Steinmetz, Michael

[["dc.bibliographiccitation.firstpage","136"],["dc.bibliographiccitation.journal","International Journal of Cardiology"],["dc.bibliographiccitation.lastpage","142"],["dc.bibliographiccitation.volume","248"],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Shang, Quanliang"],["dc.contributor.author","Joseph, Navya"],["dc.contributor.author","Kowallick, Johannes T."],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Danford, David A."],["dc.contributor.author","Beerbaum, Phillip"],["dc.contributor.author","Sarikouch, Samir"],["dc.date.accessioned","2020-12-10T14:24:31Z"],["dc.date.available","2020-12-10T14:24:31Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.ijcard.2017.06.121"],["dc.identifier.issn","0167-5273"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72276"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Abnormal right atrial performance in repaired tetralogy of Fallot: A CMR feature tracking analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e109164"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Lamata, Pablo"],["dc.contributor.author","Hussain, Shazia T."],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Fasshauer, Martin"],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Unterberg-Buchwald, Christina"],["dc.contributor.author","Bigalke, Boris"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Schuster, Andreas"],["dc.date.accessioned","2017-09-07T11:45:27Z"],["dc.date.available","2017-09-07T11:45:27Z"],["dc.date.issued","2014"],["dc.description.abstract","Objectives: Cardiovascular magnetic resonance feature tracking (CMR-FT) offers quantification of myocardial deformation from routine cine images. However, data using CMR-FT to quantify left ventricular (LV) torsion and diastolic recoil are not yet available. We therefore sought to evaluate the feasibility and reproducibility of CMR-FT to quantify LV torsion and peak recoil rate using an optimal anatomical approach. Methods: Short-axis cine stacks were acquired at rest and during dobutamine stimulation (10 and 20 mu g.kg(-1).min(-1)) in 10 healthy volunteers. Rotational displacement was analysed for all slices. A complete 3D-LV rotational model was developed using linear interpolation between adjacent slices. Torsion was defined as the difference between apical and basal rotation, divided by slice distance. Depending on the distance between the most apical (defined as 0% LV distance) and basal (defined as 100% LV distance) slices, four different models for the calculation of torsion were examined: Model-1 (25-75%), Model-2 (0-100%), Model-3 (25-100%) and Model-4 (0-75%). Analysis included subendocardial, subepicardial and global torsion and recoil rate (mean of subendocardial and subepicardial values). Results: Quantification of torsion and recoil rate was feasible in all subjects. There was no significant difference between the different models at rest. However, only Model-1 (25-75%) discriminated between rest and stress (Global Torsion: 2.7 +/- 1.5 degrees cm(-1), 3.6 +/- 2.0 degrees cm(-1), 5.1 +/- 2.2 degrees cm(-1), p<0.01; Global Recoil Rate: -30.1 +/- 11.1 degrees cm(-1) s (-1), -469 +/- 15.0 degrees cm (-1) s (-1), -68.9 +/- 32.3 degrees cm(-1) s(-1), p<0.01; for rest, 10 and 20 mu g.kg(-1).min(-1) of dobutamine, respectively). Reproducibility was sufficient for all parameters as determined by Bland-Altman analysis, intraclass correlation coefficients and coefficient of variation. Conclusions: CMR-FT based derivation of myocardial torsion and recoil rate is feasible and reproducible at rest and with dobutamine stress. Using an optimal anatomical approach measuring rotation at 25% and 75% apical and basal LV locations allows effective quantification of torsion and recoil dynamics. Application of these new measures of deformation by CMR-FT should next be explored in disease states."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2014"],["dc.identifier.doi","10.1371/journal.pone.0109164"],["dc.identifier.gro","3142035"],["dc.identifier.isi","000345743700050"],["dc.identifier.pmid","25285656"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/3823"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Quantification of Left Ventricular Torsion and Diastolic Recoil Using Cardiovascular Magnetic Resonance Myocardial Feature Tracking"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","670"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Heart Journal - Cardiovascular Imaging"],["dc.bibliographiccitation.lastpage","675"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Hoesch, Olga"],["dc.contributor.author","Thuy-Trang Ngyuen, Thuy-Trang