Fuchs, Eberhard

[["dc.bibliographiccitation.artnumber","315"],["dc.bibliographiccitation.journal","Frontiers in Aging Neuroscience"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Rodriguez-Callejas, Juan D."],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Perez-Cruz, Claudia"],["dc.date.accessioned","2019-07-09T11:43:04Z"],["dc.date.available","2019-07-09T11:43:04Z"],["dc.date.issued","2016"],["dc.description.abstract","Common marmosets (Callithrix jacchus) have recently gained popularity in biomedical research as models of aging research. Basically, they confer advantages from other non-human primates due to their shorter lifespan with onset of appearance of aging at 8 years. Old marmosets present some markers linked to neurodegeneration in the brain such as amyloid beta (Ab)1􀀀42 and Ab1􀀀40. However, there are no studies exploring other cellular markers associated with neurodegenerative diseases in this non-human primate. Using immunohistochemistry, we analyzed brains of male adolescent, adult, old, and aged marmosets. We observed accumulation of Ab1 and A in the 􀀀40 b1􀀀42 cortex of aged subjects. Tau hyperphosphorylation was already detected in the brain of adolescent animals and increased with aging in a more fibrillary form. Microglia activation was also observed in the aging process, while a dystrophic phenotype accumulates in aged subjects. Interestingly, dystrophic microglia contained hyperphosphorylated tau, but active microglia did not. These results support previous findings regarding microglia dysfunctionality in aging and neurodegenerative diseases as Alzheimer’s disease. Further studies should explore the functional consequences of these findings to position this non-human primate as animal model of aging and neurodegeneration."],["dc.identifier.doi","10.3389/fnagi.2016.00315"],["dc.identifier.pmid","28066237"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14119"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58818"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1663-4365"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","46276"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Neural plasticity"],["dc.bibliographiccitation.lastpage","14"],["dc.contributor.author","Perez-Cruz, Claudia"],["dc.contributor.author","Müller-Keuker, Jeanine I. H."],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Flügge, Gabriele"],["dc.date.accessioned","2019-07-09T11:52:28Z"],["dc.date.available","2019-07-09T11:52:28Z"],["dc.date.issued","2007"],["dc.description.abstract","The prefrontal cortex (PFC) plays an important role in the stress response. We filled pyramidal neurons in PFC layer III with neurobiotin and analyzed dendrites in rats submitted to chronic restraint stress and in controls. In the right prelimbic cortex (PL) of controls, apical and distal dendrites were longer than in the left PL. Stress reduced the total length of apical dendrites in right PL and abolished the hemispheric difference. In right infralimbic cortex (IL) of controls, proximal apical dendrites were longer than in left IL, and stress eliminated this hemispheric difference. No hemispheric difference was detected in anterior cingulate cortex (ACx) of controls, but stress reduced apical dendritic length in left ACx. These data demonstrate interhemispheric differences in the morphology of pyramidal neurons in PL and IL of control rats and selective effects of stress on the right hemisphere. In contrast, stress reduced dendritic length in the left ACx."],["dc.identifier.doi","10.1155/2007/46276"],["dc.identifier.fs","207216"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4359"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60197"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1687-5443"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.subject.ddc","599.8"],["dc.title","Morphology of Pyramidal Neurons in the Rat Prefrontal Cortex: Lateralized Dendritic Remodeling by Chronic Stress"],["dc.title.alternative","Research Article"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]