Schittkowski, Michael P.

[["dc.bibliographiccitation.firstpage","266"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Der Ophthalmologe"],["dc.bibliographiccitation.lastpage","269"],["dc.bibliographiccitation.volume","107"],["dc.contributor.author","Manousaridis, K."],["dc.contributor.author","Casper, Jochen"],["dc.contributor.author","Schittkowski, Michael P."],["dc.contributor.author","Nizze, H."],["dc.contributor.author","Guthoff, R. F."],["dc.date.accessioned","2018-11-07T08:45:41Z"],["dc.date.available","2018-11-07T08:45:41Z"],["dc.date.issued","2010"],["dc.description.abstract","A 60-year-old man presented with left exophthalmos and deterioration in visual acuity of slow evolution. Bilateral orbital Erdheim-Chester disease was diagnosed. Systemic evaluation revealed a retroperitoneal fibrosis. Treatment with interferon-alpha followed, but bilateral compressive optic neuropathy with visual acuity deterioration and visual field defects evolved. Bilateral orbital decompression was performed."],["dc.identifier.doi","10.1007/s00347-009-2041-y"],["dc.identifier.isi","000275892900011"],["dc.identifier.pmid","19777245"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20506"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0941-293X"],["dc.title","Erdheim-Chester disease of the orbit with compressive optic neuropathy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","158"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Klinische Monatsblätter für Augenheilkunde"],["dc.bibliographiccitation.lastpage","161"],["dc.bibliographiccitation.volume","229"],["dc.contributor.author","Schittkowski, Michael P."],["dc.contributor.author","Guthoff, R. F."],["dc.contributor.author","Drewelow, B."],["dc.contributor.author","Wacke, R."],["dc.date.accessioned","2018-11-07T09:13:47Z"],["dc.date.available","2018-11-07T09:13:47Z"],["dc.date.issued","2012"],["dc.description.abstract","Purpose: The suitability of a high-hydrophilic osmotic self-inflating hydrogel expander consisting of a co-polymer of N-vinylpyrolidone and methyl methacrylate as a drug delivery system for antibiotics to prevent a postoperative infection was investigated in a laboratory setting. Methods: The dry expanders were incubated in a 0.3% solution of Ofloxacin or Tobramycin for 24 hours. The completely swollen expander had increased in volume from 0.3 mL to almost 3 mL (adsorbing 2.7 mL of the 0.3% solution, i.e.,8.1 mg of Ofloxacin or Tobramycin, respectively). Addressing the elimination of both antibiotics, the concentrations in 15 mL elution medium (simulating the volume of the orbit in a newborn baby) were measured after 0.25, 1, 2, 6, 24, 48 and 72 hours of elution. 0.9% sodium chloride (B. Braun Melsungen, Germany) was used as elution medium. To imitate fluid exchange due to blood perfusion in the surrounding tissue the medium was renewed after every sampling. For each substance 10 expanders were tested. Concentrations of antibiotic were determined by HPLC/UV for Ofloxacin and by using a specific fluorescence-polarisation immunoassay (Abbott TDx) for Tobramycin. Results: Mean concentrations of Ofloxacin at 0.25, 1, 2, 6, 24, 48 and 72 hours after beginning of the elution were 50.2, 46.8, 41.2, 75.4, 88.2, 46.2 and 19.1 mu g/mL, respectively. The cumulative amount of Ofloxacin eluted after 72 hours reached 68% of the loading dose. The corresponding mean concentrations of Tobramycin were 38.8, 48.5, 40.5, 69.8, 88.7, 119.3 and 71.6 mu g/mL. The cumulative eluted amount was 88%. Conclusions: The investigated hydrogel expanders soaked in 0.3% antibiotic solution can store and later on release sufficient amounts of Ofloxacin or Tobramycin to produce antimicrobial effective concentrations in vitro in the surrounding environment. This principle, when used in a clinical setting, might help to eliminate post-implantation infection which is one of the major complications in clinical use."],["dc.identifier.doi","10.1055/s-0031-1273457"],["dc.identifier.isi","000300615300009"],["dc.identifier.pmid","21847785"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27249"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0023-2165"],["dc.title","Hydrogelexpander as Drug Delivery System for Antibiotics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","51"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Klinische Monatsblätter für Augenheilkunde"],["dc.bibliographiccitation.lastpage","55"],["dc.bibliographiccitation.volume","230"],["dc.contributor.author","Knappe, S."],["dc.contributor.author","Guthoff, R. F."],["dc.contributor.author","Kilangalanga, J."],["dc.contributor.author","Schittkowski, Michael