Ngyuen"],["dc.contributor.author","Lauerer, Peter"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Unterberg-Buchwald, Christina"],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Steinmetz, Michael"],["dc.date.accessioned","2018-11-07T09:56:17Z"],["dc.date.available","2018-11-07T09:56:17Z"],["dc.date.issued","2015"],["dc.description.abstract","Aims Ebstein's anomaly (EA) involves a displaced and dysplastic tricuspid valve resulting in an atrialized portion of the right ventricle and an enlargement of the functional right ventricle and right atrium. Biomarkers targeting heart failure such as brain natriuretic peptide (BNP) or haematological parameters [haemoglobin (Hb) and haematocrit (Hct)] are upregulated in states of pulmonary hypoperfusion. We hypothesized that decreased pulmonary perfusion dependent on the stage of right heart failure is a possible mechanism in EA, and that it can be correlated with cardiac magnetic resonance (CMR) parameters. The aim of this study was to investigate the relationship between BNP and haematological parameters with functional parameters from CMR and exercise testing in patients with EA. Methods and results Twenty-five patients with non-corrected EA were studied prospectively (mean age 26 +/- 14 years). BNP level was increased (74 +/- 127 ng/L), and in 16% markedly above the heart failure cut-off level of 100 ng/L. Hb and Hct were increased above normal levels in 20 and 24% of patients, respectively. BNP and Hct/Hb correlated with CMR [total right/left (R/L)-Volume-Index, right atrium-end-diastolic volume index (EDVi), functional right ventricle (fRV)-EDVi, fRV-ejection fraction (EF), tricuspid regurgitation, pulmonary artery flow, and left ventricular EF] and exercise testing [workload/kg, oxygen uptake (VO2), ventilatory response to carbon dioxide production (VE/VCO2), oxygen (O-2) pulse, and heart rate reserve]. The higher BNP and haematological parameters, the higher was the disease severity and the more limited was the physical exercise capacity. Conclusion In this EA cohort, BNP levels and haematological parameters correlated well with functional data from CMR and exercise testing. The total R/L-Volume-Index and BNP, and to some extent hematological parameters, may be useful as prognostic markers in patients with EA."],["dc.description.sponsorship","Faculty of Medicine, Georg-August-University Gottingen, Germany"],["dc.identifier.doi","10.1093/ehjci/jeu312"],["dc.identifier.isi","000358014000013"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36927"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","2047-2412"],["dc.relation.issn","2047-2404"],["dc.title","BNP and haematological parameters are markers of severity of Ebstein's anomaly: correlation with CMR and cardiopulmonary exercise testing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Circulation"],["dc.contributor.author","Backhaus, Sören J"],["dc.contributor.author","Lange, Torben"],["dc.contributor.author","George, Elisabeth F"],["dc.contributor.author","Hellenkamp, Kristian"],["dc.contributor.author","Gertz, Roman J"],["dc.contributor.author","Billing, Marcus"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Friede, Tim"],["dc.contributor.author","Uecker, Martin"],["dc.contributor.author","Hasenfuß, Gerd P."],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Schuster, Andreas"],["dc.date.accessioned","2021-03-08T07:13:50Z"],["dc.date.available","2021-03-08T07:13:50Z"],["dc.date.issued","2021-01-21"],["dc.description.abstract","Background: Right heart catheterisation (RHC) using exercise-stress is the reference standard for the diagnosis of heart failure with preserved ejection fraction (HFpEF) but carries the risk of the invasive procedure. We hypothesized that real-time cardiovascular magnetic resonance (RT-CMR) exercise imaging with pathophysiologic data at excellent temporal and spatial resolution may represent a contemporary non-invasive alternative for diagnosing HFpEF. Methods: The HFpEF stress trial (DZHK-17, NCT03260621) prospectively recruited 75 patients with echocardiographic signs of diastolic dysfunction and dyspnea on exertion (E/e'>8, New York Heart Association (NYHA) class ≥II) to undergo echocardiography, RHC and RT-CMR at rest and during exercise-stress. HFpEF was defined according to pulmonary capillary wedge pressure (PCWP ≥15mmHg at rest or ≥25mmHg during exercise stress). RT-CMR functional assessments included time-volume curves for total and early (1/3) diastolic left ventricular (LV) filling, left atrial (LA) emptying and LV/LA long axis strain (LAS). Results: HFpEF patients (n=34, median PCWP rest 13mmHg, stress 27mmHg) had higher E/e' (12.5 vs. 9.15), NT-proBNP (255 vs. 75ng/l) and LA volume index (43.8 vs. 36.2ml/m2) compared to non-cardiac dyspnea patients (n=34, rest 8mmHg, stress 18mmHg, p≤0.001 for all). Seven patients were excluded due to the presence