Goya-Maldonado, Roberto

[["dc.bibliographiccitation.firstpage","57"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","66"],["dc.bibliographiccitation.volume","265"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Weber, Kristina"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Diekhof, Esther"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2017-09-07T11:47:50Z"],["dc.date.available","2017-09-07T11:47:50Z"],["dc.date.issued","2014"],["dc.description.abstract","Depression is a debilitating psychiatric disorder characterized among other aspects by the inability to properly experience or respond to reward. However, it remains unclear whether patients with depression present impaired reward system due to abnormal modulatory mechanisms. We investigated the activation of the nucleus accumbens (NAcc), a crucial region involved in reward processing, with functional magnetic resonance imaging using the desire-reason-dilemma paradigm. This task allows tracking the activity of the NAcc during the acceptance or the rejection of previously conditioned reward stimuli. Patients were assigned into subgroups of lower (LA) or higher (HA) NAcc activation according to beta weights. LA patients presented significant hypoactivation in the ventral tegmental area in addition to bilateral ventral striatum, confirming impairments in the bottom-up input to the NAcc. Conversely, HA patients presented significant hyperactivation in prefrontal areas such as the rostral anterior cingulate cortex and the anterior ventral prefrontal cortex in addition to bilateral ventral striatum, suggesting disturbances in the top-down regulation of the NAcc. Demographic and clinical differences explaining the abnormal co-activations of midbrain and prefrontal regions were not identified. Therefore, we provide evidence for dysfunctional bottom-up processing in one potential neurobiological subtype of depression (LA) and dysfunctional top-down modulation in another subtype (HA). We suggest that the midbrain and prefrontal regions are more specific pathophysiological substrates for each depression subtype. Above all, our results encourage the segregation of patients by similar dysfunctional mechanisms of the dopaminergic system, which would finally contribute to disentangle more specific pathogeneses and guide the development of more personalized targets for future therapies."],["dc.identifier.doi","10.1007/s00406-014-0552-2"],["dc.identifier.gro","3150742"],["dc.identifier.pmid","25327829"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7532"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","0940-1334"],["dc.title","Dissociating pathomechanisms of depression with fMRI: bottom-up or top-down dysfunctions of the reward system"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1039"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","The American Journal of Psychiatry"],["dc.bibliographiccitation.lastpage","1049"],["dc.bibliographiccitation.volume","176"],["dc.contributor.author","de Kovel, Carolien G.F."],["dc.contributor.author","Aftanas, Lyubomir"],["dc.contributor.author","Aleman, André"],["dc.contributor.author","Alexander-Bloch, Aaron F."],["dc.contributor.author","Baune, Bernhard T."],["dc.contributor.author","Brack, Ivan"],["dc.contributor.author","Bülow, Robin"],["dc.contributor.author","Busatto Filho, Geraldo"],["dc.contributor.author","Carballedo, Angela"],["dc.contributor.author","Connolly, Colm G."],["dc.contributor.author","Cullen, Kathryn R."],["dc.contributor.author","Dannlowski, Udo"],["dc.contributor.author","Davey, Christopher G."],["dc.contributor.author","Dima, Danai"],["dc.contributor.author","Dohm, Katharina"],["dc.contributor.author","Erwin-Grabner, Tracy"],["dc.contributor.author","Frodl, Thomas"],["dc.contributor.author","Fu, Cynthia H.Y."],["dc.contributor.author","Hall, Geoffrey B."],["dc.contributor.author","Glahn, David C."],["dc.contributor.author","Godlewska, Beata"],["dc.contributor.author","Gotlib, Ian H."],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Grabe, Hans Jörgen"],["dc.contributor.author","Groenewold, Nynke A."],["dc.contributor.author","Grotegerd, Dominik"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Harris, Mathew A."],["dc.contributor.author","Harrison, Ben J."],["dc.contributor.author","Hatton, Sean N."],["dc.contributor.author","Hickie, Ian B."],["dc.contributor.author","Ho, Tiffany C."],["dc.contributor.author","Jahanshad, Neda"],["dc.contributor.author","Kircher, Tilo"],["dc.contributor.author","Krämer, Bernd"],["dc.contributor.author","Krug, Axel"],["dc.contributor.author","Lagopoulos, Jim"],["dc.contributor.author","Leehr, Elisabeth J."],["dc.contributor.author","Li, Meng"],["dc.contributor.author","MacMaster, Frank