Tezval, Mohammad

[["dc.bibliographiccitation.firstpage","850"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Planta Medica"],["dc.bibliographiccitation.lastpage","857"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Kolios, Leila"],["dc.contributor.author","Schumann, Jacob"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Rack, Thomas"],["dc.contributor.author","Tezval, Mohammed"],["dc.contributor.author","Seidlova-Wuttke, Dana"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.date.accessioned","2018-11-07T08:43:01Z"],["dc.date.available","2018-11-07T08:43:01Z"],["dc.date.issued","2010"],["dc.description.abstract","Osteoporosis and its accompanying, predominantly metaphyseal, fractures are a major health problem. Black cohosh (Cimicifuga racemosa) and estrogen positively influence osteoporotic bone. Both substances may improve fracture healing in early osteoporosis as well. In 48 twelve-week-old ovariectomized or, respectively, sham-operated (SHAM) rats, a standardized metaphyseal tibia osteotomy with bridging T-plate fixation was performed. During the healing process of 35 days, rats received soy-free (SHAM, osteopenic C), estrogen-(E) or Cimicifuga racemosa-(CR) supplemented diets. After sacrifice, the callus formation was analyzed with regard to biomechanical quality, morphology, quantity, time course of new bone built and gene expression. CR induced a high rate of metaphyseal callus formation. The biomechanical properties and the amount of new callus formation indicated that fracture healing was still in progress. Therefore, gene expression of osteoblasts was comparatively high. Body weight and the trabecular structure were influenced little by CR. Estrogen improved the biomechanical properties of the callus. Resistance to microfracturing was significantly enhanced in the E group and even superior to SHAM. Remodeling of the callus formation had already begun. The trabecular network and the typical endosteal fracture healing were especially improved. Osteoporotic metaphyseal fracture healing was improved by estrogen more than by Cimicifuga racemosa. The process of fracture healing occurred nearly physiologically. The generation of callus formation was supported by Cimicifuga racemosa as well, but the five-week duration of application was too short for Cimicifuga racemosa to show its complete potential. Already-initiated Cimicifuga racemosa therapy for menopausal symptoms could be continued during fracture healing without hesitation."],["dc.description.sponsorship","DFG [STU 478/2-1]"],["dc.identifier.doi","10.1055/s-0029-1240798"],["dc.identifier.isi","000279668400002"],["dc.identifier.pmid","20104444"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19846"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0032-0943"],["dc.title","Effects of Black Cohosh (Cimicifuga racemosa) and Estrogen on Metaphyseal Fracture Healing in the Early Stage of Osteoporosis in Ovariectomized Rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","851"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Phytotherapy Research"],["dc.bibliographiccitation.lastpage","858"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Sehmisch, Stefan"],["dc.contributor.author","Boeckhoff, J."],["dc.contributor.author","Wille, J."],["dc.contributor.author","Seidlova-Wuttke, Dana"],["dc.contributor.author","Rack, Thomas"],["dc.contributor.author","Tezval, Mohammed"],["dc.contributor.author","Wuttke, Wolfgang"],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.date.accessioned","2018-11-07T08:29:35Z"],["dc.date.available","2018-11-07T08:29:35Z"],["dc.date.issued","2009"],["dc.description.abstract","Osteoporosis research undertaken in males is rare and there are only a few therapeutic options. Phytoestrogens might be a safe alternative for prophylaxis. Sixty 3-month-old male rats were orchidectomized and divided into five groups. The groups either received soy-free food (C), estradiol (E), testosterone (T) or Vitex agnus castus in different concentrations (AC high/AC low) for 12 weeks. The tibia metaphysis was tested biomechanically and histomorphometrically. The AC high group reached 87% of the biomechanical values of the estradiol group and was significantly superior to the control group. Testosterone supplementation resulted in poor biomechanical properties. The cortical bone parameters of the AC group were similar to the control group, while supplementation with estradiol and testosterone demonstrated a reduction of cortical bone. The AC high group reached 88.4% of trabecular bone area, 80.7% of trabecular number and 66.9% of the number of trabecular nodes compared with estradiol supplementation. Vitex agnus castus demonstrated osteoprotective effects in males. It preserves the cortical as well as the trabecular bone and might be a safe alternative for HRT. Testosterone supplementation has positive effects on