Watanabe, Takashi

[["dc.bibliographiccitation.firstpage","209"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Magnetic Resonance Imaging"],["dc.bibliographiccitation.lastpage","215"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Radulovic, Jelena"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Michaelis, Thomas"],["dc.date.accessioned","2017-09-07T11:45:27Z"],["dc.date.available","2017-09-07T11:45:27Z"],["dc.date.issued","2006"],["dc.description.abstract","This magnetic resonance imaging (MRI) study describes mapping of the habenulo-interpeduncular pathway in living mice based on manganese-induced contrast. Six hours after intracerebroventricular microinjection of MnCl2, T1-weighted 3D MRI (2.35 T) at 117 μm isotropic resolution revealed a continuous pattern of anterograde labeling from the habenula via the fasciculus retroflexus to the interpeduncular nucleus. Alternatively, the less invasive systemic administration of MnCl2 allowed for monitoring of the dynamic uptake pattern of respective neural components with even higher reproducibility across animals. Time courses covered the range from 42 min to 24 h after injection. In conclusion, manganese-enhanced MRI may open new ways for functional assessments of the habenulo-interpeduncular system in animal models with cognitive impairment."],["dc.identifier.doi","10.1016/j.mri.2005.10.034"],["dc.identifier.gro","3150377"],["dc.identifier.pmid","16563949"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7135"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0730-725X"],["dc.subject","Habenula; Magnetic resonance imaging; Manganese; Mice; Neural pathways"],["dc.title","Mapping of the habenulo-interpeduncular pathway in living mice using manganese-enhanced 3D MRI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","596"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","602"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Natt, Oliver"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Utz, Sandra"],["dc.contributor.author","Schachtner, Joachim"],["dc.date.accessioned","2017-09-07T11:45:31Z"],["dc.date.available","2017-09-07T11:45:31Z"],["dc.date.issued","2005"],["dc.description.abstract","High-resolution 3D MRI of male pupae of Manduca sexta was performed at 2.35 T in order to evaluate its potential for an in vivo characterization of insect brain during metamorphosis. T1-weighted 3D FLASH (TR/TE = 20/7.8 ms, 25° flip angle) and T2-weighted 3D fast SE MRI data sets (TR/TEeff = 3000/100 ms) were acquired at different developmental stages with an isotropic resolution of 100 μm. Both T1- and T2-weighted 3D MRI allowed for the identification of cerebral structures such as the antennal nerve, antennal and optical lobe, and central brain. Pronounced developmental alterations of the morphology were observed during metamorphosis. The results demonstrate the feasibility of 3D MRI at nanoliter resolution to identify major brain systems of M. sexta and respective changes during pupal development from caterpillar to sphinx moth. Together with the use of suitable contrast agents, this approach may provide new ways for studying the axonal connectivity and neural function of the developing insect brain."],["dc.identifier.doi","10.1016/j.neuroimage.2004.08.048"],["dc.identifier.gro","3150381"],["dc.identifier.pmid","15627604"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7139"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","1053-8119"],["dc.subject","Magnetic resonance imaging; Metamorphosis; Brain development; Manduca sexta; Entomology"],["dc.title","In vivo 3D MRI of insect brain: cerebral development during metamorphosis of Manduca sexta"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","43"],["dc.bibliographiccitation.issue","1-3"],["dc.bibliographiccitation.journal","European Journal of Pharmacology"],["dc.bibliographiccitation.lastpage","50"],["dc.bibliographiccitation.volume","598"],["dc.contributor.author","Michael-Titus, Adina T."],["dc.contributor.author","Albert, Monika"],["dc.contributor.author","Michael, Gregory J."],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Pudovkina, Olga"],["dc.contributor.author","van der Hart, Marieke G.C."],["dc.contributor.author","Hesselink, Mayke B."],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Czéh, Boldizsár"],["dc.date.accessioned","2022-10-06T13:33:06Z"],["dc.date.available","2022-10-06T13:33:06Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1016/j.ejphar.2008.09.006"],["dc.identifier.pii","S0014299908009436"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115546"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0014-2999"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","SONU20176289, a compound combining partial dopamine D2 receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","480"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Brain"],["dc.bibliographiccitation.lastpage","489"],["dc.bibliographiccitation.volume","129"],["dc.contributor.author","Sirén, Anna-Leena"],["dc.contributor.author","Radyushkin, Konstantin"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Kämmer, Daniel"],["dc.contributor.author","Riechers, Claas-Christian"],["dc.contributor.author","Natt, Oliver"],["dc.contributor.author","Sargin, Derya"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Sperling, Swetlana"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Price, Jack"],["dc.contributor.author","Meyer, Barbara"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.date.accessioned","2017-09-07T11:45:33Z"],["dc.date.available","2017-09-07T11:45:33Z"],["dc.date.issued","2006"],["dc.description.abstract","In humans, neurotrauma is suspected to cause brain atrophy and accelerate slowly progressive neurodegenerative disorders, such as Alzheimer's disease or schizophrenia. However, a direct link between brain injury and subsequent delayed global neurodegeneration has remained elusive. Here