Kallenberg, Kai

[["dc.bibliographiccitation.firstpage","226"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Folia Neuropathologica"],["dc.bibliographiccitation.lastpage","233"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Goldmann, Torben"],["dc.contributor.author","Menke, Jan"],["dc.contributor.author","Strik, Herwig"],["dc.contributor.author","Bock, Hans-Christoph"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2018-11-07T09:45:46Z"],["dc.date.available","2018-11-07T09:45:46Z"],["dc.date.issued","2014"],["dc.description.abstract","Introduction: Malignant brain tumors tend to migration and invasion of surrounding brain tissue. Histopathological studies reported malignant cells in macroscopically unsuspicious parenchyma (normal appearing white matter - NAWM) remote from the tumor localization. In early stages, diffuse interneural infiltration with changes of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) is hypothesized. Material and methods: Patients' ADC and FA values from NAWM of the hemisphere contralateral to a malignant glioma were compared to age- and sex-matched normal controls. Results: Apparent diffusion coefficient levels of the entire contra lateral hemisphere revealed a significant increase and a decrease of FA levels. An even more pronounced ADC increase was found in a region mirroring the glioma location. Conclusions: In patients with previously untreated anaplastic astrocytoma or glioblastoma, an increase of the ADC and a reduction of FA were found in the brain parenchyma of the hemisphere contralateral to the tumor localization. In the absence of visible MRI abnormalities, this may be an early indicator of microstructural changes of the NAWM attributed to malignant brain tumor."],["dc.description.sponsorship","Volkswagen Stiftung [ZN1635, ZN 2193]"],["dc.identifier.doi","10.5114/fn.2014.45563"],["dc.identifier.isi","000342712000002"],["dc.identifier.pmid","25310733"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34702"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1509-572X"],["dc.relation.issn","1641-4640"],["dc.title","Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","225"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Clinical Neuroradiology"],["dc.bibliographiccitation.lastpage","229"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Ruehlmann, J."],["dc.contributor.author","Baudewig, Juergen"],["dc.contributor.author","Larsen, Finn K."],["dc.contributor.author","Groeschel, S."],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Kastrup, Andreas"],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2018-11-07T09:20:56Z"],["dc.date.available","2018-11-07T09:20:56Z"],["dc.date.issued","2013"],["dc.description.abstract","While acute internal carotid artery (ICA) occlusions are increasingly being treated with carotid angioplasty and stenting (CAS), the utility of CAS in subacute stages is unclear. A 65-year-old patient with an acute left ICA occlusion and pre-existing occlusion on the right side presented with dysarthria and central right-sided facial palsy. Carbon dioxide (CO2) reactivity within the left hemisphere was markedly reduced. Due to acute deterioration despite maximal conservative therapy CAS was performed 8 days after the initial event with an excellent result and symptoms subsided. CAS in subacute ICA occlusion is possible. Patients should be selected carefully. Assessment of cerebrovascular CO2 reactivity might provide valuable information."],["dc.identifier.doi","10.1007/s00062-012-0172-z"],["dc.identifier.isi","000322872800008"],["dc.identifier.pmid","22960936"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10274"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28996"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1869-1447"],["dc.relation.issn","1869-1439"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Analysis of Reserve Capacity and Subsequent Stenting in a Case of Subacute Occlusion of the Internal Carotid Artery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.volume","66"],["dc.contributor.author","Lang, N."],["dc.contributor.author","Baudewig, Juergen"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T10:04:50Z"],["dc.date.available","2018-11-07T10:04:50Z"],["dc.date.issued","2006"],["dc.format.extent","916"],["dc.identifier.doi","10.1212/01.wnl.0000203113.12324.57"],["dc.identifier.isi","000236292300026"],["dc.identifier.pmid","16567712"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38780"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0028-3878"],["dc.title","Transient prosopagnosia after ischemic stroke"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","217"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neuro-Oncology"],["dc.bibliographiccitation.lastpage","222"],["dc.bibliographiccitation.volume","112"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Goldmann, Torben"],["dc.contributor.author","Menke, Jan"],["dc.contributor.author","Strik, Herwig Matthias"],["dc.contributor.author","Bock, Hans-Christoph"],["dc.contributor.author","Stockhammer, Florian"],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2018-11-07T09:26:42Z"],["dc.date.available","2018-11-07T09:26:42Z"],["dc.date.issued","2013"],["dc.description.abstract","The most frequent primary brain tumors, anaplastic astrocytomas (AA) and glioblastomas (GBM): tend to invasion of the surrounding brain. Histopathological studies found malignant cells in macroscopically unsuspicious brain parenchyma remote from the primary tumor, even affecting the contralateral hemisphere. In early stages, diffuse interneural infiltration with changes of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) is