trabecular bone, which are concurrently counteracted by the loss of cortical bone. Copyright (C) 2008 John Wiley & Sons, Ltd."],["dc.identifier.doi","10.1002/ptr.2711"],["dc.identifier.isi","000267088400018"],["dc.identifier.pmid","19107741"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16686"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","John Wiley & Sons Ltd"],["dc.relation.issn","0951-418X"],["dc.title","Vitex agnus castus as Prophylaxis for Osteopenia after Orchidectomy in Rats Compared with Estradiol and Testosterone Supplementation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","23"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Calcified Tissue International"],["dc.bibliographiccitation.lastpage","32"],["dc.bibliographiccitation.volume","86"],["dc.contributor.author","Kolios, Leila"],["dc.contributor.author","Hoerster, Ann Kristin"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Malcherek, Marie Christin"],["dc.contributor.author","Rack, Thomas"],["dc.contributor.author","Tezval, Mohammed"],["dc.contributor.author","Seidlova-Wuttke, Dana"],["dc.contributor.author","Wuttke, Wolfgang"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.date.accessioned","2018-11-07T08:47:15Z"],["dc.date.available","2018-11-07T08:47:15Z"],["dc.date.issued","2010"],["dc.description.abstract","Osteoporosis is accompanied by predominantly metaphyseal fractures with a delayed and qualitatively reduced healing process. This study addressed the question of whether fracture healing in the context of osteoporosis prophylaxis is improved with estrogen (E) or alendronate (ALN). Thirty-six ovariectomized and 12 sham-operated 12-week-old rats received soy-free (osteoporotic C, sham), E-, or ALN- supplemented diets. After 10 weeks, a metaphyseal tibia osteotomy and standardized T-plate fixation were performed. After a 5-week healing process, the fracture callus was evaluated qualitatively by biomechanical bending test and quantitatively in microradiographic sections. The time course of callus formation was examined using fluorochrome-labeled histological sections. Administration of E improved the biomechanical properties of callus (stiffness [N/mm]: sham: 110.2 +/- A 76.07, C: 41.28 +/- A 33.70, E: 85.72 +/- A 47.24, ALN: 72.07 +/- A 34.68). The resistance to microfracturing seen in E-treated animals was significantly enhanced and even superior to sham (yield load [N] sham: 27.44 +/- A 9.72, C: 21.04 +/- A 12.47, E: 42.85 +/- A 13.74(a dagger), ALN: 25.28 +/- A 6.4(center dot)) ( P < 0.05 vs. sham group, (a dagger) P < 0.05 vs. C group, (aEuro cent) P < 0.05 vs. E group). Trabecular bone in particular was improved, indicating the presence of physiological endosteal bridging (Tr.Dn [%] sham: 10.53 +/- A 18.9, C: 1.01 +/- A 0.14, E: 24.13 +/- A 34.09(a dagger), ALN: 3.99 +/- A 8.3(center dot)). ALN did not help bone healing, as shown by mechanical tests. Compared to the C group, statistically, ALN did not show worse properties. The induction of callus formation under ALN treatment was slightly delayed (Tt.Cl [mm(2)] sham: 3.68 +/- A 0.66, C: 3.44 +/- A 0.42, E: 3.69 +/- A 0.58, ALN: 3.06 +/- A 0.56). Osteoporotic metaphyseal fracture healing was qualitatively and quantitatively improved by E prophylaxis. The process of fracture healing occurred nearly physiologically (shamlike). Notably, ALN hardly improved metaphyseal callus properties when assessed as osteoporosis prophylaxis, but to a lesser extent than E."],["dc.description.sponsorship","DFG [STU 478/2-1]"],["dc.identifier.doi","10.1007/s00223-009-9318-7"],["dc.identifier.isi","000273102700004"],["dc.identifier.pmid","19949941"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/4027"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20901"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0171-967X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Do Estrogen and Alendronate Improve Metaphyseal Fracture Healing When Applied as Osteoporosis Prophylaxis?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","529"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","World Journal of Urology"],["dc.bibliographiccitation.lastpage","534"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Tezval, Mohammed"],["dc.contributor.author","Serferaz, G."],["dc.contributor.author","Rack, Thomas"],["dc.contributor.author","Kolios, Leila"],["dc.contributor.author","Sehmisch, Stefan"],["dc.contributor.author","Schmelz, Ulrich"],["dc.contributor.author","Tezval, Hossein"],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.date.accessioned","2018-11-07T08:53:48Z"],["dc.date.available","2018-11-07T08:53:48Z"],["dc.date.issued","2011"],["dc.description.abstract","Management of hypogonadism-induced osteoporosis in elderly men is still a challenge. We investigated the short-term effects of parathyroid hormone (PTH) treatments on strength, micro-architecture, and