Lippert, Undine

[["dc.bibliographiccitation.firstpage","520"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.lastpage","525"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Lippert, Undine"],["dc.contributor.author","Zachmann, Karolin"],["dc.contributor.author","Henz, B. M."],["dc.contributor.author","Neumann, C."],["dc.date.accessioned","2018-11-07T10:46:44Z"],["dc.date.available","2018-11-07T10:46:44Z"],["dc.date.issued","2004"],["dc.description.abstract","CXCL8 plays a major role in cell recruitment to sites of inflammation. Apart from neutrophils, little is known, however, about the cellular distribution and regulation of CXCL8 receptors in cells involved in acquired and adaptive immune responses. In previous studies, we have demonstrated the extracellular expression and function of CXCR1/2 on mast cells and also detected an intracellular pool of CXCR1/2. Here, we have addressed the question of receptor regulation during stimulation of human mast cells (HMC-1 cell line) and have studied T cells in comparison. Cell permeabilization was performed to detect both surface and possible intracellular receptor pools. HMC-1 cells stained positive for both receptors on the cell surface (CXCR1, 50%; CXCR2, 51%) and also after cell permeabilization (CXCR1, 86%; CXCR2, 74%). Similarly, T cells exhibited both cell-surface receptor expression (CXCR1, 30%; CXCR2, 23%) and higher total receptor expression (CXCR1, 50%; CXCR2, 36%), although overall values were lower than that in HMC-1 cells. On immunoblot, molecular weights of extra- and intracellular receptors on mast cells were the same, excluding altered receptor glycosylation. On stimulation with phorbol 12-myristate 13-acetate plus calcium ionophore, a time-dependent decrease of surface-membrane receptors was observed in both cell types, while total receptor remained the same, suggesting that receptor shedding is not involved. The kinetics of membrane receptor internalization and replenishment differed for the two cell types. Furthermore, receptor internalization was associated with decreased F-actin polymerization, a basic prerequisite for cell migration. These findings demonstrate for the first time the expression of extra- and intracellular CXCR1/2 receptors on T cells and delineate the dynamics of CXCR1/2 receptors on mast cells and T cells. Furthermore, they suggest a cell-type-specific and finely tuned regulation of chemokine responses at the receptor level in the context of inflammation."],["dc.identifier.doi","10.1111/j.0906-6705.2004.00182.x"],["dc.identifier.isi","000222717800008"],["dc.identifier.pmid","15265017"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47811"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Munksgaard"],["dc.relation.issn","0906-6705"],["dc.title","Human T lymphocytes and mast cells differentially express and regulate extra- and intracellular CXCR1 and CXCR2"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Investigative Dermatology"],["dc.bibliographiccitation.volume","125"],["dc.contributor.author","Lippert, Undine"],["dc.contributor.author","Zachmann, Karolin"],["dc.contributor.author","Brunner, E."],["dc.contributor.author","Lafti, A. H."],["dc.contributor.author","Ferrari, David M."],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Soruri, Afsaneh"],["dc.date.accessioned","2018-11-07T10:56:17Z"],["dc.date.available","2018-11-07T10:56:17Z"],["dc.date.issued","2005"],["dc.format.extent","A49"],["dc.identifier.isi","000231862600286"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49976"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.publisher.place","New york"],["dc.relation.conference","35th Annual Meeting of the European-Society-for-Dermatological-Research"],["dc.relation.eventlocation","Tubingen, GERMANY"],["dc.relation.issn","0022-202X"],["dc.title","CD137 ligand mediated differentiation of immature human dendritic cells is associated with enhanced (antigen specific) T cell activation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","597"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Der Hautarzt"],["dc.bibliographiccitation.lastpage","603"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Lippert, Undine"],["dc.contributor.author","Schauder, Silvia"],["dc.contributor.author","Neumann, C."],["dc.date.accessioned","2018-11-07T10:37:06Z"],["dc.date.available","2018-11-07T10:37:06Z"],["dc.date.issued","2000"],["dc.description.abstract","The non-Native American type of actinic prurigo belongs to the group of rare idiopathic photodermatoses and therefore is often diagnosed with delay. The typical clinical and epidemiological features of actinic prurigo are described in a 10 year old girl. Detailed phototesting