Reichl, Lars

[["dc.bibliographiccitation.firstpage","208"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","220"],["dc.bibliographiccitation.volume","390"],["dc.contributor.author","Zhang, Yujun"],["dc.contributor.author","Kong, Deqing"],["dc.contributor.author","Reichl, Lars"],["dc.contributor.author","Vogt, Nina"],["dc.contributor.author","Wolf, Fred"],["dc.contributor.author","Großhans, Jörg"],["dc.date.accessioned","2017-09-07T11:45:40Z"],["dc.date.available","2017-09-07T11:45:40Z"],["dc.date.issued","2014"],["dc.description.abstract","The majority of membrane and secreted proteins, including many developmentally important signalling proteins, receptors and adhesion molecules, are cotranslationally N-glycosylated in the endoplasmic reticulum. The structure of the N-glycan is invariant for all substrates and conserved in eukaryotes. Correspondingly, the enzymes are conserved, which successively assemble the glycan precursor from activated monosaccharides prior to transfer to nascent proteins. Despite the well-defined biochemistry, the physiological and developmental role of N-glycosylation and of the responsible enzymes has not been much investigated in metazoa. We identified a mutation in the Drosophila gene, xiantuan (xit, CG4542), which encodes one of the conserved enzymes involved in addition of the terminal glucose residues to the glycan precursor. xit is required for timely apical constriction of mesoderm precursor cells and ventral furrow formation in early embryogenesis. Furthermore, cell intercalation in the lateral epidermis during germband extension is impaired in xit mutants. xit affects glycosylation and intracellular distribution of E-Cadherin, albeit not the total amount of E-Cadherin protein. As depletion of E-Cadherin by RNAi induces a similar cell intercalation defect, E-Cadherin may be the major xit target that is functionally relevant for germband extension."],["dc.identifier.doi","10.1016/j.ydbio.2014.03.007"],["dc.identifier.gro","3151839"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11361"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8666"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","public"],["dc.notes.submitter","chake"],["dc.relation.issn","0012-1606"],["dc.rights","CC BY-NC-ND 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/3.0"],["dc.title","The glucosyltransferase Xiantuan of the endoplasmic reticulum specifically affects E-Cadherin expression and is required for gastrulation movements in Drosophila"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e1002466"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","PLoS Computational Biology"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Reichl, Lars"],["dc.contributor.author","Heide, Dominik"],["dc.contributor.author","Löwel, Siegrid"],["dc.contributor.author","Crowley, Justin C."],["dc.contributor.author","Kaschube, Matthias"],["dc.contributor.author","Wolf, Fred"],["dc.date.accessioned","2017-09-07T11:46:12Z"],["dc.date.available","2017-09-07T11:46:12Z"],["dc.date.issued","2012"],["dc.description.abstract","In the primary visual cortex of primates and carnivores, functional architecture can be characterized by maps of various stimulus features such as orientation preference (OP), ocular dominance (OD), and spatial frequency. It is a long-standing question in theoretical neuroscience whether the observed maps should be interpreted as optima of a specific energy functional that summarizes the design principles of cortical functional architecture. A rigorous evaluation of this optimization hypothesis is particularly demanded by recent evidence that the functional architecture of orientation columns precisely follows species invariant quantitative laws. Because it would be desirable to infer the form of such an optimization principle from the biological data, the optimization approach to explain cortical functional architecture raises the following questions: i) What are the genuine ground states of candidate energy functionals and how can they be calculated with precision and rigor? ii) How do differences in candidate optimization principles impact on the predicted map structure and conversely what can be learned about a hypothetical underlying optimization principle from observations on map structure? iii) Is there a way to analyze the coordinated organization of cortical maps predicted by optimization principles in general? To answer these questions we developed a general dynamical systems approach to the combined optimization of visual cortical maps of OP and another scalar feature such as OD or spatial frequency preference. From basic symmetry assumptions we obtain a comprehensive phenomenological classification of possible inter-map coupling energies and examine representative examples. We show that each individual coupling energy leads to a different class of OP solutions with different correlations among the maps such that inferences about the optimization principle from map layout appear viable. We systematically assess whether quantitative laws resembling experimental observations can result from the coordinated optimization of orientation columns with other feature maps."],["dc.identifier.doi","10.1371/journal.pcbi.1002466"],["dc.identifier.gro","3151847"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8433"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8676"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","public"],["dc.notes.submitter","chake"],["dc.relation.issn","1553-7358"],["dc.relation.orgunit","Fakultät für Physik"],["dc.rights","CC BY 2.5"],["dc.rights.uri","http://creativecommons.org/licenses/by/2.5/"],["dc.title","Coordinated Optimization of Visual Cortical Maps (I) Symmetry-based Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","20"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","102"],["dc.contributor.author","Reichl, Lars"],["dc.contributor.author","Löwel, Siegrid"],["dc.contributor.author","Wolf, Fred"],["dc.date.accessioned","2017-09-07T11:46:20Z"],["dc.date.available","2017-09-07T11:46:20Z"],["dc.date.issued","2009"],["dc.description.abstract","We present an analytical approach