suspected. The purpose of this study was to investigate the value of DTI as a possible instrument of depicting evidence of tumor invasion into the corpus callosum (CC). Preoperatively, 31 patients with high-grade brain tumors (8 AA and 23 GBM) were examined by MRI at 3 T, applying a high-resolution diffusion tensor imaging (DTI) sequence. ADC- and FA-values were analyzed in the tumor-associated area of the CC as identified by fiber tracking, and were compared to matched healthy controls. In (MR-)morphologically normal appearing CC the ADC values were elevated in the tumor patients (n = 22; 0.978 x 10(-3) mmA(2)/s) compared to matched controls (0.917 x 10(-3) mmA(2)/s, p < 0.05), and the corresponding relative FA was reduced (rFA: 88 %, p < 0.01). The effect was pronounced in case of affection of the CC visible on MRI (n = 9; 0.978 x 10(-3) mmA(2)/s, p < 0.05; rFA: 72 %, p < 0.01). Changes in diffusivity and anisotropy in the CC can be interpreted as an indicator of tumor spread into the contralateral hemisphere not visible on conventional MRI."],["dc.description.sponsorship","Volkswagen Stiftung [ZN1635, ZN 2193]"],["dc.identifier.doi","10.1007/s11060-013-1049-y"],["dc.identifier.isi","000316755000009"],["dc.identifier.pmid","23344787"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10366"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30361"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0167-594X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Glioma infiltration of the corpus callosum: early signs detected by DTI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","805"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Radiology"],["dc.bibliographiccitation.lastpage","812"],["dc.bibliographiccitation.volume","253"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Bock, Hans-Christoph"],["dc.contributor.author","Helms, Gunther"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Wrede, Arne"],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Giese, Alf"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Strik, Herwig"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2018-11-07T11:21:46Z"],["dc.date.available","2018-11-07T11:21:46Z"],["dc.date.issued","2009"],["dc.description.abstract","Purpose: To use localized in vivo proton magnetic resonance (MR) spectroscopy of the contralateral hemisphere in patients with glioblastoma multiforme (GBM) to detect alterations in cerebral metabolites as potential markers of infiltrating GBM cells. Materials and Methods: The study was approved by the ethics committee, and written informed consent was obtained. Twenty-two patients with newly diagnosed and untreated GBM underwent in vivo single-voxel short echo time proton MR spectroscopy with a 3-T MR imaging system. Absolute metabolite concentrations in the hemisphere contralateral to the tumor were compared with data from five patients with low-grade gliomas (LGGs) and from a group of 14 age-matched control subjects by using analysis of variance and subsequent t tests or corresponding nonparametric tests. Results: In the contralateral hemisphere, MR spectroscopy revealed increased concentrations of myo-inositol and glutamine. Mean myo-inositol levels were significantly increased in patients with GBM (3.6 mmol/L +/- 0.8 [standard deviation]) relative to levels in control subjects (3.1 mmol/L +/- 0.6; P = .03) and tended to be higher relative to levels in patients with LGG (2.7 mmol/L +/- 0.8; P = .09). Mean glutamine concentrations in patients with GBM (3.4 mmol/L +/- 0.9) differed significantly from those in control subjects (2.7 mmol/L +/- 0.7; P < .01); mean concentrations in patients with GBM differed from those in patients with LGG (2.4 mmol/L +/- 0.5; P < .01). There were no significant differences between data in patients with LGG and in control subjects. Conclusion: Increased concentrations of myo-inositol and glutamine in the contralateral normal-appearing white matter of GBM patients are consistent with mild astrocytosis and suggest the detectability of early neoplastic infiltration by using proton MR spectroscopy in vivo. (C) RSNA, 2009"],["dc.identifier.doi","10.1148/radiol.2533071654"],["dc.identifier.isi","000272247300028"],["dc.identifier.pmid","19789222"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6268"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55854"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Radiological Soc North America"],["dc.relation.issn","0033-8419"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Untreated Glioblastoma Multiforme: Increased Myo-inositol and Glutamine Levels in the Contralateral Cerebral Hemisphere at Proton MR Spectroscopy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","473"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","481"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Baudewig, Juergen"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Kastrup, Andreas"],["dc.contributor.author","Merboldt, Klaus-Dietmar"],["dc.contributor.author","Dechent, Peter"],["dc.date.accessioned","2018-11-07T11:16:47Z"],["dc.date.available","2018-11-07T11:16:47Z"],["dc.date.issued","2008"],["dc.description.abstract","Functional magnetic resonance imaging (fMRI) based on blood oxygenation level dependent (BOLD) contrast is the most widely used technique for imaging human brain function. However, the dynamic interplay of altered cerebral blood flow (CBF), cerebral blood volume (CBV), and oxidative metabolism (CMRO2) is not yet fully understood. One of the characteristics of the BOLD response is the post-stimulation undershoot, that is increased