of non HFpEF cardiac disease causing dyspnea on imaging. There were no differences in RT-CMR LV total and early diastolic filling at rest and during exercise-stress (p≥0.164) between HFpEF and non-cardiac dyspnea. RT-CMR revealed significantly impaired LA total and early (p<0.001) diastolic emptying in HFpEF during exercise-stress. RT-CMR exercise-stress LA LAS was independently associated with HFpEF (adjusted odds ratio 0.657, 95% confidence interval [0.516; 0.838], p=0.001) after adjustment for clinical and imaging parameters and emerged as the best predictor for HFpEF (area under the curve rest 0.82 vs. exercise-stress 0.93, p=0.029). Conclusions: RT-CMR allows highly accurate identification of HFpEF during physiological exercise and qualifies as a suitable non-invasive diagnostic alternative. These results will need to be confirmed in multi-centre prospective research studies to establish widespread routine clinical use. Clinical Trial Registration: URL: https://www.clinicaltrials.gov Unique Identifier: NCT03260621."],["dc.identifier.doi","10.1161/CIRCULATIONAHA.120.051542"],["dc.identifier.pmid","33472397"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80476"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/302"],["dc.language.iso","en"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.issn","0009-7322"],["dc.relation.issn","1524-4539"],["dc.relation.workinggroup","RG Hasenfuß"],["dc.relation.workinggroup","RG Uecker"],["dc.title","Exercise-Stress Real-time Cardiac Magnetic Resonance Imaging for Non-Invasive Characterisation of Heart Failure with Preserved Ejection Fraction: The HFpEF Stress Trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","601"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Circulation Cardiovascular Imaging"],["dc.bibliographiccitation.lastpage","609"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Hoesch, Olga"],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Thuy-Trang Nguyen, Thuy-Trang Nguyen"],["dc.contributor.author","Lauerer, Peter"],["dc.contributor.author","Rosenberg, Christina"],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Unterberg, Christina"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Fasshauer, Martin"],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Steinmetz, Michael"],["dc.date.accessioned","2018-11-07T09:38:08Z"],["dc.date.available","2018-11-07T09:38:08Z"],["dc.date.issued","2014"],["dc.description.abstract","Background-The classification of clinical severity of Ebstein anomaly still remains a challenge. The aim of this study was to focus on the interaction of the pathologically altered right heart with the anatomically-supposedly-normal left heart and to derive from cardiac magnetic resonance (CMR) a simple imaging measure for the clinical severity of Ebstein anomaly. Methods and Results-Twenty-five patients at a mean age of 26 +/- 14 years with unrepaired Ebstein anomaly were examined in a prospective study. Disease severity was classified using CMR volumes and functional measurements in comparison with heart failure markers from clinical data, ECG, laboratory and cardiopulmonary exercise testing, and echocardiography. All examinations were completed within 24 hours. A total right/left-volume index was defined from end-diastolic volume measurements in CMR: total right/left-volume index=(RA+aRV+fRV)/(LA+LV). Mean total right/left-volume index was 2.6 +/- 1.7 (normal values: 1.1 +/- 0.1). This new total right/left-volume index correlated with almost all clinically used biomarkers of heart failure: brain natriuretic peptide (r=0.691; P=0.0003), QRS (r=0.432; P=0.039), peak oxygen consumption/kg (r=-0.479; P=0.024), ventilatory response to carbon dioxide production at anaerobic threshold (r=0.426; P=0.048), the severity of tricuspid regurgitation (r=0.692; P=0.009), tricuspid valve offset (r=0.583; P=0.004), and tricuspid annular plane systolic excursion (r=0.554; P=0.006). Previously described severity indices ([RA+aRV]/[fRV+LA+LV]) and fRV/LV end-diastolic volume corresponded only to some parameters. Conclusions-In patients with Ebstein anomaly, the easily acquired index of right-sided to left-sided heart volumes from CMR correlated well with established heart failure markers. Our data suggest that the total right/left-volume index should be used as a new and simplified CMR measure, allowing more accurate assessment of disease severity than previously described scoring systems."],["dc.identifier.doi","10.1161/CIRCIMAGING.113.001467"],["dc.identifier.isi","000339172100006"],["dc.identifier.pmid","24807407"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33001"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1942-0080"],["dc.relation.issn","1941-9651"],["dc.title","The Total Right/Left-Volume