Lex, Christiane

[["dc.bibliographiccitation.journal","Pediatric Pulmonology"],["dc.contributor.author","Korten, Insa"],["dc.contributor.author","Zacharasiewicz, Angela"],["dc.contributor.author","Bittkowski, Nina"],["dc.contributor.author","Hofmann, Alexander"],["dc.contributor.author","Lex, Christiane"],["dc.date.accessioned","2020-12-10T14:07:04Z"],["dc.date.available","2020-12-10T14:07:04Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1002/ppul.24320"],["dc.identifier.eissn","1099-0496"],["dc.identifier.issn","8755-6863"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70119"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Asthma control in children: Body plethysmography in addition to spirometry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","HNO"],["dc.contributor.author","Schuppe, Marie Charlotte"],["dc.contributor.author","Lex, Christiane"],["dc.contributor.author","Gliem, Nina"],["dc.contributor.author","Olgemüller, Ulrike"],["dc.contributor.author","Koziolek, Michael"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Gupta, Sidhi"],["dc.contributor.author","Dombrowski, Tobias"],["dc.contributor.author","Czech-Zechmeister, Bozena A."],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2022-11-01T10:17:33Z"],["dc.date.available","2022-11-01T10:17:33Z"],["dc.date.issued","2022"],["dc.description.abstract","Zusammenfassung\n \n Hintergrund\n Obwohl allergologische Erkrankungen zu den wichtigen Gesundheitsstörungen laut ärztlicher Approbationsordnung zählen, ist die Allergologie in Deutschland nicht als selbstständiges Fach im Studium der Humanmedizin verankert.\n \n \n Ziel der Arbeit\n Da sämtliche Universitäts- und Hochschulstandorte mit dieser Herausforderung umgehen müssen, war es Ziel unseres Lehrprojekts, eine exemplarische und mit allen beteiligten Kliniken und Instituten abgestimmte Koordination und Verzahnung der allergologischen Lehre an einem Standort zu etablieren. Insbesondere Comprehensive Allergy Centers (CAC) bieten eine bereits vorhandene Infrastruktur, in der diese Neukonzeption der allergologischen Lehre auf andere Standorte übertragen werden könnte.\n \n \n Material und Methoden\n Nach umfangreicher Bestandsaufnahme der aktuellen allergologischen Lehre an der Universitätsmedizin Göttingen wurde im interdisziplinären Konsens ein neues Lehrkonzept entwickelt, durch die Bereitstellung zusätzlicher digitaler Lehr- und Lernanteile ergänzt („blended learning“) und schließlich evaluiert.\n \n \n Ergebnisse\n Die allergologische Lehre im klinischen Studienabschnitt zeigte eine starke Fragmentierung, die ohne Koordination der zwölf beteiligten Kliniken/Institute und ohne Abstimmung der jeweiligen Lerninhalte stattfand. In der etablierten Struktur des interdisziplinären CAC erfolgte eine Neukonzeption, Koordination und Schwerpunktsetzung der studentischen Lehre zur klinischen Allergologie. Die Bereitstellung von neuen interaktiven Lerneinheiten sowie ergänzender Materialien zum Selbststudium wurden von den Studierenden positiv bewertet. Eine vergleichende Evaluation von Studierenden nach Absolvieren der unterschiedlichen Curricula zeigte signifikante Verbesserungen im Erreichen der gewünschten Lernziele."],["dc.description.abstract","Abstract\n \n Background\n Although allergic diseases are among the most important health disorders, allergology is not anchored as an independent subject in the clinical part of medical studies in Germany.\n \n \n Objective\n As all universities and institutes face the same challenge, the aim of our project was to establish exemplary coordination and networking of education in allergology at one location in agreement with all involved departments and institutes. Particularly, Comprehensive Allergy Centers (CAC) offer an established infrastructure via which the revised allergology education program can be transferred to other universities.\n \n \n Materials and methods\n After an extensive inventory of the current allergological curriculum at the University Medical Center Göttingen, a new teaching concept was developed in interdisciplinary consensus, supplemented by first-time provision of additional digital contents (“blended learning”), and finally evaluated.\n \n \n Results\n Initially, we observed a high level of fragmentation in the teaching of allergology in the clinical study sections of human medicine, with no coordination between the 12 clinical departments/institutes involved and no coherent framework for the specific learning content. Within the established structure of the interdisciplinary CAC, we revised, coordinated, and defined key areas for improved student education in clinical allergology. The allocation of new interactive learning elements as well as supplementary materials for self-studies was welcomed by the students and positively evaluated. A survey among students after completing the former vs. current curricula showed significant improvements in achieving the desired educational