Holtfreter, Birte

[["dc.bibliographiccitation.firstpage","3914"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","Proteomics"],["dc.bibliographiccitation.lastpage","3927"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Kolata, Julia"],["dc.contributor.author","Bode, Lonneke G. M."],["dc.contributor.author","Holtfreter, Silva"],["dc.contributor.author","Steil, Leif"],["dc.contributor.author","Kusch, Harald"],["dc.contributor.author","Holtfreter, Birte"],["dc.contributor.author","Albrecht, Dirk"],["dc.contributor.author","Hecker, Michael"],["dc.contributor.author","Engelmann, Susanne"],["dc.contributor.author","van Belkum, Alex"],["dc.contributor.author","Volker, Uwe"],["dc.contributor.author","Bröker, Barbara M."],["dc.date.accessioned","2019-08-06T10:50:27Z"],["dc.date.available","2019-08-06T10:50:27Z"],["dc.date.issued","2011"],["dc.description.abstract","Staphylococcus aureus is both a prominent cause of nosocomial infections with significant morbidity and mortality and a commensal with nasal carriage in around 30% of the population. The rapid spread of multi-resistant strains necessitates novel therapeutic strategies, a challenging task because the species S. aureus and the host response against it are highly variable. In a prospective study among 2023 surgical and non-surgical patients, 12 patients developed S. aureus bacteremia. They were analysed in detail using a personalized approach. For each patient, the extracellular proteins of the infecting S. aureus strain were identified and the developing antibody response was assessed on 2-D immunoblots. S. aureus carriers showed clear evidence of strain-specific pre-immunization. In all immune-competent bacteremia patients, antibody binding increased strongly, in most cases already at diagnosis. In endogenous infections, the pattern of antibody binding was similar to the pre-infection pattern. In exogenous infections, in contrast, the pre-infection pattern was radically altered with the acquisition of new specificities. These were characteristic for individual patients. Nevertheless, a common signature of 11 conserved S. aureus proteins, recognized in at least half of the bacteremic patients, was identified. All patients mounted a dynamic antibody response to a subset of these proteins."],["dc.identifier.doi","10.1002/pmic.201000760"],["dc.identifier.pmid","21805632"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62303"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1615-9861"],["dc.relation.issn","1615-9853"],["dc.title","Distinctive patterns in the human antibody response to Staphylococcus aureus bacteremia in carriers and non-carriers"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]