for studying the coupled development of ocular dominance and orientation preference columns. Using this approach we demonstrate that ocular dominance segregation can induce the stabilization and even the production of pinwheels by their crystallization in two types of periodic lattices. Pinwheel crystallization depends on the overall dominance of one eye over the other, a condition that is fulfilled during early cortical development. Increasing the strength of intermap coupling induces a transition from pinwheel-free stripe solutions to intermediate and high pinwheel density states."],["dc.identifier.doi","10.1103/physrevlett.102.208101"],["dc.identifier.gro","3151891"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8723"],["dc.language.iso","en"],["dc.notes.status","public"],["dc.notes.submitter","chake"],["dc.relation.issn","0031-9007"],["dc.title","Pinwheel Stabilization by Ocular Dominance Segregation"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Wolf, F."],["dc.contributor.author","Reichl, L."],["dc.contributor.author","Loewel, S."],["dc.date.accessioned","2017-11-21T14:18:16Z"],["dc.date.available","2017-11-21T14:18:16Z"],["dc.date.issued","2008"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/10156"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eventend","2008-11-19"],["dc.relation.eventlocation","Washington D.C."],["dc.relation.eventstart","2008-11-15"],["dc.title","Contralateral eye dominance induces pinwheel crystallization in models of visual cortical development"],["dc.type","conference_abstract"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e1002756"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","PLoS Computational Biology"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Reichl, Lars"],["dc.contributor.author","Heide, Dominik"],["dc.contributor.author","Löwel, Siegrid"],["dc.contributor.author","Crowley, Justin C."],["dc.contributor.author","Kaschube, Matthias"],["dc.contributor.author","Wolf, Fred"],["dc.date.accessioned","2017-09-07T11:46:12Z"],["dc.date.available","2017-09-07T11:46:12Z"],["dc.date.issued","2012"],["dc.description.abstract","In the juvenile brain, the synaptic architecture of the visual cortex remains in a state of flux for months after the natural onset of vision and the initial emergence of feature selectivity in visual cortical neurons. It is an attractive hypothesis that visual cortical architecture is shaped during this extended period of juvenile plasticity by the coordinated optimization of multiple visual cortical maps such as orientation preference (OP), ocular dominance (OD), spatial frequency, or direction preference. In part (I) of this study we introduced a class of analytically tractable coordinated optimization models and solved representative examples, in which a spatially complex organization of the OP map is induced by interactions between the maps. We found that these solutions near symmetry breaking threshold predict a highly ordered map layout. Here we examine the time course of the convergence towards attractor states and optima of these models. In particular, we determine the timescales on which map optimization takes place and how these timescales can be compared to those of visual cortical development and plasticity. We also assess whether our models exhibit biologically more realistic, spatially irregular solutions at a finite distance from threshold, when the spatial periodicities of the two maps are detuned and when considering more than 2 feature dimensions. We show that, although maps typically undergo substantial rearrangement, no other solutions than pinwheel crystals and stripes dominate in the emerging layouts. Pinwheel crystallization takes place on a rather short timescale and can also occur for detuned wavelengths of different maps. Our numerical results thus support the view that neither minimal energy states nor intermediate transient states of our coordinated optimization models successfully explain the architecture of the visual cortex. We discuss several alternative scenarios that may improve the agreement between model solutions and biological observations."],["dc.identifier.doi","10.1371/journal.pcbi.1002756"],["dc.identifier.gro","3151848"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8432"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8677"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","public"],["dc.notes.submitter","chake"],["dc.relation.issn","1553-7358"],["dc.relation.orgunit","Fakultät für Physik"],["dc.rights","CC BY 2.5"],["dc.rights.uri","http://creativecommons.org/licenses/by/2.5/"],["dc.title","Coordinated Optimization of Visual Cortical Maps (II) Numerical Studies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","476"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Der Ophthalmologe"],["dc.bibliographiccitation.lastpage","488"],["dc.bibliographiccitation.volume","115"],["dc.contributor.author","Walz, J. M."],["dc.contributor.author","Bemme, S."],["dc.contributor.author","Reichl, S."],["dc.contributor.author","Akman, S."],["dc.contributor.author","Breuß, H."],["dc.contributor.author","Süsskind, D."],["dc.contributor.author","Glitz, B."],["dc.contributor.author","Müller, V. C."],["dc.contributor.author","Wagenfeld, L."],["dc.contributor.author","Gabel-Pfisterer, A."],["dc.contributor.author","Aisenbrey, S."],["dc.contributor.author","Engelmann, K."],["dc.contributor.author","Koutsonas, A."],["dc.contributor.author","Krohne, T. U."],["dc.contributor.author","Stahl, A."],["dc.date.accessioned","2020-12-10T14:10:16Z"],["dc.date.available","2020-12-10T14:10:16Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s00347-018-0701-5"],["dc.identifier.eissn","1433-0423"],["dc.identifier.issn","0941-293X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70702"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Behandelte Frühgeborenenretinopathie in Deutschland"],["dc.title.alternative","Treated cases of retinopathy of prematurity in Germany. 5-year data from the Retina.net ROP registry"],["dc.title.subtitle","5-Jahres-Daten des Retina.net ROP-Registers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]