Mörer, Onnen

[["dc.bibliographiccitation.firstpage","413"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Critical Care Clinics"],["dc.bibliographiccitation.lastpage","422"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Vasques, Francesco"],["dc.contributor.author","Duscio, Eleonora"],["dc.contributor.author","Cipulli, Francesco"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Quintel, Michael"],["dc.date.accessioned","2020-12-10T14:22:56Z"],["dc.date.available","2020-12-10T14:22:56Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.ccc.2018.03.011"],["dc.identifier.issn","0749-0704"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71782"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Extracorporeal Gas Exchange"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","252"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Critical Care Medicine"],["dc.bibliographiccitation.lastpage","264"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Cressoni, Massimo"],["dc.contributor.author","Carlesso, Eleonora"],["dc.contributor.author","Caspani, Maria L."],["dc.contributor.author","Marino, Antonella"],["dc.contributor.author","Gallazzi, Elisabetta"],["dc.contributor.author","Caironi, Pietro"],["dc.contributor.author","Lazzerini, Marco"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2018-11-07T09:44:43Z"],["dc.date.available","2018-11-07T09:44:43Z"],["dc.date.issued","2014"],["dc.description.abstract","Objective: Positive end-expiratory pressure exerts its effects keeping open at end-expiration previously collapsed areas of the lung; consequently, higher positive end-expiratory pressure should be limited to patients with high recruitability. We aimed to determine which bedside method would provide positive end-expiratory pressure better related to lung recruitability. Design: Prospective study performed between 2008 and 2011. Setting: Two university hospitals (Italy and Germany). Patients: Fifty-one patients with acute respiratory distress syndrome. Interventions: Whole lung CT scans were taken in static conditions at 5 and 45 cm H2O during an end-expiratory/end-inspiratory pause to measure lung recruitability. To select individual positive end-expiratory pressure, we applied bedside methods based on lung mechanics (ExPress, stress index), esophageal pressure, and oxygenation (higher positive end-expiratory pressure table of lung open ventilation study). Measurements and Main Results: Patients were classified in mild, moderate and severe acute respiratory distress syndrome. Positive end-expiratory pressure levels selected by the ExPress, stress index, and absolute esophageal pressures methods were unrelated with lung recruitability, whereas positive end-expiratory pressure levels selected by the lung open ventilation method showed a weak relationship with lung recruitability (r(2) = 0.29; p < 0.0001). When patients were classified according to the acute respiratory distress syndrome Berlin definition, the lung open ventilation method was the only one which gave lower positive end-expiratory pressure levels in mild and moderate acute respiratory distress syndrome compared with severe acute respiratory distress syndrome (8 2 and 11 +/- 3 cm H2O vs 15 +/- 3 cm H2O; p < 0.05), whereas ExPress, stress index, and esophageal pressure methods gave similar positive end-expiratory pressure values in mild, moderate, and severe acute respiratory distress syndrome. The positive end-expiratory pressure selected by the different methods were unrelated to each other with the exception of the two methods based on lung mechanics (ExPress and stress index). Conclusions: Bedside positive end-expiratory pressure selection methods based on lung mechanics or absolute esophageal pressures provide positive end-expiratory pressure levels unrelated to lung recruitability and similar in mild, moderate, and severe acute respiratory distress syndrome, whereas the oxygenation-based method provided positive end-expiratory pressure levels related with lung recruitability progressively increasing from mild to moderate and severe acute respiratory distress syndrome."],["dc.identifier.doi","10.1097/CCM.0b013e3182a6384f"],["dc.identifier.isi","000329863400020"],["dc.identifier.pmid","24196193"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34453"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1530-0293"],["dc.relation.issn","0090-3493"],["dc.title","Bedside Selection of Positive End-Expiratory Pressure in Mild, Moderate, and Severe Acute Respiratory Distress Syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1220"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.lastpage","1223"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Neilson, A. R."],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Burchardi, Hilmar"],["dc.contributor.author","Schneider, H."],["dc.date.accessioned","2018-11-07T10:48:29Z"],["dc.date.available","2018-11-07T10:48:29Z"],["dc.date.issued","2004"],["dc.description.abstract","Objective. To evaluate LOS in developing a concept of borderline ICU LOS for a realistic reimbursement of intensive care. Design. Retrospective analysis of LOS and cost data extracted from patients' electronic records. Setting. Surgical ICU of the University Hospital Gottingen, Germany. Patients and participants. All adult ICU admissions with LOS >24 h over a 24-month period (1 January 2000 to 31 December 2001; n=1631.) Interventions. None. Measurements and results. Cluster analysis partitioned the ICU population into three homogenous groups based on ICU LOS and total direct costs: cluster 1 (n=1405; mean LOS=2.8; mean cost=e2399); cluster 2 (n=190; mean LOS=13.4; mean cost=e12,754); cluster 3 (n=36; mean LOS=34.9; mean cost=e34,173). Cost distribution between cluster 1 and clusters 2 and 3 combined was 48 vs 52%. Upper 95 percentile LOS of 6.7 allowed cluster 1 to be replaced by an LOS profile population of less than or equal to 7 days population (n=1355; 96% population and 91% total ICU cost overlap with cluster 1) representing 83% of total ICU population and 44% of total ICU costs. Stratification of >7 day population into LOS less than or >20 days (n=220; n=56) were further differentiated by mortality (11 vs 23%) and sepsis incidence (33 vs 79%). Conclusions. It may be feasible to formulate a LOS-based reimbursement scheme for ICU services in Germany based on the selection of (appropriate) patients' ICU LOS profiles."],["dc.identifier.doi","10.1007/s00134-004-2168-x"],["dc.identifier.isi","000221730300034"],["dc.identifier.pmid","14985961"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48204"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0342-4642"],["dc.title","A new concept for DRG-based reimbursement of services in German intensive care units: results of a pilot study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","640"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie"],["dc.bibliographiccitation.lastpage","647"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Moerer, Onnen"],["dc.date.accessioned","2018-11-07T09:19:01Z"],["dc.date.available","2018-11-07T09:19:01Z"],["dc.date.issued","2013"],["dc.description.abstract","During acute respiratory failure, intubation and invasive mechanical ventilation may be life saving procedures. However, with increasing time on the ventilator, the rate of complications increases and prolonged mechanical ventilation is associated with increased morbidity, mortality and high ICU cost. Since the weaning period accounts for 40% of the overall ventilation period, optimizing weaning is mandatory to shorten mechanical ventilation. Various concepts to facilitate weaning have been proposed and there is an ongoing debate about the most effective methods. These include an early screening of weaning readiness based on established criteria, the choice of the concept of ventilation and ventilator modes, the use of weaning protocols, closed loop automated ventilation and weaning. This article describes the relevance of the different ventilator strategies that are applied during weaning from mechanical ventilation."],["dc.identifier.doi","10.1055/s-0033-1358629"],["dc.identifier.isi","000326541300011"],["dc.identifier.pmid","24193691"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28538"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","1439-1074"],["dc.relation.issn","0939-2661"],["dc.title","Weaning off Respirators Which Procedures are suitable"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","217"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie"],["dc.bibliographiccitation.lastpage","224"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Bittner, J."],["dc.contributor.author","Hinz, Jose Maria"],["dc.contributor.author","Sydow, M."],["dc.date.accessioned","2018-11-07T11:09:13Z"],["dc.date.available","2018-11-07T11:09:13Z"],["dc.date.issued","2005"],["dc.description.abstract","Objective: Onset time and recovery from non depolarising neuromuscular blockade depends on the tested muscle and is influenced by the age of the patient. This study compares the neuromuscular blocking effect of rocuronium on the diaphragm, adductor pollicis and orbicularis oculi muscle in young