P."],["dc.contributor.author","MacQueen, Glenda"],["dc.contributor.author","McIntosh, Andrew M."],["dc.contributor.author","McLellan, Quinn"],["dc.contributor.author","Medland, Sarah E."],["dc.contributor.author","Mueller, Bryon A."],["dc.contributor.author","Nenadic, Igor"],["dc.contributor.author","Osipov, Evgeny"],["dc.contributor.author","Papmeyer, Martina"],["dc.contributor.author","Portella, Maria J."],["dc.contributor.author","Reneman, Liesbeth"],["dc.contributor.author","Rosa, Pedro G.P."],["dc.contributor.author","Sacchet, Matthew D."],["dc.contributor.author","Schnell, Knut"],["dc.contributor.author","Schrantee, Anouk"],["dc.contributor.author","Sim, Kang"],["dc.contributor.author","Simulionyte, Egle"],["dc.contributor.author","Sindermann, Lisa"],["dc.contributor.author","Singh, Aditya"],["dc.contributor.author","Stein, Dan J."],["dc.contributor.author","Ubani, Benjamin N."],["dc.contributor.author","Van der Wee, Nic J.A."],["dc.contributor.author","Van der Werff, Steven J.A."],["dc.contributor.author","Veer, Ilya M."],["dc.contributor.author","Vives-Gilabert, Yolanda"],["dc.contributor.author","Völzke, Henry"],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Walter, Martin"],["dc.contributor.author","Schreiner, Melinda Westlund"],["dc.contributor.author","Whalley, Heather"],["dc.contributor.author","Winter, Nils"],["dc.contributor.author","Wittfeld, Katharina"],["dc.contributor.author","Yang, Tony T."],["dc.contributor.author","Yüksel, Dilara"],["dc.contributor.author","Zaremba, Dario"],["dc.contributor.author","Thompson, Paul M."],["dc.contributor.author","Veltman, Dick J."],["dc.contributor.author","Schmaal, Lianne"],["dc.contributor.author","Francks, Clyde"],["dc.date.accessioned","2020-12-10T18:38:21Z"],["dc.date.available","2020-12-10T18:38:21Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1176/appi.ajp.2019.18101144"],["dc.identifier.eissn","1535-7228"],["dc.identifier.issn","0002-953X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77281"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e2230367"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","JAMA Network Open"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Hellmann-Regen, Julian"],["dc.contributor.author","Clemens, Vera"],["dc.contributor.author","Grözinger, Michael"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Reif, Andreas"],["dc.contributor.author","Prvulovic, David"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Schüle, Cornelius"],["dc.contributor.author","Heuser, Isabella"],["dc.date.accessioned","2022-10-04T10:21:24Z"],["dc.date.available","2022-10-04T10:21:24Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1001/jamanetworkopen.2022.30367"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114402"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.relation.eissn","2574-3805"],["dc.title","Effect of Minocycline on Depressive Symptoms in Patients With Treatment-Resistant Depression"],["dc.title.alternative","A Randomized Clinical Trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e94973"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Schilbach, Leonhard"],["dc.contributor.author","Müller, Veronika I."],["dc.contributor.author","Hoffstaedter, Felix"],["dc.contributor.author","Clos, Mareike"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Eickhoff, Simon B."],["dc.contributor.editor","Marinazzo, Daniele"],["dc.date.accessioned","2017-09-07T11:47:50Z"],["dc.date.available","2017-09-07T11:47:50Z"],["dc.date.issued","2014"],["dc.description.abstract","Alterations of social cognition and dysfunctional interpersonal expectations are thought to play an important role in the etiology of depression and have, thus, become a key target of psychotherapeutic interventions. The underlying neurobiology, however, remains elusive. Based upon the idea of a close link between affective and introspective processes relevant for social interactions and alterations thereof in states of depression, we used a meta-analytically informed network analysis to investigate resting-state functional connectivity in an introspective socio-affective (ISA) network in individuals with and without depression. Results of our analysis demonstrate significant differences between the groups with depressed individuals showing hyperconnectivity of the ISA network. These findings demonstrate that neurofunctional alterations exist in individuals with depression in a neural network relevant for introspection and socio-affective processing, which may contribute to the interpersonal difficulties that are linked to depressive