Fuchs, Eberhard

[["dc.bibliographiccitation.firstpage","33"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Psychoneuroendocrinology"],["dc.bibliographiccitation.lastpage","51"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Flügge, Gabriele"],["dc.date.accessioned","2022-10-06T13:32:51Z"],["dc.date.available","2022-10-06T13:32:51Z"],["dc.date.issued","1995"],["dc.identifier.doi","10.1016/0306-4530(94)E0006-U"],["dc.identifier.pii","0306453094E0006U"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115473"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0306-4530"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Modulation of binding sites for corticotropin-releasing hormone by chronic psychosocial stress"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","557"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Psychoneuroendocrinology"],["dc.bibliographiccitation.lastpage","565"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Johren, O."],["dc.contributor.author","Flugge, G."],["dc.date.accessioned","2022-10-06T13:32:51Z"],["dc.date.available","2022-10-06T13:32:51Z"],["dc.date.issued","1993"],["dc.identifier.doi","10.1016/0306-4530(93)90033-H"],["dc.identifier.pii","030645309390033H"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115472"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0306-4530"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Psychosocial conflict in the tree shrew: Effects on sympathoadrenal activity and blood pressure"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","417"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Physiology & Behavior"],["dc.bibliographiccitation.lastpage","427"],["dc.bibliographiccitation.volume","79"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Flügge, Gabriele"],["dc.date.accessioned","2022-10-06T13:33:43Z"],["dc.date.available","2022-10-06T13:33:43Z"],["dc.date.issued","2003"],["dc.identifier.doi","10.1016/S0031-9384(03)00161-6"],["dc.identifier.pii","S0031938403001616"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115712"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0031-9384"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Chronic social stress: effects on limbic brain structures"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","247"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Pharmacology Biochemistry and Behavior"],["dc.bibliographiccitation.lastpage","258"],["dc.bibliographiccitation.volume","73"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Flügge, Gabriele"],["dc.date.accessioned","2022-10-06T13:33:46Z"],["dc.date.available","2022-10-06T13:33:46Z"],["dc.date.issued","2002"],["dc.identifier.doi","10.1016/S0091-3057(02)00795-5"],["dc.identifier.pii","S0091305702007955"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115722"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0091-3057"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Social stress in tree shrews"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e3659"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Cooper, Ben"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Fluegge, Gabriele"],["dc.date.accessioned","2018-11-07T08:33:25Z"],["dc.date.available","2018-11-07T08:33:25Z"],["dc.date.issued","2009"],["dc.description.abstract","It has been repeatedly shown that chronic stress changes dendrites, spines and modulates expression of synaptic molecules. These effects all may impair information transfer between neurons. The present study shows that chronic stress also regulates expression of M6a, a glycoprotein which is localised in axonal membranes. We have previously demonstrated that M6a is a component of glutamatergic axons. The present data reveal that it is the splice variant M6a-Ib, not M6a-Ia, which is strongly expressed in the brain. Chronic stress in male rats (3 weeks daily restraint) has regional effects: quantitative in situ hybridization demonstrated that M6a-Ib mRNA in dentate gyrus granule neurons and in CA3 pyramidal neurons is downregulated, whereas M6a-Ib mRNA in the medial prefrontal cortex is upregulated by chronic stress. This is the first study showing that expression of an axonal membrane molecule is differentially affected by stress in a region-dependent manner. Therefore, one may speculate that diminished expression of the glycoprotein in the hippocampus leads to altered output in the corresponding cortical projection areas. Enhanced M6a-Ib expression in the medial prefrontal cortex (in areas prelimbic and infralimbic cortex) might be interpreted as a compensatory mechanism in response to changes in axonal projections from the hippocampus. Our findings provide evidence that in addition to alterations in dendrites and spines chronic stress also changes the integrity of axons and may thus impair information transfer even between distant brain regions."],["dc.identifier.doi","10.1371/journal.pone.0003659"],["dc.identifier.isi","000265483100001"],["dc.identifier.pmid","19180239"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5822"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17571"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","Expression