showed urticarial early onset and prurigo-like late onset reactions towards long-wave UVA. Repetitive photoprovocation with UVB induced delayed development of papules. HLA typing showed the typical association with HLA-DR4, in particular DRB1 0407. Treatment is usually extremely difficult and unrewarding. In this patient, the course was considerably improved by more intense physical photoprotection."],["dc.identifier.doi","10.1007/s001050051178"],["dc.identifier.isi","000088944700007"],["dc.identifier.pmid","10997316"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45482"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0017-8470"],["dc.title","Actinic prurigo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Lippert, Undine"],["dc.contributor.author","Zachmann, Karolin"],["dc.contributor.author","Ferrari, David M."],["dc.contributor.author","Schwarz, H."],["dc.contributor.author","Brunner, E."],["dc.contributor.author","Latif, A. H. M. Mahbub"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Soruri, Afsaneh"],["dc.date.accessioned","2018-11-07T10:12:05Z"],["dc.date.available","2018-11-07T10:12:05Z"],["dc.date.issued","2006"],["dc.format.extent","201"],["dc.identifier.isi","000235370600050"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40169"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","33rd Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF)"],["dc.relation.eventlocation","Aachen, GERMANY"],["dc.relation.issn","0906-6705"],["dc.title","CD137 ligand induced differentiation of human dendritic cells to potent activators of antigen-specific T cells"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Lippert, Undine"],["dc.contributor.author","Babina, M."],["dc.contributor.author","Ferrari, David M."],["dc.contributor.author","Schwarz, H."],["dc.contributor.author","Zachmann, Karolin"],["dc.contributor.author","Knosalla, M."],["dc.contributor.author","Middel, Peter"],["dc.contributor.author","Neumann, C."],["dc.date.accessioned","2018-11-07T11:04:24Z"],["dc.date.available","2018-11-07T11:04:24Z"],["dc.date.issued","2007"],["dc.format.extent","226"],["dc.identifier.isi","000244056600108"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51836"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","34th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung"],["dc.relation.eventlocation","Freiburg, GERMANY"],["dc.relation.issn","0906-6705"],["dc.title","Expression and function of CD137 receptor and ligand in human mast cells"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","41"],["dc.bibliographiccitation.journal","Allergy"],["dc.bibliographiccitation.lastpage","42"],["dc.bibliographiccitation.volume","62"],["dc.contributor.author","Lippert, Undine"],["dc.contributor.author","Zachmann, Karolin"],["dc.contributor.author","Ferrari, David M."],["dc.contributor.author","Schwarz, H."],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Brunner, E."],["dc.contributor.author","Ul-Latif, A."],["dc.contributor.author","Soruri, Afsaneh"],["dc.date.accessioned","2018-11-07T11:01:31Z"],["dc.date.available","2018-11-07T11:01:31Z"],["dc.date.issued","2007"],["dc.identifier.isi","000246800000102"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51169"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.conference","26th Congress of the European-Academy-of-Allergology-and-Clinical-Immunology"],["dc.relation.eventlocation","Gothenburg, SWEDEN"],["dc.relation.issn","0105-4538"],["dc.title","Possible bidirectional function of CD137 ligand expressed on dendritic cells in antigen specific T cell activation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Lippert, Undine"],["dc.contributor.author","Zachmann, Karolin"],["dc.contributor.author","Ferrari, David M."],["dc.contributor.author","Schwarz, H."],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Soruri, Afsaneh"],["dc.date.accessioned","2018-11-07T11:17:36Z"],["dc.date.available","2018-11-07T11:17:36Z"],["dc.date.issued","2008"],["dc.format.extent","249"],["dc.identifier.isi","000252897700058"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54845"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.publisher.place","Oxford"],["dc.relation.conference","35th Annual Meeting of the Arbeitsgemeinschaft-Dermatolog-Forschung"],["dc.relation.eventlocation","Eriangen, GERMANY"],["dc.relation.issn","0906-6705"],["dc.title","CD137 ligand induces dendritic cell maturation and migration via TNF-alpha? and