Schittkowski, Michael P.

[["dc.bibliographiccitation.journal","Deutsches Ärzteblatt"],["dc.contributor.author","Schittkowski, Michael P."],["dc.contributor.author","Horn, Maren"],["dc.date.accessioned","2021-04-14T08:31:21Z"],["dc.date.available","2021-04-14T08:31:21Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3238/arztebl.2020.0808a"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83566"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1866-0452"],["dc.title","Treatment-refractory canaliculitis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","57"],["dc.bibliographiccitation.issue","01"],["dc.bibliographiccitation.journal","Klinische Monatsblätter für Augenheilkunde"],["dc.bibliographiccitation.lastpage","63"],["dc.bibliographiccitation.volume","239"],["dc.contributor.author","Schittkowski, Michael P."],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Horn, Maren"],["dc.contributor.author","Naxer, Sabine"],["dc.date.accessioned","2022-04-01T10:02:44Z"],["dc.date.available","2022-04-01T10:02:44Z"],["dc.date.issued","2022"],["dc.description.abstract","Zusammenfassung Hintergrund Darstellung der klinischen Befunde der ableitenden Tränenwege bei Patienten mit kongenitalem klinischen Anophthalmus und funktionslosem Mikrophthalmus (MAC-Komplex). Methoden Retrospektive Studie von 207 konsekutiven Patienten, die zwischen 1998 und 2021 mindestens einmal mit hochhydrophilen selbstquellenden Expandern bei MAC operiert wurden. Das Tränenwegssystem wurde in Vollnarkose immer vor allen anderen operativen Maßnahmen sondiert und gespült. Ergebnisse 64 Patienten wurden wegen möglicher Fehldiagnosen aufgrund vorheriger Lid- oder Orbitachirurgie an anderer Stelle oder wegen fehlender Daten ausgeschlossen. Die Analyse umfasste daher 67 Mädchen und 76 Jungen im Alter zwischen 1 und 126 Monaten (medianes Alter: 5 Monate). 72 Patienten wiesen einen unilateralen und 42 einen bilateralen Anophthalmus auf, 24 einen unilateralen und 5 einen bilateralen Mikrophthalmus; somit standen 286 Augenhöhlen (davon 190 mit Pathologie) zur Beurteilung zur Verfügung. Bei einseitigen Fällen war das Tränenwegssystem auf der normalen Seite nie betroffen. Auf der anophthalmischen oder mikrophthalmischen Seite war das Tränenwegssystem nur in 68 Augenhöhlen (35,8%) unauffällig. Der häufigste Befund war eine Kanalikulusstenose (91 Augenhöhlen; 48%). Eine Stenose des Canaliculus communis wurde in 12 Augenhöhlen (6,3%) und eine Obstruktion des Ductus nasolacrimalis in 9 Augenhöhlen (4,7%) festgestellt. Es gab 4 Fälle von Aplasie beider Tränenpünktchen, andere Anomalien waren nicht auffällig. Beim einseitigen Anophthalmus ließ sich bei pathologischen Befunden der Tränenwegssondierung ein signifikanter Zusammenhang mit einer Lippen-Kiefer-Gaumen-Spalte feststellen, was in den 3 anderen Gruppen nicht der Fall war. Schlussfolgerungen Beim kongenitalen klinischen Anophthalmus ist das Tränensystem in bis zu 66,5% der Fälle betroffen, meist aufgrund einer Kanalikulusstenose. Auch wenn es keine eindeutigen Hinweise auf einen embryologischen Zusammenhang gibt, ist diese Assoziation sicher kein Zufallsbefund."],["dc.identifier.doi","10.1055/a-1721-2375"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105993"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1439-3999"],["dc.relation.issn","0023-2165"],["dc.title","Tränenwegsbefunde von 143 Kindern mit Mikrophthalmus-Anophthalmus-Komplex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","555"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Klinische Monatsblätter für Augenheilkunde"],["dc.bibliographiccitation.lastpage","564"],["dc.bibliographiccitation.volume","228"],["dc.contributor.author","Naxer, S."],["dc.contributor.author","Behnes, Carl Ludwig"],["dc.contributor.author","Schittkowski, Michael P."],["dc.date.accessioned","2018-11-07T08:55:20Z"],["dc.date.available","2018-11-07T08:55:20Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: Amyloidosis is a disorder caused by a misfoulding of proteins. The deposition of these proteins in tissues and organs can affect the normal function of those tissues and organs. Materials and Methods: Two patients are presented and an overview over the so far published cases with a localised orbital amyloidosis is given. Results: The first case is a 50-year-old woman with progressive ptosis since half a year, progressive proptosis since three months and deterioration of motility and deviation of the left globe. The second case is a 68-year-old man with progressive ptosis since four years and with affection of the subtarsal conjunctiva of the right eye. Macroscopically a yellow-brown, gelatinous, easily