Reinhold, Robert

[["dc.bibliographiccitation.firstpage","139"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","EMBO Molecular Medicine"],["dc.bibliographiccitation.lastpage","154"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Dudek, Jan"],["dc.contributor.author","Cheng, I-Fen"],["dc.contributor.author","Chowdhury, Arpita"],["dc.contributor.author","Wozny, Katharina"],["dc.contributor.author","Balleininger, Martina"],["dc.contributor.author","Reinhold, Robert"],["dc.contributor.author","Grunau, Silke"],["dc.contributor.author","Callegari, Sylvie"],["dc.contributor.author","Toischer, Karl"],["dc.contributor.author","Wanders, Ronald JA"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Brügger, Britta"],["dc.contributor.author","Guan, Kaomei"],["dc.contributor.author","Rehling, Peter"],["dc.date.accessioned","2017-09-07T11:53:31Z"],["dc.date.available","2017-09-07T11:53:31Z"],["dc.date.issued","2016"],["dc.description.abstract","Barth syndrome (BTHS) is a cardiomyopathy caused by the loss of tafazzin, a mitochondrial acyltransferase involved in the maturation of the glycerophospholipid cardiolipin. It has remained enigmatic as to why a systemic loss of cardiolipin leads to cardiomyopathy. Using a genetic ablation of tafazzin function in the BTHS mouse model, we identified severe structural changes in respiratory chain supercomplexes at a pre‐onset stage of the disease. This reorganization of supercomplexes was specific to cardiac tissue and could be recapitulated in cardiomyocytes derived from BTHS patients. Moreover, our analyses demonstrate a cardiac‐specific loss of succinate dehydrogenase (SDH), an enzyme linking the respiratory chain with the tricarboxylic acid cycle. As a similar defect of SDH is apparent in patient cell‐derived cardiomyocytes, we conclude that these defects represent a molecular basis for the cardiac pathology in Barth syndrome."],["dc.identifier.doi","10.15252/emmm.201505644"],["dc.identifier.fs","615879"],["dc.identifier.gro","3145083"],["dc.identifier.pmid","26697888"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13136"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2780"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/101"],["dc.language.iso","en"],["dc.notes.intern","Crossref Import"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | A06: Molekulare Grundlagen mitochondrialer Kardiomyopathien"],["dc.relation.issn","1757-4676"],["dc.relation.issn","1757-4684"],["dc.relation.workinggroup","RG Guan (Application of patient-specific induced pluripotent stem cells in disease modelling)"],["dc.relation.workinggroup","RG Hasenfuß (Transition zur Herzinsuffizienz)"],["dc.relation.workinggroup","RG Rehling (Mitochondrial Protein Biogenesis)"],["dc.relation.workinggroup","RG Toischer (Kardiales Remodeling)"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject","Barth syndrome; Cardiolipin, Mitochondriar; Respiratory chain; Succinate dehydrogenase"],["dc.title","Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","A11"],["dc.bibliographiccitation.journal","Astronomy and Astrophysics"],["dc.bibliographiccitation.volume","557"],["dc.contributor.author","Reinhold, T."],["dc.contributor.author","Reiners, Ansgar"],["dc.date.accessioned","2018-11-07T09:20:26Z"],["dc.date.available","2018-11-07T09:20:26Z"],["dc.date.issued","2013"],["dc.description.abstract","Context. Co-rotating spots at different latitudes on the stellar surface generate periodic photometric variability and can be useful proxies for detecting differential rotation (DR). This is a major ingredient of the solar dynamo, but observations of stellar DR are very sparse. Because the Kepler space telescope steadily collects more data, we are interested in detecting DR using photometric information of a star. Aims. The main goal of this paper is to develop a fast method for determining stellar DR from photometric data. Methods. We ran an extensive Monte Carlo simulation of differentially rotating spotted stars with very different properties to investigate the detectability of DR. For different noise levels the resulting light curves were prewhitened using Lomb-Scargle periodograms to derive parameters for a global sine fit to detect periodicities. Results. We show under which conditions DR can successfully be detected from photometric data, and in which cases the light curve provides insufficient or even misleading information on the stellar rotation law. In our simulations, the most significant period P1(out) is on average 2.4% shorter than the actual spot rotation-rate. This period was detected in 96.2% of all light curves. The signature of DR is a second period close to P1(out) in our model. For the noise-free case, we found such a period in 64.2% of all stars. Calculating the measured latitudinal shear of two distinct spots alpha(out), and comparing this with the known original spot rotation-rates shows that the real value is on average 3.2% lower. Comparing the total equator-to-pole shear alpha to alpha(out), we find that alpha is underestimated by 8.8%, especially the detection of DR for stars with alpha < 6% is challenging. Finally, we applied our method to four differentially rotating Kepler stars and found close agreement with results from detailed modeling. Conclusions. The method we developed is capable of measuring stellar rotation periods and detecting DR with relatively high accuracy and is suitable for large data sets. We will apply our analysis to more Kepler data in a forthcoming paper."],["dc.description.sponsorship","DFG [Graduiertenkolleg 1351 Extrasolar Planets, RE 1664/9-1]"],["dc.identifier.doi","10.1051/0004-6361/201321161"],["dc.identifier.isi","000325211900041"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10137"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28874"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Edp Sciences S A"],["dc.relation.issn","1432-0746"],["dc.relation.orgunit","Fakultät für Physik"],["dc.title","Fast and reliable method for measuring stellar differential rotation from photometric data"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]