Kallenberg, Kai

[["dc.bibliographiccitation.firstpage","2288"],["dc.bibliographiccitation.journal","Brain"],["dc.bibliographiccitation.lastpage","2296"],["dc.bibliographiccitation.volume","129"],["dc.contributor.author","Krasnianski, Anna"],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Meissner, Bettina"],["dc.contributor.author","Collie, Donald A."],["dc.contributor.author","Roeber, Sigrun"],["dc.contributor.author","Bartl, Mario"],["dc.contributor.author","Heinemann, Uta"],["dc.contributor.author","Varges, Daniel. A."],["dc.contributor.author","Kretzschmar, Hans A."],["dc.contributor.author","Zerr, Inga"],["dc.date.accessioned","2018-11-07T09:17:31Z"],["dc.date.available","2018-11-07T09:17:31Z"],["dc.date.issued","2006"],["dc.description.abstract","A typical clinical course and low sensitivity of established diagnostic tests are the main diagnostic problems in the MV2 subtype of sporadic Creutzfeldt-Jakob disease (sCJD). Clinical symptoms and signs, MRI, EEG and biochemical CSF markers were studied in 26 patients. Histological findings were semiquantitatively evaluated. Compared with typical sCJD, the disease duration was prolonged (median 12 months). Dementia, ataxia and psychiatric symptoms were present in all patients. Extrapyramidal signs were observed in 88%. T2-weighted MRI showed basal ganglia hyperintensities in 90%. Increased thalamic signal intensity was detected in 88% on diffusion-weighted MRI. Increased CSF tau-protein was found in 83%, and the 14-3-3 test was positive in 76%. The EEG revealed periodic sharp wave complexes in only two patients. Kuru plaques, severe thalamic and basal ganglia gliosis and spongiform changes, and neuronal loss in the pulvinar were the prominent histological features. At least one of the three diagnostic tests (MRI, tau- and 14-3-3 protein) supported the clinical diagnosis in all patients. MRI was the most sensitive of the diagnostic tests applied. Thalamic hyperintensities were observed unusually frequently. Prolonged disease duration, early and prominent psychiatric symptoms, absence of typical EEG, thalamic hyperintensities on MRI and relatively low 14-3-3 protein sensitivity may be suspicious for variant CJD. However, distinct sensory symptoms and young age at onset, which are often found in the latter, are not common in the MV2 subtype, and the pulvinar sign was observed in only one case."],["dc.identifier.doi","10.1093/brain/awl123"],["dc.identifier.isi","000240679700006"],["dc.identifier.pmid","16720682"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28191"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0006-8950"],["dc.title","Clinical findings and diagnostic tests in the MV2 subtype of sporadic CJD"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Journal of Clinical Oncology"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Strik, Herwig Matthias"],["dc.contributor.author","Rock, Hans"],["dc.contributor.author","Kallenberg, Kai"],["dc.date.accessioned","2018-11-07T09:10:23Z"],["dc.date.available","2018-11-07T09:10:23Z"],["dc.date.issued","2012"],["dc.identifier.isi","000318009801393"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26475"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Clinical Oncology"],["dc.publisher.place","Alexandria"],["dc.relation.conference","48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO)"],["dc.relation.eventlocation","Chicago, IL"],["dc.relation.issn","0732-183X"],["dc.title","Tegwondo-CCNU: A novel combination of protracted, near-continuous temozolomide and CCNU with activity in recurrent malignant gliomas."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1544"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","1550"],["dc.bibliographiccitation.volume","65"],["dc.contributor.author","Meissner, Bettina"],["dc.contributor.author","Westner, I. M."],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Krasnianski, Anna"],["dc.contributor.author","Bartl, Mario"],["dc.contributor.author","Varges, Daniel. A."],["dc.contributor.author","Bosenberg, C."],["dc.contributor.author","Kretzschmar, Hans A."],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Zerr, I."],["dc.date.accessioned","2018-11-07T10:54:10Z"],["dc.date.available","2018-11-07T10:54:10Z"],["dc.date.issued","2005"],["dc.description.abstract","Background: Recently, six molecular subtypes of sporadic CJD ( sCJD) have been identified showing differences regarding the disease course, neuropathologic lesion patterns, and sensitivity to diagnostic tools. Only isolated cases of the rare VV1 type have been reported so far. Objective: To