Index: A New and Simplified Cardiac Magnetic Resonance Measure to Evaluate the Severity of Ebstein Anomaly of the Tricuspid Valve A Comparison With Heart Failure Markers From Various Modalities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Circulation: Cardiovascular Imaging"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Stümpfig, Thomas"],["dc.contributor.author","Seehase, Matthias"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Kowallick, Johannes"],["dc.contributor.author","Müller, Matthias"],["dc.contributor.author","Unterberg-Buchwald, Christina"],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Uecker, Martin"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2021-09-01T06:42:57Z"],["dc.date.available","2021-09-01T06:42:57Z"],["dc.date.issued","2021"],["dc.description.abstract","Background: Correction of tetralogy of Fallot (cTOF) often results in pulmonary valve pathology and right ventricular (RV) dysfunction. Reduced exercise capacity in cTOF patients cannot be explained by these findings alone. We aimed to explore why cTOF patients exhibit impaired exercise capacity with the aid of a comprehensive cardiopulmonary exercise testing (CPET) and real-time cardiovascular magnetic resonance exercise testing (CMR-ET) protocol. Methods: Thirty three cTOF patients and 35 matched healthy controls underwent CPET and CMR-ET in a prospective case-control study. Real-time steady-state free precession cine and phase-contrast sequences were obtained during incremental supine in-scanner cycling at 50, 70, and 90 W. RV and left ventricle (LV) volumes and pulmonary blood flow (Qp) were calculated. Differences of CPET and CMR-ET between cTOF versus controls and correlations between CPET and CMR-ET parameters in cTOF were evaluated statistically for all CMR exercise levels using Mann-Whitney U and Spearman rank-order correlation tests. Results: CPET capacity was significantly lower in cTOF than in controls. cTOF patients exhibited not only significantly reduced Qp and RV function but also lower LV function on CMR-ET. Higher CPET values in cTOF correlated with higher Qp (Qp 90 W versus carbon dioxide ventilatory equivalent %: R =−0.519, P <0.05), higher LV–end-diastolic volume indexed to body surface area (LV–end-diastolic volume indexed to body surface area at 50 W versus oxygen uptake in % at maximum exercise on CPET R =0.452, P <0.05), and change in LV ejection fraction (EF; LV-EF at 90 W versus Watt %: r =−0.463, P <0.05). No correlation was found with regard to RV-EF. Significant RV-LV interaction was observed during CMR-ET (RV-EF versus LV-EF at 50 W and 70 W: r =0.66, P <0.02 and r =0.52, P <0.05, respectively). Conclusions: Impaired exercise capacity in cTOF resulted from a reduction in not only RV, but also LV function. cTOF with good exercise capacity on CPET demonstrated higher LV reserve and pulmonary blood flow during incremental CMR-ET. Apart from RV parameters, CMR-ET–derived LV function could be a valuable tool to stratify cTOF patients for pulmonary valve replacement."],["dc.description.abstract","Background: Correction of tetralogy of Fallot (cTOF) often results in pulmonary valve pathology and right ventricular (RV) dysfunction. Reduced exercise capacity in cTOF patients cannot be explained by these findings alone. We aimed to explore why cTOF patients exhibit impaired exercise capacity with the aid of a comprehensive cardiopulmonary exercise testing (CPET) and real-time cardiovascular magnetic resonance exercise testing (CMR-ET) protocol. Methods: Thirty three cTOF patients and 35 matched healthy controls underwent CPET and CMR-ET in a prospective case-control study. Real-time steady-state free precession cine and phase-contrast sequences were obtained during incremental supine in-scanner cycling at 50, 70, and 90 W. RV and left ventricle (LV) volumes and pulmonary blood flow (Qp) were calculated. Differences of CPET and CMR-ET between cTOF versus controls and correlations between CPET and CMR-ET parameters in cTOF were evaluated statistically for all CMR exercise levels using Mann-Whitney U and Spearman rank-order correlation tests. Results: CPET capacity was significantly lower in cTOF than in controls. cTOF patients exhibited not only significantly reduced Qp and RV function but also lower LV function on CMR-ET. Higher CPET values in cTOF correlated with higher Qp (Qp 90 W versus carbon dioxide ventilatory equivalent %: R =−0.519, P <0.05), higher LV–end-diastolic volume indexed to body surface area (LV–end-diastolic volume indexed to body surface area at 50 W versus oxygen uptake in % at maximum exercise on CPET R =0.452, P <0.05), and change in LV ejection fraction (EF; LV-EF at 90 W versus Watt %: r =−0.463, P <0.05). No correlation was found with