Goya-Maldonado, Roberto

[["dc.bibliographiccitation.journal","Frontiers in Aging Neuroscience"],["dc.bibliographiccitation.volume","13"],["dc.contributor.affiliation","Hansen, Niels; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany"],["dc.contributor.affiliation","Singh, Aditya; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany"],["dc.contributor.affiliation","Bartels, Claudia; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany"],["dc.contributor.affiliation","Brosseron, Frederic; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],["dc.contributor.affiliation","Buerger, Katharina; 5German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany"],["dc.contributor.affiliation","Cetindag, Arda C.; 7Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany"],["dc.contributor.affiliation","Dobisch, Laura; 9German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"],["dc.contributor.affiliation","Dechent, Peter; 10MR-Research in Neurology and Psychiatry, University Medical Center Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Ertl-Wagner, Birgit B.; 11Institute for Clinical Radiology, Ludwig-Maximilians-University, Munich, Germany"],["dc.contributor.affiliation","Fliessbach, Klaus; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],["dc.contributor.affiliation","Haynes, John D.; 12Bernstein Center for Computational Neuroscience, Charité—Universitätsmedizin, Berlin, Germany"],["dc.contributor.affiliation","Heneka, Michael T.; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],["dc.contributor.affiliation","Janowitz, Daniel; 6Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany"],["dc.contributor.affiliation","Kilimann, Ingo; 13German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany"],["dc.contributor.affiliation","Laske, Christoph; 15German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany"],["dc.contributor.affiliation","Metzger, Coraline D.; 9German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"],["dc.contributor.affiliation","Munk, Matthias H.; 15German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany"],["dc.contributor.affiliation","Peters, Oliver; 7Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany"],["dc.contributor.affiliation","Priller, Josef; 8German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany"],["dc.contributor.affiliation","Roy, Nina; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],["dc.contributor.affiliation","Scheffler, Klaus; 21Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany"],["dc.contributor.affiliation","Schneider, Anja; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],["dc.contributor.affiliation","Spottke, Annika; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],["dc.contributor.affiliation","Spruth, Eike J.; 8German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany"],["dc.contributor.affiliation","Teipel, Stefan; 13German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany"],["dc.contributor.affiliation","Tscheuschler, Maike; 23Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany"],["dc.contributor.affiliation","Vukovich, Ruth; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany"],["dc.contributor.affiliation","Wiltfang, Jens; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany"],["dc.contributor.affiliation","Duezel, Emrah; 9German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"],["dc.contributor.affiliation","Jessen, Frank; 23Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany"],["dc.contributor.affiliation","Goya-Maldonado, Roberto; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany"],["dc.contributor.author","Hansen, Niels"],["dc.contributor.author","Singh, Aditya"],["dc.contributor.author","Bartels, Claudia"],["dc.contributor.author","Brosseron, Frederic"],["dc.contributor.author","Buerger, Katharina"],["dc.contributor.author","Cetindag, Arda C."],["dc.contributor.author","Dobisch, Laura"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Ertl-Wagner, Birgit B."],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Haynes, John D."],["dc.contributor.author","Heneka, Michael T."],["dc.contributor.author","Janowitz, Daniel"],["dc.contributor.author","Kilimann, Ingo"],["dc.contributor.author","Laske, Christoph"],["dc.contributor.author","Metzger, Coraline D."],["dc.contributor.author","Munk, Matthias H."],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Roy, Nina"],["dc.contributor.author","Scheffler, Klaus"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Spruth, Eike