Rankovic, Vladan

[["dc.bibliographiccitation.artnumber","12191"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific reports"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Schidlitzki, Alina"],["dc.contributor.author","Twele, Friederike"],["dc.contributor.author","Klee, Rebecca"],["dc.contributor.author","Waltl, Inken"],["dc.contributor.author","Römermann, Kerstin"],["dc.contributor.author","Bröer, Sonja"],["dc.contributor.author","Meller, Sebastian"],["dc.contributor.author","Gerhauser, Ingo"],["dc.contributor.author","Rankovic, Vladan"],["dc.contributor.author","Li, Dandan"],["dc.contributor.author","Brandt, Claudia"],["dc.contributor.author","Bankstahl, Marion"],["dc.contributor.author","Töllner, Kathrin"],["dc.contributor.author","Löscher, Wolfgang"],["dc.date.accessioned","2019-07-09T11:44:52Z"],["dc.date.available","2019-07-09T11:44:52Z"],["dc.date.issued","2017-09-22"],["dc.description.abstract","Epilepsy may arise following acute brain insults, but no treatments exist that prevent epilepsy in patients at risk. Here we examined whether a combination of two glutamate receptor antagonists, NBQX and ifenprodil, acting at different receptor subtypes, exerts antiepileptogenic effects in the intrahippocampal kainate mouse model of epilepsy. These drugs were administered over 5 days following kainate. Spontaneous seizures were recorded by video/EEG at different intervals up to 3 months. Initial trials showed that drug treatment during the latent period led to higher mortality than treatment after onset of epilepsy, and further, that combined therapy with both drugs caused higher mortality at doses that appear safe when used singly. We therefore refined the combined-drug protocol, using lower doses. Two weeks after kainate, significantly less mice of the NBQX/ifenprodil group exhibited electroclinical seizures compared to vehicle controls, but this effect was lost at subsequent weeks. The disease modifying effect of the treatment was associated with a transient prevention of granule cell dispersion and less neuronal degeneration in the dentate hilus. These data substantiate the involvement of altered glutamatergic transmission in the early phase of epileptogenesis. Longer treatment with NBQX and ifenprodil may shed further light on the apparent temporal relationship between dentate gyrus reorganization and development of spontaneous seizures."],["dc.identifier.doi","10.1038/s41598-017-12368-6"],["dc.identifier.pmid","28939854"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14940"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59116"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/602102/EU//EPITARGET"],["dc.relation.issn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","599"],["dc.title","A combination of NMDA and AMPA receptor antagonists retards granule cell dispersion and epileptogenesis in a model of acquired epilepsy."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","120"],["dc.bibliographiccitation.journal","Epilepsy & Behavior"],["dc.bibliographiccitation.lastpage","131"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Brandt, Claudia"],["dc.contributor.author","Rankovic, Vladan"],["dc.contributor.author","Töllner, Kathrin"],["dc.contributor.author","Klee, Rebecca"],["dc.contributor.author","Bröer, Sonja"],["dc.contributor.author","Löscher, Wolfgang"],["dc.date.accessioned","2018-11-07T10:10:59Z"],["dc.date.available","2018-11-07T10:10:59Z"],["dc.date.issued","2016"],["dc.description.abstract","In rodent models in which status epilepticus (SE) is used to induce epilepsy, typically most animals develop spontaneous recurrent seizures (SRS). The SE duration for induction of epileptogenesis depends on the type of SE induction. In models with electrical SE induction, the minimum duration of SE to induce epileptogenesis in >90% of animals ranges from 3-4 h. A high incidence of epilepsy is an advantage in the search of antiepileptogenic treatments, whereas it is a disadvantage in the search for biomarkers of epileptogenesis, because it does not allow a comparison of potential biomarkers in animals that either develop or do not develop epilepsy. The aim of this project was the refinement of an established SE rat model so that only similar to 50% of the animals develop epilepsy. For this purpose, we used an electrical model of SE induction, in which a self-sustained SE develops after prolonged stimulation of the basolateral amygdala. Previous experiments had shown that the majority of rats develop SRS after 4-h SE in this model so that the SE reduced duration to 2.5 h by administering diazepam. This resulted in epilepsy development in only 50% of rats, thus reaching the goal of the project. The latent period to onset of SRS was >2 weeks in most rats. Development of epilepsy could be predicted in most rats by behavioral hyperexcitability, whereas seizure threshold did not differentiate rats that did and did not develop SRS. The refined SE model may offer a platform to identify and validate biomarkers of epileptogenesis. (C) 2016 Elsevier Inc. All rights reserved."],["dc.description.sponsorship","European Union's Seventh Framework Programme (EPITARGET) [602102]"],["dc.identifier.doi","10.1016/j.yebeh.2016.05.012"],["dc.identifier.isi","000381248000023"],["dc.identifier.pmid","27343814"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39960"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","1525-5069"],["dc.relation.issn","1525-5050"],["dc.title","Refinement of a model of acquired epilepsy for identification and validation of biomarkers of epileptogenesis in rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]