objectives."],["dc.identifier.doi","10.1007/s00106-022-01222-5"],["dc.identifier.pii","1222"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/116840"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-605"],["dc.relation.eissn","1433-0458"],["dc.relation.issn","0017-6192"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Interdisziplinäre Neukonzeption der Lehre im Querschnittsfach „Allergologie“ im Studiengang Humanmedizin"],["dc.title.translated","New interdisciplinary teaching concept for the cross-sectional subject of allergology in human medicine studies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","703"],["dc.bibliographiccitation.issue","09"],["dc.bibliographiccitation.journal","Allergologie"],["dc.bibliographiccitation.lastpage","711"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Lex, C."],["dc.contributor.author","Beutner, D."],["dc.contributor.author","Buhl, T."],["dc.contributor.author","Czech-Zechmeister, B.A."],["dc.contributor.author","Dombrowski, T."],["dc.contributor.author","Ellenrieder, V."],["dc.contributor.author","Fischer, A."],["dc.contributor.author","Geier, J."],["dc.contributor.author","Gliem, N."],["dc.contributor.author","Hasenfuß, G."],["dc.contributor.author","Beutner, C."],["dc.date.accessioned","2022-12-01T08:31:49Z"],["dc.date.available","2022-12-01T08:31:49Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.5414/ALX02350"],["dc.identifier.pii","02350"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118274"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.issn","0344-5062"],["dc.title","Allergiezentrum Südniedersachsen – Das Comprehensive Allergy Center der Universitätsmedizin Göttingen"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","375"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Cystic Fibrosis"],["dc.bibliographiccitation.lastpage","377"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Lex, Christiane"],["dc.contributor.author","Minso, Rebecca"],["dc.contributor.author","Alfeis, Nadine"],["dc.contributor.author","Rosewich, Hendrik"],["dc.contributor.author","Schucht, Sylvia"],["dc.contributor.author","Tümmler, Burkhard"],["dc.date.accessioned","2022-09-01T09:49:39Z"],["dc.date.available","2022-09-01T09:49:39Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1016/j.jcf.2021.08.018"],["dc.identifier.pii","S156919932101359X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113490"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.issn","1569-1993"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Clinical presentation and basic defect of the CFTR genotype p.Phe508del / p.Arg117His in a mother and her monozygous twin daughters"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2004173"],["dc.bibliographiccitation.journal","European Respiratory Journal"],["dc.contributor.author","Gaillard, Erol A."],["dc.contributor.author","Kuehni, Claudia E."],["dc.contributor.author","Turner, Steve"],["dc.contributor.author","Goutaki, Myrofora"],["dc.contributor.author","Holden, Karl A."],["dc.contributor.author","de Jong, Carmen C.M."],["dc.contributor.author","Lex, Christiane"],["dc.contributor.author","Lo, David K.H."],["dc.contributor.author","Lucas, Jane S."],["dc.contributor.author","Moeller, Alexander"],["dc.date.accessioned","2021-06-01T10:47:57Z"],["dc.date.available","2021-06-01T10:47:57Z"],["dc.date.issued","2021"],["dc.description.abstract","Diagnosing asthma in children represents an important clinical challenge. There is no single gold standard test to confirm the diagnosis. Consequently, both over-, and under-diagnosis of asthma are frequent in children. A Task Force (TF) supported by the European Respiratory Society has developed these evidence-based clinical practice guidelines for the diagnosis of asthma in children aged 5–16 years using nine PICO (Population, Intervention, Comparator and Outcome) questions. The TF conducted systematic literature searches for all PICO questions and screened the outputs from these, including relevant full text articles. All TF members approved the final decision for inclusion of research papers. The TF assessed the quality of the evidence using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach. The TF then developed a diagnostic algorithm based on the critical appraisal of the PICO questions, preferences expressed by lay members and test availability. Proposed cut-offs were determined based on the best available evidence. The TF formulated recommendations using the GRADE Evidence to Decision framework. Based on the critical appraisal of the evidence and the Evidence to Decision Framework the TF recommends spirometry, bronchodilator reversibility testing and FeNO as first line diagnostic tests in children under investigation for asthma. The TF recommends against diagnosing asthma in children based on clinical history alone or following a single abnormal objective test. Finally, this guideline also proposes a set of research priorities to improve asthma diagnosis in children in the