Hofer, Sabine

[["dc.bibliographiccitation.journal","Infection"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Zausig, York A."],["dc.contributor.author","Geilfuss, D."],["dc.contributor.author","Loeffler, E. K."],["dc.contributor.author","Hofer, Sabine"],["dc.contributor.author","Sinner, Barbara"],["dc.contributor.author","Weigand, Markus A."],["dc.contributor.author","Zink, Wolfgang"],["dc.contributor.author","Graf, Bernhard Martin"],["dc.date.accessioned","2018-11-07T10:59:01Z"],["dc.date.available","2018-11-07T10:59:01Z"],["dc.date.issued","2007"],["dc.format.extent","27"],["dc.identifier.isi","000249997100062"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50600"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.issn","0300-8126"],["dc.title","Dobutamine, Dopamine, and Epinephrine, but not Levosimendan improve the cardiac performance in isolated septic depressed rat heart"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Neuroradiology"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Dreha-Kulaczewski, Steffi F."],["dc.contributor.author","Gaertner, J."],["dc.contributor.author","Helms, G."],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Hofer, Sabine"],["dc.contributor.author","Frahm, Jens"],["dc.date.accessioned","2018-11-07T11:23:58Z"],["dc.date.available","2018-11-07T11:23:58Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1007/s00234-009-0582-z"],["dc.identifier.isi","000269859800010"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56301"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0028-3940"],["dc.title","Serial proton MR spectroscopy and diffusion tensor imaging in infantile Balo's concentric sclerosis (vol 51, pg 113, 2009)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","428"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Investigative Radiology"],["dc.bibliographiccitation.lastpage","433"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Merrem, Andreas"],["dc.contributor.author","Hofer, Sabine"],["dc.contributor.author","Voit, Dirk"],["dc.contributor.author","Merboldt, K.-Dietmar"],["dc.contributor.author","Klosowski, Jakob"],["dc.contributor.author","Untenberger, Markus"],["dc.contributor.author","Fleischhammer, Julius"],["dc.contributor.author","Frahm, Jens"],["dc.date.accessioned","2020-12-10T18:20:12Z"],["dc.date.available","2020-12-10T18:20:12Z"],["dc.date.issued","2017"],["dc.description.abstract","Objective: The aim of this study was to develop a rapid diffusion-weighted (DW) magnetic resonance imaging (MRI) technique for whole-brain studies without susceptibility artifacts and measuring times below 3 minutes. Materials and Methods: The proposed method combines a DWspin-echo module with a single-shot stimulated echo acquisition mode MRI sequence. Previous deficiencies in image quality due to limited signal-to-noise ratio are compensated for (1) by radial undersampling to enhance the flip angle and thus the signal strength of stimulated echoes; (2) by defining the image reconstruction as a non-linear inverse problem, which is solved by the iteratively regularized Gauss-Newton method; and (3) by denoising with use of a modified nonlocal means filter. The method was implemented on a 3 TMRI system(64-channel head coil, 80 mT . m gradients) and evaluated for 10 healthy subjects and 2 patients with an ischemic lesion and epidermoid cyst, respectively. Results: High-quality mean DW images of the entire brain were obtained by acquiring 1 non-DW image and 6 DW images with different diffusion directions at b = 1000 s . mm. The achievable resolution for a total measuring time of 84 seconds was 1.5 mm in plane with a section thickness of 4 mm (55 sections). A measuring time of 168 seconds allowed for an in-plane resolution of 1.25 mm and a section thickness of 3 mm (54 sections). Apparent diffusion coefficient values were in agreement with literature data. Conclusions: The proposed method for DWMRI offers immunity against susceptibility problems, high spatial resolution, adequate signal-to-noise ratio and clinically feasible scan times of less than 3 minutes for whole-brain studies. More extended clinical trials require accelerated computation and online reconstruction."],["dc.identifier.doi","10.1097/RLI.0000000000000357"],["dc.identifier.isi","000403234600006"],["dc.identifier.issn","0020-9996"],["dc.identifier.pmid","28151734"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75482"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1536-0210"],["dc.relation.issn","0020-9996"],["dc.title","Rapid Diffusion-Weighted Magnetic Resonance Imaging of the Brain Without Susceptibility Artifacts"],["dc.title.subtitle","Single-Shot STEAM With Radial Undersampling and Iterative Reconstruction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","113"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Neuroradiology"],["dc.bibliographiccitation.lastpage","121"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Dreha-Kulaczewski, Steffi F."],["dc.contributor.author","Helms, Gunther"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Hofer, Sabine"],["dc.contributor.author","Gärtner, Jutta"],["dc.contributor.author","Frahm, Jens"],["dc.date.accessioned","2017-09-07T11:47:35Z"],["dc.date.available","2017-09-07T11:47:35Z"],["dc.date.issued","2009"],["dc.description.abstract","Proton magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) yield different parameters for characterizing the evolution of a demyelinating white matter disease. The purpose was to elucidate biochemical and microstructural changes in Balo's concentric sclerosis lesions and to correlate the findings with the clinical course. Localized short-echo time MRS and DTI were performed over 6 years in a left occipital lesion of a female