Steinmetz, Michael

[["dc.bibliographiccitation.firstpage","136"],["dc.bibliographiccitation.journal","International Journal of Cardiology"],["dc.bibliographiccitation.lastpage","142"],["dc.bibliographiccitation.volume","248"],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Shang, Quanliang"],["dc.contributor.author","Joseph, Navya"],["dc.contributor.author","Kowallick, Johannes T."],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Danford, David A."],["dc.contributor.author","Beerbaum, Phillip"],["dc.contributor.author","Sarikouch, Samir"],["dc.date.accessioned","2020-12-10T14:24:31Z"],["dc.date.available","2020-12-10T14:24:31Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.ijcard.2017.06.121"],["dc.identifier.issn","0167-5273"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72276"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Abnormal right atrial performance in repaired tetralogy of Fallot: A CMR feature tracking analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","433"],["dc.bibliographiccitation.journal","SpringerPlus"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Fasshauer, Martin"],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Unterberg-Buchwald, Christina"],["dc.date.accessioned","2018-11-07T09:36:37Z"],["dc.date.available","2018-11-07T09:36:37Z"],["dc.date.issued","2014"],["dc.description.abstract","Introduction: A 66-years old man suffering from coronary artery disease appeared without symptoms for routine follow-up in our clinic. Case description: The echocardiogram revealed a tumorous mass of the right atrium and right ventricle. In the past, coronary revascularization with venous grafts of the right coronary artery and circumflex artery as well as internal mammaria graft to the left anterior descending artery was performed 20 years before. The general clinicians presented the case to the surgeons and it was decided to perform cardiac MRI as a preoperative diagnostic modality. Discussion and evaluation: Following cardiac magnetic resonance imaging (MRI) showed a mass in the pericardium in the right atrioventricular groove with thrombotic material. Due to the MRI the patient underwent coronary angiography to confirm an aneurysm. Conclusions: The learning points from this case are that cardiac MRI is a very useful tool for further evaluation of suspected cardiac masses and should be performed for further characterization."],["dc.identifier.doi","10.1186/2193-1801-3-433"],["dc.identifier.isi","000359078400004"],["dc.identifier.pmid","25184106"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10853"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32660"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","2193-1801"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Giant bypass aneurysm, a cause of suspected cardiac mass"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The Journal of Heart and Lung Transplantation"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Schubert, S."],["dc.contributor.author","Degener, Franziska"],["dc.contributor.author","Opgen-Rhein, Bernd"],["dc.contributor.author","Schmidt, Fabian"],["dc.contributor.author","Weigelt, Alexandra"],["dc.contributor.author","Wagner, R."],["dc.contributor.author","Mir, T."],["dc.contributor.author","Rentzsch, A."],["dc.contributor.author","Knyphausen, E. Z."],["dc.contributor.author","Papkostas, K."],["dc.contributor.author","Wiegand, G."],["dc.contributor.author","Ruf, Bettina"],["dc.contributor.author","Hannes, T."],["dc.contributor.author","Reineker, K."],["dc.contributor.author","Kiski, Daniela"],["dc.contributor.author","Khalil, Markus"],["dc.contributor.author","Steinmetz, M."],["dc.contributor.author","Fischer, G."],["dc.contributor.author","Pickardt, Thomas"],["dc.contributor.author","Messroghli, Daniel R."],["dc.date.accessioned","2018-11-07T10:25:27Z"],["dc.date.available","2018-11-07T10:25:27Z"],["dc.date.issued","2017"],["dc.format.extent","S23"],["dc.identifier.isi","000398839800037"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42861"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.conference","37th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation (ISHLT)"],["dc.relation.eventlocation","San Diego, CA"],["dc.relation.issn","1557-3117"],["dc.relation.issn","1053-2498"],["dc.title","Assist Device Therapy for Myocarditis - Analysis from the German Multi-Centre Prospective Myocarditis Registry in Pediatric Patients: \"Mykke\""],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1066"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Clinical Radiology"],["dc.bibliographiccitation.lastpage","1071"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Fasshauer, Martin"],["dc.contributor.author","Joseph, Arun A."],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Unterberg-Buchwald, Christine"],["dc.contributor.author","Merboldt, Klaus-Dietmar"],["dc.contributor.author","Voit, Dirk"],["dc.contributor.author","Steinmetz, M."],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Schaetz, S."],["dc.contributor.author","Zhang, S."],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Sohns, J. M."],["dc.date.accessioned","2018-11-07T09:34:30Z"],["dc.date.available","2018-11-07T09:34:30Z"],["dc.date.issued","2014"],["dc.description.abstract","AIM: To evaluate the potential of real-time phase-contrast flow magnetic resonance imaging (MRI) at 40 ms