J."],["dc.contributor.author","Teipel, Stefan"],["dc.contributor.author","Tscheuschler, Maike"],["dc.contributor.author","Vukovich, Ruth"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Duezel, Emrah"],["dc.contributor.author","Jessen, Frank"],["dc.date.accessioned","2021-06-01T09:42:25Z"],["dc.date.available","2021-06-01T09:42:25Z"],["dc.date.issued","2021"],["dc.date.updated","2022-02-09T13:21:10Z"],["dc.description.abstract","Background: The hippocampus and its subfields (HippSub) are reported to be diminished in patients with Alzheimer's disease (AD), bipolar disorder (BD), and major depressive disorder (MDD). We examined these groups vs healthy controls (HC) to reveal HippSub alterations between diseases. Methods: We segmented 3T-MRI T2-weighted hippocampal images of 67 HC, 58 BD, and MDD patients from the AFFDIS study and 137 patients from the DELCODE study assessing cognitive decline, including subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), and AD, via Free Surfer 6.0 to compare volumes across groups. Results: Groups differed significantly in several HippSub volumes, particularly between patients with AD and mood disorders. In comparison to HC, significant lower volumes appear in aMCI and AD groups in specific subfields. Smaller volumes in the left presubiculum are detected in aMCI and AD patients, differing from the BD group. A significant linear regression is seen between left hippocampus volume and duration since the first depressive episode. Conclusions: HippSub volume alterations were observed in AD, but not in early-onset MDD and BD, reinforcing the notion of different neural mechanisms in hippocampal degeneration. Moreover, duration since the first depressive episode was a relevant factor explaining the lower left hippocampal volumes present in groups."],["dc.identifier.doi","10.3389/fnagi.2021.626974"],["dc.identifier.eissn","1663-4365"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85247"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1663-4365"],["dc.rights","http://creativecommons.org/licenses/by/4.0/"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Translational Psychiatry"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Singh, Aditya"],["dc.contributor.author","Erwin-Grabner, Tracy"],["dc.contributor.author","Sutcliffe, Grant"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.date.accessioned","2020-12-10T18:09:40Z"],["dc.date.available","2020-12-10T18:09:40Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1038/s41398-020-0754-5"],["dc.identifier.eissn","2158-3188"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17202"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73723"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Default mode network alterations after intermittent theta burst stimulation in healthy subjects"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e94973"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Schilbach, Leonhard"],["dc.contributor.author","Müller, Veronika I."],["dc.contributor.author","Hoffstaedter, Felix"],["dc.contributor.author","Clos, Mareike"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Eickhoff, Simon B."],["dc.contributor.editor","Marinazzo, Daniele"],["dc.date.accessioned","2017-09-07T11:47:50Z"],["dc.date.available","2017-09-07T11:47:50Z"],["dc.date.issued","2014"],["dc.description.abstract","Alterations of social cognition and dysfunctional interpersonal expectations are thought to play an important role in the etiology of depression and have, thus, become a key target of psychotherapeutic interventions. The underlying neurobiology, however, remains elusive. Based upon the idea of a close link between affective and introspective processes relevant for social interactions and alterations thereof in states of depression, we used a meta-analytically informed network analysis to investigate resting-state functional connectivity in an introspective socio-affective (ISA) network in individuals with and without depression. Results of our analysis demonstrate significant differences between the groups with depressed individuals showing hyperconnectivity of the ISA network. These findings demonstrate that neurofunctional alterations exist in individuals with depression in a neural network relevant for introspection and socio-affective processing, which may contribute to the interpersonal difficulties that are linked to depressive symptomatology."],["dc.identifier.doi","10.1371/journal.pone.0094973"],["dc.identifier.gro","3150741"],["dc.identifier.pmid","24759619"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11609"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7531"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","public"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Meta-Analytically Informed Network Analysis of Resting State fMRI Reveals Hyperconnectivity in an Introspective Socio-Affective Network in