deoxyhemoglobin, which has been suggested to originate from a delayed recovery of elevated CBV or CMRO2 to baseline. To investigate the CBV contribution to the post-stimulation BOLD undershoot, we performed bolus-tracking experiments using a paramagnetic contrast agent in eight healthy subjects at 3 T. In an initial BOLD experiment without contrast agent, we determined the individual hemodynamic responsiveness. In two separate experiments, we then evaluated the relative CBV (rCBV) during visual stimulation and the post-stimulation undershoot, respectively. The results confirm a pronounced rCBV increase during stimulation (31.4+/-8.6%), but reveal no change in rCBV relative to baseline in the post-stimulation phase (0.7+/-7.2%). This finding renders a CBV contribution to the BOLD MRI undershoot unlikely and - in conjunction with a rapid post-stimulation return of CBF to baseline - supports the idea of a prolonged elevation of oxidative metabolism. (C) 2007 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.neuroimage.2007.12.005"],["dc.identifier.isi","000254627700010"],["dc.identifier.pmid","18201912"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54672"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1053-8119"],["dc.title","The post-stimulation undershoot in BOLD fMRI of human brain is not caused by elevated cerebral blood volume"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","855"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Neuroradiology"],["dc.bibliographiccitation.lastpage","861"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2018-11-07T11:10:45Z"],["dc.date.available","2018-11-07T11:10:45Z"],["dc.date.issued","2008"],["dc.description.abstract","Introduction Long-term follow-up after coil embolization of intracranial aneurysms is mandatory to monitor coil compacting and aneurysm recurrence. Most centers perform one digital subtraction angiography (DSA) on follow-up continuing with time-of-flight magnetic resonance angiography (TOF-MRA). This study explores the diagnostic value of TOF-MRA at 1.5 T versus 3 T compared to DSA. Materials and methods In 18 patients with 20 aneurysms treated with coil embolization, TOF-MRA at 1.5 and 3 T were performed the day before follow-up DSA, the latter serving as reference. Optimized diagnostic protocols were applied (1.5 T: 0.78 x 0.55 x 0.8 mm, voxel size; acquisition time (TA), 6.37 min; 3 T: 0.56 x 0.45 x 0.65 mm, voxel size; TA, 3.12 min). Three independent neuroradiologists experienced in neuroendovascular therapy rated the occlusion rate (\"complete occlusion\" vs. \"residual neck\" vs. \"residual aneurysm\") and compared the two methods subjectively. Weighted kappa statistics were calculated to assess the level of interobserver agreement. Results Compared to DSA, TOF-MRA was more sensitive in detecting neck remnants, with a slight advantage at 3 T. Regarding artifact load, there are advantages at 1.5 T. Ratings of the occlusion rate correlated highly between all observers (r > 0.85, p < 0.001, respectively). Interobserver agreement was high in all cases (kappa(w) approximate to 0.8, respectively). Conclusion TOF-MRA is a reliable tool for follow-up imaging of cerebral aneurysms after endovascular treatment. Our study shows no advantage of TOF-MRA at 3 T over 1.5 T, when comparable measurement protocols are applied. TOF-MRA at 1.5 T therefore provides appropriate information regarding a therapeutic decision."],["dc.identifier.doi","10.1007/s00234-008-0413-7"],["dc.identifier.isi","000259576300005"],["dc.identifier.pmid","18523761"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3105"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53277"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0028-3940"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","No advantage of time-of-flight magnetic resonance angiography at 3 Tesla compared to 1.5 Tesla in the follow-up after endovascular treatment of cerebral aneurysms"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","183"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","191"],["dc.bibliographiccitation.volume","43"],["dc.contributor.author","Seseke, Sandra"],["dc.contributor.author","Baudewig, Juergen"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Ringert, Rolf-Hermann"],["dc.contributor.author","Seseke, Florian"],["dc.contributor.author","Dechent, Peter"],["dc.date.accessioned","2018-11-07T11:09:42Z"],["dc.date.available","2018-11-07T11:09:42Z"],["dc.date.issued","2008"],["dc.description.abstract","In the last decade functional imaging has gained substantial importance for identifying cortical and subcortical brain regions being involved in the micturition circuit. However, possible gender differences are still a matter of debate. In the present study we used functional magnetic resonance imaging (fMRI) to determine micturition related brain regions in healthy men and compared them with those in women to elucidate gender-related differences. fMRI was performed at 3 T in 12 healthy men with urge to void due to a filled bladder. In a non-voiding model they were instructed to contract or to relax the pelvic floor muscles repetitively. As previously reported in women, contraction and relaxation of pelvic floor muscles induced strong activations in the brainstem and more rostral areas in our group of healthy men. In general, men had stronger activations during contraction than women in nearly all identified areas. In contrast, results for the relaxation condition were similar. Some of the differences between contraction and relaxation, formerly detected in females, could be found in our group of males as well. The results suggest