mineral density of trochanteric region of orchiectomized rat femur. Eight-month-old male Sprague-Dawley rats (n = 44) were divided into two groups: (1) orchiectomized (ORX) and (2) sham group. Twelve weeks after orchiectomy, half of the orchiectomized animals were treated with daily subcutaneously injected PTH (0.040 mg/kg/BW) (ORX-PTH) for 5 weeks. The other half remained untreated (ORX). The sham-operated group was divided and treated in the same way (sham, sham-PTH). After 5 weeks, both femurs were excised for biomechanical and histomorphometric analysis, trabecular measurements, mineral content assessment, and immunofluorescence analysis. The femoral trochanteric strength after PTH treatment was enhanced in the breaking test (ORX-F-max = 158.7 N vs. ORX + PTH-F-max = 202 N). Stiffness of treated ORX animals reached nearly the levels observed in untreated sham rats. PTH therapy improved the trabecular connectivity, width, and area (ORX-Tb.Ar = 47.79% vs. ORX + PTH-Tb.Ar = 68.47%, P < 0.05) in the proximal femur. The treated rats showed significantly improved mineral content in ashed femurs (ORX-mineral content = 43.73% vs. ORX + PTH-mineral content = 49.49%) when compared to the untreated animals. A comparison of widths of fluorescence bands in cortical bone of the subtrochanteric cross-sections showed a significant increase in oppositions after the PTH therapy. Our finding supports the hypothesis that PTH therapy seems to be a rational therapy in patients with hypogonadism induced bone loss and improves the bone strength of trochanteric region of rat femur."],["dc.identifier.doi","10.1007/s00345-011-0652-9"],["dc.identifier.isi","000293136200019"],["dc.identifier.pmid","21298272"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7116"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22511"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1433-8726"],["dc.relation.issn","0724-4983"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Effect of parathyroid hormone on hypogonadism induced bone loss of proximal femur of orchiectomized rat"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","251"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Osteoporosis International"],["dc.bibliographiccitation.lastpage","261"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Tezval, Mohammed"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.contributor.author","Sehmisch, Stefan"],["dc.contributor.author","Rack, Thomas"],["dc.contributor.author","Stary, A."],["dc.contributor.author","Stebener, M."],["dc.contributor.author","Konietschke, Frank"],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.date.accessioned","2018-11-07T08:46:31Z"],["dc.date.available","2018-11-07T08:46:31Z"],["dc.date.issued","2010"],["dc.description.abstract","We have examined the changes induced in the trochanteric region of femur of ovariectomized rat after administration of estradiol and p.arathyroid hormone. We have developed a reproducible biomechanical test and produced trochanteric fractures to evaluate stiffness and strength of this region in addition to histomorphometry. We investigated the short-term effects of parathyroid hormone (PTH) and estrogen (E) on the strength of the rat trochanteric region in a new mechanical test. Forty-four 3-month-old female Sprague-Dawley rats were ovariectomized and 8 weeks later treated with soy-free diet (C), daily applications of orally supplied E (0.5 mg/kg food) or subcutaneously injected PTH (0.014 mg/kg), for 5 weeks, and an additional untreated group was added as sham-operated. The femurs were examined for biomechanical and histomorphometric changes. Our new mechanical test was validated in a right-left comparison. The PTH treatment induced significantly superior biomechanical results (F (max) = 225.3 N, stiffness = 314.9 N/mm) compared to E (F (max) = 182.9 N, stiffness = 237.2 N/mm), C (F (max) = 166.03 N, stiffness = 235.56 N/mm), and sham (F (max) = 192.1 N, stiffness = 267.2 N/mm). Animals of the PTH group demonstrated a significantly improved trabecular bone structure and area (75.67%) in comparison to the E (61.04%) and C (57.18%) groups. Our new biomechanical test is valid and produces trochanteric fracture. Our results show that the short-term antiosteoporotic effects of PTH are in the trochanteric region of ovariectomized rat superior to E."],["dc.identifier.doi","10.1007/s00198-009-0941-y"],["dc.identifier.isi","000273327000006"],["dc.identifier.pmid","19436940"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/4023"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20712"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","London"],["dc.relation.issn","0937-941X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Improvement of trochanteric bone quality in an osteoporosis model after short-term treatment with parathyroid hormone: a new mechanical test for