Depression"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","806"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Molecular Psychiatry"],["dc.bibliographiccitation.lastpage","812"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Schmaal, L."],["dc.contributor.author","Veltman, D. J."],["dc.contributor.author","Erp, T. G. M. van"],["dc.contributor.author","Sämann, P. G."],["dc.contributor.author","Frodl, T."],["dc.contributor.author","Jahanshad, N."],["dc.contributor.author","Loehrer, E."],["dc.contributor.author","Tienson, H."],["dc.contributor.author","Hofman, A."],["dc.contributor.author","Niessen, W. J."],["dc.contributor.author","Vernooij, M. W."],["dc.contributor.author","Ikram, M. A."],["dc.contributor.author","Wittfeld, K."],["dc.contributor.author","Grabe, H. J."],["dc.contributor.author","Block, A."],["dc.contributor.author","Hegenscheid, K."],["dc.contributor.author","Völzke, H."],["dc.contributor.author","Hoehn, D."],["dc.contributor.author","Czisch, M."],["dc.contributor.author","Lagopoulos, J."],["dc.contributor.author","Hatton, S. N."],["dc.contributor.author","Hickie, I. B."],["dc.contributor.author","Goya-Maldonado, R."],["dc.contributor.author","Krämer, B."],["dc.contributor.author","Gruber, O."],["dc.contributor.author","Couvy-Duchesne, B."],["dc.contributor.author","Renteria, M. E."],["dc.contributor.author","Strike, L. T."],["dc.contributor.author","Mills, N. T."],["dc.contributor.author","Zubicaray, G. I. de"],["dc.contributor.author","McMahon, K. L."],["dc.contributor.author","Medland, S. E."],["dc.contributor.author","Martin, N. G."],["dc.contributor.author","Gillespie, N. A."],["dc.contributor.author","Wright, M. J."],["dc.contributor.author","Hall, G. B."],["dc.contributor.author","MacQueen, G. M."],["dc.contributor.author","Frey, E. M."],["dc.contributor.author","Carballedo, A."],["dc.contributor.author","van Velzen, L. S."],["dc.contributor.author","Tol, M.-J. van"],["dc.contributor.author","Wee, N. J. A. van der"],["dc.contributor.author","Veer, I. M."],["dc.contributor.author","Walter, H."],["dc.contributor.author","Schnell, K."],["dc.contributor.author","Schramm, E."],["dc.contributor.author","Normann, C."],["dc.contributor.author","Schoepf, D."],["dc.contributor.author","Konrad, C."],["dc.contributor.author","Zurowski, B."],["dc.contributor.author","Nickson, T."],["dc.contributor.author","McIntosh, A. M."],["dc.contributor.author","Papmeyer, M."],["dc.contributor.author","Whalley, H. C."],["dc.contributor.author","Sussmann, J. E."],["dc.contributor.author","Godlewska, B. R."],["dc.contributor.author","Cowen, P. J."],["dc.contributor.author","Fischer, F. H."],["dc.contributor.author","Rose, M."],["dc.contributor.author","Penninx, B. W. J. H."],["dc.contributor.author","Thompson, P. M."],["dc.contributor.author","Hibar, D. P."],["dc.date.accessioned","2017-09-07T11:47:51Z"],["dc.date.available","2017-09-07T11:47:51Z"],["dc.date.issued","2015"],["dc.description.abstract","The pattern of structural brain alterations associated with major depressive disorder (MDD) remains unresolved. This is in part due to small sample sizes of neuroimaging studies resulting in limited statistical power, disease heterogeneity and the complex interactions between clinical characteristics and brain morphology. To address this, we meta-analyzed three-dimensional brain magnetic resonance imaging data from 1728 MDD patients and 7199 controls from 15 research samples worldwide, to identify subcortical brain volumes that robustly discriminate MDD patients from healthy controls. Relative to controls, patients had significantly lower hippocampal volumes (Cohen's d=-0.14, % difference=-1.24). This effect was driven by patients with recurrent MDD (Cohen's d=-0.17, % difference=-1.44), and we detected no differences between first episode patients and controls. Age of onset ⩽21 was associated with a smaller hippocampus (Cohen's d=-0.20, % difference=-1.85) and a trend toward smaller amygdala (Cohen's d=-0.11, % difference=-1.23) and larger lateral ventricles (Cohen's d=0.12, % difference=5.11). Symptom severity at study inclusion was not associated with any regional brain volumes. Sample characteristics such as mean age, proportion of antidepressant users and proportion of remitted patients, and methodological characteristics did not significantly moderate alterations in brain volumes in MDD. Samples with a higher proportion of antipsychotic medication users showed larger caudate volumes in MDD patients compared with controls. This currently largest worldwide effort to identify subcortical brain alterations showed robust smaller hippocampal volumes in MDD patients, moderated by age of onset and first episode versus recurrent episode