symptomatology."],["dc.identifier.doi","10.1371/journal.pone.0094973"],["dc.identifier.gro","3150741"],["dc.identifier.pmid","24759619"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11609"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7531"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","public"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Meta-Analytically Informed Network Analysis of Resting State fMRI Reveals Hyperconnectivity in an Introspective Socio-Affective Network in Depression"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","806"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Molecular Psychiatry"],["dc.bibliographiccitation.lastpage","812"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Schmaal, L."],["dc.contributor.author","Veltman, D. J."],["dc.contributor.author","Erp, T. G. M. van"],["dc.contributor.author","Sämann, P. G."],["dc.contributor.author","Frodl, T."],["dc.contributor.author","Jahanshad, N."],["dc.contributor.author","Loehrer, E."],["dc.contributor.author","Tienson, H."],["dc.contributor.author","Hofman, A."],["dc.contributor.author","Niessen, W. J."],["dc.contributor.author","Vernooij, M. W."],["dc.contributor.author","Ikram, M. A."],["dc.contributor.author","Wittfeld, K."],["dc.contributor.author","Grabe, H. J."],["dc.contributor.author","Block, A."],["dc.contributor.author","Hegenscheid, K."],["dc.contributor.author","Völzke, H."],["dc.contributor.author","Hoehn, D."],["dc.contributor.author","Czisch, M."],["dc.contributor.author","Lagopoulos, J."],["dc.contributor.author","Hatton, S. N."],["dc.contributor.author","Hickie, I. B."],["dc.contributor.author","Goya-Maldonado, R."],["dc.contributor.author","Krämer, B."],["dc.contributor.author","Gruber, O."],["dc.contributor.author","Couvy-Duchesne, B."],["dc.contributor.author","Renteria, M. E."],["dc.contributor.author","Strike, L. T."],["dc.contributor.author","Mills, N. T."],["dc.contributor.author","Zubicaray, G. I. de"],["dc.contributor.author","McMahon, K. L."],["dc.contributor.author","Medland, S. E."],["dc.contributor.author","Martin, N. G."],["dc.contributor.author","Gillespie, N. A."],["dc.contributor.author","Wright, M. J."],["dc.contributor.author","Hall, G. B."],["dc.contributor.author","MacQueen, G. M."],["dc.contributor.author","Frey, E. M."],["dc.contributor.author","Carballedo, A."],["dc.contributor.author","van Velzen, L. S."],["dc.contributor.author","Tol, M.-J. van"],["dc.contributor.author","Wee, N. J. A. van der"],["dc.contributor.author","Veer, I. M."],["dc.contributor.author","Walter, H."],["dc.contributor.author","Schnell, K."],["dc.contributor.author","Schramm, E."],["dc.contributor.author","Normann, C."],["dc.contributor.author","Schoepf, D."],["dc.contributor.author","Konrad, C."],["dc.contributor.author","Zurowski, B."],["dc.contributor.author","Nickson, T."],["dc.contributor.author","McIntosh, A. M."],["dc.contributor.author","Papmeyer, M."],["dc.contributor.author","Whalley, H. C."],["dc.contributor.author","Sussmann, J. E."],["dc.contributor.author","Godlewska, B. R."],["dc.contributor.author","Cowen, P. J."],["dc.contributor.author","Fischer, F. H."],["dc.contributor.author","Rose, M."],["dc.contributor.author","Penninx, B. W. J. H."],["dc.contributor.author","Thompson, P. M."],["dc.contributor.author","Hibar, D. P."],["dc.date.accessioned","2017-09-07T11:47:51Z"],["dc.date.available","2017-09-07T11:47:51Z"],["dc.date.issued","2015"],["dc.description.abstract","The pattern of structural brain alterations associated with major depressive disorder (MDD) remains unresolved. This is in part due to small sample sizes of neuroimaging studies resulting in limited statistical power, disease heterogeneity and the complex interactions between clinical characteristics and brain morphology. To address this, we meta-analyzed three-dimensional brain magnetic resonance imaging data from 1728 MDD patients and 7199 controls from 15 research samples worldwide, to identify subcortical brain volumes that robustly discriminate MDD patients from healthy controls. Relative to controls, patients had significantly lower hippocampal volumes (Cohen's d=-0.14, % difference=-1.24). This effect was driven by patients with recurrent MDD (Cohen's d=-0.17, % difference=-1.44), and we detected no differences between first episode patients and controls. Age of onset ⩽21 was associated with a smaller hippocampus (Cohen's d=-0.20, % difference=-1.85) and a trend toward smaller amygdala (Cohen's d=-0.11, % difference=-1.23) and larger lateral ventricles (Cohen's d=0.12, % difference=5.11). Symptom severity at study inclusion was not associated with any regional brain volumes. Sample characteristics such as mean age, proportion of antidepressant users and proportion of remitted patients, and methodological characteristics did not significantly moderate alterations in brain volumes in MDD. Samples with a higher proportion