Fuchs, Eberhard

[["dc.bibliographiccitation.journal","Frontiers in Aging Neuroscience"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Rodriguez-Callejas, Juan D."],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Perez-Cruz, Claudia"],["dc.date.accessioned","2022-10-06T13:26:45Z"],["dc.date.available","2022-10-06T13:26:45Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.3389/fnagi.2017.00032"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115157"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1663-4365"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Corrigendum: Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","315"],["dc.bibliographiccitation.journal","Frontiers in Aging Neuroscience"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Rodriguez-Callejas, Juan D."],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Perez-Cruz, Claudia"],["dc.date.accessioned","2019-07-09T11:43:04Z"],["dc.date.available","2019-07-09T11:43:04Z"],["dc.date.issued","2016"],["dc.description.abstract","Common marmosets (Callithrix jacchus) have recently gained popularity in biomedical research as models of aging research. Basically, they confer advantages from other non-human primates due to their shorter lifespan with onset of appearance of aging at 8 years. Old marmosets present some markers linked to neurodegeneration in the brain such as amyloid beta (Ab)1􀀀42 and Ab1􀀀40. However, there are no studies exploring other cellular markers associated with neurodegenerative diseases in this non-human primate. Using immunohistochemistry, we analyzed brains of male adolescent, adult, old, and aged marmosets. We observed accumulation of Ab1 and A in the 􀀀40 b1􀀀42 cortex of aged subjects. Tau hyperphosphorylation was already detected in the brain of adolescent animals and increased with aging in a more fibrillary form. Microglia activation was also observed in the aging process, while a dystrophic phenotype accumulates in aged subjects. Interestingly, dystrophic microglia contained hyperphosphorylated tau, but active microglia did not. These results support previous findings regarding microglia dysfunctionality in aging and neurodegenerative diseases as Alzheimer’s disease. Further studies should explore the functional consequences of these findings to position this non-human primate as animal model of aging and neurodegeneration."],["dc.identifier.doi","10.3389/fnagi.2016.00315"],["dc.identifier.pmid","28066237"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14119"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58818"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1663-4365"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Behavioural Brain Research"],["dc.bibliographiccitation.lastpage","13"],["dc.bibliographiccitation.volume","190"],["dc.contributor.author","Czeh, Boldizsar"],["dc.contributor.author","Perez-Cruz, Claudia"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Fluegge, Gabriele"],["dc.date.accessioned","2018-11-07T11:13:53Z"],["dc.date.available","2018-11-07T11:13:53Z"],["dc.date.issued","2008"],["dc.description.abstract","The prefrontal cortex (PFC) is implicated in a number of higher cognitive functions as well as processing emotions and regulation of stress responses. Hemispheric specialization of the PFC in humans in emotional processing is well documented, and there is evidence that a similar functional lateralization is present in all mammals. Recent findings suggest the possibility of an intrinsic structural hemispheric asymmetry in the rat medial PFC (mPFC). Specifically, interhemispheric differences have been found in the architecture of pyramidal cell apical dendritic trees together with hemispheric asymmetry in cell proliferation including gliogenesis. It is now well established that chronic stress has a profound impact on neural plasticity in a number of corticolimbic structures and affects the etiology, pathophysiology, and therapeutic outcome of most psychiatric disorders. We summarize recent experimental data documenting pronounced dendritic remodeling of pyramidal cells and suppressed gliogenesis in the mPFC of rats subjected to chronic stress or to artificially elevated glucocorticoid levels. The stress affect on these structural elements seems to be hemispheric specific, often abolishing or even reversing natural asymmetries seen at the cellular level. We discuss these preclinical observations with respect to clinical findings that show impaired function, altered lateralization and histopathological changes in the PFC in psychiatric patients. We argue that it is important to define the kinds of structural changes that result from long-term stress exposure because this knowledge will improve the identification of cellular endophenotypes in various psychiatric disorders. (c) 2008 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.bbr.2008.02.031"],["dc.identifier.isi","000255766800001"],["dc.identifier.pmid","18384891"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54000"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0166-4328"],["dc.title","Chronic stress-induced cellular changes in the medial prefrontal cortex and their potential clinical implications: Does hemisphere location matter?"