Buchwald, Arnd B.

[["dc.bibliographiccitation.firstpage","1632"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of the American College of Cardiology"],["dc.bibliographiccitation.lastpage","1636"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Meyer, Thomas"],["dc.contributor.author","Binder, L."],["dc.contributor.author","Hruska, N."],["dc.contributor.author","Luthe, Hilmar"],["dc.contributor.author","Buchwald, Arnd B."],["dc.date.accessioned","2018-11-07T08:36:53Z"],["dc.date.available","2018-11-07T08:36:53Z"],["dc.date.issued","2000"],["dc.description.abstract","OBJECTIVES The purpose of this study was to evaluate the prevalence and diagnostic utility of cardiac troponin I to identify patients with right ventricular (RV) dysfunction in pulmonary embolism. BACKGROUND Right ventricular overload resulting from elevated pulmonary resistance is a common finding in major pulmonary embolism. However, biochemical markers to assess the degree of RV dysfunction have not been evaluated so far. METHODS In this prospective, double-blind study we included 36 study patients diagnosed as having acute pulmonary embolism. RESULTS Among the whole study population, 14 patients (39%) had positive troponin I tests. Ten of 16 patients (62.5%) with RV dilatation had increased serum troponin I levels, while only 4 of 14 patients (28.6%) with elevated troponin I values had a normal RV diameter as assessed by echocardiography, indicating that positive troponin I tests were significantly associated with RV dilatation (p = 0.009). Patients with positive troponin I tests had significantly more segmental defects in ventilation/perfusion lung scans than patients with normal serum troponin I (p = 0.0002). CONCLUSIONS Our data demonstrate that more than one-third of patients clinically diagnosed as having pulmonary embolism presented with elevated serum troponin I concentrations. Troponin I tests helped to identify patients with RV dilatation who had significantly more segmental defects in lung scans. Thus, troponin I assays are useful to detect minor myocardial damage in pulmonary embolism. (C) 2000 by the American College of Cardiology."],["dc.identifier.doi","10.1016/S0735-1097(00)00905-0"],["dc.identifier.isi","000165171500028"],["dc.identifier.pmid","11079669"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18410"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","0735-1097"],["dc.title","Cardiac troponin I elevation in acute pulmonary embolism is associated with right ventricular dysfunction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","467"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.lastpage","468"],["dc.bibliographiccitation.volume","104"],["dc.contributor.author","Hruska, N."],["dc.contributor.author","Binder, L."],["dc.contributor.author","Geibel, Annette"],["dc.contributor.author","Olschewski, Manfred"],["dc.contributor.author","Kasper, W."],["dc.contributor.author","Jackle, S."],["dc.contributor.author","Buchwald, Arnd B."],["dc.contributor.author","Schafer, K."],["dc.contributor.author","Konstantinides, Stavros V."],["dc.date.accessioned","2018-11-07T08:32:13Z"],["dc.date.available","2018-11-07T08:32:13Z"],["dc.date.issued","2001"],["dc.identifier.isi","000171895002199"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17286"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.issn","0009-7322"],["dc.title","Cardiac Troponins I and T are highly significant predictors of outcome in patients with acute pulmonary embolism: Findings of the management strategies and prognosis of pulmonary embolism 2 (MAPPET 2) study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]