Bittermann, Hans-Joachim

[["dc.bibliographiccitation.firstpage","206"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Ultraschall in der Medizin - European Journal of Ultrasound"],["dc.bibliographiccitation.lastpage","213"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Bartels, E."],["dc.contributor.author","Bittermann, H. J."],["dc.date.accessioned","2018-11-07T10:48:49Z"],["dc.date.available","2018-11-07T10:48:49Z"],["dc.date.issued","2004"],["dc.description.abstract","Aim: Contrast-enhanced transcranial triggered B-mode technology can be used to examine cerebral perfusion. However, this technique is still faced with methodological problems, especially the difficulty of overcoming the temporal bone window. The aim of the present study is to evaluate a deficit in cerebral perfusion after administration of the contrast agent SonoVue(TM) in acute stroke patients following decompressive craniectomy. Methods: Ten stroke patients (aged 39 to 59 years, mean age 57 years), in whom a decompressive craniectomy due to a malignant space-occupying infarction or intracerebral haemorrhage was performed, were examined with transcranial duplex sonography after application of the contrast agent SonoVue(TM). The transcranial examination was performed using transient response harmonic grey scale imaging with bolus kinetics based on a contrast harmonic imaging software with single-pulse transmission technology. The mechanical index was set at 1.0 to 1.1. Triggered images with pulsing intervals of 1000 ms were used for the evaluation of time intensity curves in several regions of interest. The sonographically imaged areas of hypoperfusion were compared with CT or MRI findings. Results: After injection of the contrast agent, the perfusion deficit could be detected ipsilaterally according to the affected vascular territory in the area of the MCA in 5 patients, in the area of ACA and MCA in 2 patients, in the area of the MCA, ACA and PCA in one patient and in the area of intracranial haemorrhage in 2 patients. The calculated average peak images corresponded precisely with the superimposed CT or MRI images in shape and size in all patients. Additionally, it was possible to observe several interesting contrast-induced phenomena in the cerebral parenchyma, as well as specific transit-time curve characteristics in the perfusion deficit area. Conclusions: Using contrast-enhanced transcranial duplex sonography with transient response harmonic imaging, it is possible to depict the perfusion deficit in cerebral microcirculation in patients following decompressive craniectomy and to obtain new insights into the pathophysiology of the hypoperfusion areas. Further studies should be done in stroke patients through the intact skull to standardise this method for early diagnosis of acute deficit in cerebral perfusion."],["dc.identifier.doi","10.1055/s-2004-813123"],["dc.identifier.isi","000221843600010"],["dc.identifier.pmid","15146361"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48287"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0172-4614"],["dc.title","Transcranial contrast Imaging of cerebral perfusion in stroke patients following decompressive craniectomy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","499"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Ultrasound in Medicine"],["dc.bibliographiccitation.lastpage","507"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Bartels, E."],["dc.contributor.author","Bittermann, H. J."],["dc.date.accessioned","2018-11-07T10:03:07Z"],["dc.date.available","2018-11-07T10:03:07Z"],["dc.date.issued","2006"],["dc.description.abstract","Objective, The aim of this study was to evaluate a deficit in cerebral perfusion after administration of the contrast agent SonoVue (Bracco Altana Pharma, Konstanz, Germany) in patients with intracranial space-occupying lesions. Methods. We used transcranial duplex sonography to examine 10 healthy volunteers and 4 patients. Of the patients, one 55-year-old woman had an intracranial glioblastoma,one 54-year-old woman had an intracranial hemorrhage; and one 49-year-old woman and one 69-year-old man had a malignant middle cerebral artery infarction. A decompressive craniectomy was performed in the 2 patients with malignant middle cerebral artery infarction. Triggered images with pulsing intervals of 1000 milliseconds were used for the evaluation of time-intensity curves in several regions of interest. The mechanical index was set at 1.6; in patients with a craniectomy, the mechanical index was set at 1.1. Results. In all patients, the perfusion deficit could be recognized in the ipsilateral hemisphere. The superimposition of the sonographic images with those from computed tomography or magnetic resonance imaging showed a good correspondence in shape and size in patients with a craniectomy. In patients without a craniectomy, a rough correspondence with findings from magnetic resonance imaging or computed tomography could be recognized. Conclusions. By using contrast-enhanced transcranial duplex sonography, it is possible to image the perfusion deficit in cerebral microcirculation in patients with intracranial space-occupying lesions. These results should be confirmed by more pathologic cases and correlated with magnetic resonance imaging and other neuroimaging techniques. Additionally, further technical development in sonographic systems is necessary to improve the diagnostics of cerebral perfusion deficit."],["dc.identifier.isi","000236785600011"],["dc.identifier.pmid","16567439"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38381"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Inst Ultrasound Medicine"],["dc.relation.issn","0278-4297"],["dc.title","Transcranial contrast imaging of cerebral perfusion in patients with space-occupying intracranial lesions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]