Dudakova, Anna

[["dc.bibliographiccitation.firstpage","4356"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Antimicrobial Agents and Chemotherapy"],["dc.bibliographiccitation.lastpage","4359"],["dc.bibliographiccitation.volume","59"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Tuennermann, Jana"],["dc.contributor.author","Dudakova, Anna"],["dc.contributor.author","Tangwattanachuleeporn, Marut"],["dc.contributor.author","Weig, Michael S."],["dc.contributor.author","Gross, Uwe"],["dc.date.accessioned","2018-11-07T09:54:53Z"],["dc.date.available","2018-11-07T09:54:53Z"],["dc.date.issued","2015"],["dc.description.abstract","Azole antifungal drug resistance in Aspergillus fumigatus is an emerging problem in several parts of the world. Here we investigated the distribution of such strains in soils from Germany. At a general positivity rate of 12%, most prevalently, we found strains with the TR34/L98H and TR46/Y121F/T289A alleles, dispersed along a corridor across northern Germany. Comparison of the distributions of resistance alleles and genotypes between environment and clinical samples suggests the presence of local clinical clusters."],["dc.description.sponsorship","Pfizer Pharma Germany [WS2275398]"],["dc.identifier.doi","10.1128/AAC.00100-15"],["dc.identifier.isi","000360896000088"],["dc.identifier.pmid","25941229"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36631"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Microbiology"],["dc.relation.issn","1098-6596"],["dc.relation.issn","0066-4804"],["dc.title","Environmental Isolates of Azole-Resistant Aspergillus fumigatus in Germany"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1065"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Clinical Microbiology Reviews"],["dc.bibliographiccitation.lastpage","1091"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Dudakova, Anna"],["dc.contributor.author","Spiess, Birgit"],["dc.contributor.author","Tangwattanachuleeporn, Marut"],["dc.contributor.author","Sasse, Christoph"],["dc.contributor.author","Buchheidt, Dieter"],["dc.contributor.author","Weig, Michael"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Bader, Oliver"],["dc.date.accessioned","2020-12-10T18:36:52Z"],["dc.date.available","2020-12-10T18:36:52Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1128/CMR.00095-16"],["dc.identifier.eissn","1098-6618"],["dc.identifier.issn","0893-8512"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76764"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Molecular Tools for the Detection and Deduction of Azole Antifungal Drug Resistance Phenotypes in Aspergillus Species"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Microbiology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Gómez-Molero, Emilia"],["dc.contributor.author","Willis, Jesse R."],["dc.contributor.author","Dudakova, Anna"],["dc.contributor.author","Carreté, Laia"],["dc.contributor.author","Weig, Michael"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Gácser, Attila"],["dc.contributor.author","Gabaldón, Toni"],["dc.contributor.author","Bader, Oliver"],["dc.date.accessioned","2021-04-14T08:32:38Z"],["dc.date.available","2021-04-14T08:32:38Z"],["dc.date.issued","2020"],["dc.description.abstract","The human pathogenic yeast Candida parapsilosis has gained significant importance over the past decades as one of the principal causes of fungal bloodstream infections. Isolates of C. parapsilosis are known to be able to switch between several different colony morphologies in vitro, which are correlated with different cell shapes, altered cell surface properties, and thus different capacities to form biofilms on indwelling medical devices. In a set of six clinical specimens from a single surgery patient yielding stable smooth- as well as crepe-morphology isolates, we investigated the differences between five of them on a phenotypic and genomic level. In contrast to the initial assumption that they were switched forms of a clonal strain, karyotyping and genome sequencing showed that the patient was colonized by at least three distinct linages. Statistical analysis placed these groups distantly across the population of C. parapsilosis. Interestingly the single blood culture isolate was of smooth morphology and matched with an isolate from the patient’s nose of similar morphology. Strong variation between the isolates was seen in adhesin-encoding genes, where repeat regions showed significant variation in length and repeat-numbers, most strikingly in HWP1 of the smooth isolates. Although no differences in drug susceptibility were evident, the high phylogenetic distance separating the individual strains highlights the need for testing of multiple colonies in routine practice. The absence of biofilm formation in the blood stream isolate indicates a lack of respective adhesins in the cell wall, in turn pointing toward lack of adhesion as a positively contributing factor for dissemination."],["dc.identifier.doi","10.3389/fmicb.2020.01994"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17528"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83971"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-302X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Phenotypic Variability in a Coinfection With Three Independent Candida parapsilosis Lineages"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","150"],["dc.bibliographiccitation.journal","International Journal of Infectious Diseases"],["dc.bibliographiccitation.lastpage","159"],["dc.bibliographiccitation.volume","119"],["dc.contributor.author","Dudakova, Anna"],["dc.contributor.author","Blei, Claudia"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Schulze, Marco H."],["dc.date.accessioned","2022-12-01T08:30:37Z"],["dc.date.available","2022-12-01T08:30:37Z"],["dc.date.issued","2022"],["dc.description.abstract","Background: Candidemia is rare and has a high mortality rate. This study analyses the impact of bedside antifungal stewardship (AFS) on clinical management and prognosis of patients with candidemia at a university hospital in Germany. Methods: All patients with at least one positive blood culture with Candida species between 2014 and 2016 received bedside AFS with standardized recommendations. Medical records were retrospectively an- alyzed. Results from the intervention period from 2014-2016 (n=109), with focus on 2016 (n=39), were compared with those from the pre-intervention period in 2013 (n=30). Results: Bedside AFS was performed in 24/35 (69%) surviving patients in 2016 within the first 3 days after diagnosis of candidemia. All surviving patients (n=35) in 2016 received antifungal treatment compared with 24/28 (86%) in 2013 (p=0.0344). Follow-up blood cultures were performed in 25/35 (71%) in 2016 compared with 10/25 (40%) in 2013 (p=0.0046). Survival in the intervention compared with the pre- intervention group did not differ significantly (p=0.58) one year after the diagnosis of candidemia was made. However, patients with candidemia often have multiple serious comorbidities. Conclusions: Individualized bedside AFS significantly improves adherence to recommendations for pa- tients with Candida fungemia, especially guideline-oriented diagnostics and therapy. Improving the prog- nosis of patients with candidemia remains a huge challenge for AFS."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.1016/j.ijid.2022.03.054"],["dc.identifier.pii","S1201971222001916"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/117935"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.issn","1201-9712"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Impact of routine bedside infectious diseases service on clinical management and prognosis of patients with Candida fungemia – an example for Antifungal Stewardship at university level in Germany"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]