of the Axonal Membrane Glycoprotein M6a Is Regulated by Chronic Stress"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1071"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","1078"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Isovich, Eleonora"],["dc.contributor.author","Mijnster, M. Janneke"],["dc.contributor.author","Flügge, Gabriele"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2022-10-06T13:34:26Z"],["dc.date.available","2022-10-06T13:34:26Z"],["dc.date.issued","2001"],["dc.identifier.doi","10.1046/j.1460-9568.2000.00969.x"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115907"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0953-816X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Chronic psychosocial stress reduces the density of dopamine transporters"],["dc.title.alternative","Chronic stress and dopamine transporters"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","121"],["dc.bibliographiccitation.issue","2-3"],["dc.bibliographiccitation.journal","Neuroscience Letters"],["dc.bibliographiccitation.lastpage","124"],["dc.bibliographiccitation.volume","233"],["dc.contributor.author","Vollmann-Honsdorf, Gesa K"],["dc.contributor.author","Flügge, Gabriele"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2022-10-06T13:33:52Z"],["dc.date.available","2022-10-06T13:33:52Z"],["dc.date.issued","1997"],["dc.identifier.doi","10.1016/S0304-3940(97)00647-2"],["dc.identifier.pii","S0304394097006472"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115757"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0304-3940"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Chronic psychosocial stress does not affect the number of pyramidal neurons in tree shrew hippocampus"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","31"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Cell and Tissue Research"],["dc.bibliographiccitation.lastpage","41"],["dc.bibliographiccitation.volume","357"],["dc.contributor.author","Fluegge, Gabriele"],["dc.contributor.author","Araya-Callis, Carolina"],["dc.contributor.author","Garea-Rodriguez, Enrique"],["dc.contributor.author","Stadelmann-Nessler, Christine"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2018-11-07T09:38:14Z"],["dc.date.available","2018-11-07T09:38:14Z"],["dc.date.issued","2014"],["dc.description.abstract","The protein NDRG2 (N-myc downregulated gene 2) is expressed in astrocytes. We show here that NDRG2 is located in the cytosol of protoplasmic and fibrous astrocytes throughout the mammalian brain, including Bergmann glia as observed in mouse, rat, tree shrew, marmoset and human. NDRG2 immunoreactivity is detectable in the astrocytic cell bodies and excrescencies including fine distal processes. Glutamatergic and GABAergic nerve terminals are associated with NDRG2 immunopositive astrocytic processes. Muller glia in the retina displays no NDRG2 immunoreactivity. NDRG2 positive astrocytes are more abundant and more evenly distributed in the brain than GFAP (glial fibrillary acidic protein) immunoreactive cells. Some regions with very little GFAP such as the caudate nucleus show pronounced NDRG2 immunoreactivity. In white matter areas, NDRG2 is less strong than GFAP labeling. Most NDRG2 positive somata are immunoreactive for S100 but not all S100 cells express NDRG2. NDRG2 positive astrocytes do not express nestin and NG2 (chondroitin sulfate proteoglycan 4). The localization of NDRG2 overlaps only partially with that of aquaporin 4, the membrane-bound water channel that is concentrated in the astrocytic endfeet. Reactive astrocytes at a cortical lesion display very little NDRG2, which indicates that expression of the protein is reduced in reactive astrocytes. In conclusion, our data show that NDRG2 is a specific marker for a large population of mature, non-reactive brain astrocytes. Visualization of NDRG2 immunoreactive structures may serve as a reliable tool for quantitative studies on numbers of astrocytes in distinct brain regions and for high-resolution microscopy studies on distal astrocytic processes."],["dc.identifier.doi","10.1007/s00441-014-1837-5"],["dc.identifier.isi","000338759900003"],["dc.identifier.pmid","24816982"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10233"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33027"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-0878"],["dc.relation.issn","0302-766X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","NDRG2 as a marker protein for brain astrocytes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Behavioural Brain Research"],["dc.bibliographiccitation.lastpage","13"],["dc.bibliographiccitation.volume","190"],["dc.contributor.author","Czeh, Boldizsar"],["dc.contributor.author","Perez-Cruz, Claudia"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Fluegge, Gabriele"],["dc.date.accessioned","2018-11-07T11:13:53Z"],["dc.date.available","2018-11-07T11:13:53Z"],["dc.date.issued","2008"],["dc.description.abstract","The prefrontal cortex (PFC) is implicated in a number of