P."],["dc.contributor.author","Klett, A."],["dc.contributor.author","Zhivov, A."],["dc.date.accessioned","2018-11-07T09:30:28Z"],["dc.date.available","2018-11-07T09:30:28Z"],["dc.date.issued","2013"],["dc.description.abstract","The partnership between Saint Joseph Hospital in Kinshasa (Capital city of DRC) and University Eye Clinic Rostock, Germany exists since 2000. The ophthalmologists from Rostock University performed 12 visits of St. Josef Hospital with the aim to perform oculoplastic surgery in complicated cases as well as to teach the local ophthalmologists. There they performed about 150 surgeries (entropion, ectropion, ptosis, repair of lid injuries, eye lid reconstruction and tumour management, lacrimal surgery) in joint teams. The programme of on-site training was established during this time. Meanwhile, the Kinshasa colleagues are able to perform the basic techniques by themselves. Two colleagues have obtained advanced training in oculoplastics in Rostock. The fruitful cooperation enabled the development of oculoplastic surgery in St. Josef Hospital in Kinshasa. The further education and training proccesses will support the continuous advancement in ophthalmological health care in DRC."],["dc.identifier.doi","10.1055/s-0032-1328097"],["dc.identifier.isi","000313967600009"],["dc.identifier.pmid","23345149"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31315"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0023-2165"],["dc.title","Development of Oculoplastic Surgery in Kinshasa (Capital of Democratic Republic of Congo)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","844"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Klinische Monatsblätter für Augenheilkunde"],["dc.bibliographiccitation.lastpage","848"],["dc.bibliographiccitation.volume","226"],["dc.contributor.author","Krueger, H."],["dc.contributor.author","Schittkowski, Michael P."],["dc.contributor.author","Kilangalanga, N."],["dc.contributor.author","Hopkins, A."],["dc.contributor.author","Guthoff, R. F."],["dc.date.accessioned","2018-11-07T11:23:57Z"],["dc.date.available","2018-11-07T11:23:57Z"],["dc.date.issued","2009"],["dc.description.abstract","Background: Glaucoma is the main cause of irreversible blindness in the world. Because of the increasing mean age, glaucoma is expected to become more common in the developing countries. Besides tonometry and perimetry the appearance of the optic nerve head is a main part of glaucoma diagnosis. Ethnic differences have to be considered. This study compares the appearance of the optic nerve head between blacks and whites. Study Design: This is a retrospective analysis of 225 whites of a Swiss population and 1027 blacks of a Congolese population. Using a matched pairs technique 207 whites and 207 blacks were chosen, regarding age, sex, intraocular pressure and examined eye (right/left). The analysis of the optic nerve head was performed by using the \"Heidelberg-Retina-Tomograph II\" (HRT). Results: Among the 207 persons of both groups we found 116 females and 91 males. There were 103 right eyes and 104 left eyes examined. The mean age was 45.6 +/- 15.6 years. Compared with European population in the African population we found a greater disc area (2.56 vs. 1.81 mm(2)) as well as a greater cup area (0.65 vs. 0.41 mm(2)) and a greater rim area (1.91 vs. 1.40 mm(2)). Regarding the cup disc area ratio there was no significant difference between both populations found (Kinshasa: 0.24 vs. Basel: 0.21). Although there was no significant difference of the maximum cup depth of both groups we found a deeper mean cup depth in the African population. Furthermore, we found differences regarding the cup shape measure, the RNFL thickness and the height variation contour. Conclusion: As already described in different studies, there are significant differences in the morphology of the optic nerve head between blacks and whites. Although blacks are expected to have a greater cup disc area ratio, this fact could not be proved in this Study. As a new fact we found a different mean cup depth between Africans and Europeans, which might be explained by the different cup shape of both populations."],["dc.identifier.doi","10.1055/s-0028-1109644"],["dc.identifier.isi","000271421500017"],["dc.identifier.pmid","19830640"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56295"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0023-2165"],["dc.title","Comparing Specific Disc Findings of a European and a Bantu