Mörer, Onnen

[["dc.bibliographiccitation.artnumber","155"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Lier, Martin"],["dc.contributor.author","Nessler, Stefan"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Pressler, Meike"],["dc.contributor.author","Saager, Leif"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Roessler, Markus"],["dc.contributor.author","Meissner, Konrad"],["dc.contributor.author","Winkler, Martin S."],["dc.date.accessioned","2021-11-25T11:12:41Z"],["dc.date.accessioned","2022-08-18T12:33:00Z"],["dc.date.available","2021-11-25T11:12:41Z"],["dc.date.available","2022-08-18T12:33:00Z"],["dc.date.issued","2021-10-30"],["dc.date.updated","2022-07-29T12:17:57Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious airborne virus inducing pandemic coronavirus disease 2019 (COVID-19). This is most relevant for medical staff working under harmful conditions in emergencies often dealing with patients and an undefined SARS-CoV-2 status. We aimed to measure the effect of high-class filtering facepieces (FFP) in emergency medical service (EMS) staff by analyzing seroprevalence and history of positive polymerase chain reaction (PCR) for SARS-CoV-2.\r\n \r\n \r\n Method\r\n This observational cohort study included workers in EMS, who were compared with hospital staff (HS) and staff, which was not directly involved in patient care (NPC). All direct patient contacts of EMS workers were protected by FFP2/N95 (filtering face piece protection class 2/non-oil-based particulates filter efficiency 95%) masks, whereas HS was protected by FFP2/N95 exclusively when a patient had a proven or suspected SARS-CoV-2 infection. NPC was not protected by higher FFP. The seroprevalence of SARS-CoV-2 antibodies was analyzed by immunoassay by end of 12/2020 together with the history of a positive PCR. In addition, a self-assessment was performed regarding the quantity of SARS-CoV-2 positive contacts, about flu symptoms and personal belief of previous COVID-19 infections.\r\n \r\n \r\n Results\r\n The period in which contact to SARS-CoV-2 positive patients has been possible was 10 months (March to December 2020)—with 54,681 patient contacts documented for EMS—either emergencies (n = 33,241) or transportation services (n = 21,440). Seven hundred-thirty (n = 730) participants were included into the study (n = EMS: 325, HS: 322 and NPC: 83). The analysis of the survey showed that the exposure to patients with an unknown and consecutive positive SARS-CoV-2 result was significantly higher for EMS when compared to HS (EMS 55% vs. HS 30%, p = 0.01). The incidence of a SARS-CoV-2 infection in our cohort was 1.2% (EMS), 2.2% (HS) and 2.4% (NPC) within the three groups (ns) and lowest in EMS. Furthermore, the belief of previous COVID-19 was significant higher in EMS (19% vs. 10%),\r\n \r\n \r\n Conclusion\r\n The consistent use of FFP2/N95 in EMS is able to prevent work-related SARS-CoV-2 infections in emergency situations. The significance of physical airway protection in exposed medical staff is still relevant especially under the aspect of new viral variants and unclear effectiveness of new vaccines.\r\n \r\n \r\n Graphical Abstract"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.citation","Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 2021 Oct 30;29(1):155"],["dc.identifier.doi","10.1186/s13049-021-00969-0"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/93536"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112914"],["dc.language.iso","en"],["dc.publisher","BioMed Central"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","Personal protection equipment"],["dc.subject","Filtering facepiece"],["dc.subject","FFP2"],["dc.subject","N95"],["dc.subject","SARS-CoV-2"],["dc.subject","Seroprevalence"],["dc.subject","Emergency medical services"],["dc.title","High class filtering facepiece (FFP) are fundamental and effective in protection of emergency health care workers: an observational cohort study in a German community"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","736"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Infectious Diseases"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Meyer, Eva C."],["dc.contributor.author","Alt-Epping, Sabine"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Büttner, Benedikt"],["dc.date.accessioned","2021-11-25T10:47:25Z"],["dc.date.accessioned","2022-08-16T12:43:01Z"],["dc.date.available","2021-11-25T10:47:25Z"],["dc.date.available","2022-08-16T12:43:01Z"],["dc.date.issued","2021-08-03"],["dc.date.updated","2022-07-29T12:00:23Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Capnocytophaga canimorsus (C. canimorsus) infections are rare and usually present with unspecific symptoms, which can eventually end in fatal septic shock and multiorgan failure. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) related coronavirus disease 2019 (COVID-19), on the other hand, is predominantly characterized by acute respiratory failure, although other organ complications can occur. Both infectious diseases have in common that hyperinflammation with a cytokine storm can occur. While microbial detection of C. canimorsus in blood cultures can take over 48 h, diagnosis of SARS-CoV-2 is facilitated by a widely available rapid antigen diagnostic test (Ag-RDT) the results of which are available within half an hour. These Ag-RDT results are commonly verified by a nucleic acid amplification test (NAAT), whose results are only available after a further 24 h.\r\n \r\n \r\n Case presentation\r\n A 68-year-old male patient with the diagnosis of COVID-19 pneumonia was referred to our Intensive Care Unit (ICU) from another hospital after testing positive on an Ag-RDT. While the initial therapy was focused on COVID-19, the patient developed a fulminant septic shock within a few hours after admission to the ICU, unresponsive to maximum treatment. SARS-CoV-2 NAATs were negative, but bacteremia of C. canimorsus was diagnosed post-mortem. Further anamnestic information suggest that a small skin injury caused by a dog leash or the subsequent contact of this injury with the patient’s dog could be the possible point of entry for these bacteria.\r\n \r\n \r\n Conclusion\r\n During the acute phase of hyperinflammation and cytokine storm, laboratory results can resemble both, sepsis of bacterial origin or SARS-CoV-2. This means that even in the light of a global SARS-CoV-2 pandemic, where this diagnosis provides the most salient train of thoughts, differential diagnoses must be considered. Ag-RDT can contribute to early detection of a SARS-CoV-2 infection, but false-positive results may cause fixation errors with severe consequences for patient outcome."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.citation","BMC Infectious Diseases. 2021 Aug 03;21(1):736"],["dc.identifier.doi","10.1186/s12879-021-06422-y"],["dc.identifier.pii","6422"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/93512"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112741"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-455"],["dc.relation.eissn","1471-2334"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","SARS-CoV-2"],["dc.subject","Rapid antigen diagnostic test"],["dc.subject","Capnocytophaga canimorsus"],["dc.subject","Septic shock"],["dc.subject","COVID-19"],["dc.subject","Case report"],["dc.title","Fatal septic shock due to Capnocytophaga canimorsus bacteremia masquerading as COVID-19 pneumonia - a case report"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]