resolution for the simultaneous determination of blood flow in the ascending aorta (AA) and superior vena cava (SVC) in response to reduced intrathoracic pressure (Mueller manoeuvre). MATERIALS AND METHODS: Through-plane flow was assessed in 20 healthy young subjects using real-time phase-contrast MRI based on highly undersampled radial fast low-angle shot (FLASH) with image reconstruction by regularized non-linear inversion. Haemodynamic alterations (three repetitions per subject = 60 events) were evaluated during normal breathing (10 s), inhalation with nearly closed epiglottis (10 s), and recovery (20 s). RESULTS: Relative to normal breathing and despite interindividual differences, reduced intrathoracic pressure by at least 30 mmHg significantly decreased the initial peak mean velocity (averaged across the lumen) in the AA by -24 +/- 9% and increased the velocity in the SVC by +28 +/- 25% (p < 0.0001, n = 23 successful events). Respective changes in flow volume per heartbeat were -25 +/- 9% in the AA and +49 +/- 44% in the SVC (p < 0.0001, n = 23). Flow parameters returned to baseline during sustained pressure reduction, while the heart rate was elevated by 10% (p < 0.0001) after the start (n = 24) and end (n = 17) of the manoeuvre. CONCLUSIONS: Real-time flow MRI during low intrathoracic pressure non-invasively revealed quantitative haemodynamic adjustments in both the AA and SVC. (C) 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved."],["dc.description.sponsorship","DFG [LO 1773/1]"],["dc.identifier.doi","10.1016/j.crad.2014.06.004"],["dc.identifier.isi","000342881800013"],["dc.identifier.pmid","25060931"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32184"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co Ltd"],["dc.relation.issn","1365-229X"],["dc.relation.issn","0009-9260"],["dc.title","Real-time phase-contrast flow MRI of haemodynamic changes in the ascending aorta and superior vena cava during Mueller manoeuvre"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1149"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Radiology"],["dc.bibliographiccitation.lastpage","1156"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Fasshauer, Martin"],["dc.contributor.author","Krüwel, Thomas"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Stahnke, Vera C."],["dc.contributor.author","Rave-Fränk, Margret"],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Sohns, Jan M."],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Unterberg-Buchwald, Christina"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Ritter, Christian"],["dc.contributor.author","Lotz, Joachim"],["dc.date.accessioned","2020-12-10T14:10:11Z"],["dc.date.available","2020-12-10T14:10:11Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00330-017-5056-9"],["dc.identifier.eissn","1432-1084"],["dc.identifier.issn","0938-7994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70672"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Absence of DNA double-strand breaks in human peripheral blood mononuclear cells after 3 Tesla magnetic resonance imaging assessed by γH2AX flow cytometry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","218"],["dc.bibliographiccitation.journal","SpringerPlus"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Goth, Sabrina"],["dc.contributor.author","Sohns, Christian"],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Buchwald, Christina Unterberg"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Fasshauer, Martin"],["dc.contributor.author","Lotz, Joachim"],["dc.date.accessioned","2018-11-07T09:41:07Z"],["dc.date.available","2018-11-07T09:41:07Z"],["dc.date.issued","2014"],["dc.description.abstract","Purpose: Aim of the study was to investigate diagnostic accuracy of cardiac computed tomography angiography (CCTA) between left ventricular end-systolic (LVES) and left ventricular end-diastolic (LVED) cardiac phase for thrombus detection in patient's prior to pulmonary vein isolation (PVI). Materials and methods: 182 consecutive Patients with drug refractory AF scheduled for PVI (62.6% male, mean age 64.1 +/- 10.2 years) underwent routine pre-procedural evaluation including transesophageal echocardiography (TEE) and CCTA for evaluation of left atrial (LA)/left atrial appendage (LAA) anatomy and thrombus formation. Qualitative and quantitative analysis (using aorta ascendens (AA)/LAA ratio) was performed. Measurements of the LA/LAA in LVES and LVED cardiac phase were obtained. Results: End-systolic volumes (LA/LAA) measured in 30 patients without filling defects as control group and all 14 with filling defects of 182 patients were significantly larger (p < 0.01) than in end-diastolic phase. Qualitative analysis was inferior to quantitative analysis using LA/LAA ratio (<0.5; accuracy: 100%, 88%, 100%, 99% vs 100%). 5 out of 182 patients (2.7%) showed thrombus formation of the LAA in CCTA confirmed by TEE and quantitative analysis. Intra/-interobserver variability was lower in end-systolic vs end-diastolic reconstruction interval. Conclusion: For evaluating CCTA datasets in patients prior PVI, the LVES reconstruction interval is recommended due to significantly larger LA/LAA volumes and lower intra/-interobserver variability's."