoma from Germany in comparison with 162 healthy cancer-free Caucasian control participants from the same area matched by age. Using multivariate analysis for the number of nevi and skin type, the IL-10 'higher producing' haplotype ITAGC was found to be significantly associated with a reduced risk of developing melanoma ( adjusted P = 0.02). Although our findings need to be confirmed by independent and larger multicenter studies, we have described for the first time the association of distal gene variants of the IL-10 gene as an independent risk factor for melanoma. Genes and Immunity ( 2009) 10, 586-590; doi:10.1038/gene.2009.40; published online 21 May 2009"],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft DFG [GRK1034]"],["dc.identifier.doi","10.1038/gene.2009.40"],["dc.identifier.isi","000269493400005"],["dc.identifier.pmid","19458621"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56507"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1466-4879"],["dc.title","Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case-control study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Investigative Dermatology"],["dc.bibliographiccitation.volume","123"],["dc.contributor.author","Blankenburg, S."],["dc.contributor.author","Konig, I. R."],["dc.contributor.author","Moessner, R."],["dc.contributor.author","Laspe, Petra"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Krueger, Ulrich"],["dc.contributor.author","Khan, G."],["dc.contributor.author","Westphal, G."],["dc.contributor.author","Volkenandt, Matthias"],["dc.contributor.author","Reich, Kristian"],["dc.contributor.author","Ziegler, Andreas"],["dc.contributor.author","Kraemer, Kenneth H."],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T10:46:48Z"],["dc.date.available","2018-11-07T10:46:48Z"],["dc.date.issued","2004"],["dc.identifier.isi","000222483400325"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47829"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing Inc"],["dc.publisher.place","Malden"],["dc.relation.conference","34th Annual Meeting of the European-Society-for-Dermatological-Research"],["dc.relation.eventlocation","Vienna, AUSTRIA"],["dc.relation.issn","0022-202X"],["dc.title","Assessment of 4 xeroderma pigmentosum group C and G gene polymorphisms and risk of cutaneous malignant melanoma: A case-control study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Schoof, Nils"],["dc.contributor.author","von Bonin, Frederike"],["dc.contributor.author","Koenig, Inke R."],["dc.contributor.author","Moessner, R."],["dc.contributor.author","Krueger, Ulrich"],["dc.contributor.author","Reich, Kristian"],["dc.contributor.author","Ziegler, Andreas"],["dc.contributor.author","Boeckmann, L."],["dc.contributor.author","Kuschal, Christiane"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Kube, Dieter"],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T08:32:01Z"],["dc.date.available","2018-11-07T08:32:01Z"],["dc.date.issued","2009"],["dc.format.extent","284"],["dc.identifier.isi","000263520200070"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17251"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.publisher.place","Malden"],["dc.relation.conference","36th Annual Meeting of the Arbeitsgemeinschaft-Dermatologishche-Forschung"],["dc.relation.eventlocation","Heidelberg, GERMANY"],["dc.relation.issn","0906-6705"],["dc.title","Distal and proximal interleukin-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case-control study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1191"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Allergy and Clinical Immunology"],["dc.bibliographiccitation.lastpage","1194"],["dc.bibliographiccitation.volume","112"],["dc.contributor.author","Reich, Kristian"],["dc.contributor.author","Westphal, G."],["dc.contributor.author","Konig, I. R."],["dc.contributor.author","Mossner, Rotraut"],["dc.contributor.author","Kruger, Ullrich"],["dc.contributor.author","Ziegler, Andreas"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Schnuch, Axel"],["dc.date.accessioned","2018-11-07T10:34:24Z"],["dc.date.available","2018-11-07T10:34:24Z"],["dc.date.issued","2003"],["dc.description.abstract","Background: There is evidence that IL-16, a cytokine that induces chemotactic responses in CD4(+) T cells, eosinophils, and dendritic cells, plays an important role during different types of cutaneous inflammatory responses, including allergic contact dermatitis (ACD) and atopic dermatitis (AD). Objectives: We sought to test for association between a promoter polymorphism in the IL16 gene (T to C transition at position -295) and ACD and AD, respectively. Methods: IL16 -295 genotypes were determined in samples from 2 separate case-control studies with white individuals. The first study included healthy individuals (n = 310) and patients with ACD (n = 86). These patients were polysensitized as defined by a contact sensitization to para-substituted aryl compounds and at least one other structurally unrelated allergen. The second study comprised healthy subjects (n = 214) and patients with AD (n = 94). Results: IL16 -295 genotypes were differently distributed among polysensitized and healthy control subjects (P = .0021). In particular, the IL16 -295 C/C genotype was overrepresented among polysensitized individuals (7.0% vs 1.0% in the control group; odds ratio, 7.68; 95% Cl, 1.59-48.12). In contrast, there was no evidence for an association between the IL16 -295 polymorphism and AD. Conclusion: The IL16 -295 promoter polymorphism might influence susceptibility