Horn, Sebastian

[["dc.bibliographiccitation.artnumber","8940"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Dieks, Jana-K."],["dc.contributor.author","Jünemann, Laura"],["dc.contributor.author","Hensel, Kai O."],["dc.contributor.author","Bergmann, Charlotte"],["dc.contributor.author","Schmidt, Stefan"],["dc.contributor.author","Quast, Anja"],["dc.contributor.author","Horn, Sebastian"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Meyer-Marcotty, Philipp"],["dc.contributor.author","Santander, Petra"],["dc.date.accessioned","2022-06-01T09:39:11Z"],["dc.date.available","2022-06-01T09:39:11Z"],["dc.date.issued","2022"],["dc.description.abstract","Head development is a surrogate for brain development in infants and is related to neurocognitive outcome. There is only limited knowledge on early extra-uterine head shape and size assessment in very preterm infants. Here, 26 very preterm infants with a mean gestational age of 29.1 ± 2.2 weeks and a mean birth weight of 1273.8 ± 427.7 g underwent serial stereophotogrammetric 3D head imaging in weekly intervals from birth to term-equivalent age. The main outcome was the longitudinal assessment of the ‘physiological’ preterm head development with cephalometric size (head circumference, cranial volume) and shape parameters (cranial index, cranial vault asymmetry index) according to chronological and postmenstrual age (PMA). Potential clinical risk factors for the development of an abnormal low cranial index (dolichocephaly) were analysed. In serial measurements of 26 infants, the estimated head volume (95% confidence interval) increased from 244 (226–263) cm 3 at 28 weeks PMA to 705 (688–721) cm 3 at 40 weeks PMA. Moderate or severe dolichocephaly occurred in 21/26 infants (80.8%). Cranial index decreased over time (72.4%; 70.7–74 95% confidence interval). Brachycephaly and plagiocephaly were uncommon. No risk factors for severe dolichocephaly were identified. Our study shows that early detection of head shape and size anomalies utilizing 3D stereophotogrammetry is feasible and safe even in very preterm infants < 1500 g and/or < 32 weeks. 3D stereophotogrammetry could be used for timely identification of infants at risk for head shape anomalies. No specific risk factors for head shape anomalies were identified, especially not mode and duration of respiratory support."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.1038/s41598-022-12887-x"],["dc.identifier.pii","12887"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108408"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.eissn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Stereophotogrammetry can feasibly assess ‘physiological’ longitudinal three-dimensional head development of very preterm infants from birth to term"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","481"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Antibiotics"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Tilkorn, Friederike K. M. T."],["dc.contributor.author","Frickmann, Hagen"],["dc.contributor.author","Simon, Isabel S."],["dc.contributor.author","Schwanbeck, Julian"],["dc.contributor.author","Horn, Sebastian"],["dc.contributor.author","Zimmermann, Ortrud"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Bohne, Wolfgang"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.date.accessioned","2020-08-06T06:04:43Z"],["dc.date.available","2020-08-06T06:04:43Z"],["dc.date.issued","2020"],["dc.description.abstract","Young children are frequently colonized with Clostridioides (C.) difficile. Depending on their resistance patterns, antibiotic treatment can facilitate gastrointestinal spreading in colonized individuals, potentially leading to transmission to others. C. difficile was isolated from stool samples from infants born in two hospitals in Göttingen and Darmstadt, Germany. All isolates were subjected to phenotypic antimicrobial resistance testing, PCR-based screening for toxin genes and mass spectrometry-based exclusion of ribotypes 027 and 176. Within an initial cohort of 324 neonates with a longitudinal survey of C. difficile, 137 strains were isolated from 48 individuals. Antimicrobial resistance was recorded against metronidazole in one (0.7%), erythromycin in 16 (11.7%) and moxifloxacin in 2 (1.5%) of the strains, whereas no resistance was observed against vancomycin (0.0%) or rifampicin (0.0%). Newly observed resistance against erythromycin in children with detection of previously completely sensitive isolates was reported for C. difficile isolates from 2 out of 48 children. In 20 children (42%), non-toxigenic strains were detected, and from 27 children (56%), toxigenic strains were isolated, while both toxigenic and non-toxigenic strains were recorded for 1 child (2%). Ribotypes 027 or 176 were not observed. In conclusion, the German C. difficile strains isolated from the children showed mild to moderate resistance with predominance of macrolide resistance, a substance class which is frequently applied in children. The observed switches to the dominance of macrolide-resistant isolates suggests likely selection of resistant C. difficile strains already in children"],["dc.identifier.doi","10.3390/antibiotics9080481"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17510"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67527"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","MDPI"],["dc.relation.eissn","2079-6382"],["dc.relation.issn","2079-6382"],["dc.relation.orgunit","Institut für Medizinische Mikrobiologie"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.gro","C. difficile"],["dc.subject.gro","Rifaximin"],["dc.title","Antimicrobial Resistance Patterns in Clostridioides difficile Strains Isolated from Neonates in Germany"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","725"],["dc.bibliographiccitation.journal","Climate of the Past"],["dc.bibliographiccitation.lastpage","767"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Marchant, R."],["dc.contributor.author","Cleef, A."],["dc.contributor.author","Harrison, S. P."],["dc.contributor.author","Hooghiemstra, H."],["dc.contributor.author","Markgraf, V."],["dc.contributor.author","van Boxel, J."],["dc.contributor.author","Ager, T."],["dc.contributor.author","Almeida, L."],["dc.contributor.author","Anderson, R."],["dc.contributor.author","Baied, C."],["dc.contributor.author","Behling, Hermann"],["dc.contributor.author","Berrio, J. C."],["dc.contributor.author","Burbridge, R."],["dc.contributor.author","Björck, S."],["dc.contributor.author","Byrne, R."],["dc.contributor.author","Bush, M."],["dc.contributor.author","Duivenvoorden, J."],["dc.contributor.author","Flenley, J."],["dc.contributor.author","De Oliveira, P."],["dc.contributor.author","van Geel, B."],["dc.contributor.author","Graf, K."],["dc.contributor.author","Gosling, W. D."],["dc.contributor.author","Harbele, S."],["dc.contributor.author","van der Hammen, T."],["dc.contributor.author","Hansen, B."],["dc.contributor.author","Kuhry, P."],["dc.contributor.author","Ledru, M.