CCR7"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Knosalla, M."],["dc.contributor.author","Zachmann, Karolin"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Lippert, Undine"],["dc.date.accessioned","2018-11-07T08:32:01Z"],["dc.date.available","2018-11-07T08:32:01Z"],["dc.date.issued","2009"],["dc.format.extent","281"],["dc.identifier.isi","000263520200055"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17250"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.publisher.place","Malden"],["dc.relation.conference","36th Annual Meeting of the Arbeitsgemeinschaft-Dermatologishche-Forschung"],["dc.relation.eventlocation","Heidelberg, GERMANY"],["dc.relation.issn","0906-6705"],["dc.title","T cells in psoriasis lesions lack ICOS expression"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","319"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Investigative Dermatology"],["dc.bibliographiccitation.lastpage","329"],["dc.bibliographiccitation.volume","116"],["dc.contributor.author","Reich, Kristian"],["dc.contributor.author","Garbe, Claus"],["dc.contributor.author","Blaschke, V."],["dc.contributor.author","Maurer, C."],["dc.contributor.author","Middel, Peter"],["dc.contributor.author","Westphal, G."],["dc.contributor.author","Lippert, Undine"],["dc.contributor.author","Neumann, C."],["dc.date.accessioned","2018-11-07T09:24:44Z"],["dc.date.available","2018-11-07T09:24:44Z"],["dc.date.issued","2001"],["dc.description.abstract","Psoriasis is a chronic inflammatory skin disease in which epidermal hyperplasia results from the release of cytokines by infiltrating type 1 T cells. Up-regulation of endogenous interleukin-10 controls type 1 skin responses in animal models; however, interleukin-10 production is low in psoriatic lesions. Consistent with an important role of interleukin-10 in psoriasis, we and colleagues have recently demonstrated clinical efficacy of subcutaneous administration of recombinant interleukin-10 to affected patients. Here, we studied the effects of interleukin-10 on disease-related inflammatory pathways, Patients were treated with recombinant interleukin-10 over 6 wk in an open-label phase II clinical trial. Tissue was obtained before and after therapy and examined by histology/immunohistochemistry, in situ hybridization, and quantitative real-time reverse transcription-polymerase chain reaction. Ten of 14 patients showed a marked reduction of the clinical disease activity. The clinical response was associated with a significant decrease of cutaneous T cell infiltration and the lesional expression of type 1 cytokines interferon-gamma and tumor necrosis factor-alpha. Interleukin-10 inhibited the epidermal interleukin-8 pathway by downregulating the expression of interleukin-8, its receptor CXCR2, and its inducer interleukin-17, and partially reversed the aberrant keratinocyte maturation defining psoriatic epidermal pathology. Remarkably, there was evidence that genetic factors are involved in the response to interleukin-10 as individual variations in the downregulation of tumor necrosis factor-alpha were related to the presence of polymorphisms in the tumor necrosis factor-alpha promoter. These data suggest that excessive production of type 1 cytokines in human skin disease can be counter-regulated by the administration of recombinant interleukin-10, Genotypic analysis may help to identify patients that will preferentially respond to interleukin-10 therapy."],["dc.identifier.doi","10.1046/j.1523-1747.2001.01248.x"],["dc.identifier.isi","000167170700017"],["dc.identifier.pmid","11180010"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29897"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0022-202X"],["dc.title","Response of psoriasis to interleukin-10 is associated with suppression of cutaneous type 1 inflammation, downregulation of the epidermal interleukin-8/CXCR2 pathway and normalization of keratinocyte maturation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Investigative Dermatology"],["dc.bibliographiccitation.volume","132"],["dc.contributor.author","Knosalla, M."],["dc.contributor.author","Zachmann, Karolin"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Moessner, R."],["dc.contributor.author","Zouboulis, Christos C."],["dc.contributor.author","Lippert, Undine"],["dc.date.accessioned","2018-11-07T09:06:56Z"],["dc.date.available","2018-11-07T09:06:56Z"],["dc.date.issued","2012"],["dc.format.extent","S33"],["dc.identifier.isi","000307814000187"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25669"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.publisher.place","New york"],["dc.relation.conference","42nd Annual Meeting of the European-Society-for-Dermatological-Research (ESDR)"],["dc.relation.eventlocation","Venice, ITALY"],["dc.relation.issn","0022-202X"],["dc.title","Expression of CD137 and its Ligand on Mast Cells in Lesional and Non-lesional Psoriatic Skin"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]