trochanteric region of rat femur"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","235"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Planta Medica"],["dc.bibliographiccitation.lastpage","240"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Tezval, Mohammad"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Seidlova-Wuttke, Dana"],["dc.contributor.author","Rack, Thomas"],["dc.contributor.author","Kolios, Leila"],["dc.contributor.author","Wuttke, Wolfgang"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.date.accessioned","2018-11-07T08:46:36Z"],["dc.date.available","2018-11-07T08:46:36Z"],["dc.date.issued","2010"],["dc.description.abstract","The isoflavonoids found in soy have attracted great interest as dietary phytoestrogens that might be effective for postmenopausal hormone replacement therapy. Special attention has been devoted to the hormonal effects of various isoflavonoids, like genistein (GEN) and daidzein's (DAID) potent metabolite, equol (EQ). Here we aimed to investigate the short-term effects of genistein and equol on the proximal femur of ovariectomized (OVX) rats. Forty-eight, 3-month-old female Sprague-Dawley rats were ovarectomized; after eight weeks the bilateral osteotomy and osteosynthesis (OS) of their tibiae was performed and the rats were randomly divided into the following four groups: OVX control group (C), treated with estradiol-17beta (E2) -benzoate (E; daily intake 0.086 mg/d per animal), genistein (GEN; daily intake 12.7 mg/d per animal) and equol (EQ; daily intake 4.65 mg/d per animal). At 5 weeks postoperatively (OS), the breaking test was performed on the trochanteric region of femur. Additionally, histomorphometric assessment, and trabecular and cortical bone microstructure analyses were performed. The relative gain of body weight (BW) in the EQ (24%) group was significantly (p < 0.05) lower than in the C (33%) and GEN (30%) groups. After treatment for 5 weeks, the maximal load (F(max)) and yield load (yL) were higher (p < 0.05 for the weight-adapted results) in the E (188.4 N resp. 113.1 N) and EQ (177.3 N resp. 112 N) groups as compared to C (162.8 N resp. 109.1 N) and GEN (165.7 N resp. 108.8 N). In the histomorphometric tests the E-(trabecular area (Tb.Ar) = 74.93%, trabecular nodes/mm(2) (N.Nd/mm(2)) = 48.65) and EQ-treated (Tb.Ar = 63.13%, N.Nd/mm(2) = 43.72) animals showed significant improvement with regard to Tb.Ar and trabecular connectivity (N.Nd./mm(2)) in comparison to C (Tb.Ar = 46.84, N.Nd/mm(2) = 31.86) and GEN (Tb.Ar = 48.22%, N.Nd/mm(2) = 34.15). There were no differences in relative cortical width (Ct.Wi) among the four groups. The treatment with EQ resulted in improved biomechanical and histomorphometric properties as compared to the treatment with GEN. Thus, of the studied substances, EQ seems to be a possible alternative to hormone replacement therapy, but further studies are needed."],["dc.description.sponsorship","DFG [STU 478/2-1]"],["dc.identifier.doi","10.1055/s-0029-1186136"],["dc.identifier.isi","000274392700005"],["dc.identifier.pmid","19764010"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20732"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0032-0943"],["dc.title","Changes in the Histomorphometric and Biomechanical Properties of the Proximal Femur of Ovariectomized Rat after Treatment with the Phytoestrogens Genistein and Equol"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","33"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Calcified Tissue International"],["dc.bibliographiccitation.lastpage","40"],["dc.bibliographiccitation.volume","88"],["dc.contributor.author","Tezval, Mohammed"],["dc.contributor.author","Biblis, M."],["dc.contributor.author","Sehmisch, Stefan"],["dc.contributor.author","Schmelz, Ulrich"],["dc.contributor.author","Kolios, Leila"],["dc.contributor.author","Rack, Thomas"],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.date.accessioned","2018-11-07T09:00:55Z"],["dc.date.available","2018-11-07T09:00:55Z"],["dc.date.issued","2011"],["dc.description.abstract","The treatment and prevention of osteoporosis involve great challenges. Nonpharmacological and supportive therapy procedures, sport, and physical exercises seem to prevent bone loss and improve bone mass. In the present study, we examined the effect of whole-body vertical vibration (WBVV) on femoral intertrochanteric bone quality in the rat osteoporosis model. Sixty female Sprague-Dawley rats, 3-month old, were ovariectomized (OVX) or sham-operated. After 3 months, each group was divided into two subgroups. In one of the subgroups, rats were treated with WBVV at 90 Hz (3.9 g) for 35 days; the second subgroup remained untreated. After killing the animals, biomechanical strength and trabecular bone architecture of the proximal region of femurs were analyzed. New cortical bone appositions and mineral density of femurs were