future."],["dc.identifier.doi","10.1183/13993003.04173-2020"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85776"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1399-3003"],["dc.relation.issn","0903-1936"],["dc.title","European Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5–16 years"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Pediatric Allergy and Immunology"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Wahn, Ulrich"],["dc.contributor.author","Lau, Susanne"],["dc.contributor.author","Eigenmann, Philippe"],["dc.contributor.author","Melen, Erik"],["dc.contributor.author","Krauss‐Etschmann, Susanne"],["dc.contributor.author","Lex, Christiane"],["dc.contributor.author","Matricardi, Paolo"],["dc.contributor.author","Schaub, Bianca"],["dc.contributor.author","Halken, Susanne"],["dc.contributor.author","Ege, Markus"],["dc.contributor.author","Mutius, Erika"],["dc.date.accessioned","2022-05-02T08:02:30Z"],["dc.date.available","2022-05-02T08:02:30Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1111/pai.13773"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107338"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-561"],["dc.relation.eissn","1399-3038"],["dc.relation.issn","0905-6157"],["dc.rights.uri","http://onlinelibrary.wiley.com/termsAndConditions#vor"],["dc.title","Early priming of asthma and respiratory allergies: Future aspects of prevention"],["dc.title.alternative","A statement by the European Forum for Education and Research in Allergy and Airway Disease (EUFOREA) and the EAACI‐Clemens von Pirquet Foundation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e00526"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Molecular Genetics & Genomic Medicine"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Schucht, Sylvia"],["dc.contributor.author","Minso, Rebecca"],["dc.contributor.author","Lex, Christiane"],["dc.contributor.author","Reiss, Jochen"],["dc.contributor.author","Stanke, Frauke"],["dc.contributor.author","Tamm, Stephanie"],["dc.contributor.author","van Barneveld, Andrea"],["dc.contributor.author","Tümmler, Burkhard"],["dc.date.accessioned","2020-12-10T14:06:58Z"],["dc.date.available","2020-12-10T14:06:58Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1002/mgg3.526"],["dc.identifier.issn","2324-9269"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70091"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Functional analysis of the p.[Arg74Trp;Val201Met;Asp1270Asn]/p.Phe508del CFTR mutation genotype in human native colon"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","906"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European Respiratory Journal"],["dc.bibliographiccitation.lastpage","925"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Pijnenburg, Marille W."],["dc.contributor.author","Baraldi, Eugenio"],["dc.contributor.author","Brand, Paul L. P."],["dc.contributor.author","Carlsen, Kai-Hakon"],["dc.contributor.author","Eber, Ernst"],["dc.contributor.author","Frischer, Thomas"],["dc.contributor.author","Hedlin, Gunilla"],["dc.contributor.author","Kulkarni, Neeta"],["dc.contributor.author","Lex, Christiane"],["dc.contributor.author","Makela, Mika J."],["dc.contributor.author","Mantzouranis, Eva"],["dc.contributor.author","Moeller, Alexander"],["dc.contributor.author","Pavord, Ian"],["dc.contributor.author","Piacentini, Giorgio"],["dc.contributor.author","Price, David T."],["dc.contributor.author","Rottier, Bart L."],["dc.contributor.author","Saglani, Sejal"],["dc.contributor.author","Sly, Peter D."],["dc.contributor.author","Szefler, Stanley J."],["dc.contributor.author","Tonia, Thomy"],["dc.contributor.author","Turner, Steve"],["dc.contributor.author","Wooler, Edwina"],["dc.contributor.author","Carlsen, Karin C. Lodrup"],["dc.date.accessioned","2018-11-07T09:59:05Z"],["dc.date.available","2018-11-07T09:59:05Z"],["dc.date.issued","2015"],["dc.description.abstract","The goal of asthma treatment is to obtain clinical control and reduce future risks to the patient. To reach this goal in children with asthma, ongoing monitoring is essential. While all components of asthma, such as symptoms, lung function, bronchial hyperresponsiveness and inflammation, may exist in various combinations in different individuals, to date there is limited evidence on how to integrate these for optimal monitoring of children with asthma. The aims of this ERS Task Force were to describe the current practise and give an overview of the best available evidence on how to monitor children with asthma. 