status."],["dc.identifier.doi","10.1038/mp.2015.69"],["dc.identifier.gro","3150737"],["dc.identifier.pmid","26122586"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12869"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7526"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.issn","1359-4184"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.contributor.author","Komorowski, Arkadiusz"],["dc.contributor.author","Murgaš, Matej"],["dc.contributor.author","Vidal, Ramon"],["dc.contributor.author","Singh, Aditya"],["dc.contributor.author","Gryglewski, Gregor"],["dc.contributor.author","Kasper, Siegfried"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Lanzenberger, Rupert"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.date.accessioned","2022-08-11T12:45:29Z"],["dc.date.available","2022-08-11T12:45:29Z"],["dc.date.issued","2022-07-07"],["dc.description.abstract","The exploration of the spatial relationship between gene expression profiles and task-evoked response patterns known to be altered in neuropsychiatric disorders, for example depression, can guide the development of more targeted therapies. Here, we estimated the correlation between human transcriptome data and two different brain activation maps measured with functional magnetic resonance imaging (fMRI) in healthy subjects. Whole-brain activation patterns evoked during an emotional face recognition task were associated with topological mRNA expression of genes involved in cellular transport. In contrast, fMRI activation patterns related to the acceptance of monetary rewards were associated with genes implicated in cellular localization processes, metabolism, translation, and synapse regulation. An overlap of these genes with risk genes from major depressive disorder genome-wide association studies revealed the involvement of the master regulators TCF4 and PAX6 in emotion and reward processing. Overall, the identification of stable relationships between spatial gene expression profiles and fMRI data may reshape the prospects for imaging transcriptomics studies."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.1002/hbm.26001"],["dc.identifier.pmid","35796185"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112712"],["dc.language.iso","en"],["dc.relation.eissn","1097-0193"],["dc.relation.issn","1065-9471"],["dc.relation.issn","1097-0193"],["dc.rights","CC BY 4.0"],["dc.title","Regional gene expression patterns are associated with task-specific brain activation during reward and emotion processing measured with functional MRI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","acps.13502"],["dc.bibliographiccitation.firstpage","540"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Acta Psychiatrica Scandinavica"],["dc.bibliographiccitation.lastpage","556"],["dc.bibliographiccitation.volume","146"],["dc.contributor.affiliation","Wilkening, Jonas; 1\r\nLaboratory of Systems Neuroscience and Imaging in Psychiatry (SNIP‐Lab), Department of Psychiatry and Psychotherapy\r\nUniversity Medical Center Göttingen (UMG)\r\nGöttingen Germany"],["dc.contributor.affiliation","Witteler, Fabian; 1\r\nLaboratory of Systems Neuroscience and Imaging in Psychiatry (SNIP‐Lab), Department of Psychiatry and Psychotherapy\r\nUniversity Medical Center Göttingen (UMG)\r\nGöttingen Germany"],["dc.contributor.author","Wilkening, Jonas"],["dc.contributor.author","Witteler, Fabian"],["dc.contributor.author","Goya‐Maldonado, Roberto"],["dc.date.accessioned","2022-11-28T08:47:31Z"],["dc.date.available","2022-11-28T08:47:31Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-27T10:10:42Z"],["dc.description.abstract","Abstract\r\n\r\nObjectives\r\nSuicidality is a serious public health problem and is closely associated with the severity of depression. In this work, we examined the effects of accelerated intermittent theta burst stimulation (iTBS) on suicidal status, risk factors for suicide, and severity of depressive symptoms in subjects with major depressive disorder (MDD).\r\n\r\n\r\nMethods\r\nWe present data from a quadruple‐blind (patient, care provider, investigator, rater) sham‐controlled crossover randomized clinical trial. During a 6‐week observation period, each participant underwent 2 weeks of stimulation ‐ each week with 20 sessions of active or sham iTBS. A suicide score was created using a composite of individual items from Montgomery–Åsberg Depression Scale (MADRS), Hamilton Depression Scale, and Beck Depression Inventory. The severity of depression was determined by MADRS total scores. In addition, we used demographic and Columbia Suicidality Rating Scale information to assess suicide risk.