Population"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","422"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","International Journal of Clinical Pharmacology and Therapeutics"],["dc.bibliographiccitation.lastpage","427"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Wacke, R."],["dc.contributor.author","Drewelow, B."],["dc.contributor.author","Mundkowski, R. G."],["dc.contributor.author","Guthoff, R. F."],["dc.contributor.author","Schittkowski, Michael P."],["dc.date.accessioned","2018-11-07T08:54:29Z"],["dc.date.available","2018-11-07T08:54:29Z"],["dc.date.issued","2011"],["dc.description.abstract","Objective: High-hydrophilic osmotic self-inflating hydro gel expanders are well-accepted for implantation to achieve tissue expansion in defined parts of the body like skin, breast and orbital soft tissue. To prevent post-implantation infections effective antibiotic prophylaxis might be helpful. The suitability of this hydro gel consisting of a co-polymer of N-vinyl-pyrolidone and methyl-methacrylate as a drug delivery system for antibiotics was investigated in a laboratory setting simulating the orbit in a newborn. Methods: In a first setting the dry expanders were incubated in a 0.3% solution (5 ml) of tobramycin and ofloxacin for 24 h (n = 10 for each substance, adsorbing 2.4 ml of the 0.3% solution, i.e. 7,200 mu g antibiotic). Addressing the release of both antibiotics, the concentrations in 15 ml elution medium (0.9% sodium chloride, renewed after every sampling) were measured after 0.25, 1, 2, 6, 24, 48 and 72 h of elution. To simulate the clinical use in a second setting the expanders were dried after incubation in a 0.3% and 0.03% solution of tobramycin (n = 5 for each concentration) before measuring the release. Results: The cumulative amount of tobramycin released after 72 h reached 7,157 mu g, i.e. 99% of the initially loaded antibiotic. The cumulatively released amount of ofloxacin was 5,505 mu g (76% of loading dose). Main fraction of release (about two thirds) was detected for both antibiotics for a elution period 0 - 24 h. In the periods 24 48 and 48 - 72 h the released amount of tobramycin was significantly higher than for ofloxacin. The release from expander dried after loading tobramycin was comparable: The cumulatively released amount of 0.3% and 0.03% incubation solution was 99% and 79% of loading dose, respectively. Conclusions: The investigated hydro gel expanders soaked in antibiotic solution can store and further on release sufficient amounts of tobramycin or ofloxacin to produce antimicrobial effective concentrations in vitro in the surrounding environment according to the breakpoints reported by EUCAST [14]. This principle, when used in a clinical setting, might help to eliminate post-implantation infection, which is one of the major complications in clinical use."],["dc.description.sponsorship","Faculty of Medicine, University of Rostock, Germany"],["dc.identifier.doi","10.5414/CP201516"],["dc.identifier.isi","000293766200002"],["dc.identifier.pmid","21726492"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22682"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dustri-verlag Dr Karl Feistle"],["dc.relation.issn","0946-1965"],["dc.title","In vitro kinetics of delivery of tobramycin and ofloxacin from osmotic hydro gel expanders"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","ISRN Ophthalmology"],["dc.bibliographiccitation.lastpage","12"],["dc.bibliographiccitation.volume","2012"],["dc.contributor.author","Fichter, N."],["dc.contributor.author","Guthoff, R. F."],["dc.contributor.author","Schittkowski, M. P."],["dc.date.accessioned","2021-06-01T10:48:57Z"],["dc.date.available","2021-06-01T10:48:57Z"],["dc.date.issued","2012"],["dc.description.abstract","Though enlargement of the bony orbit by orbital decompression surgery has been known for about a century, surgical techniques vary all around the world mostly depending on the patient's clinical presentation but also on the institutional habits or the surgeon's skills. Ideally every surgical intervention should be tailored to the patient's specific needs. Therefore the aim of this paper is to review outcomes, hints, trends, and perspectives in orbital decompression surgery in thyroid eye disease regarding different surgical techniques."],["dc.identifier.doi","10.5402/2012/739236"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86112"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","2090-5696"],["dc.title","Orbital Decompression in Thyroid Eye Disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]