crumbled material was seen during operation. Conclusion: the histological proof of amyloidosis can be made visually in intense unidirectional polarised light after congo red staining. This should be done in suspected cases every time. The orbita can also be involved in systemic forms of amyloidosis, so a systemic form should be excluded. The localised amyloidosis has no effect on the survival time in contrast to the systemic forms does have an effect. An untreated systemic form may be associuated with a prognosis of only 9 to 13 months."],["dc.identifier.doi","10.1055/s-0029-1245462"],["dc.identifier.isi","000291710100011"],["dc.identifier.pmid","20725885"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22877"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0023-2165"],["dc.title","Amyloidosis - a Rare Differential Diagnosis of an Orbital Tumour"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1194"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Klinische Monatsblätter für Augenheilkunde"],["dc.bibliographiccitation.lastpage","1201"],["dc.bibliographiccitation.volume","237"],["dc.contributor.author","Karstädt, Nadja"],["dc.contributor.author","Crozier, Thomas A."],["dc.contributor.author","Horn, Maren"],["dc.contributor.author","Naxer, Sabine"],["dc.contributor.author","Schittkowski, Michael P."],["dc.date.accessioned","2021-04-14T08:31:42Z"],["dc.date.available","2021-04-14T08:31:42Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1055/a-1260-3023"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83688"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1439-3999"],["dc.relation.issn","0023-2165"],["dc.title","Postoperative Behaviour after Primary Strabismus Surgery in Children: Is There an Influence of Intraoperative Topical Anaesthesia?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","266"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Der Ophthalmologe"],["dc.bibliographiccitation.lastpage","269"],["dc.bibliographiccitation.volume","107"],["dc.contributor.author","Manousaridis, K."],["dc.contributor.author","Casper, Jochen"],["dc.contributor.author","Schittkowski, Michael P."],["dc.contributor.author","Nizze, H."],["dc.contributor.author","Guthoff, R. F."],["dc.date.accessioned","2018-11-07T08:45:41Z"],["dc.date.available","2018-11-07T08:45:41Z"],["dc.date.issued","2010"],["dc.description.abstract","A 60-year-old man presented with left exophthalmos and deterioration in visual acuity of slow evolution. Bilateral orbital Erdheim-Chester disease was diagnosed. Systemic evaluation revealed a retroperitoneal fibrosis. Treatment with interferon-alpha followed, but bilateral compressive optic neuropathy with visual acuity deterioration and visual field defects evolved. Bilateral orbital decompression was performed."],["dc.identifier.doi","10.1007/s00347-009-2041-y"],["dc.identifier.isi","000275892900011"],["dc.identifier.pmid","19777245"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20506"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0941-293X"],["dc.title","Erdheim-Chester disease of the orbit with compressive optic neuropathy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Ophthalmology"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Schittkowski, Michael P."],["dc.date.accessioned","2018-11-07T10:26:19Z"],["dc.date.available","2018-11-07T10:26:19Z"],["dc.date.issued","2017"],["dc.format.extent","E59"],["dc.identifier.doi","10.5301/ejo.5000895"],["dc.identifier.isi","000401747200011"],["dc.identifier.pmid","27791247"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43012"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wichtig Publishing"],["dc.relation.issn","1724-6016"],["dc.relation.issn","1120-6721"],["dc.title","The use of Mersilene mesh for tendon elongation in restrictive strabismus due to Graves disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","20"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Klinische Monatsblätter für Augenheilkunde"],["dc.bibliographiccitation.lastpage","25"],["dc.bibliographiccitation.volume","234"],["dc.contributor.author","Schittkowski, Michael P."],["dc.date.accessioned","2018-11-07T10:28:48Z"],["dc.date.available","2018-11-07T10:28:48Z"],["dc.date.issued","2017"],["dc.description.abstract","A case is presented of a 54-year old patient who had been treated 10 months previously with enucleation for a painful blind eye. This led to severe and chronic pain in the orbital region that did not respond to conventional pain management. However, a single 1.5ml injection of 96% ethanol led to almost complete resolution of pain for the followup period of 6 