additionally measured. Treatment with WBVV resulted in improved biomechanical properties. Maximal load and stiffness of the intertrochanteric region of femurs after WBVV were significantly enhanced. Maximal load and stiffness in treated OVX animals reached the levels observed in untreated sham rats. WBVV significantly improved all measured histomorphometric parameters in the trabecular area. Treated rats showed significantly improved mineral content in ashed femurs compared to untreated animals. A comparison of widths of fluorescence bands in cortical bone of subtrochanteric cross sections did not show any significant differences between the groups after WBVV. Low-magnitude, high-frequency mechanical stimulation improves bone strength in the proximal femur and may be a possible nonpharmacologic treatment option for postmenopausal osteoporosis."],["dc.identifier.doi","10.1007/s00223-010-9423-7"],["dc.identifier.isi","000286201200005"],["dc.identifier.pmid","21052653"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7296"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24279"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0171-967X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Improvement of Femoral Bone Quality After Low-Magnitude, High-Frequency Mechanical Stimulation in the Ovariectomized Rat as an Osteopenia Model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","147"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Trauma and Emergency Surgery"],["dc.bibliographiccitation.lastpage","152"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Rack, Thomas"],["dc.contributor.author","Dumont, Clemens"],["dc.contributor.author","Tezval, Mohammad"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.date.accessioned","2018-11-07T08:31:04Z"],["dc.date.available","2018-11-07T08:31:04Z"],["dc.date.issued","2009"],["dc.description.abstract","Rigid plate osteosynthesis with compression is still the treatment of choice for forearm fractures to gain anatomic reposition, provide proper rotation and avoid a bridging callus. Due to necessary operative dissection there is a serious risk for infection and malunion. Based on good clinical results with elastic bridge plating at femur, humerus and tibia, this technique was also started to be used for forearm fractures in our clinic in 1995. In a prospective study, 86 of 124 consecutive patients at the age of 35.2 +/- 14.7 years with 129 diaphyseal fractures of the radius or ulna (AO: 37 type A, 36 type B, 13 type C) were analyzed between January 1998 and December 2003. All fractures were stabilized by bridge plating. Radiographic union and clinical outcome were documented. Of the 129, 122 diaphyseal fractures (94.5%) healed within 10.2 +/- 3.4 weeks without complications (no nerve lesions, nonunion, synostosis callus). One re-osteosynthesis, one secondary lag screw, and five cancellous bone grafts were necessary before final healing. About 79.1% of the patients had a perfect clinical outcome; 17.4% had additional severe injuries of the same arm. Bridge plating, without interfragmentary compression is a reliable surgical procedure even for forearm fractures with low risk of infection and nonunion."],["dc.identifier.doi","10.1007/s00068-008-8002-3"],["dc.identifier.isi","000265340900011"],["dc.identifier.pmid","26814768"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5045"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17036"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.relation.issn","1863-9933"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","The Elastic Bridge Plating of the Forearm Fracture: A Prospective Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","547"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","World Journal of Urology"],["dc.bibliographiccitation.lastpage","555"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.contributor.author","Sehmisch, Stefan"],["dc.contributor.author","Tezval, Mohammed"],["dc.contributor.author","Tezval, Hossein"],["dc.contributor.author","Rack, Thomas"],["dc.contributor.author","Boekhoff, J."],["dc.contributor.author","Wuttke, Wolfgang"],["dc.contributor.author","Herrmann, Thomas R."],["dc.contributor.author","Seidlova-Wuttke, Dana"],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.date.accessioned","2018-11-07T08:27:37Z"],["dc.date.available","2018-11-07T08:27:37Z"],["dc.date.issued","2009"],["dc.description.abstract","Currently, osteoporosis research is rarely undertaken in males but an increase in male life expectancy in the company of hypogonadism suggests the necessity for potential therapeutic options. In this study, the changes in bone structure under standardized testosterone- (T), raloxifene- (R) and estrogen (E)-supplemented diets were analyzed in osteoporotic castrated male rats. Unexpected biomechanical results could be only explained by the histomorphometry, but