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e22956"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","American Journal of Primatology"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Rodríguez-Callejas, Juan de Dios"],["dc.contributor.author","Cuervo-Zanatta, Daniel"],["dc.contributor.author","Rosas-Arellano, Abraham"],["dc.contributor.author","Fonta, Caroline"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Perez-Cruz, Claudia"],["dc.date.accessioned","2022-10-06T13:34:05Z"],["dc.date.available","2022-10-06T13:34:05Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1002/ajp.22956"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115821"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0275-2565"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Loss of ferritin-positive microglia relates to increased iron, RNA oxidation, and dystrophic microglia in the brains of aged male marmosets"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","275"],["dc.bibliographiccitation.journal","Neuroscience"],["dc.bibliographiccitation.lastpage","286"],["dc.bibliographiccitation.volume","439"],["dc.contributor.author","Flores-Maldonado, Catalina"],["dc.contributor.author","Albino-Sánchez, M. Estela"],["dc.contributor.author","Rodríguez-Callejas, Juan D."],["dc.contributor.author","Estrada-Mondragon, Argel"],["dc.contributor.author","León-Galicia, Ismael"],["dc.contributor.author","Maqueda-Alfaro, Raúl"],["dc.contributor.author","Perez-Cruz, Claudia"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","García-Carrancá, Alejandro"],["dc.contributor.author","Contreras, Rubén G."],["dc.contributor.author","Rosas-Arellano, Abraham"],["dc.date.accessioned","2022-10-06T13:33:20Z"],["dc.date.available","2022-10-06T13:33:20Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.neuroscience.2020.01.009"],["dc.identifier.pii","S0306452220300221"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115609"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0306-4522"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","A Low Cost Antibody Signal Enhancer Improves Immunolabeling in Cell Culture, Primate Brain and Human Cancer Biopsy"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","738"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","747"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Perez-Cruz, Claudia"],["dc.contributor.author","Simon, Maria"],["dc.contributor.author","Czeh, Boldizsar"],["dc.contributor.author","Fluegge, Gabriele"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2018-11-07T08:33:00Z"],["dc.date.available","2018-11-07T08:33:00Z"],["dc.date.issued","2009"],["dc.description.abstract","Pyramidal neurons of the rat medial prefrontal cortex have been shown to react to chronic stress by retracting their apical dendrites and by spine loss. We extended these findings by focusing on the basilar dendritic tree of layer III pyramidal neurons in both hemispheres of the rat prelimbic cortex. Animals were subjected to daily restraint stress for 1 week (6 h/day), during either the resting or the activity period. The morphology of basilar dendrites and spines of Golgi-Cox-stained neurons in the left and right hemispheres was digitally reconstructed and analyzed. We observed the following: (i) there was an inherent hemispheric asymmetry in control rats during the resting period: the number of spines on proximal dendrites was higher in the left than in the right hemisphere; (ii) basal dendrites in controls displayed a diurnal variation: there was more dendritic material during the resting period than in the activity period; (iii) chronic stress reduced the length of basal dendrites in only the right prelimbic cortex; (iv) chronic stress reduced spine density on proximal basal dendrites; (v) restraint stress during the activity period had more pronounced effects on the physiological stress parameters than restraint stress during the resting period. Our results show dynamic hemisphere-dependent structural changes in pyramidal neurons of the rat prelimbic cortex that are tightly linked to periods of resting and activity. These morphological alterations reflect the capacity of the neurons to react to external stimuli and mirror presumptive changes in neuronal communication."],["dc.identifier.doi","10.1111/j.1460-9568.2009.06622.x"],["dc.identifier.isi","000263451700008"],["dc.identifier.pmid","19200065"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17466"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","0953-816X"],["dc.title","Hemispheric