we show that juvenile (4-week-old) mice that are given a discrete unilateral lesion of the parietal cortex, develop to adulthood without obvious clinical symptoms. However, when monitored 3 and 9 months after lesioning, using high-resolution three-dimensional MRI and behavioural testing, the same mice display global neurodegenerative changes. Surprisingly, erythropoietin, a haematopoietic growth factor with potent neuroprotective activity, prevents behavioural abnormalities, cognitive dysfunction and brain atrophy when given for 2 weeks after acute brain injury. This demonstrates that a localized brain lesion is a primary cause of delayed global neurodegeneration that can be efficiently counteracted by neuroprotection."],["dc.identifier.doi","10.1093/brain/awh703"],["dc.identifier.doi","10.1093/brain/awh703"],["dc.identifier.gro","3150392"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7151"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0006-8950"],["dc.subject","EPO; MRI; neuroprotection; neurodegeneration; neurotrauma; schizophrenia"],["dc.title","Global brain atrophy after unilateral parietal lesion and its prevention by erythropoietin"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","860"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","867"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Radulovic, Jelena"],["dc.contributor.author","Spiess, Joachim"],["dc.contributor.author","Natt, Oliver"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Michaelis, Thomas"],["dc.date.accessioned","2017-09-07T11:45:29Z"],["dc.date.available","2017-09-07T11:45:29Z"],["dc.date.issued","2004"],["dc.description.abstract","The morphology and function of the hippocampal system of C57BL/6J mice (n = 8) was studied in vivo using T1-weighted 3D magnetic resonance imaging (MRI) (117 μm isotropic resolution) after bilateral injection of MnCl2 (0.25 μl, 5 or 200 mM) into the posterior hippocampal formation. The neuronal uptake of the T1-shortening Mn2+ ions resulted in a pronounced MRI signal enhancement within the CA3 subfield and dentate gyrus with milder increases in CA1 and subiculum. This finding is in line with differences in the excitability of hippocampal neurons previously reported using electrophysiologic recordings. The subsequent axonal transport of Mn2+ highlighted the principal extrinsic projections from the posterior hippocampal formation via the fimbria and the precommissural fornix to the dorsal part of the lateral septal nucleus. A strong MRI signal enhancement was also observed in the ventral hippocampal commissure. A time-course analysis revealed unsaturated conditions of Mn2+ accumulation at about 2 h after injection and optimal contrast-to-noise ratios at about 6 h after injection. The present results using Mn2+-enhanced 3D MRI open new ways for studying the role of the hippocampal system in specific aspects of learning and memory in normal and mutant mice."],["dc.identifier.doi","10.1016/j.neuroimage.2004.01.028"],["dc.identifier.gro","3150384"],["dc.identifier.pmid","15193616"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7143"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","1053-8119"],["dc.subject","Hippocampus; Efferent pathways; Fornix; Manganese-enhanced MRI; Neuroanatomic tracing"],["dc.title","In vivo 3D MRI staining of the mouse hippocampal system using intracerebral injection of MnCl2"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","548"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Psychopharmacology"],["dc.bibliographiccitation.lastpage","557"],["dc.bibliographiccitation.volume","180"],["dc.contributor.author","Czéh, Boldizsár"],["dc.contributor.author","Pudovkina, Olga"],["dc.contributor.author","van der Hart, Marieke G. C."],["dc.contributor.author","Simon, Mária"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2022-10-06T13:27:11Z"],["dc.date.available","2022-10-06T13:27:11Z"],["dc.date.issued","2005"],["dc.identifier.doi","10.1007/s00213-005-2184-8"],["dc.identifier.pii","2184"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115273"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1432-2072"],["dc.relation.issn","0033-3158"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Examining SLV-323, a novel NK1 receptor antagonist, in a chronic psychosocial stress model for depression"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","933"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Molecular Psychiatry"],["dc.bibliographiccitation.lastpage","941"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","van der Hart, M G C"],["dc.contributor.author","Czéh, B"],["dc.contributor.author","de Biurrun, G"],["dc.contributor.author","Michaelis, T"],["dc.contributor.author","Watanabe, T"],["dc.contributor.author","Natt, O"],["dc.contributor.author","Frahm, J"],["dc.contributor.author","Fuchs, E"],["dc.date.accessioned","2022-10-06T13:34:20Z"],["dc.date.available","2022-10-06T13:34:20Z"],["dc.date.issued","2002"],["dc.identifier.doi","10.1038/sj.mp.4001130"],["dc.identifier.pii","BF4001130"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115886"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1476-5578"],["dc.relation.issn","1359-4184"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://www.springer.com/tdm"],["dc.title","Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","203"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neuroscience Methods"],["dc.bibliographiccitation.lastpage","209"],["dc.bibliographiccitation.volume","120"],["dc.contributor.author","Natt, Oliver"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Radulovic, Jelena"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Michaelis, Thomas"],["dc.date.accessioned","2017-09-07T11:45:33Z"],["dc.date.available","2017-09-07T11:45:33Z"],["dc.date.issued","2002"],["dc.description.abstract","This work demonstrates technical approaches to high-quality magnetic resonance imaging (MRI) of small structures of the mouse brain in vivo. It turns out that excellent soft-tissue contrast requires the reduction of partial volume effects by using 3D MRI at high (isotropic) resolution with linear voxel dimensions of about 100–150 μm. The long T2 relaxation times at relatively low magnetic fields (2.35 T) offer the benefit of a small receiver bandwidth (increased signal-to-noise) at a moderate echo time which together with the small voxel size avoids visual susceptibility artifacts. For measuring times of 1–1.5 h both T1-weighted (FLASH) and T2-weighted (Fast Spin-Echo) 3D MRI acquisitions exhibit detailed anatomical insights in accordance with histological sections from a mouse brain atlas. Preliminary applications address the identification of neuroanatomical variations in different mouse strains and the use of Mn2+ as a T1 contrast agent for neuroaxonal tracing of fiber tracts within the mouse visual pathway."],["dc.identifier.doi","10.1016/s0165-0270(02)00211-x"],["dc.identifier.gro","3150389"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7148"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","0165-0270"],["dc.title","High-resolution 3D MRI of mouse brain reveals small cerebral structures in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","12796"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences"],["dc.bibliographiccitation.lastpage","12801"],["dc.bibliographiccitation.volume","98"],["dc.contributor.author","Czéh, Boldizsár"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","de Biurrun, Gabriel"],["dc.contributor.author","van Kampen, Marja"],["dc.contributor.author","Bartolomucci, Alessandro"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2022-10-06T13:34:33Z"],["dc.date.available","2022-10-06T13:34:33Z"],["dc.date.issued","2001"],["dc.description.abstract","Stress-induced structural remodeling in the adult hippocampus, involving debranching and shortening of dendrites and suppression of neurogenesis, provides a cellular basis for understanding the impairment of neural plasticity in the human hippocampus in depressive illness. Accordingly, reversal of structural remodeling may be a desirable goal for antidepressant therapy. The present study investigated the effect of tianeptine, a modified tricyclic antidepressant, in the chronic psychosocial stress model of adult male tree shrews (\n Tupaia belangeri\n ), a model with high validity for research on the pathophysiology of major depression. Animals were subjected to a 7-day period of psychosocial stress to elicit stress-induced endocrine and central nervous alterations before the onset of daily oral administration of tianeptine (50 mg/kg). The psychosocial stress continued throughout the treatment period of 28 days. Brain metabolite concentrations were determined\n in vivo\n by proton magnetic resonance spectroscopy, cell proliferation in the dentate gyrus was quantified by using BrdUrd immunohistochemistry, and hippocampal volume was measured post mortem. Chronic psychosocial stress significantly decreased\n in vivo\n concentrations of\n N\n -acetyl-aspartate (−13%), creatine and phosphocreatine (−15%), and choline-containing compounds (−13%). The proliferation rate of the granule precursor cells in the dentate gyrus was reduced (−33%). These stress effects were prevented by the simultaneous administration of tianeptine yielding normal values. In stressed animals treated with tianeptine, hippocampal volume increased above the small decrease produced by stress alone. These findings provide a cellular and neurochemical basis for evaluating antidepressant treatments with regard to possible reversal of structural changes in brain that have been reported in depressive disorders."],["dc.identifier.doi","10.1073/pnas.211427898"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115936"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1091-6490"],["dc.relation.issn","0027-8424"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","311s"],["dc.bibliographiccitation.issue","S3"],["dc.bibliographiccitation.journal","European Psychiatry"],["dc.bibliographiccitation.lastpage","317s"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Czéh, B."],["dc.contributor.author","Michaelis, T."],["dc.contributor.author","de Biurrun, G."],["dc.contributor.author","Watanabe, T."],["dc.contributor.author","Frahm, J."],["dc.date.accessioned","2022-10-06T13:33:55Z"],["dc.date.available","2022-10-06T13:33:55Z"],["dc.date.issued","2020"],["dc.description.abstract","Summary\n Stress-induced structural and cellular alterations in the hippocampus can contribute to the pathophysiology of depression. The reversal of these alterations may be a mechanism by which antidepressants achieve their therapeutic effect. The aim of the present study was therefore to investigate  the effect of tianeptine on stress-induced structural changes and alterations in cerebral metabolites. To this end, psychosocially stressed male tree shrews were treated with tianeptine. A combination of in vivo and postmortem methods was used to evaluate the antidepressant treatment on the preservation of neuronal plasticity. It was found that all stress-induced effects were prevented by the administration of tianeptine. It is concluded that these findings provide experimental evidence for recent theories that impairment of neuronal viability and neuroplasticity might be important causal factors in mood disorders, suggesting tianeptine as a potential stimulator of neural resilience."],["dc.identifier.doi","10.1016/S0924-9338(02)00652-1"],["dc.identifier.pii","S0924933800016631"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115774"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1778-3585"],["dc.relation.issn","0924-9338"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Synaptic plasticity and tianeptine: structural regulation"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]