\r\n\r\n\r\nResults\r\nAmong 81 participants, we observed a significant reduction in suicidality and this change was positively correlated with a change in depressive symptoms. A significant difference between active and sham iTBS provided evidence for antidepressant effects. Higher changes in levels of anxiety and impulsiviness also correlated with larger changes in suicidality.\r\n\r\n\r\nConclusions\r\nAs neither suicide nor other serious adverse events were evidenced, this intervention was a safe and viable procedure to reduce suicidality and severity of depressive symptoms. Moreover, we identified more pronounced anti‐suicidal effects in those with higher risk profiles. Unlike MADRS, composite suicidal scores did not provide evidence of an effect between stimulation conditions in this crossover design study. Even so, based on our promising results, parallel and larger studies could contribute to a better characterization of the anti‐suicidal placebo effect and the benefit of using iTBS against suicidal symptoms."],["dc.description.sponsorship","German Federal Ministry of Education and Research"],["dc.identifier.doi","10.1111/acps.13502"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/117277"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.relation.eissn","1600-0447"],["dc.relation.issn","0001-690X"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited."],["dc.rights.uri","http://onlinelibrary.wiley.com/termsAndConditions#vor"],["dc.title","Suicidality and relief of depressive symptoms with intermittent theta burst stimulation in a sham‐controlled randomized clinical trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","5631"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Singh, Aditya"],["dc.contributor.author","Erwin-Grabner, Tracy"],["dc.contributor.author","Sutcliffe, Grant"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.date.accessioned","2019-07-09T11:50:48Z"],["dc.date.available","2019-07-09T11:50:48Z"],["dc.date.issued","2019"],["dc.description.abstract","High frequency repetitive transcranial magnetic stimulation (HF-rTMS) delivered to the left dorsolateral prefrontal cortex (DLPFC) is an effective treatment option for treatment resistant depression. However, the underlying mechanisms of a full session of HF-rTMS in healthy volunteers have not yet been described. Here we investigated, with a personalized selection of DLPFC stimulation sites, the effects driven by HF-rTMS in healthy volunteers (n = 23) over the default mode network (DMN) in multiple time windows. After a complete 10 Hz rTMS (3000 pulses) session, we observe a decrease of functional connectivity between the DMN and the subgenual Anterior Cingulate Cortex (sgACC), as well as the ventral striatum (vStr). A negative correlation between the magnitude of this decrease in the right sgACC and the harm avoidance domain measure from the Temperament and Character Inventory was observed. Moreover, we identify that coupling strength of right vStr with the DMN post-stimulation was proportional to a decrease in self-reports of negative mood from the Positive and Negative Affect Schedule. This shows HF-rTMS attenuates perception of negative mood in healthy recipients in agreement with the expected effects in patients. Our study, by using a personalized selection of DLPFC stimulation sites, contributes understanding the effects of a full session of rTMS approved for clinical use in depression over related brain regions in healthy volunteers."],["dc.identifier.doi","10.1038/s41598-019-42067-3"],["dc.identifier.pmid","30948765"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16005"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59835"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Personalized repetitive transcranial magnetic stimulation temporarily alters default mode network in healthy subjects"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","326"],["dc.bibliographiccitation.journal","NeuroImage: Clinical"],["dc.bibliographiccitation.lastpage","335"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Schilbach, Leonhard"],["dc.contributor.author","Hoffstaedter, F."],["dc.contributor.author","Müller, V."],["dc.contributor.author","Cieslik, E.C."],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Sorg, Christian"],["dc.contributor.author","Riedl, Valentin"],["dc.contributor.author","Jardri, R."],["dc.contributor.author","Sommer, Jan Henning"],["dc.contributor.author","Kogler, L."],["dc.contributor.author","Derntl, B."],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Eickhoff, Simon B."],["dc.date.accessioned","2017-09-07T11:47:52Z"],["dc.date.available","2017-09-07T11:47:52Z"],["dc.date.issued","2015"],["dc.description.abstract","Schizophrenia and depression are prevalent psychiatric disorders, but their