higher cognitive functions as well as processing emotions and regulation of stress responses. Hemispheric specialization of the PFC in humans in emotional processing is well documented, and there is evidence that a similar functional lateralization is present in all mammals. Recent findings suggest the possibility of an intrinsic structural hemispheric asymmetry in the rat medial PFC (mPFC). Specifically, interhemispheric differences have been found in the architecture of pyramidal cell apical dendritic trees together with hemispheric asymmetry in cell proliferation including gliogenesis. It is now well established that chronic stress has a profound impact on neural plasticity in a number of corticolimbic structures and affects the etiology, pathophysiology, and therapeutic outcome of most psychiatric disorders. We summarize recent experimental data documenting pronounced dendritic remodeling of pyramidal cells and suppressed gliogenesis in the mPFC of rats subjected to chronic stress or to artificially elevated glucocorticoid levels. The stress affect on these structural elements seems to be hemispheric specific, often abolishing or even reversing natural asymmetries seen at the cellular level. We discuss these preclinical observations with respect to clinical findings that show impaired function, altered lateralization and histopathological changes in the PFC in psychiatric patients. We argue that it is important to define the kinds of structural changes that result from long-term stress exposure because this knowledge will improve the identification of cellular endophenotypes in various psychiatric disorders. (c) 2008 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.bbr.2008.02.031"],["dc.identifier.isi","000255766800001"],["dc.identifier.pmid","18384891"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54000"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0166-4328"],["dc.title","Chronic stress-induced cellular changes in the medial prefrontal cortex and their potential clinical implications: Does hemisphere location matter?"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","396"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Stem Cells"],["dc.bibliographiccitation.lastpage","404"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Baier, Paul Christian"],["dc.contributor.author","Schindehutte, J."],["dc.contributor.author","Thinyane, K."],["dc.contributor.author","Flugge, G."],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Mansouri, Ahmed"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Gruss, P."],["dc.contributor.author","Trenkwalder, Claudia"],["dc.date.accessioned","2018-11-07T10:53:15Z"],["dc.date.available","2018-11-07T10:53:15Z"],["dc.date.issued","2004"],["dc.description.abstract","Objective. Transplantation of fetal mesencephalic cells into the striatum has been performed in about 350 patients with Parkinson's disease and has been intensively studied in rat models of Parkinson's disease. Limited access to this material has shifted the focus toward embryonic stem (ES) cells. The grafting of undifferentiated ES cells to 6-hydroxy-dopamine (6-OHDA)-lesioned rats leads to behavioral improvements but may induce teratoma-like structures. This risk might be avoided by using more differentiated ES cells. In this study, we aimed to investigate differentiated mouse ES cells regarding their in vivo development and fate after transplantation in the striatum in the 6-OHDA rat model and the behavioral changes induced after transplantation. Methods. Mouse ES cells were differentiated on PA6 feeder cells for 14 days before grafting. Twenty to twenty-five percent of the neurons obtained were positive for tyrosine-hydroxylase (TH). PKH26-labeled cells were transplanted in the striata of unilaterally 6-OHDA-lesioned rats. Results. Direct PKH26 fluorescence visualization and TH staining proved the existence of cell deposits in the striata of all grafted animals, indicating cell survival for at least 5 weeks posttransplantation. There was no evidence of tumor formation. Immunocytochemical staining showed glial immunoreactivity surrounding the grafted cell deposits, probably inhibiting axonal outgrowth into the surrounding host tissue. There was a significant reduction in amphetamine-induced rotational behavior seen in grafted animals, which was not observed in sham-operated animals. Conclusions. The findings of this study suggest that the amphetamine-induced rotational behavioral test without histological confirmation is not proof of morphological integration with axonal outgrowth within the first 4 weeks posttransplantation."],["dc.identifier.doi","10.1634/stemcells.22-3-396"],["dc.identifier.isi","000221869600019"],["dc.identifier.pmid","15153616"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49315"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1066-5099"],["dc.title","Behavioral changes in unilaterally 6-hydroxy-dopamine lesioned rats after transplantation of differentiated mouse embryonic stem cells without morphological integration"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]