months. Orbital pain after enucleation or evisceration may originate from the implant itself, the prosthesis, the socket or the sinuses. Taking a careful medical history and an examination, including orbital scans, are necessary to decide on the correct differential diagnosis. If any pathology is excluded, one should keep in mind that phantom pain in the orbit seems common after removing an eye, more often when pain originating from the ball and/or headache was present before removal. The management of chronic pain in the orbital region has received little attention. Retrobulbar alcohol injection still has a place in modern ophthalmology, because it delivers effective pain relief in certain chronic conditions."],["dc.identifier.doi","10.1055/s-0042-118882"],["dc.identifier.isi","000397127600012"],["dc.identifier.pmid","28135743"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43505"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","1439-3999"],["dc.relation.issn","0023-2165"],["dc.title","Alcohol Injection in a Patient with Chronic Orbital Pain after Enucleation - a Case Report and Review of the Literature"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","158"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Klinische Monatsblätter für Augenheilkunde"],["dc.bibliographiccitation.lastpage","161"],["dc.bibliographiccitation.volume","229"],["dc.contributor.author","Schittkowski, Michael P."],["dc.contributor.author","Guthoff, R. F."],["dc.contributor.author","Drewelow, B."],["dc.contributor.author","Wacke, R."],["dc.date.accessioned","2018-11-07T09:13:47Z"],["dc.date.available","2018-11-07T09:13:47Z"],["dc.date.issued","2012"],["dc.description.abstract","Purpose: The suitability of a high-hydrophilic osmotic self-inflating hydrogel expander consisting of a co-polymer of N-vinylpyrolidone and methyl methacrylate as a drug delivery system for antibiotics to prevent a postoperative infection was investigated in a laboratory setting. Methods: The dry expanders were incubated in a 0.3% solution of Ofloxacin or Tobramycin for 24 hours. The completely swollen expander had increased in volume from 0.3 mL to almost 3 mL (adsorbing 2.7 mL of the 0.3% solution, i.e.,8.1 mg of Ofloxacin or Tobramycin, respectively). Addressing the elimination of both antibiotics, the concentrations in 15 mL elution medium (simulating the volume of the orbit in a newborn baby) were measured after 0.25, 1, 2, 6, 24, 48 and 72 hours of elution. 0.9% sodium chloride (B. Braun Melsungen, Germany) was used as elution medium. To imitate fluid exchange due to blood perfusion in the surrounding tissue the medium was renewed after every sampling. For each substance 10 expanders were tested. Concentrations of antibiotic were determined by HPLC/UV for Ofloxacin and by using a specific fluorescence-polarisation immunoassay (Abbott TDx) for Tobramycin. Results: Mean concentrations of Ofloxacin at 0.25, 1, 2, 6, 24, 48 and 72 hours after beginning of the elution were 50.2, 46.8, 41.2, 75.4, 88.2, 46.2 and 19.1 mu g/mL, respectively. The cumulative amount of Ofloxacin eluted after 72 hours reached 68% of the loading dose. The corresponding mean concentrations of Tobramycin were 38.8, 48.5, 40.5, 69.8, 88.7, 119.3 and 71.6 mu g/mL. The cumulative eluted amount was 88%. Conclusions: The investigated hydrogel expanders soaked in 0.3% antibiotic solution can store and later on release sufficient amounts of Ofloxacin or Tobramycin to produce antimicrobial effective concentrations in vitro in the surrounding environment. This principle, when used in a clinical setting, might help to eliminate post-implantation infection which is one of the major complications in clinical use."],["dc.identifier.doi","10.1055/s-0031-1273457"],["dc.identifier.isi","000300615300009"],["dc.identifier.pmid","21847785"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27249"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0023-2165"],["dc.title","Hydrogelexpander as Drug Delivery System for Antibiotics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","51"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Klinische Monatsblätter für Augenheilkunde"],["dc.bibliographiccitation.lastpage","55"],["dc.bibliographiccitation.volume","230"],["dc.contributor.author","Knappe, S."],["dc.contributor.author","Guthoff, R. F."],["dc.contributor.author","Kilangalanga, J."],["dc.contributor.author","Schittkowski, Michael P."],["dc.contributor.author","Klett, A."],["dc.contributor.author","Zhivov, A."],["dc.date.accessioned","2018-11-07T09:30:28Z"],["dc.date.available","2018-11-07T09:30:28Z"],["dc.date.issued","2013"],["dc.description.abstract","The