regard to RV-EF. Significant RV-LV interaction was observed during CMR-ET (RV-EF versus LV-EF at 50 W and 70 W: r =0.66, P <0.02 and r =0.52, P <0.05, respectively). Conclusions: Impaired exercise capacity in cTOF resulted from a reduction in not only RV, but also LV function. cTOF with good exercise capacity on CPET demonstrated higher LV reserve and pulmonary blood flow during incremental CMR-ET. Apart from RV parameters, CMR-ET–derived LV function could be a valuable tool to stratify cTOF patients for pulmonary valve replacement."],["dc.identifier.doi","10.1161/CIRCIMAGING.120.011823"],["dc.identifier.pmid","34384226"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89183"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/427"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-455"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.eissn","1942-0080"],["dc.relation.issn","1941-9651"],["dc.relation.workinggroup","RG Uecker"],["dc.title","Impaired Exercise Tolerance in Repaired Tetralogy of Fallot Is Associated With Impaired Biventricular Contractile Reserve: An Exercise-Stress Real-Time Cardiovascular Magnetic Resonance Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","943"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","JACC: Cardiovascular Imaging"],["dc.bibliographiccitation.lastpage","945"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Backhaus, Sören J."],["dc.contributor.author","Rösel, Simon F."],["dc.contributor.author","Schulz, Alexander"],["dc.contributor.author","Lange, Torben"],["dc.contributor.author","Hellenkamp, Kristian"],["dc.contributor.author","Gertz, Roman J."],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Schuster, Andreas"],["dc.date.accessioned","2022-07-01T07:35:48Z"],["dc.date.available","2022-07-01T07:35:48Z"],["dc.date.issued","2022"],["dc.description.sponsorship"," http://dx.doi.org/10.13039/100010447 Deutsches Zentrum für Herz-Kreislaufforschung"],["dc.identifier.doi","10.1016/j.jcmg.2021.11.013"],["dc.identifier.pii","S1936878X21008421"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112270"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-581"],["dc.relation.issn","1936-878X"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","RT-CMR Imaging for Noninvasive Characterization of HFpEF"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","54"],["dc.bibliographiccitation.journal","International Journal of Cardiology"],["dc.bibliographiccitation.lastpage","61"],["dc.bibliographiccitation.volume","257"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Broder, Marike"],["dc.contributor.author","Hösch, Olga"],["dc.contributor.author","Lamata, Pablo"],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Kowallick, Johannes T."],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Ritter, Christian Oliver"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Schuster, Andreas"],["dc.date.accessioned","2018-04-23T11:48:00Z"],["dc.date.available","2018-04-23T11:48:00Z"],["dc.date.issued","2018"],["dc.description.abstract","Purpose We aimed to quantify atrial and ventricular myocardial deformation in Ebstein's Anomaly (EA) in a case-control study with cardiovascular magnetic resonance (CMR) feature tracking and to correlate changes in cardiac performance with the severity of disease and clinical heart failure parameters. Materials and methods Atrial and ventricular deformation was measured using CMR feature tracking in 30 EA and 20 healthy control subjects. Atrial performance was characterized using longitudinal strain and strain rate parameters for reservoir function, conduit function and booster pump function. Ventricular performance was characterized using RV and LV global longitudinal strain (εl) and LV circumferential and radial strain (εc and εr). Volumetric measurements for the ventricles including the Total Right/Left-Volume-Index (R/L-Volume-Index) and heart failure markers (BNP, NYHA class) were also quantified. Results EA patients showed significantly impaired right atrial performance, which correlated with heart failure markers (NYHA, BNP, R/L-Volume-Index). LA function in EA patients was also impaired with atrial contractile function correlating with NYHA class. EA patients exhibited impaired RV myocardial deformation, also with a significant correlation with heart failure markers. Conclusion CMR feature tracking can be used to quantify ventricular and atrial function in a complex cardiac malformation such as EA. EA is characterized by impaired quantitative right heart atrio-ventricular deformation, which is associated with heart failure severity. While LV function remains preserved, there is also significant impairment of LA function. These quantitative performance parameters may represent early markers of cardiac