and elderly patients. Methods: After institutional ethics committee approval and written informed consent, 20 adult patients (ASA I - II), age 18 - 59 and > 65, have been included. Neuromuscular response was measured by accelerography for the adductor pollicis and orbicularis oculi muscle. Monitoring of the diaphragm consisted of measurement of the airway pressure against an occluded tracheal tube during magnetic phrenic nerve stimulation. Onset time and recovery were measured after injection of 0.6 mg/kg Rocuronium. Results: The adductor pollicis had the fastest onset time (young 2.3 min, old 2.2 min), followed by diaphragm (young 3.6 min, old 3.4 min) and orbicularis oculi muscle (young 3.7 min, old 4.8 min). There was a complete blockade of the diaphragm in 50% of all patients (Adductor pollicis 100%, orbicularis oculi 40%). Neuromuscular recovery, recovery index and TOF 0.8 differed significantly between young and elderly patients. Onset of recovery was earlier at the diaphragm (young 15.9 min, old 22.0 min) compared to the peripheral muscles (adductor pollicis young 25.6 min, old 37.9 min, orbicularis oculi young 23.8 min, old 27.5 min). Conclusion: 2fould ED95 of rocuronium often results in an incomplete neuromuscular blockade of the diaphragm. Therefore monitoring of the peripheral muscles in patients given a single dose of rocuronium often overestimates the degree of diaphragmatic relaxation, but is a save predictor of recovery. Especially in elderly patients were prolonged neuro-muscular blockade should be expected, a neuromuscular monitoring is recommended."],["dc.identifier.doi","10.1055/s-2005-861037"],["dc.identifier.isi","000228422100009"],["dc.identifier.pmid","15832241"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52959"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0939-2661"],["dc.title","Effect of rocuronium on the diaphragm, musculus adductor pollicis and orbicularis oculi in two groups of different age"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","138"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie"],["dc.bibliographiccitation.lastpage","146"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Brauer, Anselm"],["dc.contributor.author","Weyland, Wolfgang"],["dc.contributor.author","Braun, Ulrich"],["dc.date.accessioned","2018-11-07T10:50:26Z"],["dc.date.available","2018-11-07T10:50:26Z"],["dc.date.issued","2004"],["dc.description.abstract","Question: Inadequately warmed blood or infusions contribute to the development of perioperative hypothermia. Therefore we analysed the efficiency of several infusion warmers. Method: Tested infusion warmers: Model Autoline(R) (Barkey) 500OR(R)/241(R) (Arizant), BW385L(R) (Biotest), H250(R)/D50(R) und D60(R) (Level-1), H500(R)/D300(R) (Level-1), Warmflo FW537-I(R)/HEC40(R) (Tyco). Different solutions (saline, colloid solution and packed red blood cells PRBC) were tested varying the infusion flow, temperature of the solution and infusion pressure. Effective warming was defined as an infusion temperature greater than or equal to 33 degreesC. Haemolysis was measured by the increase of free plasma haemoglobin. Results: The infusion warmers were effective within the following flow ranges: Low flow rate (< 250ml/h): Autoline(R), 500OR(R)/241(R) and H250(R)/D60(R). Medium flow rate (250-2500 ml/h): Autoline(R), 500OR(R)/241(R) BW385L(R) (> 480ml/h), H250(R)/D60(R) und D50(R) (greater than or equal to 1300 ml/h), FW537-I(R)/HEC40(R) (> 950 ml/h. High flow rate (2500-10 000 ml/h): BW385L(R) (up to 5000 ml/h), H 250(R)/ D50(R), H250(R)/D60(R), H500(R)/D300(R) and FW537-I(R)/HEC40(R). Highest flow rates(> 10000ml/h): H250(R)/ D60(R), H500(R)/D300(R) and FW537-I(R) HEC40(R). Colloidal solutions were warmed nearly as good as saline, cooled PRBC had a smaller range of effective warming. There was no relevant haemolysis in any of the tested systems (plasma free haemoglobin raise < 24 mg/dl in all systems). Conclusion: The warming capacity of the system and the length of the uninsulated infusion system determine the efficiency of an infusion warmer. The range of effective warming of an infusion warmer should be known for proper application."],["dc.identifier.doi","10.1055/s-2004-814326"],["dc.identifier.isi","000220327200004"],["dc.identifier.pmid","15042503"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48649"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0939-2661"],["dc.title","Warming efficacy and blood damaging of blood and infusion