of antipsychotic medication users showed larger caudate volumes in MDD patients compared with controls. This currently largest worldwide effort to identify subcortical brain alterations showed robust smaller hippocampal volumes in MDD patients, moderated by age of onset and first episode versus recurrent episode status."],["dc.identifier.doi","10.1038/mp.2015.69"],["dc.identifier.gro","3150737"],["dc.identifier.pmid","26122586"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12869"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7526"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.issn","1359-4184"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","808"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","818"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Brodmann, Katja"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2017-09-07T11:47:50Z"],["dc.date.available","2017-09-07T11:47:50Z"],["dc.date.issued","2015"],["dc.description.abstract","Misdiagnosing bipolar depression can lead to very deleterious consequences of mistreatment. Although depressive symptoms may be similarly expressed in unipolar and bipolar disorder, changes in specific brain networks could be very distinct, being therefore informative markers for the differential diagnosis. We aimed to characterize specific alterations in candidate large-scale networks (frontoparietal, cingulo-opercular, and default mode) in symptomatic unipolar and bipolar patients using resting state fMRI, a cognitively low demanding paradigm ideal to investigate patients.MethodsNetworks were selected after independent component analysis, compared across 40 patients acutely depressed (20 unipolar, 20 bipolar), and 20 controls well-matched for age, gender, and education levels, and alterations were correlated to clinical parameters.ResultsDespite comparable symptoms, patient groups were robustly differentiated by large-scale network alterations. Differences were driven in bipolar patients by increased functional connectivity in the frontoparietal network, a central executive and externally-oriented network. Conversely, unipolar patients presented increased functional connectivity in the default mode network, an introspective and self-referential network, as much as reduced connectivity of the cingulo-opercular network to default mode regions, a network involved in detecting the need to switch between internally and externally oriented demands. These findings were mostly unaffected by current medication, comorbidity, and structural changes. Moreover, network alterations in unipolar patients were significantly correlated to the number of depressive episodes. Conclusion: Unipolar and bipolar groups displaying similar symptomatology could be clearly distinguished by characteristic changes in large-scale networks, encouraging further investigation of network fingerprints for clinical use."],["dc.identifier.doi","10.1002/hbm.23070"],["dc.identifier.gro","3150744"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7534"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","1065-9471"],["dc.title","Differentiating unipolar and bipolar depression by alterations in large-scale brain networks"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2931"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","2942"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Poeppl, Timm B."],["dc.contributor.author","Müller, Veronika I."],["dc.contributor.author","Hoffstaedter, Felix"],["dc.contributor.author","Bzdok, Danilo"],["dc.contributor.author","Laird, Angela R."],["dc.contributor.author","Fox, Peter T."],["dc.contributor.author","Langguth, Berthold"],["dc.contributor.author","Rupprecht, Rainer"],["dc.contributor.author","Sorg, Christian"],["dc.contributor.author","Riedl, Valentin"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Eickhoff, Simon B."],["dc.date.accessioned","2017-09-07T11:47:52Z"],["dc.date.available","2017-09-07T11:47:52Z"],["dc.date.issued","2016"],["dc.description.abstract","Major depressive disorder (MDD) involves impairment in cognitive and interpersonal functioning. The right temporoparietal junction (RTPJ) is a key brain region subserving cognitive-attentional and social processes. Yet, findings on the involvement of the RTPJ in the pathophysiology of MDD have so far been controversial. Recent connectivity-based parcellation data revealed a topofunctional dualism within the RTPJ, linking its anterior and posterior part (aRTPJ/pRTPJ) to antagonistic brain networks for attentional and social processing, respectively. Comparing functional resting-state connectivity of the aRTPJ and pRTPJ in 72 MDD patients and 76 well-matched healthy controls, we found a seed (aRTPJ/pRTPJ) × diagnosis (MDD/controls) interaction in functional connectivity for eight regions. Employing meta-data from a large-scale neuroimaging database, functional characterization of these regions exhibiting differentially altered connectivity with the aRTPJ/pRTPJ revealed associations with cognitive (dorsolateral prefrontal cortex, parahippocampus) and behavioral (posterior medial frontal cortex) control, visuospatial processing (dorsal visual cortex), reward (subgenual anterior cingulate cortex, medial orbitofrontal cortex, posterior cingulate cortex), as well as memory retrieval and social cognition (precuneus). These findings suggest that an imbalance in connectivity of subregions, rather than disturbed connectivity of the RTPJ as a whole, characterizes the connectional disruption of the RTPJ in MDD. This imbalance may account for key symptoms of MDD in cognitive, emotional, and social domains. Hum Brain Mapp 37:2931-2942, 2016. © 2016 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/hbm.23217"],["dc.identifier.gro","3150740"],["dc.identifier.pmid","27090056"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7529"],["dc.language.iso","en"],["dc.notes.status","public"],["dc.relation.issn","1065-9471"],["dc.subject","connectivity; depression; functional magnetic resonance imaging; major depressive disorder; resting state; right temporoparietal junction"],["dc.title","Imbalance in subregional connectivity of the right temporoparietal junction in major depression"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2970"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.bibliographiccitation.lastpage","2981"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Wolf, Claudia"],["dc.contributor.author","Mohr, Holger"],["dc.contributor.author","Diekhof, Esther"],["dc.contributor.author","Vieker, Henning"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Krämer, Bernd"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Binder, Elisabeth B."],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2017-09-07T11:47:50Z"],["dc.date.available","2017-09-07T11:47:50Z"],["dc.date.issued","2015"],["dc.description.abstract","Cyclic AMP response element-binding protein (CREB) contributes to adaptation of mesocorticolimbic networks by modulating activity-regulated transcription and plasticity in neurons. Activity or expression changes of CREB in the nucleus accumbens (NAc) and orbital frontal cortex (OFC) interact with behavioral changes during reward-motivated learning. However, these findings from animal models have not been evaluated in humans. We tested whether CREB1 genotypes affect reward-motivated decisions and related brain activation, using BOLD fMRI in 224 young and healthy participants. More specifically, participants needed to adapt their decision to either pursue or resist immediate rewards to optimize the reward outcome. We found significant CREB1 genotype effects on choices to pursue increases of the reward outcome and on BOLD signal in the NAc, OFC, insula cortex, cingulate gyrus, hippocampus, amygdala, and precuneus during these decisions in comparison with those decisions avoiding total reward loss. Our results suggest that CREB1 genotype effects in these regions could contribute to individual differences in reward- and associative memory-based decision-making."],["dc.identifier.doi","10.1093/cercor/bhv104"],["dc.identifier.gro","3150743"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7533"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","1047-3211"],["dc.title","CREB1Genotype Modulates Adaptive Reward-Based Decisions in Humans"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S394"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","S395"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Schmaal, L."],["dc.contributor.author","Veltman, D. J."],["dc.contributor.author","van Erp, T. G."],["dc.contributor.author","Saemann, P. G."],["dc.contributor.author","Frodl, T."],["dc.contributor.author","Jahanshad, N."],["dc.contributor.author","Loehrer, E."],["dc.contributor.author","Tiemeier, Henning"],["dc.contributor.author","Hofman, Albert"],["dc.contributor.author","Niessen, W. J."],["dc.contributor.author","Vernooij, M. W."],["dc.contributor.author","Ikram, M. Arfan"],["dc.contributor.author","Wittfeld, K."],["dc.contributor.author","Grabe, Hans Joergen"],["dc.contributor.author","Block, Alan J."],["dc.contributor.author","Hegenscheid, K."],["dc.contributor.author","Voelzke, Henry"],["dc.contributor.author","Hoehn, D."],["dc.contributor.author","Czisch, Michael"],["dc.contributor.author","Lagopoulos, J."],["dc.contributor.author","Hatton, S. N."],["dc.contributor.author","Hickie, I. B."],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Kraemer, Bernd"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Couvy-Duchesne, B."],["dc.contributor.author","Renteria, M. E."],["dc.contributor.author","Strike, L. T."],["dc.contributor.author","Mills, N. T."],["dc.contributor.author","De