deterioration of potential value in the clinical management of EA."],["dc.identifier.doi","10.1016/j.ijcard.2017.11.097"],["dc.identifier.gro","3142316"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13449"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.relation.issn","0167-5273"],["dc.title","Atrio-ventricular deformation and heart failure in Ebstein's Anomaly - A cardiovascular magnetic resonance study"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1257"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Radiology"],["dc.bibliographiccitation.lastpage","1266"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Shang, Quanliang"],["dc.contributor.author","Patel, Shivani"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Danford, David A."],["dc.contributor.author","Beerbaum, Philipp"],["dc.contributor.author","Sarikouch, Samir"],["dc.contributor.author","Kutty, Shelby"],["dc.date.accessioned","2020-12-10T14:10:11Z"],["dc.date.available","2020-12-10T14:10:11Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00330-017-5034-2"],["dc.identifier.eissn","1432-1084"],["dc.identifier.issn","0938-7994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70671"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Myocardial deformation assessed by longitudinal strain: Chamber specific normative data for CMR-feature tracking from the German competence network for congenital heart defects"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","989"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Clinical Radiology"],["dc.bibliographiccitation.lastpage","998"],["dc.bibliographiccitation.volume","70"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Stahnke, V. -C."],["dc.contributor.author","Unterberg-Buchwald, Christina"],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Lamata, Pablo"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Faßhauer, M."],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Bigalke, Boris"],["dc.contributor.author","Ritter, Caroline"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Beerbaum, P."],["dc.contributor.author","Lotz, Joachim"],["dc.date.accessioned","2017-09-07T11:43:34Z"],["dc.date.available","2017-09-07T11:43:34Z"],["dc.date.issued","2015"],["dc.description.abstract","AIM: To assess intervendor agreement of cardiovascular magnetic resonance feature tracking (CMR-FT) and to study the impact of repeated measures on reproducibility. MATERIALS AND METHODS: Ten healthy volunteers underwent cine imaging in short-axis orientation at rest and with dobutamine stimulation (10 and 20 mu g/kg/min). All images were analysed three times using two types of software (TomTec, Unterschleissheim, Germany and Circle, cvi(42), Calgary, Canada) to assess global left ventricular circumferential (Ecc) and radial (Err) strains and torsion. Differences in intra-and interobserver variability within and between software types were assessed based on single and averaged measurements (two and three repetitions with subsequent averaging of results, respectively) as determined by Bland-Altman analysis, intraclass correlation coefficients (ICC), and coefficient of variation (CoV). RESULTS: Myocardial strains and torsion significantly increased on dobutamine stimulation with both types of software (p<0.05). Resting Ecc and torsion as well as Ecc values during dobutamine stimulation were lower measured with Circle (p<0.05). Intra-and interobserver variability between software types was lowest for Ecc (ICC 0.81 [0.63-0.91], 0.87 [0.72-0.94] and CoV 12.47% and 14.3%, respectively) irrespective of the number of analysis repetitions. Err and torsion showed higher variability that markedly improved for torsion with repeated analyses and to a lesser extent for Err. On an intravendor level TomTec showed better reproducibility for Ecc and torsion and Circle for Err. CONCLUSIONS: CMR-FT strain and torsion measurements are subject to considerable intervendor variability, which can be reduced using three analysis repetitions. For both vendors, Ecc qualifies as the most robust parameter with the best agreement, albeit lower Ecc values obtained using Circle, and warrants further investigation of incremental clinical merit. (C) 2015 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.crad.2015.05.006"],["dc.identifier.gro","3141835"],["dc.identifier.isi","000361899600012"],["dc.identifier.pmid","26139384"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1601"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1365-229X"],["dc.relation.issn","0009-9260"],["dc.title","Cardiovascular magnetic resonance feature-tracking assessment of myocardial mechanics: Intervendor agreement and considerations regarding reproducibility"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]