-P."],["dc.contributor.author","Mayle, F."],["dc.contributor.author","Leyden, B."],["dc.contributor.author","Lozano-Garcia, S."],["dc.contributor.author","Melief, A. M."],["dc.contributor.author","Moreno, P."],["dc.contributor.author","Moar, N. T."],["dc.contributor.author","Prieto, A."],["dc.contributor.author","van Reenen, G."],["dc.contributor.author","Salgado-Labouriau, M."],["dc.contributor.author","Schäbitz, F."],["dc.contributor.author","Schreve-Brinkman, E. J."],["dc.contributor.author","Wille, M."],["dc.contributor.author","Horn, S."],["dc.date.accessioned","2019-07-10T08:13:18Z"],["dc.date.available","2019-07-10T08:13:18Z"],["dc.date.issued","2009"],["dc.description.abstract","The biomisation method is used to reconstruct Latin American vegetation at 6000±500 and 18 000±1000 radiocarbon years before present (14C yr BP) from pollen data. Tests using modern pollen data from 381 samples derived from 287 locations broadly reproduce potential natural vegetation. The strong temperature gradient associated with the Andes is recorded by a transition from high altitude cool grass/shrubland and cool mixed forest to mid-altitude cool temperate rain forest, to tropical dry, seasonal and rain forest at low altitudes. Reconstructed biomes from a number of sites do not match the potential vegetation due to local factors such as human impact, methodological artefacts and mechanisms of pollen representivity of the parent vegetation. At 6000±500 14C yr BP 255 samples are analysed from 127 sites. Differences between the modern and the 6000±500 14C yr BP reconstruction are comparatively small; change relative to the modern reconstruction are mainly to biomes characteristic of drier climate in the north of the region with a slight more mesic shift in the south. Cool temperate rain forest remains dominant in western South America. In northwestern South America a number of sites record transitions from tropical seasonal forest to tropical dry forest and tropical rain forest to tropical seasonal forest. Sites in Central America show a change in biome assignment, but to more mesic vegetation, indicative of greater plant available moisture, e.g. on the Yucatán peninsula sites record warm evergreen forest, replacing tropical dry forest and warm mixed forest presently recorded. At 18 000±1000 14C yr BP 61 samples from 34 sites record vegetation reflecting a generally cool and dry environment. Cool grass/shrubland is prevalent in southeast Brazil whereas Amazonian sites record tropical dry forest, warm temperate rain forest and tropical seasonal forest. Southernmost South America is dominated by cool grass/shrubland, a single site retains cool temperate rain forest indicating that forest was present at some locations at the LGM. Some sites in Central Mexico and lowland Colombia remain unchanged in the biome assignments of warm mixed forest and tropical dry forest respectively, although the affinities that these sites have to different biomes do change between 18 000±1000 14C yr BP and present. The \"unresponsive\" nature of these sites results from their location and the impact of local edaphic influence."],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5845"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61200"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.rights","Goescholar"],["dc.rights.access","openAccess"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject","Pollen-based biome"],["dc.subject.ddc","570"],["dc.title","Pollen-based biome reconstructions for Latin America at 0, 6000 and 18 000 radiocarbon years ago"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","21155"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Santander, Petra"],["dc.contributor.author","Quast, Anja"],["dc.contributor.author","Hubbert, Johanna"],["dc.contributor.author","Juenemann, Laura"],["dc.contributor.author","Horn, Sebastian"],["dc.contributor.author","Hensel, Kai O."],["dc.contributor.author","Meyer-Marcotty, Philipp"],["dc.contributor.author","Dieks, Jana-Katharina"],["dc.date.accessioned","2021-12-01T09:23:10Z"],["dc.date.available","2021-12-01T09:23:10Z"],["dc.date.issued","2021"],["dc.description.abstract","The development of head shape and volume may reflect neurodevelopmental outcome and therefore is of paramount importance in neonatal care. Here, we compare head morphology in 25 very preterm infants with a birth weight of below 1500 g and / or a gestational age (GA) before 32 completed weeks to 25 term infants with a GA of 37–42 weeks at term equivalent age (TEA) and identify possible risk factors for non-synostotic head shape deformities. For three-dimensional head assessments, a portable stereophotogrammetric device was used. The most common and distinct head shape deformity in preterm infants was dolichocephaly. Severity of dolichocephaly correlated with GA and body weight at TEA but not with other factors such as neonatal morbidity, sex or total duration of respiratory support. Head circumference (HC) and cranial volume (CV) were not significantly different between the preterm and term infant group. Digitally measured HC and the CV significantly correlated even in infants with head shape deformities. Our study shows that stereophotogrammetric head assessment is feasible in all preterm and term infants and provides valuable information on volumetry and comprehensive head shape characteristics. In a small sample of preterm infants, body weight at TEA was identified as a specific risk factor for the development of dolichocephaly."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.1038/s41598-021-00680-1"],["dc.identifier.pii","680"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94581"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.title","Stereophotogrammetric head shape assessment in neonates is feasible and can identify distinct differences between term-born and very preterm infants at term equivalent age"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]