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2014"],["dc.identifier.doi","10.1186/2193-1801-3-218"],["dc.identifier.isi","000359026000005"],["dc.identifier.pmid","25279273"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11751"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33654"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","2193-1801"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Comparison of end-diastolic versus end-systolic cardiac-computed tomography reconstruction interval in patient's prior to pulmonary vein isolation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","33"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.lastpage","42"],["dc.bibliographiccitation.volume","102"],["dc.contributor.author","Schneider, Heike E."],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Krause, Ulrich J."],["dc.contributor.author","Kriebel, Thomas"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T09:30:45Z"],["dc.date.available","2018-11-07T09:30:45Z"],["dc.date.issued","2013"],["dc.description.abstract","Left cardiac sympathetic denervation (LCSD) may be a therapeutic adjunct for young patients with catecholaminergic polymorphic ventricular tachycardia (CPVT) and long QT syndrome (LQTS) who are not fully protected by beta-blockade. The objective of this analysis was to report our institutional experience with LSCD in young patients for the management of life-threatening ventricular arrhythmias in CPVT and LQTS. Ten young patients with CPVT and LQTS underwent transaxillary LSCD at our institution. Mean age at surgery was 14.0 (range 3.9-42) years, mean body weight was 45.7 (range 15.5-90) kg. Five patients had the clinical diagnosis of CPVT, three were genotype positive for a mutation in the ryanodine-receptor-2-gene. Four of five LQTS patients were genotype positive. Indications for LCSD were recurrent syncope, symptomatic episodes of ventricular tachycardias and/or internal cardioverter-defibrillator (ICD) discharges, and aborted cardiac arrest despite high doses of beta-blockers. LCSD was performed via the transaxillary approach. No significant complications were observed. Two patients already had an ICD, 6 patients received an ICD at the same operation or shortly thereafter. Median length of follow-up after LCSD was 2.3 (range 0.6-3.9) years. After LCSD a marked reduction in arrhythmia burden and cardiac events was observed in all patients while medication was continued. None of the patients had any further ICD discharge for sustained VT. After LCSD, arrhythmia burden could significantly be reduced in all our young patients with CPVT and LQTS."],["dc.identifier.doi","10.1007/s00392-012-0492-7"],["dc.identifier.isi","000313070900004"],["dc.identifier.pmid","22821214"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8805"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31382"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1861-0684"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Left cardiac sympathetic denervation for the management of life-threatening ventricular tachyarrhythmias in young patients with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","31"],["dc.bibliographiccitation.journal","Journal of Molecular and Cellular Cardiology"],["dc.bibliographiccitation.lastpage","43"],["dc.bibliographiccitation.volume","127"],["dc.contributor.author","Morhenn, Karoline"],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Wichmann, Helen"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Prondzynski, Maksymilian"],["dc.contributor.author","Söhren, Klaus-Dieter"],["dc.contributor.author","Christ, Torsten"],["dc.contributor.author","Geertz, Birgit"],["dc.contributor.author","Schröder, Sabine"],["dc.contributor.author","Schöndube, Friedrich A."],["dc.contributor.author","Hasenfuss, Gerd"],["dc.contributor.author","Schlossarek, Saskia"],["dc.contributor.author","Zimmermann, Wolfram H."],["dc.contributor.author","Carrier, Lucie"],["dc.contributor.author","Eschenhagen, Thomas"],["dc.contributor.author","Cardinaux, Jean-René"],["dc.contributor.author","Lutz, Susanne"],["dc.contributor.author","Oetjen, Elke"],["dc.date.accessioned","2020-12-10T15:21:48Z"],["dc.date.available","2020-12-10T15:21:48Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.yjmcc.2018.12.001"],["dc.identifier.issn","0022-2828"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73167"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e109164"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Lamata, Pablo"],["dc.contributor.author","Hussain, Shazia T."],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Fasshauer, Martin"],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Unterberg-Buchwald, Christina"],["dc.contributor.author","Bigalke, Boris"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Schuster, Andreas"],["dc.date.accessioned","2017-09-07T11:45:27Z"],["dc.date.available","2017-09-07T11:45:27Z"],["dc.date.issued","2014"],["dc.description.abstract","Objectives: Cardiovascular magnetic resonance feature tracking (CMR-FT) offers quantification of myocardial deformation from routine cine images. However, data using CMR-FT to quantify left ventricular (LV) torsion and diastolic recoil are not yet available. We therefore sought to evaluate the feasibility and reproducibility of CMR-FT to quantify LV torsion and peak recoil rate using an optimal anatomical approach. Methods: Short-axis cine stacks were acquired at rest and during dobutamine stimulation (10 and 20 mu g.kg(-1).min(-1)) in 10 healthy