Lex, Christiane

[["dc.bibliographiccitation.journal","Pediatric Pulmonology"],["dc.contributor.author","Korten, Insa"],["dc.contributor.author","Zacharasiewicz, Angela"],["dc.contributor.author","Bittkowski, Nina"],["dc.contributor.author","Hofmann, Alexander"],["dc.contributor.author","Lex, Christiane"],["dc.date.accessioned","2020-12-10T14:07:04Z"],["dc.date.available","2020-12-10T14:07:04Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1002/ppul.24320"],["dc.identifier.eissn","1099-0496"],["dc.identifier.issn","8755-6863"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70119"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Asthma control in children: Body plethysmography in addition to spirometry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","361"],["dc.bibliographiccitation.issue","17-18"],["dc.bibliographiccitation.journal","Wiener Medizinische Wochenschrift"],["dc.bibliographiccitation.lastpage","365"],["dc.bibliographiccitation.volume","165"],["dc.contributor.author","Lex, Christiane"],["dc.contributor.author","Korten, Insa"],["dc.contributor.author","Hofmann, Alexander"],["dc.contributor.author","Renner, Sabine"],["dc.contributor.author","Szepfalusi, Zsolt"],["dc.contributor.author","Frischer, Thomas"],["dc.contributor.author","Zacharasiewicz, Angela"],["dc.date.accessioned","2021-06-01T10:49:18Z"],["dc.date.available","2021-06-01T10:49:18Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.1007/s10354-015-0387-0"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86237"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1563-258X"],["dc.relation.issn","0043-5341"],["dc.title","Neue internationale Referenzwerte für die Spirometrie – Implikation für die Praxis anhand einer vergleichenden Analyse eines pädiatrischen Patientenkollektivs"],["dc.title.translated","New international reference values for spirometry: implications for clinical issues using a comparative analysis of a paediatric population"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","111"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Annals of Allergy Asthma & Immunology"],["dc.bibliographiccitation.lastpage","116"],["dc.bibliographiccitation.volume","114"],["dc.contributor.author","Trischler, Jordis"],["dc.contributor.author","Mueller, Christina-Maria"],["dc.contributor.author","Koenitzer, Stephanie"],["dc.contributor.author","Prell, Erik"],["dc.contributor.author","Korten, Insa"],["dc.contributor.author","Unverzagt, Susanne"],["dc.contributor.author","Lex, Christiane"],["dc.date.accessioned","2018-11-07T10:01:41Z"],["dc.date.available","2018-11-07T10:01:41Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: Inflammatory processes in the asthmatic lung involve the large and small airway and alveolar sites. Leukotriene B-4 (LTB4) is an important disease marker, but its role in inflammation of the small airways in asthma has not been established yet. Objective: To distinguish between large and small airway or alveolar LTB4 concentrations in children with asthma using the new technique of fractionated exhaled breath condensate sampling. Methods: Sixty-eight children (9-17 years old, 33 children with asthma and 35 controls) underwent fractional exhaled nitric oxide (FeNO) measurements, lung function testing, and collection of fractionated exhaled breath condensate using a capnograph-based approach. The LTB4 concentrations in the small airway or alveolar and large airway fractions were correlated to disease status, lung function impairment, and clinical parameters. Results: Children with asthma had significantly higher LTB4 concentrations in the small airway or alveolar fraction than controls (5.58 pg/mL; 95% interquartile range [IQR], 2.0-11.77 pg/mL; vs 2.0 pg/mL; 95% IQR, 2.0-6.2 pg/mL; P=.003). No difference was found between the groups in the large airway fraction. Children with obstructive lung function impairment (forced expiratory volume in 1 second z score < -1.65) had increased small airway or alveolar LTB4 concentrations compared with children without impairment (2.0 pg/ mL; 95% IQR, 2.0-9.21 pg/mL; vs 18.32 pg/mL; 95% IQR, 3.7-23.02 pg/mL; P=.04). Children with asthma but without pathologic obstructive lung function still had higher LTB4 concentrations than controls (5.57 pg/mL; 95% IQR, 2.00-10.60 pg/mL; vs 2.00 pg/mL; 95% IQR, 2.00-6.20 pg/mL; P=.01). Conclusion: LTB4 is detectable and elevated in the small airway or alveolar fraction of exhaled breath condensate in pediatric asthma. Because of the possibility of detecting elevated levels in patients without lung function impairment in controlled disease, it may be used as a noninvasive marker of small airways disease; however, future long-term studies are needed. (C) 2015 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.anai.2014.11.022"],["dc.identifier.isi","000348454700008"],["dc.identifier.pmid","25624130"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38072"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1534-4436"],["dc.relation.issn","1081-1206"],["dc.title","Elevated exhaled leukotriene B-4 in the small airway compartment in children with asthma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]