patient (age at onset 13.8 years) with Balo's concentric sclerosis. A right homonym hemianopsia persisted. Metabolite patterns were in line with initial active demyelination followed by gliosis and partial recovery of neuroaxonal metabolites. Fractional anisotropy and mean diffusivity of tissue water remained severely altered. Fiber tracking confirmed a disruption in the geniculo-calcarine tract as well as involvement of the corpus callosum. MRS and DTI depict complementary parameters, but DTI seems to correlate better with clinical symptoms."],["dc.identifier.doi","10.1007/s00234-008-0470-y"],["dc.identifier.gro","3143158"],["dc.identifier.isi","000262536300006"],["dc.identifier.pmid","18958461"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/641"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.relation.issn","0028-3940"],["dc.title","Serial proton MR spectroscopy and diffusion tensor imaging in infantile Balo's concentric sclerosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","189"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Restorative Neurology and Neuroscience"],["dc.bibliographiccitation.lastpage","197"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","von Lewinski, Friederike"],["dc.contributor.author","Hofer, Sabine"],["dc.contributor.author","Kaus, Juergen"],["dc.contributor.author","Merboldt, Klaus-Dietmar"],["dc.contributor.author","Rothkegel, Holger"],["dc.contributor.author","Schweizer, Renate"],["dc.contributor.author","Liebetanz, David"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T08:35:28Z"],["dc.date.available","2018-11-07T08:35:28Z"],["dc.date.issued","2009"],["dc.description.abstract","Purpose: EMG-triggered electrostimulation (EMG-ES) may improve the motor performance of affected limbs of hemiparetic stroke patients even in the chronic stage. This study was designed to characterize cortical activation changes following intensified EMG-ES in chronic stroke patients and to identify predictors for successful rehabilitation depending on disease severity. Methods: We studied 9 patients with severe residual hemiparesis, who underwent 8 weeks of daily task-orientated multi-channel EMG-ES of the paretic arm. Before and after treatment, arm function was evaluated clinically and cortical activation patterns were assessed with functional MRI (fMRI) and/or transcranial magnetic stimulation (TMS). Results: As response to therapy, arm function improved in a subset of patients with more capacity in less affected subjects, but there was no significant gain for those with Box & Block test values below 4 at inception. The clinical improvement, if any, was accompanied by an ipsilesional increase in the sensorimotor cortex (SMC) activation area in fMRI and enhanced intracortical facilitation (ICF) as revealed by paired TMS. The SMC activation change in fMRI was predicted by the presence or absence of motor-evoked potentials (MEPs) on the affected side. Conclusions: The present findings support the notion that intensified EMG-ES may improve the arm function in individual chronic hemiparetic stroke patients but not in more severely impaired individuals. Functional improvements are paralleled by increased ipsilesional SMC activation and enhanced ICF supporting neuroplasticity as contributor to rehabilitation. The clinical score at inception and the presence of MEPs have the best predictive potential."],["dc.identifier.doi","10.3233/RNN-2009-0469"],["dc.identifier.isi","000267763500004"],["dc.identifier.pmid","19531874"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18074"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Ios Press"],["dc.relation.issn","0922-6028"],["dc.title","Efficacy of EMG-triggered electrical arm stimulation in chronic hemiparetic stroke patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","398"],["dc.bibliographiccitation.journal","Neuromuscular Disorders"],["dc.bibliographiccitation.lastpage","407"],["dc.contributor.author","Bartels, Claudia"],["dc.contributor.author","Mertens, Nina"],["dc.contributor.author","Hofer, Sabine"],["dc.contributor.author","Merboldt, Klaus-Dietmar"],["dc.contributor.author","Dietrich, Jeannine"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.date.accessioned","2017-09-07T11:46:20Z"],["dc.date.available","2017-09-07T11:46:20Z"],["dc.date.issued","2008"],["dc.description.abstract","We investigated the frequency and functional relevance of corpus callosum degeneration in amyotrophic lateral sclerosis (ALS). A total of 22 ALS patients and 29 healthy controls performed the newly developed Contralateral Co-Movement Test as indicator of callosal dysfunction. Diffusion tensor imaging was applied to determine fractional anisotropy values in the callosal area containing the crossing motor fibers and in the pyramidal tracts in 13 subjects of each group.ALS patients had more than twice the amount of co-movements as compared to healthy subjects. Contralateral co-movements correlated with fractional anisotropy values of the corpus callosum motor region as did ALS Functional Rating Scale as measure of disease progression. In both groups, contralateral co-movements correlated with the central motor index (ratio of the mean of fractional anisotropy values of both pyramidal tracts and corpus callosum motor region). Neuropsychological test results failed to show correlations with functional or morphological parameters.Combining Contralateral Co-Movement Test and diffusion tensor imaging in ALS revealed the close relation between functional and morphological impairment in the degenerating central motor-neuronal network. The Contralateral Co-Movement Test delivers simple means of symptom quantification, independent of ALS Functional Rating Scale, for future neuroprotective