volunteers. Rotational displacement was analysed for all slices. A complete 3D-LV rotational model was developed using linear interpolation between adjacent slices. Torsion was defined as the difference between apical and basal rotation, divided by slice distance. Depending on the distance between the most apical (defined as 0% LV distance) and basal (defined as 100% LV distance) slices, four different models for the calculation of torsion were examined: Model-1 (25-75%), Model-2 (0-100%), Model-3 (25-100%) and Model-4 (0-75%). Analysis included subendocardial, subepicardial and global torsion and recoil rate (mean of subendocardial and subepicardial values). Results: Quantification of torsion and recoil rate was feasible in all subjects. There was no significant difference between the different models at rest. However, only Model-1 (25-75%) discriminated between rest and stress (Global Torsion: 2.7 +/- 1.5 degrees cm(-1), 3.6 +/- 2.0 degrees cm(-1), 5.1 +/- 2.2 degrees cm(-1), p<0.01; Global Recoil Rate: -30.1 +/- 11.1 degrees cm(-1) s (-1), -469 +/- 15.0 degrees cm (-1) s (-1), -68.9 +/- 32.3 degrees cm(-1) s(-1), p<0.01; for rest, 10 and 20 mu g.kg(-1).min(-1) of dobutamine, respectively). Reproducibility was sufficient for all parameters as determined by Bland-Altman analysis, intraclass correlation coefficients and coefficient of variation. Conclusions: CMR-FT based derivation of myocardial torsion and recoil rate is feasible and reproducible at rest and with dobutamine stress. Using an optimal anatomical approach measuring rotation at 25% and 75% apical and basal LV locations allows effective quantification of torsion and recoil dynamics. Application of these new measures of deformation by CMR-FT should next be explored in disease states."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2014"],["dc.identifier.doi","10.1371/journal.pone.0109164"],["dc.identifier.gro","3142035"],["dc.identifier.isi","000345743700050"],["dc.identifier.pmid","25285656"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/3823"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Quantification of Left Ventricular Torsion and Diastolic Recoil Using Cardiovascular Magnetic Resonance Myocardial Feature Tracking"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","670"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Heart Journal - Cardiovascular Imaging"],["dc.bibliographiccitation.lastpage","675"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Hoesch, Olga"],["dc.contributor.author","Thuy-Trang Ngyuen, Thuy-Trang Ngyuen"],["dc.contributor.author","Lauerer, Peter"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Unterberg-Buchwald, Christina"],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Steinmetz, Michael"],["dc.date.accessioned","2018-11-07T09:56:17Z"],["dc.date.available","2018-11-07T09:56:17Z"],["dc.date.issued","2015"],["dc.description.abstract","Aims Ebstein's anomaly (EA) involves a displaced and dysplastic tricuspid valve resulting in an atrialized portion of the right ventricle and an enlargement of the functional right ventricle and right atrium. Biomarkers targeting heart failure such as brain natriuretic peptide (BNP) or haematological parameters [haemoglobin (Hb) and haematocrit (Hct)] are upregulated in states of pulmonary hypoperfusion. We hypothesized that decreased pulmonary perfusion dependent on the stage of right heart failure is a possible mechanism in EA, and that it can be correlated with cardiac magnetic resonance (CMR) parameters. The aim of this study was to investigate the relationship between BNP and haematological parameters with functional parameters from CMR and exercise testing in patients with EA. Methods and results Twenty-five patients with non-corrected EA were studied prospectively (mean age 26 +/- 14 years). BNP level was increased (74 +/- 127 ng/L), and in 16% markedly above the heart failure cut-off level of 100 ng/L. Hb and Hct were increased above normal levels in 20 and 24% of patients, respectively. BNP and Hct/Hb correlated with CMR [total right/left (R/L)-Volume-Index, right atrium-end-diastolic volume index (EDVi), functional right ventricle (fRV)-EDVi, fRV-ejection fraction (EF), tricuspid regurgitation, pulmonary artery flow, and left ventricular EF] and exercise testing [workload/kg, oxygen uptake (VO2), ventilatory response to carbon dioxide production (VE/VCO2), oxygen (O-2) pulse, and heart rate reserve]. The higher BNP and haematological parameters, the higher was the disease severity and the more limited was the physical exercise capacity. Conclusion In this EA cohort, BNP levels and haematological parameters correlated well with functional data from CMR and exercise testing. The total R/L-Volume-Index and BNP, and to some extent hematological parameters, may be useful as prognostic markers in patients with EA."],["dc.description.sponsorship","Faculty of Medicine, Georg-August-University Gottingen, Germany"],["dc.identifier.doi","10.1093/ehjci/jeu312"],["dc.identifier.isi","000358014000013"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36927"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","2047-2412"],["dc.relation.issn","2047-2404"],["dc.title","BNP and haematological parameters are markers of severity of Ebstein's anomaly: correlation with CMR and cardiopulmonary exercise testing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]