warmers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","608"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie"],["dc.bibliographiccitation.lastpage","609"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Weber-Carstens, Steffen"],["dc.date.accessioned","2018-11-07T09:19:00Z"],["dc.date.available","2018-11-07T09:19:00Z"],["dc.date.issued","2013"],["dc.description.abstract","Die Zahl beatmeter Patienten auf Intensivstationen steigt stetig 1. Dies betrifft v.a. Patienten mit (akuter) prolongierter maschineller Beatmung, fur die kurzlich fur die USA eine jahrliche Zuwachsrate von 5,5% geschatzt wurde. Bis zum Jahr 2020 kommt es demnach im Vergleich zum Jahr 2000 zu einem Anstieg von 250000 Fallen auf 605898 Falle/Jahr, d.h., dass sich die Zahl der Falle mehr als verdoppelt 1. Erkrankungen des respiratorischen Systems sind mittlerweile nach den kardiovaskularen Erkrankungen die haufigste Ursache fur eine Behandlung auf einer Intensivstation 2. Die Respiratorentwohnung nimmt in der Behandlung beatmeter Patienten eine zentrale Rolle ein. Esteban et al. beschrieben 2002 3, dass >50% der gesamten Beatmungsdauer auf die Entwohnung vom Respirator entfallt. Vor dem Hintergrund der o.g. Prognose muss alles daran gelegt werden, sowohl die Beatmungsdauer verlangernde beatmungsassoziierte Komplikationen zu minimieren als auch den Prozess der Entwohnung von der Beatmung zu optimieren."],["dc.identifier.doi","10.1055/s-0033-1358623"],["dc.identifier.isi","000326541300005"],["dc.identifier.pmid","24193685"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28535"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","1439-1074"],["dc.relation.issn","0939-2661"],["dc.title","Weaning off Respirators Sounds simple, but it is not!"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","260"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Current Opinion in Critical Care"],["dc.bibliographiccitation.lastpage","267"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Hahn, Guenter"],["dc.contributor.author","Quintel, Michael"],["dc.date.accessioned","2018-11-07T08:55:54Z"],["dc.date.available","2018-11-07T08:55:54Z"],["dc.date.issued","2011"],["dc.description.abstract","Purpose of review Electrical impedance tomography (EIT) is an attractive method of monitoring patients during mechanical ventilation because it can provide a noninvasive continuous image of pulmonary impedance, which indicates the distribution of ventilation. This article will discuss ongoing research on EIT, with a focus on methodological aspects and limitations and novel approaches in terms of pathophysiology, diagnosis and therapeutic advancements. Recent findings EIT enables the detection of regional distribution of alveolar ventilation and, thus, the quantification of local inhomogeneities in lung mechanics. By detecting recruitment and derecruitment, a positive end-expiratory pressure level at which tidal ventilation is relatively homogeneous in all lung regions can be defined. Additionally, different approaches to characterize the temporal local behaviour of lung tissue during ventilation have been proposed, which adds important information. Summary There is growing evidence that supports EIT usage as a bedside measure to individually optimize ventilator settings in critically ill patients in order to prevent ventilator-induced lung injury. A standardization of current approaches to analyse and interpret EIT data is required in order to facilitate the clinical implementation."],["dc.identifier.doi","10.1097/MCC.0b013e3283463c9c"],["dc.identifier.isi","000290040400010"],["dc.identifier.pmid","21478747"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23016"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1531-7072"],["dc.relation.issn","1070-5295"],["dc.title","Lung impedance measurements to monitor alveolar ventilation"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","15"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Respiratory Care"],["dc.bibliographiccitation.lastpage","22"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Harnisch, Lars-Olav"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Zippel, Carsten"],["dc.contributor.author","Quintel, Michael"],["dc.date.accessioned","2018-11-07T10:21:44Z"],["dc.date.available","2018-11-07T10:21:44Z"],["dc.date.issued","2016"],["dc.description.abstract","BACKGROUND: During noninvasive ventilation (NIV) of COPD patients, delayed off-cycling of pressure support can cause patient ventilator mismatch and NIV failure. This systematic experimental study analyzes the effects of varying cycling criteria on patient-ventilator interaction. METHODS: A lung simulator with COPD settings was connected to