differences in basilar dendrites and spines of pyramidal neurons in the rat prelimbic cortex: activity- and stress-induced changes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","46276"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Neural plasticity"],["dc.bibliographiccitation.lastpage","14"],["dc.contributor.author","Perez-Cruz, Claudia"],["dc.contributor.author","Müller-Keuker, Jeanine I. H."],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Flügge, Gabriele"],["dc.date.accessioned","2019-07-09T11:52:28Z"],["dc.date.available","2019-07-09T11:52:28Z"],["dc.date.issued","2007"],["dc.description.abstract","The prefrontal cortex (PFC) plays an important role in the stress response. We filled pyramidal neurons in PFC layer III with neurobiotin and analyzed dendrites in rats submitted to chronic restraint stress and in controls. In the right prelimbic cortex (PL) of controls, apical and distal dendrites were longer than in the left PL. Stress reduced the total length of apical dendrites in right PL and abolished the hemispheric difference. In right infralimbic cortex (IL) of controls, proximal apical dendrites were longer than in left IL, and stress eliminated this hemispheric difference. No hemispheric difference was detected in anterior cingulate cortex (ACx) of controls, but stress reduced apical dendritic length in left ACx. These data demonstrate interhemispheric differences in the morphology of pyramidal neurons in PL and IL of control rats and selective effects of stress on the right hemisphere. In contrast, stress reduced dendritic length in the left ACx."],["dc.identifier.doi","10.1155/2007/46276"],["dc.identifier.fs","207216"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4359"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60197"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1687-5443"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.subject.ddc","599.8"],["dc.title","Morphology of Pyramidal Neurons in the Rat Prefrontal Cortex: Lateralized Dendritic Remodeling by Chronic Stress"],["dc.title.alternative","Research Article"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","406"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Behavioural Brain Research"],["dc.bibliographiccitation.lastpage","413"],["dc.bibliographiccitation.volume","205"],["dc.contributor.author","Perez-Cruz, Claudia"],["dc.contributor.author","Simon, Maria"],["dc.contributor.author","Fluegge, Gabriele"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Czeh, Boldizsar"],["dc.date.accessioned","2018-11-07T11:21:01Z"],["dc.date.available","2018-11-07T11:21:01Z"],["dc.date.issued","2009"],["dc.description.abstract","The medial prefrontal cortex (mPFC) participates in several higher order cognitive functions and is involved in the regulation of the stress response. The infralimbic cortex (ILC), the most ventral part of the mPFC, receives a strong afferent input from the master circadian pacemaker, the suprachiasmatic nucleus. This fact raises the possibility that, similarly to stress. the diurnal rhythm may affect structural plasticity of neurons in the ILC. Here we investigated, whether diurnal changes in combination with immobilization stress have any impact on the dendritic morphology of layer III pyramidal neurons in the ILC. Prefrontal cortices were collected from control rats at two different time points of the diurnal cycle (12 h apart), and from rats exposed to 1-week of daily restraint stress either during their active or resting period. Dendritic architecture and spine density of Golgi-Cox stained neurons were digitally reconstructed and analyzed. We found that in control rats during the active period, the basilar dendrites were always longer and more complex, and had more spines than during the resting period. Similar although less pronounced diurnal differences exist in the apical dendrites Stress affected dendritic architecture in a way that the diurnal differences either disappeared or became reduced in their magnitude Our findings indicate that the diurnal rhythm has a unique impact on the structural plasticity of pyramidal cells in the ILC and that stress interferes with this form of neuroplasticity. (C) 2009 Elsevier B V. All rights reserved."],["dc.identifier.doi","10.1016/j.bbr.2009.07.021"],["dc.identifier.isi","000271253100013"],["dc.identifier.pmid","19643147"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55678"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0166-4328"],["dc.title","Diurnal rhythm and stress regulate dendritic architecture and spine density of pyramidal neurons in the rat infralimbic cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]