describe the clinical characteristics and neuropathologic lesion profiles in nine cases. Methods: In the years 1993 until late 2003, 571 definite neuropathologically confirmed cases of sporadic CJD were identified in Germany. Of these, nine were homozygous for valine and displayed type 1 of the pathologic PrPSc in the brain ( VV1 type). Results: The authors describe eight men and one woman belonging to the VV1 type. All patients were relatively young at disease onset ( median 44 years vs 65 years in all sCJD) with prolonged disease duration ( median 21 months vs 6 months in all sCJD). During the initial stages, their main clinical signs were personality changes and slowly progressive dementia as well as focal neurologic deficits. None of the nine VV1 patients had periodic sharp- wave complexes ( PSWCs) in the EEG. Only two out of seven displayed the typical signal increase of the basal ganglia on MRI, whereas signal increase of the cortex was seen in all patients. The 14- 3- 3 protein levels were elevated in CSF in all cases tested. Conclusions: The clinical diagnosis of the VV1 type of sCJD can be best supported by the 14- 3- 3 test and cortical signal increase on MRI. Because of the young age at onset vCJD is sometimes suspected as a differential diagnosis. MRI plays an important role in differentiating these two disease types and should be performed early during the disease course."],["dc.identifier.doi","10.1212/01.wnl.0000184674.32924.c9"],["dc.identifier.isi","000233428100008"],["dc.identifier.pmid","16221949"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49508"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0028-3878"],["dc.title","Sporadic Creutzfeldt-Jakob disease - Clinical and diagnostic characteristics of the rare VV1 type"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","226"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Folia Neuropathologica"],["dc.bibliographiccitation.lastpage","233"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Goldmann, Torben"],["dc.contributor.author","Menke, Jan"],["dc.contributor.author","Strik, Herwig"],["dc.contributor.author","Bock, Hans-Christoph"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2018-11-07T09:45:46Z"],["dc.date.available","2018-11-07T09:45:46Z"],["dc.date.issued","2014"],["dc.description.abstract","Introduction: Malignant brain tumors tend to migration and invasion of surrounding brain tissue. Histopathological studies reported malignant cells in macroscopically unsuspicious parenchyma (normal appearing white matter - NAWM) remote from the tumor localization. In early stages, diffuse interneural infiltration with changes of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) is hypothesized. Material and methods: Patients' ADC and FA values from NAWM of the hemisphere contralateral to a malignant glioma were compared to age- and sex-matched normal controls. Results: Apparent diffusion coefficient levels of the entire contra lateral hemisphere revealed a significant increase and a decrease of FA levels. An even more pronounced ADC increase was found in a region mirroring the glioma location. Conclusions: In patients with previously untreated anaplastic astrocytoma or glioblastoma, an increase of the ADC and a reduction of FA were found in the brain parenchyma of the hemisphere contralateral to the tumor localization. In the absence of visible MRI abnormalities, this may be an early indicator of microstructural changes of the NAWM attributed to malignant brain tumor."],["dc.description.sponsorship","Volkswagen Stiftung [ZN1635, ZN 2193]"],["dc.identifier.doi","10.5114/fn.2014.45563"],["dc.identifier.isi","000342712000002"],["dc.identifier.pmid","25310733"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34702"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1509-572X"],["dc.relation.issn","1641-4640"],["dc.title","Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","99"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Cerebral Blood Flow & Metabolism"],["dc.bibliographiccitation.lastpage","111"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Bailey, Damian Miles"],["dc.contributor.author","Roukens, R."],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Christ, S."],["dc.contributor.author","Mohr, A."],["dc.contributor.author","Genius, J."],["dc.contributor.author","Storch-Hagenlocher, B."],["dc.contributor.author","Meisel, F."],["dc.contributor.author","McEneny, J."],["dc.contributor.author","Young, I. S."],["dc.contributor.author","Steiner, Tamara"],["dc.contributor.author","Hess, Katharina"],["dc.contributor.author","Bartsch, P."],["dc.date.accessioned","2018-11-07T10:36:06Z"],["dc.date.available","2018-11-07T10:36:06Z"],["dc.date.issued","2006"],["dc.description.abstract","The