Zubicaray, G. I."],["dc.contributor.author","McMahon, K. L."],["dc.contributor.author","Medland, Sarah E."],["dc.contributor.author","Martin, Nicholas G."],["dc.contributor.author","Gillespie, N. A."],["dc.contributor.author","Wright, Margaret J."],["dc.contributor.author","Hall, G. B."],["dc.contributor.author","MacQueen, Glenda"],["dc.contributor.author","Frey, Erwin"],["dc.contributor.author","Carballedo, A."],["dc.contributor.author","van Velzen, L. S."],["dc.contributor.author","van Tol, M. J."],["dc.contributor.author","van der Wee, N. J."],["dc.contributor.author","Veer, I. M."],["dc.contributor.author","Walter, H."],["dc.contributor.author","Schnell, K."],["dc.contributor.author","Schramm, E."],["dc.contributor.author","Normann, C."],["dc.contributor.author","Schoepf, D."],["dc.contributor.author","Konrad, Christian"],["dc.contributor.author","Zurowski, B."],["dc.contributor.author","Nickson, T."],["dc.contributor.author","McIntosh, Andrew M."],["dc.contributor.author","Papmeyer, M."],["dc.contributor.author","Whalley, H. C."],["dc.contributor.author","Sussmann, J. E."],["dc.contributor.author","Godlewska, B. R."],["dc.contributor.author","Cowen, P. J."],["dc.contributor.author","Fischer, F. H."],["dc.contributor.author","Rose, Matthias"],["dc.contributor.author","Penninx, B. W."],["dc.contributor.author","Thompson, Paul M."],["dc.contributor.author","Hibar, Derrek P."],["dc.date.accessioned","2018-11-07T09:52:05Z"],["dc.date.available","2018-11-07T09:52:05Z"],["dc.date.issued","2015"],["dc.identifier.isi","000365518200505"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36043"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","28th Congress of the European-College-of-Neuropsychopharmacology (ECNP)"],["dc.relation.eventlocation","Amsterdam, NETHERLANDS"],["dc.relation.issn","1873-7862"],["dc.relation.issn","0924-977X"],["dc.title","Structural brain alterations in major depression: findings from the ENIGMA Major Depressive Disorder Working Group"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1741"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","1750"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Chahine, George"],["dc.contributor.author","Richter, Anja"],["dc.contributor.author","Wolter, Sarah"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2017-09-07T11:47:50Z"],["dc.date.available","2017-09-07T11:47:50Z"],["dc.date.issued","2016"],["dc.description.abstract","Advances in functional brain imaging have improved the search for potential endophenotypic markers in schizophrenia. Here, we employed independent component analysis (ICA) and dynamic causal modeling (DCM) in resting state fMRI on a sample of 35 schizophrenia patients, 20 first-degree relatives and 35 control subjects. Analysis on ICA-derived networks revealed increased functional connectivity between the left frontoparietal network (FPN) and left temporal and parietal regions in schizophrenia patients (P < 0.001). First-degree relatives shared this hyperconnectivity, in particular in the supramarginal gyrus (SMG; P = 0.008). DCM analysis was employed to further explore underlying effective connectivity. Results showed increased inhibitory connections to the left angular gyrus (AG) in schizophrenia patients from all other nodes of the left FPN (P < 0.001), and in particular from the left SMG (P = 0.001). Relatives also showed a pattern of increased inhibitory connections to the left AG (P = 0.008). Furthermore, the patient group showed increased excitatory connectivity between the left fusiform gyrus and the left SMG (P = 0.002). This connection was negatively correlated to inhibitory afferents to the left AG (P = 0.005) and to the negative symptom score on the PANSS scale (P = 0.001, r = −0.51). Left frontoparietotemporal dysfunction in schizophrenia has been previously associated with a range of abnormalities, including formal thought disorder, working memory dysfunction and sensory hallucinations. Our analysis uncovered new potential endophenotypic markers of schizophrenia and shed light on the organization of the left FPN in patients and their first-degree relatives."],["dc.identifier.doi","10.1002/hbm.23477"],["dc.identifier.gro","3150745"],["dc.identifier.pmid","28009080"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7535"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","1065-9471"],["dc.title","Disruptions in the left frontoparietal network underlie resting state endophenotypic markers in schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]