to contact allergy."],["dc.identifier.doi","10.1016/j.jaci.2003.09.012"],["dc.identifier.isi","000187154200024"],["dc.identifier.pmid","14657881"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44862"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosby, Inc"],["dc.relation.issn","0091-6749"],["dc.title","Association of allergic contact dermatitis with a promoter polymorphism in the IL16 gene"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Investigative Dermatology"],["dc.bibliographiccitation.volume","126"],["dc.contributor.author","Moessner, R."],["dc.contributor.author","Anders, N."],["dc.contributor.author","Koenig, Inke R."],["dc.contributor.author","Krueger, Ulrich"],["dc.contributor.author","Berking, Carola"],["dc.contributor.author","Ziegler, Andreas"],["dc.contributor.author","Volkenandt, Matthias"],["dc.contributor.author","Kaiser, R."],["dc.contributor.author","Westphal, G."],["dc.contributor.author","Reich, Kristian"],["dc.date.accessioned","2018-11-07T09:29:16Z"],["dc.date.available","2018-11-07T09:29:16Z"],["dc.date.issued","2006"],["dc.format.extent","83"],["dc.identifier.isi","000242891900482"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30980"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.publisher.place","New york"],["dc.relation.conference","36th Annual Meeting of the European-Society-of-Dermatology-Research (ESDR)"],["dc.relation.eventlocation","Paris, FRANCE"],["dc.relation.issn","0022-202X"],["dc.title","Variations of the MC1R and the GSTM1 and T1 genes in cutaneous malignant melanoma"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","371"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Archives of Dermatological Research"],["dc.bibliographiccitation.lastpage","379"],["dc.bibliographiccitation.volume","298"],["dc.contributor.author","Mössner, Rotraut"],["dc.contributor.author","Anders, Nils"],["dc.contributor.author","König, Inke R."],["dc.contributor.author","Krüger, Ullrich"],["dc.contributor.author","Schmidt, Diane"],["dc.contributor.author","Berking, Carola"],["dc.contributor.author","Ziegler, Andreas"],["dc.contributor.author","Brockmöller, Jürgen"],["dc.contributor.author","Kaiser, Rolf"],["dc.contributor.author","Volkenandt, Matthias"],["dc.contributor.author","Westphal, Götz Alexander"],["dc.contributor.author","Reich, Kristian"],["dc.date.accessioned","2018-11-07T11:06:01Z"],["dc.date.available","2018-11-07T11:06:01Z"],["dc.date.issued","2007"],["dc.description.abstract","Variations in the melanocortin-1 receptor (MC1R) and in the glutathione-S transferase genes mu1 (GSTM1) and theta 1 (GSTT1) have been reported to influence UV sensitivity and melanoma risk. MC1R is one of the major genes that determine skin pigmentation because the melanocortin-1 receptor regulates eumelanin synthesis. GSTT1 and GSTM1 are enzymes expressed in the skin that detoxify products of oxidative stress reactions caused by UV irradiation. In this study variations in the MC1R, GSTM1 and T1 genes were analyzed in 347 healthy subjects and 322 patients with cutaneous malignant melanoma by direct cycle sequencing, RFLP and multiplex PCR. Important phenotypic characteristics of the study participants were obtained to assess whether genetic associations occurred independently of phenotypic risk factors for melanoma. We found an association of the MC1R D84E and R151C polymorphisms with melanoma (odds ratios for carriage of the rare allele 4.96, 95% CI [1.06-23.13], P = 0.032, and 1.69, 95% CI [1.12-2.55], P = 0.013, respectively). Melanoma risk increased with the number of variant MC1R alleles carried by an individual (P = 0.003). In a multivariate model, however, only the D84E polymorphism influenced melanoma risk independently of the risk factors fair skin type, high nevus count and high age (P = 0.047). There was no effect of homozygous GST M1 or T1 deletions on melanoma risk. In contrast to previous data, there was no evidence that GSTM1 deficiency influences melanoma risk in the subgroup of individuals with red or blond hair."],["dc.identifier.doi","10.1007/s00403-006-0708-7"],["dc.identifier.isi","000242603700002"],["dc.identifier.pmid","17072629"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52205"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","0340-3696"],["dc.title","Variations of the melanocortin-1 receptor and the glutathione-S transferase T1 and M1 genes in cutaneous malignant melanoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Investigative Dermatology"],["dc.bibliographiccitation.volume","123"],["dc.contributor.author","Kruger, Ullrich"],["dc.contributor.author","Konig, I. R."],["dc.contributor.author","Anders, N."],["dc.contributor.author","Schulz, U."],["dc.contributor.author","Westphal, Goetz Alexander"],["dc.contributor.author","Mossner, Rotraut"],["dc.contributor.author","Ziegler, Andreas"],["dc.contributor.author","Kaiser, R."],["dc.contributor.author","Reich, Kristian"],["dc.date.accessioned","2018-11-07T10:46:49Z"],["dc.date.available","2018-11-07T10:46:49Z"],["dc.date.issued","2004"],["dc.identifier.isi","000222483400313"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47831"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing Inc"],["dc.publisher.place","Malden"],["dc.relation.conference","34th Annual Meeting of the European-Society-for-Dermatological-Research"],["dc.relation.eventlocation","Vienna, AUSTRIA"],["dc.relation.issn","0022-202X"],["dc.title","Influence of MC1R, GSTT1 and GSTM1 genotypes on UV sensitivity"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]