present study combined molecular and neuroimaging techniques to examine if free radical-mediated damage to barrier function in hypoxia would result in extracellular edema, raise intracranial pressure (ICP) and account for the neurological symptoms typical of high-altitude headache (HAH) also known as acute mountain sickness (AMS). Twenty-two subjects were randomly exposed for 18 h to 12% (hypoxia) and 21% oxygen (O-2 (normoxia)) for collection of venous blood (0 h, 8 h, 15 h, 18 h) and CSF (18 h) after lumbar puncture (LP). Electron paramagnetic resonance (EPR) spectroscopy identified a clear increase in the blood and CSF concentration of O-2 and carbon-centered free radicals (P < 0.05 versus normoxia) subsequently identified as lipid-derived alkoxyl (LO center dot) and alkyl (LC center dot) species. Magnetic resonance imaging (MRI) demonstrated a mild increase in brain volume (7.0 +/- 4.8 mL or 0.6% +/- 0.4%, P < 0.05 versus normoxia) that resolved within 6 h of normoxic recovery. However, there was no detectable evidence for gross barrier dysfunction, elevated lumbar pressures, T-2 prolongation or associated neuronal and astroglial damage. Clinical AMS was diagnosed in 50% of subjects during the hypoxic trial and corresponding headache scores were markedly elevated (P < 0.05 versus non-AMS). A greater increase in brain volume was observed, though this was slight, independent of oxidative stress, barrier dysfunction, raised lumbar pressure, vascular damage and measurable evidence of cerebral edema and only apparent in the most severe of cases. These findings suggest that free-radical-mediated vasogenic edema is not an important pathophysiological event that contributes to the mild brain swelling observed in HAH."],["dc.identifier.doi","10.1038/sj.jcbfm.9600169"],["dc.identifier.isi","000235975500010"],["dc.identifier.pmid","15959459"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45246"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","0271-678X"],["dc.title","Free radical-mediated damage to barrier function is not associated with altered brain morphology in high-altitude headache"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Journal of Clinical Oncology"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Strik, H. M."],["dc.contributor.author","Bock, C.-H."],["dc.contributor.author","Kallenberg, K."],["dc.date.accessioned","2018-11-07T08:43:11Z"],["dc.date.available","2018-11-07T08:43:11Z"],["dc.date.issued","2010"],["dc.identifier.isi","000208852000233"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19898"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Clinical Oncology"],["dc.publisher.place","Alexandria"],["dc.title","Near-continuous temozolomide and low-dose weekly CCNU: A novel chemotherapy regimen with activity in malignant gliomas resistant to dose-dense temozolomide alone."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","834"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of NeuroInterventional Surgery"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Solymosi, Laszlo"],["dc.contributor.author","Taschner, Christian A."],["dc.contributor.author","Berkefeld, Joachim"],["dc.contributor.author","Schlamann, Marc"],["dc.contributor.author","Jansen, Olav"],["dc.contributor.author","Arnold, Sebastian"],["dc.contributor.author","Tomandl, Bernd"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Turowski, Bernd"],["dc.date.accessioned","2018-11-07T10:10:51Z"],["dc.date.available","2018-11-07T10:10:51Z"],["dc.date.issued","2016"],["dc.description.abstract","Background The pharmaceutical therapy for acute ischemic stroke has shortcomings in reopening large vessels and dissolving long thrombi, and endovascular treatment has been found to provide added value. The Aperio thrombectomy device showed promising results in an experimental study. The purpose of this study was to evaluate the device clinically. Methods 119 patients with acute stroke were treated in nine centers using the Aperio thrombectomy device. Target vessel, diameter, thrombus length, procedure time, recanalization, number of deployments, additional use of anticoagulants, complications, and the use of additional devices were assessed. Results The median thrombus length was 15mm (range 1.5-20mm) and the average time from device insertion to recanalization was 30min (range 5-120min). Blood flow restoration (Thrombolysis In Cerebral Infarction (TICI) 