underlying neural bases remains poorly understood. Neuroimaging evidence has pointed towards the relevance of functional connectivity aberrations in default mode network (DMN) hubs, dorso-medial prefrontal cortex and precuneus, in both disorders, but commonalities and differences in resting state functional connectivity of those two regions across disorders has not been formally assessed. Here, we took a transdiagnostic approach to investigate resting state functional connectivity of those two regions in 75 patients with schizophrenia and 82 controls from 4 scanning sites and 102 patients with depression and 106 controls from 3 sites. Our results demonstrate common dysconnectivity patterns as indexed by a significant reduction of functional connectivity between precuneus and bilateral superior parietal lobe in schizophrenia and depression. Furthermore, our findings highlight diagnosis-specific connectivity reductions of the parietal operculum in schizophrenia relative to depression. In light of evidence that points towards the importance of the DMN for social cognitive abilities and well documented impairments of social interaction in both patient groups, it is conceivable that the observed transdiagnostic connectivity alterations may contribute to interpersonal difficulties, but this could not be assessed directly in our study as measures of social behavior were not available. Given the operculum's role in somatosensory integration, diagnosis-specific connectivity reductions may indicate a pathophysiological mechanism for basic self-disturbances that is characteristic of schizophrenia, but not depression."],["dc.identifier.doi","10.1016/j.nicl.2015.11.021"],["dc.identifier.gro","3150739"],["dc.identifier.pmid","26904405"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13320"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7528"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","public"],["dc.relation.issn","2213-1582"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.subject","Default mode network; Major depression; Resting state functional connectivity; Schizophrenia; Transdiagnostic analysis; fMRI"],["dc.title","Transdiagnostic commonalities and differences in resting state functional connectivity of the default mode network in schizophrenia and major depression"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","172"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Creativity Research Journal"],["dc.bibliographiccitation.lastpage","178"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Brodmann, Katja"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2019-11-18T13:04:52Z"],["dc.date.accessioned","2021-10-27T13:21:29Z"],["dc.date.available","2019-11-18T13:04:52Z"],["dc.date.available","2021-10-27T13:21:29Z"],["dc.date.issued","2018"],["dc.description.abstract","creativity, reward, artist, fMRI"],["dc.description.abstract","Humans possess an invaluable ability of self-expression that extends into visual, literary, musical and many other fields of creation. More than any other profession, artists are in close contact with this subdomain of creativity. Probably one of the most intriguing aspects of creativity is its negative correlation with the availability of monetary reward. With this study we aimed to investigate the reactivity of the dopaminergic reward system in artists and non-artist controls using the desire-reason-dilemma (DRD) paradigm, which allows separate evaluation of reactivity to the acceptance and rejection of rewards. Using fMRI, we measured blood-oxygen-level-dependent (BOLD) responses in key regions of the reward system, namely the ventral striatum (VS), the ventral tegmental area (VTA), and the anterior ventral prefrontal cortex (AVPFC). In contrast to controls, artists presented significantly weaker VS activation in reward acceptance. Additionally, they showed stronger suppression of the VS by the AVPFC in reward rejection. No other differences in demographic or behavioral data were evidenced. These results support the existence of characteristic neural traits in artists, who display reduced reactions to monetary reward acceptance and increased reactions to monetary reward rejection."],["dc.identifier.doi","10.1080/10400419.2018.1414994"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16683"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92025"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.haserratum","/handle/2/74688"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Reactivity of the reward system in artists during acceptance and rejection of monetary rewards"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","submitted_version"],["dspace.entity.type","Publication"]]