22 clinical and research experts reviewed the literature. A modified Delphi method and four Task Force meetings were used to reach a consensus. This statement summarises the literature on monitoring children with asthma. Available tools for monitoring children with asthma, such as clinical tools, lung function, bronchial responsiveness and inflammatory markers, are described as are the ways in which they may be used in children with asthma. Management-related issues, comorbidities and environmental factors are summarised. Despite considerable interest in monitoring asthma in children, for many aspects of monitoring asthma in children there is a substantial lack of evidence."],["dc.identifier.doi","10.1183/09031936.00088814"],["dc.identifier.isi","000352023800007"],["dc.identifier.pmid","25745042"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37509"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","European Respiratory Soc Journals Ltd"],["dc.relation.issn","1399-3003"],["dc.relation.issn","0903-1936"],["dc.title","Monitoring asthma in children"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","361"],["dc.bibliographiccitation.issue","17-18"],["dc.bibliographiccitation.journal","Wiener Medizinische Wochenschrift"],["dc.bibliographiccitation.lastpage","365"],["dc.bibliographiccitation.volume","165"],["dc.contributor.author","Lex, Christiane"],["dc.contributor.author","Korten, Insa"],["dc.contributor.author","Hofmann, Alexander"],["dc.contributor.author","Renner, Sabine"],["dc.contributor.author","Szepfalusi, Zsolt"],["dc.contributor.author","Frischer, Thomas"],["dc.contributor.author","Zacharasiewicz, Angela"],["dc.date.accessioned","2021-06-01T10:49:18Z"],["dc.date.available","2021-06-01T10:49:18Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.1007/s10354-015-0387-0"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86237"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1563-258X"],["dc.relation.issn","0043-5341"],["dc.title","Neue internationale Referenzwerte für die Spirometrie – Implikation für die Praxis anhand einer vergleichenden Analyse eines pädiatrischen Patientenkollektivs"],["dc.title.translated","New international reference values for spirometry: implications for clinical issues using a comparative analysis of a paediatric population"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","111"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Annals of Allergy Asthma & Immunology"],["dc.bibliographiccitation.lastpage","116"],["dc.bibliographiccitation.volume","114"],["dc.contributor.author","Trischler, Jordis"],["dc.contributor.author","Mueller, Christina-Maria"],["dc.contributor.author","Koenitzer, Stephanie"],["dc.contributor.author","Prell, Erik"],["dc.contributor.author","Korten, Insa"],["dc.contributor.author","Unverzagt, Susanne"],["dc.contributor.author","Lex, Christiane"],["dc.date.accessioned","2018-11-07T10:01:41Z"],["dc.date.available","2018-11-07T10:01:41Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: Inflammatory processes in the asthmatic lung involve the large and small airway and alveolar sites. Leukotriene B-4 (LTB4) is an important disease marker, but its role in inflammation of the small airways in asthma has not been established yet. Objective: To distinguish between large and small airway or alveolar LTB4 concentrations in children with asthma using the new technique of fractionated exhaled breath condensate sampling. Methods: Sixty-eight children (9-17 years old, 33 children with asthma and 35 controls) underwent fractional exhaled nitric oxide (FeNO) measurements, lung function testing, and collection of fractionated exhaled breath condensate using a capnograph-based approach. The LTB4 concentrations in the small airway or alveolar and large airway fractions were correlated to disease status, lung function impairment, and clinical parameters. Results: Children with asthma had significantly higher LTB4 concentrations in the small airway or alveolar fraction than controls (5.58 pg/mL; 95% interquartile range [IQR], 2.0-11.77 pg/mL; vs 2.0 pg/mL; 95% IQR, 2.0-6.2 pg/mL; P=.003). No difference was found between the groups in the large airway fraction. Children with obstructive lung function impairment (forced expiratory volume in 1 second z score < -1.65) had increased small airway or alveolar LTB4 concentrations compared with children without impairment (2.0 pg/ mL; 95% IQR, 2.0-9.21 pg/mL; vs 18.32 pg/mL; 95% IQR, 3.7-23.02 pg/mL; P=.04). Children with asthma but without pathologic obstructive lung function still had higher LTB4 concentrations than controls (5.57 pg/mL; 95% IQR, 2.00-10.60 pg/mL; vs 2.00 pg/mL; 95% IQR, 2.00-6.20 pg/mL; P=.01). Conclusion: LTB4 is detectable and elevated in the small airway or alveolar fraction of exhaled breath condensate in pediatric asthma. Because of the possibility of detecting elevated levels in patients without lung function impairment in controlled disease, it may be used as a noninvasive marker of small airways disease; however, future long-term studies are needed. (C) 2015 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.anai.2014.11.022"],["dc.identifier.isi","000348454700008"],["dc.identifier.pmid","25624130"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38072"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1534-4436"],["dc.relation.issn","1081-1206"],["dc.title","Elevated exhaled leukotriene B-4 in the small airway compartment in children with asthma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]