partnership between Saint Joseph Hospital in Kinshasa (Capital city of DRC) and University Eye Clinic Rostock, Germany exists since 2000. The ophthalmologists from Rostock University performed 12 visits of St. Josef Hospital with the aim to perform oculoplastic surgery in complicated cases as well as to teach the local ophthalmologists. There they performed about 150 surgeries (entropion, ectropion, ptosis, repair of lid injuries, eye lid reconstruction and tumour management, lacrimal surgery) in joint teams. The programme of on-site training was established during this time. Meanwhile, the Kinshasa colleagues are able to perform the basic techniques by themselves. Two colleagues have obtained advanced training in oculoplastics in Rostock. The fruitful cooperation enabled the development of oculoplastic surgery in St. Josef Hospital in Kinshasa. The further education and training proccesses will support the continuous advancement in ophthalmological health care in DRC."],["dc.identifier.doi","10.1055/s-0032-1328097"],["dc.identifier.isi","000313967600009"],["dc.identifier.pmid","23345149"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31315"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0023-2165"],["dc.title","Development of Oculoplastic Surgery in Kinshasa (Capital of Democratic Republic of Congo)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","64"],["dc.bibliographiccitation.issue","01"],["dc.bibliographiccitation.journal","Klinische Monatsblätter für Augenheilkunde"],["dc.bibliographiccitation.lastpage","72"],["dc.bibliographiccitation.volume","239"],["dc.contributor.author","Schittkowski, Michael P."],["dc.contributor.author","Martius, Stefanie"],["dc.contributor.author","Elabbasy, Mohamed"],["dc.contributor.author","Knappe, Steffi"],["dc.contributor.author","Guthoff, Rudolf F."],["dc.date.accessioned","2022-04-01T10:02:44Z"],["dc.date.available","2022-04-01T10:02:44Z"],["dc.date.issued","2022"],["dc.description.abstract","Zusammenfassung Einleitung Ein kongenitaler Mikrophthalmus kann entweder isoliert auftreten (einfacher Mikrophthalmus) oder mit weiteren okulären Fehlbildungen, wie einer Sklerokornea oder einer Katarakt, assoziiert sein (komplexer Mikrophthalmus). Aufgrund des seltenen Auftretens fehlen einheitliche Behandlungsempfehlungen. Material und Methoden Retrospektive Fallserie von 103 Patienten bzw. insgesamt 114 Augen mit kongenitalem Mikrophthalmus mit Erfassung von Alter, Geschlecht, Visus, Pupillenreaktion, axialer Bulbuslänge, horizontaler Weite der Lidspalte, Art der durchgeführten Therapie, Komplikationen. Ergebnisse Alle Patienten waren ausnahmslos primär prothesenfähig. Die Größe der Lidspalte hing vom zugrunde liegenden Befund ab: „beidseits Mikrophthalmus“ < „Mikrophthalmus und gesundes Partnerauge“ < „Mikrophthalmus und Anophthalmus der anderen Seite“. Um bei einem Säugling in den ersten Lebenswochen oder -monaten die visuelle (Rest-)Funktion als wichtigsten Faktor für die Entscheidung über die Therapie zu beurteilen, ist die Pupillenreaktion, speziell bei einseitiger Erkrankung die indirekte Lichtreaktion des gesunden Auges, von größter Bedeutung. In etwa der Hälfte der Fälle war eine konservative Prothesenbehandlung ausreichend. Nach der erfolgreichen Erstanpassung einer Vorlegeprothese fand eine regelmäßige Prothesenvergrößerung nach Maßgabe des Okularisten statt. Wenn die Bulbuslängendifferenz so groß war, dass auch mit einer doppelwandigen Prothese keine Symmetrie zu erzielen war, wurde eine Volumenauffüllung durch retrobulbär implantierte selbstquellende Pelletexpander (osmed GmbH, Ilmenau) angeboten. Bei knapp einem Drittel der Patienten erfolgte keine operative Therapie oder prothetische Versorgung. Die Ursache dafür war meist das Vorliegen einer minimalen Sehfunktion des Mikrophthalmus (Wahrnehmung von Lichtschein bis Angabe von Handbewegungen). Schlussfolgerung Bei vorhandener Sehfähigkeit des Mikrophthalmus sollten operative Maßnahmen nicht oder nur mit äußerster Zurückhaltung indiziert werden, da der Erhalt des vorhandenen Visus als vorrangig vor dem kosmetischen Befund angesehen werden muss. Bei Asymmetrie oder unterentwickelter Lidspalte kann der Therapiebeginn frühzeitig im 1. Lebensjahr erfolgen, ohne dass daraus resultierende Komplikationen zu befürchten sind."],["dc.identifier.doi","10.1055/a-1685-5002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105991"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1439-3999"],["dc.relation.issn","0023-2165"],["dc.title","Therapiestrategien bei 103 Kindern mit kongenitalem Mikrophthalmus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]