trials."],["dc.identifier.doi","10.1016/j.nmd.2008.02.005"],["dc.identifier.gro","3150478"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7247"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.title","Callosal dysfunction in amyotrophic lateral sclerosis correlates with diffusion tensor imaging of the central motor system"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Clinical Neuroradiology"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Heide, Marielle"],["dc.contributor.author","Hofer, Sabine"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Fiss, Ingo"],["dc.contributor.author","von der Brelie, Christian"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Liman, Jan"],["dc.date.accessioned","2022-05-02T08:09:26Z"],["dc.date.available","2022-05-02T08:09:26Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract Purpose The diagnosis of idiopathic normal pressure hydrocephalus (iNPH) can be challenging. Aim of this study was to use a novel T1 mapping method to enrich the diagnostic work-up of patients with suspected iNPH. Methods Using 3T magnetic resonance imaging (MRI) we prospectively evaluated rapid high-resolution T1 mapping at 0.5 mm resolution and 4 s acquisition time in 15 patients with suspected iNPH and 8 age-matched, healthy controls. T1 mapping in axial sections of the cerebrum, clinical and neuropsychological testing were performed prior to and after cerebrospinal fluid tap test (CSF-TT). T1 relaxation times were measured in 5 predefined periventricular regions. Results All 15 patients with suspected iNPH showed gait impairment, 13 (86.6%) showed signs of cognitive impairment and 8 (53.3%) patients had urinary incontinence. Gait improvement was noted in 12 patients (80%) after CSF-TT. T1 relaxation times in all periventricular regions were elevated in patients with iNPH compared to controls with the most pronounced differences in the anterior (1006 ± 93 ms vs. 911 ± 77 ms; p  = 0.023) and posterior horns (983 ± 103 ms vs. 893 ± 68 ms; p  = 0.037) of the lateral ventricles. Montreal cognitive assessment (MoCA) scores at baseline were negatively correlated with T1 relaxation times (r < −0.5, p  < 0.02). Higher T1 relaxation times were significantly correlated with an improvement of the 3‑m timed up and go test (r > 0.6 and p  < 0.03) after CSF-TT. Conclusion In iNPH-patients, periventricular T1 relaxation times are increased compared to age-matched controls and predict gait improvement after CSF-TT. T1 mapping might enrich iNPH work-up and might be useful to indicate permanent shunting."],["dc.description.abstract","Abstract Purpose The diagnosis of idiopathic normal pressure hydrocephalus (iNPH) can be challenging. Aim of this study was to use a novel T1 mapping method to enrich the diagnostic work-up of patients with suspected iNPH. Methods Using 3T magnetic resonance imaging (MRI) we prospectively evaluated rapid high-resolution T1 mapping at 0.5 mm resolution and 4 s acquisition time in 15 patients with suspected iNPH and 8 age-matched, healthy controls. T1 mapping in axial sections of the cerebrum, clinical and neuropsychological testing were performed prior to and after cerebrospinal fluid tap test (CSF-TT). T1 relaxation times were measured in 5 predefined periventricular regions. Results All 15 patients with suspected iNPH showed gait impairment, 13 (86.6%) showed signs of cognitive impairment and 8 (53.3%) patients had urinary incontinence. Gait improvement was noted in 12 patients (80%) after CSF-TT. T1 relaxation times in all periventricular regions were elevated in patients with iNPH compared to controls with the most pronounced differences in the anterior (1006 ± 93 ms vs. 911 ± 77 ms; p  = 0.023) and posterior horns (983 ± 103 ms vs. 893 ± 68 ms; p  = 0.037) of the lateral ventricles. Montreal cognitive assessment (MoCA) scores at baseline were negatively correlated with T1 relaxation times (r < −0.5, p  < 0.02). Higher T1 relaxation times were significantly correlated with an improvement of the 3‑m timed up and go test (r > 0.6 and p  < 0.03) after CSF-TT. Conclusion In iNPH-patients, periventricular T1 relaxation times are increased compared to age-matched controls and predict gait improvement after CSF-TT. T1 mapping might enrich iNPH work-up and might be useful to indicate permanent shunting."],["dc.identifier.doi","10.1007/s00062-022-01155-0"],["dc.identifier.pii","1155"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107377"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-561"],["dc.relation.eissn","1869-1447"],["dc.relation.issn","1869-1439"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","High Periventricular T1 Relaxation Times Predict Gait Improvement After Spinal Tap in Patients with Idiopathic Normal Pressure Hydrocephalus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","38"],["dc.bibliographiccitation.journal","European Journal of Radiology"],["dc.bibliographiccitation.lastpage","45"],["dc.bibliographiccitation.volume","106"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Hofer, Sabine"],["dc.contributor.author","Joseph, Arun A."],["dc.contributor.author","Merboldt, K. Dietmar"],["dc.contributor.author","Tan, Zhengguo"],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Frahm, Jens"],["dc.date.accessioned","2020-12-10T14:23:43Z"],["dc.date.available","2020-12-10T14:23:43Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.ejrad.2018.07.011"],["dc.identifier.issn","0720-048X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72022"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Carotid artery flow as determined by real-time phase-contrast flow MRI and neurovascular ultrasound: A comparative study of healthy subjects"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]