2-3) was achieved in 85%. In the majority of cases complete clot removal was achieved (TICI 0, 12%; TICI 1, 2%; TICI 2a, 14%; TICI 2b, 18%; TICI 3, 53%). The median number of deployments was 2 (range 1-6). Twelve procedural complications (10%) occurred. Conclusions The Aperio thrombectomy device seems to be an effective and adequately safe tool for reopening occluded cerebral arteries in the setting of acute stroke."],["dc.description.sponsorship","Acandis; Covidien; Strykker"],["dc.identifier.doi","10.1136/neurintsurg-2015-011678"],["dc.identifier.isi","000382148800021"],["dc.identifier.pmid","26220408"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39937"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Bmj Publishing Group"],["dc.relation.issn","1759-8486"],["dc.relation.issn","1759-8478"],["dc.title","Endovascular stroke therapy with the Aperio thrombectomy device"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1652"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Stroke"],["dc.bibliographiccitation.lastpage","1657"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Schramm, Peter"],["dc.contributor.author","Schellinger, Peter D."],["dc.contributor.author","Klotz, Ernst"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Fiebach, J. B."],["dc.contributor.author","Kulkens, S."],["dc.contributor.author","Heiland, S."],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Sartor, K."],["dc.date.accessioned","2018-11-07T10:47:57Z"],["dc.date.available","2018-11-07T10:47:57Z"],["dc.date.issued","2004"],["dc.description.abstract","Background and Purpose - We aimed to determine the diagnostic value of perfusion computed tomography (PCT) and CT angiography (CTA) including CTA source images (CTA-SI) in comparison with perfusion-weighted magnetic resonance imaging (MRI) (PWI) and diffusion-weighted MRI (DWI) in acute stroke <6 hours. Methods - Noncontrast-enhanced CT, PCT, CTA, stroke MRI, including PWI and DWI, and MR angiography (MRA), were performed in patients with symptoms of acute stroke lasting <6 hours. We analyzed ischemic lesion volumes on patients' arrival as shown on NECT, PCT, CTA-SI, DWI, and PWI ( Wilcoxon, Spearman, Bland - Altman) and compared them to the infarct extent as shown on day 5 NECT. Results - Twenty-two stroke patients underwent CT and MRI scanning within 6 hours. PCT time to peak (PCT-TTP) volumes did not differ from PWI-TTP ( P = 0.686 for patients who did not undergo thrombolysis/P = 0.328 for patients who underwent thrombolysis), nor did PCT cerebral blood volume (PCT-CBV) differ from PWI-CBV ( P = 0.893/ P = 0.169). CTA-SI volumes did not differ from DWI volumes ( P = 0.465/ P = 0.086). Lesion volumes measured in PCT maps significantly correlated with lesion volumes on PWI ( P = 0.0047, r = 1.0/ P = 0.0019, r = 0.897 for TTP; P = 0.0054, r = 0.983/P = 0.0026, r = 0.871 for CBV). Also, PCT-CBV lesion volumes significantly correlated with follow-up CT lesion volumes ( P = 0.0047, r = 1.0/ P = 0.0046, r = 0.819). Conclusions - In hyperacute stroke, the combination of PCT and CTA can render important diagnostic information regarding the infarct extent and the perfusion deficit. Lesions on PCT-TTP and PCT-CBV do not differ from lesions on PWI-TTP and PWI-CBV; lesions on CTA source images do not differ from lesions on DWI. The combination of noncontrast-enhanced CT ( NECT), perfusion CT ( PCT), and CT angiography ( CTA) can render additional information within <15 minutes and may help in therapeutic decision-making if PWI and DWI are not available or cannot be performed on specific patients."],["dc.identifier.doi","10.1161/01.STR.0000131271.54098.22"],["dc.identifier.isi","000222257300025"],["dc.identifier.pmid","15155964"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48086"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0039-2499"],["dc.title","Comparison of perfusion computed tomography and computed tomography angiography source images with perfusion-weighted imaging and diffusion-weighted Imaging in patients with acute stroke of less than 6 hours' duration"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1114"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","American Journal of Neuroradiology"],["dc.bibliographiccitation.lastpage","1118"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Tschampa, Henriette J."],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Kretzschmar, Hans A."],["dc.contributor.author","Meissner, Bettina"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Urbach, Horst"],["dc.contributor.author","Zerr, I."],["dc.date.accessioned","2018-11-07T11:01:33Z"],["dc.date.available","2018-11-07T11:01:33Z"],["dc.date.issued","2007"],["dc.description.abstract","BACKGROUND