that in women and men the same cortical and subcortical networks exist for micturition control. Especially, the well located activations in the Putative pontine micturition centre and the periaqueductal grey could be identified in both sexes. However, pelvic floor muscle control seems to induce different activation intensities in men and women. (c) 2008 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.neuroimage.2008.07.044"],["dc.identifier.isi","000260215700001"],["dc.identifier.pmid","18721889"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6148"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53064"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1053-8119"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Gender differences in voluntary micturition control - An fMRI study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","430"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Radiology"],["dc.bibliographiccitation.lastpage","436"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2018-11-07T08:33:01Z"],["dc.date.available","2018-11-07T08:33:01Z"],["dc.date.issued","2009"],["dc.description.abstract","Following coil embolization of intracranial aneurysms, many centers perform at least one digital subtraction angiography (DSA) continuing with time-of-flight magnetic resonance angiography (TOF-MRA). Angiographic computed tomography (ACT) provides high-resolution data from a rotational acquisition of a c-arm-mounted flat panel detector. This study evaluates possible advantages of applying ACT in aneurysm follow-up. In 22 patients DSA examinations with a rotational acquisition were performed. Rotational data were processed into an isotropic high-resolution volume. TOF-MRA was performed the day before DSA. Three experienced neuroradiologists performed a rating of the occlusion rate and a subjective method comparison. Weighted kappa statistics were calculated to assess the level of interobserver agreement. Compared to DSA, the diagnostic value of ACT as well as of TOF-MRA was rated to be inferior, although the sensitivity of detecting residual necks was higher with both techniques. Compared to TOF-MRA, ACT achieves favorable ratings only in aneurysms after stent-remodeling. Interobserver agreement was high for all techniques. Ratings of the occlusion rate correlated highly between all observers (r > 0.85, p < 0.001, respectively). In selected patients ACT can add valuable diagnostic information to DSA. TOF-MRA remains a highly sensitive method for aneurysm follow-up."],["dc.identifier.doi","10.1007/s00330-008-1171-y"],["dc.identifier.isi","000262579000020"],["dc.identifier.pmid","18810455"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3502"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17474"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0938-7994"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Evaluation of angiographic computed tomography in the follow-up after endovascular treatment of cerebral aneurysms-a comparative study with DSA and TOF-MRA"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S88"],["dc.bibliographiccitation.journal","Translational Stroke Research"],["dc.bibliographiccitation.lastpage","S93"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Keric, Naureen"],["dc.contributor.author","Maier, Gerrit Steffen"],["dc.contributor.author","Samadani, Uzma"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Heuer, J. F."],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2018-11-07T09:08:53Z"],["dc.date.available","2018-11-07T09:08:53Z"],["dc.date.issued","2012"],["dc.description.abstract","Hematoma puncture and subsequent clot lysis with recombinant tissue plasminogen activator (rtPA) emerged as an alternative therapy for spontaneous intracerebral hemorrhage (ICH) and is associated with delayed edema possibly counteracting the beneficial effects of hematoma volume reduction. We hypothesized that immediate reversal of rtPA activity after clot lysis and hematoma drainage diminishes edema formation. To test this hypothesis, we administered plasminogen activator inhibitor (PAI)-1 after rtPA lysis of experimentally induced ICH. A right frontal ICH was placed through a twist drill burr hole and autologous blood injection. Following creation of the frontal ICH, pigs received no further treatment (n=5), lysis with rtPA (n=7), or lysis with rtPA followed by administration of PAI-1 (n=6). Hematoma and edema volumes were assessed with magnetic resonance imaging on days 0, 4, and 10. The rtPA significantly reduced hematoma volume and contributed to edema on day 10 after experimentally induced ICH. Administration of PAI-1 attenuated the rtPA-induced edema volume on day 10, but the hematoma volume reduction was less pronounced. In conclusion, PAI-1 attenuated delayed cerebral edema after rtPA lysis of experimental ICH but also reduced the lytic activity of rtPA. The combination of rtPA clot lysis with PAI-1 might have the potential to further improve the effect of the lytic therapy of ICH, but additional studies to define the optimum time point for PAI-1 administration are required."],["dc.identifier.doi","10.1007/s12975-012-0188-3"],["dc.identifier.isi","000305436500011"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8890"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26132"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1868-4483"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Tissue Plasminogen Activator Induced Delayed Edema in Experimental Porcine Intracranial Hemorrhage: Reduction with Plasminogen Activator Inhibitor-1 Administration"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]