an ICU ventilator via helmet or face mask. Cycling was varied between 10 and 70% of peak inspiratory flow at different breathing frequencies (15 and 30 breaths/min) and pressure support levels (5 and 15 cm H2O) using the ventilator's invasive and NIV mode with and without an applied leakage. RESULTS: Low cycling criteria led to severe expiratory cycle latency. Augmenting off-cycling reduced expiratory cycle latency (P < .001), decreased intrinsic PEEP, and avoided non-supported breaths. Setting cycling to 50% of peak inspiratory flow achieved best synchronization. Overall, using the helmet interface increased expiratory cycle latency in almost all settings (P < .001). Augmenting cycling from 10 to 40% progressively decreased expiratory pressure load (P < .001). NIV mode decreased expiratory cycle latency compared with the invasive mode (P < .001). CONCLUSION: Augmenting the cycling criterion above the default setting (20-30% peak inspiratory flow) improved patient ventilator synchrony in a simulated COPD model. This suggests that an individual approach to cycling should be considered, since interface, level of pressure support, breathing frequency, and leakage influence patient-ventilator interaction and thus need to be considered."],["dc.identifier.doi","10.4187/respcare.04141"],["dc.identifier.isi","000367062300005"],["dc.identifier.pmid","26556898"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42144"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Daedalus Enterprises Inc"],["dc.relation.issn","1943-3654"],["dc.relation.issn","0020-1324"],["dc.title","Patient-Ventilator Interaction During Noninvasive Ventilation in Simulated COPD"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","543"],["dc.bibliographiccitation.issue","33-34"],["dc.bibliographiccitation.journal","DEUTSCHES ARZTEBLATT INTERNATIONAL"],["dc.bibliographiccitation.lastpage","U50"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Weber-Carstens, Steffen"],["dc.contributor.author","Goldmann, Anton"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Kalenka, Armin"],["dc.contributor.author","Kluge, Stefan"],["dc.contributor.author","Peters, Juergen"],["dc.contributor.author","Putensen, Christian"],["dc.contributor.author","Mueller, Thomas"],["dc.contributor.author","Rosseau, Simone"],["dc.contributor.author","Zwissler, Bernhard"],["dc.contributor.author","Moerer, Onnen"],["dc.date.accessioned","2018-11-07T09:21:13Z"],["dc.date.available","2018-11-07T09:21:13Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: During the H1N1 pandemic of 2009 and 2010, the large number of patients with severe respiratory failure due to H1N1 infection strained the capacities of treatment facilities for extracorporeal membrane oxygenation (ECMO) around the world. No data on this topic have yet been published for Germany. Methods: During the pandemic, the German ARDS Network (a task force of the DIVI's respiratory failure section) kept track of the availability of ECMO treatment facilities with a day-to-day, Internet-based capacity assessment. In cooperation with the Robert Koch Institute, epidemiological and clinical data were obtained on all patients treated for influenza in intensive care units. Results: 116 patients were identified who had H1N1 disease and were treated in the intensive care units of 9 university hospitals and 3 other maximum medical care hospitals. 61 of them received ECMO. The overall mortality was 38% (44 of 116 patients); among patients receiving ECMO, the mortality was 54% (33 of 61 patients). The mortality was higher among patients who had an accompanying malignancy or immune deficiency (72.2%). Conclusion: Even persons without any other accompanying disease developed life-threatening respiratory failure as a result of H1N1 infection, and many of these patients needed ECMO. This study reveals for the first time that the mortality of H1N1 infection in Germany is comparable to that in other countries. H1N1 patients with acute respiratory failure had a worse outcome if they also had serious accompanying diseases."],["dc.description.sponsorship","Maquet; Novalung; hemodec"],["dc.identifier.doi","10.3238/arztebl.2013.0543"],["dc.identifier.isi","000326726800001"],["dc.identifier.pmid","24069078"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29061"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Deutscher Aerzte-verlag Gmbh"],["dc.relation.issn","1866-0452"],["dc.title","Extracorporeal Lung Support in H1N1 Provoked Acute Respiratory Failure The Experience of the German ARDS Network"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]