not by BMD measurements obtained from the qCT. All tested substances showed a significant improvement in the trabecular network (trabecular bone area for C: 2.55 mm(2), T: 4.25 mm(2), R: 4.22 mm(2) and E: 4.28 mm(2)), and suggests that the bone structure was preserved. For the metaphyseal cortical bone, a significant loss was detected in T (CBP: 18.7%) compared to R (CBP: 30.0%), E (CBP: 26.8%) and even to the osteoporotic control (CBP: 28.6%). This explains the observed early mechanical final failure after T supplementation. However, due to the preserved trabecular bone in T, the occurrence of the first microfractures (yL: 49 +/- A 21.4 N) was significantly later than in the osteoporotic control (yL: 39.5 +/- A 15.5 N). Raloxifene performed well in hindering the bone loss associated with osteoporosis. However, its effect (yL: 83.3 +/- A 16.5 N) did not approach the protective effect of E (yL: 99.2 +/- A 21.1 N). Testosterone only preserved the deterioration of the trabecular bone but not of the cortical bone. Raloxifene prevented the bone loss associated with osteoporosis at all bony structures. This effect did not approach the protective effect of estrogen on trabecular bone, but it is more suitable for male individuals because it has no feminizing effects on the subject."],["dc.identifier.doi","10.1007/s00345-009-0373-5"],["dc.identifier.isi","000268985700021"],["dc.identifier.pmid","19221760"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3511"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16245"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0724-4983"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Effect of testosterone, raloxifene and estrogen replacement on the microstructure and biomechanics of metaphyseal osteoporotic bones in orchiectomized male rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","394"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Academic Radiology"],["dc.bibliographiccitation.lastpage","400"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","Zaroban, Artur"],["dc.contributor.author","Tezval, Mohammad"],["dc.contributor.author","Rack, Thomas"],["dc.contributor.author","Schmelz, Ullrich"],["dc.contributor.author","Seidlova-Wuttke, Dana"],["dc.contributor.author","Dunkelberg, Hartmut"],["dc.contributor.author","Wuttke, Wolfgang"],["dc.contributor.author","Marten, Katharina"],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.date.accessioned","2018-11-07T08:30:49Z"],["dc.date.available","2018-11-07T08:30:49Z"],["dc.date.issued","2009"],["dc.description.abstract","Rationale and Objectives. Improvements in imaging technology have led to the increased use Of computed tomography (CT). For example. micro-CT and quantitative CT (QCT) are now often used in osteoporosis research. in which micro-CT is able to analyze small bones or bone samples with high spatial resolution. In contrast, QCT is able to investigate large samples with low spatial resolution. The aim of this Study was to test the usefulness of flat-panel volumetric CT (fpVCT) in a rat model of osteopenia. Material and Methods. Twenty-two 3-month-old rats underwent ovariectomy and were either left untreated or supplemented with estradiol for 15 weeks. After sacrificing, the rats' second lumbar vertebral body bone mineral density (BMD) was analyzed using fpVCT and ashing. The results were compared to those of a microstructural analysis of the first lumbar vertebrae and a biomechanical evaluation of the fourth lumbar vertebrae. Results. BMD measurements using both fpVCT (0.39 vs 0.35 mg/cm(3)) and ashing (0.52 vs 0.48 mg/cm(3)) demonstrated a significant improvement after estradiol supplementation. The correlation coefficient of the two methods was 0.858. After estradiol supplementation, the bone microstructural and bone biomechanical parameters were improved, compared to no treatment. The correlations of both the microstructural and the biomechanical evaluations were closer for BNID measured using fpVCT (r = 0.482-0.769) than on the basis of ashing (r = 0.345-0.573). FpVCT was not able to display the trabecular microstructure of the rat lumbar vertebrae. Conclusion. The use of fpVCT demonstrated a close relationship between morphologic and biomechanical evaluations in a rat model of osteopenia. Because of its different proportions. fpVCT might be able to bridge the gap between micro-CT and QCT in analyzing larger animals."],["dc.description.sponsorship","German Research Society (DFG) [STU 478]"],["dc.identifier.doi","10.1016/j.acra.2008.09.017"],["dc.identifier.isi","000264412100002"],["dc.identifier.pmid","19268850"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16981"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1076-6332"],["dc.title","The Use of Flat Panel Volumetric Computed Tomography (fpVCT) in Osteoporosis Research"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]