AND PURPOSE: High cortical signal intensity on diffusion-weighted (DW) or fluid-attenuated inversion recovery (FLAIR) images is increasingly described in sporadic Creutzfeldt-Jakob disease (sCJD). The aim of this study was to assess the extent and location of high cortical signal intensity, to investigate whether DW or FLAIR is superior in showing changes in cortical signal intensity, and to find out whether the distribution of the signal intensity changes is random or follows a common pattern. MATERIALS AND METHODS: We analyzed FLAIR and DW MR imaging scans of 39 patients with sCJD for hyperintense cortical signal intensity. We compared the sensitivity of the DW and FLAIR scans. We correlated the extent and location of the cortical signal intensity changes with concomitant changes in deep gray matter and the genotype of codon 129 of the prion protein gene. RESULTS: There was high signal intensity in the insula, the cingulate gyrus, and the superior frontal gyrus in 95%. The cortical areas near the midline also frequently showed the abnormal signal intensity (precuneus 87%, paracentral lobe 77%). The precentral and postcentral gyri were affected less frequently (41% and 28%, respectively). The DW MR imaging showed the cortical changes more effectively than FLAIR. There was no correlation between the distribution of changes and additional signal alterations in deep gray matter or the genotype of codon 129. CONCLUSION: The distribution of cortical signal intensity abnormalities in patients with sCJD follows a common pattern, affecting mainly the cortical areas near the midline, the insula, cingulum, and the superior frontal cortex. DW imaging is superior to FLAIR in the detection of cortical high signal intensity."],["dc.identifier.doi","10.3174/ajnr.A0496"],["dc.identifier.isi","000247395800028"],["dc.identifier.pmid","17569970"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51174"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Neuroradiology"],["dc.publisher.place","Oak brook"],["dc.relation.conference","91st Scientific Assembly and Annual Meeting of the Radiological-Society-of-North-America"],["dc.relation.eventlocation","Chicago, IL"],["dc.relation.issn","0195-6108"],["dc.title","Pattern of cortical changes in sporadic Creutzfeldt-Jakob disease"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","65"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Journal of the Neurological Sciences"],["dc.bibliographiccitation.lastpage","71"],["dc.bibliographiccitation.volume","236"],["dc.contributor.author","Marquardt, L."],["dc.contributor.author","Ruf, A."],["dc.contributor.author","Mansmann, U."],["dc.contributor.author","Winter, R."],["dc.contributor.author","Buggle, F."],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Grau, A. J."],["dc.date.accessioned","2018-11-07T10:55:46Z"],["dc.date.available","2018-11-07T10:55:46Z"],["dc.date.issued","2005"],["dc.description.abstract","Background and purpose: This study aimed to characterize the time course of inflammatory parameters after acute ischemic stroke. Methods: We serially determined high sensitivity C-reactive protein (CRP), fibrinogen, and leukocyte counts at 10 time points between days I and 90 after ischemic stroke and in control subjects. Results: CRP did not significantly change, whereas fibrinogen increased after stroke. At all time points, CRP and fibrinogen were higher than in healthy control subjects, but not risk factor control subjects. The leukocyte count declined after stroke and was significantly elevated as compared to both control groups only on day 1 but not later. NIHSS levels were positively correlated with CRP and fibrinogen at all time points. Larger infarcts were associated with a higher CRP and leukocyte counts on day 90. Treatment with aspirin was associated with lower values for all three inflammatory parameters in the subacute phase after ischemia. Conclusions: The course after stroke was different between the parameters of inflammation. Only the leukocytes followed the paradigm of an acute phase response. (c) 2005 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.jns.2005.05.006"],["dc.identifier.isi","000231929900011"],["dc.identifier.pmid","15961109"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49860"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0022-510X"],["dc.title","Inflammatory response after acute ischemic stroke"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]