Heimel, Kai

[["dc.bibliographiccitation.firstpage","2388"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","The Plant Cell"],["dc.bibliographiccitation.lastpage","2401"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Scherer, Mario"],["dc.contributor.author","Heimel, Kai"],["dc.contributor.author","Starke, Verena"],["dc.contributor.author","Kämper, Jörg"],["dc.date.accessioned","2022-04-05T15:35:33Z"],["dc.date.available","2022-04-05T15:35:33Z"],["dc.date.issued","2006-09"],["dc.description.abstract","In the phytopathogenic fungus Ustilago maydis, pathogenic development is controlled by a heterodimer of the two homeodomain proteins bE and bW, encoded by the b-mating-type locus. We have identified a b-dependently induced gene, clampless1 (clp1), that is required for the proliferation of dikaryotic filaments in planta. We show that U. maydis hyphae develop structures functionally equivalent to clamp cells that participate in the distribution of nuclei during cell division. In clp1 mutant strains, dikaryotic filaments penetrate the plant cuticle, but development is stalled before the first mitotic division, and the clamp-like structures are not formed. Although clp1 is immediately activated upon b-induction on the transcriptional level, nuclear-localized Clp1 protein is first observed at the stage of plant penetration prior to the first cell division. Induced expression of clp1 strongly interferes with b-dependent gene regulation and blocks b-dependent filament formation and b-dependent cell cycle arrest. We speculate that the Clp1 protein inhibits the activity of the bE/bW heterodimer to facilitate the cell cycle progression during hyphal growth."],["dc.identifier.doi","10.1105/tpc.106.043521"],["dc.identifier.pmid","16920779"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106404"],["dc.language.iso","en"],["dc.relation.issn","1040-4651"],["dc.title","The Clp1 protein is required for clamp formation and pathogenic development of Ustilago maydis"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e1001035"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","PLoS Pathogens"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Heimel, Kai"],["dc.contributor.author","Scherer, Mario"],["dc.contributor.author","Vranes, Miroslav"],["dc.contributor.author","Wahl, Ramon"],["dc.contributor.author","Pothiratana, Chetsada"],["dc.contributor.author","Schuler, David"],["dc.contributor.author","Vincon, Volker"],["dc.contributor.author","Finkernagel, Florian"],["dc.contributor.author","Flor-Parra, Ignacio"],["dc.contributor.author","Kämper, Jörg"],["dc.date.accessioned","2022-04-05T15:35:54Z"],["dc.date.available","2022-04-05T15:35:54Z"],["dc.date.issued","2010-08-05"],["dc.description.abstract","In the phytopathogenic basidiomycete Ustilago maydis, sexual and pathogenic development are tightly connected and controlled by the heterodimeric bE/bW transcription factor complex encoded by the b-mating type locus. The formation of the active bE/bW heterodimer leads to the formation of filaments, induces a G2 cell cycle arrest, and triggers pathogenicity. Here, we identify a set of 345 bE/bW responsive genes which show altered expression during these developmental changes; several of these genes are associated with cell cycle coordination, morphogenesis and pathogenicity. 90% of the genes that show altered expression upon bE/bW-activation require the zinc finger transcription factor Rbf1, one of the few factors directly regulated by the bE/bW heterodimer. Rbf1 is a novel master regulator in a multilayered network of transcription factors that facilitates the complex regulatory traits of sexual and pathogenic development."],["dc.identifier.doi","10.1371/journal.ppat.1001035"],["dc.identifier.pmid","20700446"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106406"],["dc.language.iso","en"],["dc.relation.eissn","1553-7374"],["dc.title","The transcription factor Rbf1 is the master regulator for b-mating type controlled pathogenic development in Ustilago maydis"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]