Bouter, Yvonne

[["dc.bibliographiccitation.artnumber","11159"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.volume","23"],["dc.contributor.affiliation","Schleicher, Eva Maria; 1Department of Psychiatry and Psychotherapy, Division of Molecular Psychiatry, University Medical Center, Georg-August University, 37075 Goettingen, Germany"],["dc.contributor.affiliation","Bayer, Thomas A.; 1Department of Psychiatry and Psychotherapy, Division of Molecular Psychiatry, University Medical Center, Georg-August University, 37075 Goettingen, Germany"],["dc.contributor.affiliation","Iseni, Trendelina; 1Department of Psychiatry and Psychotherapy, Division of Molecular Psychiatry, University Medical Center, Georg-August University, 37075 Goettingen, Germany"],["dc.contributor.affiliation","Ott, Frederik Wilhelm; 1Department of Psychiatry and Psychotherapy, Division of Molecular Psychiatry, University Medical Center, Georg-August University, 37075 Goettingen, Germany"],["dc.contributor.affiliation","Wagner, Jannek Moritz; 1Department of Psychiatry and Psychotherapy, Division of Molecular Psychiatry, University Medical Center, Georg-August University, 37075 Goettingen, Germany"],["dc.contributor.affiliation","Viotti, Julio S.; 4Institute of Anatomy and Embryology, University Medical Center Goettingen, Georg-August University, 37075 Goettingen, Germany"],["dc.contributor.affiliation","Dresbach, Thomas; 4Institute of Anatomy and Embryology, University Medical Center Goettingen, Georg-August University, 37075 Goettingen, Germany"],["dc.contributor.affiliation","Bouter, Yvonne; 1Department of Psychiatry and Psychotherapy, Division of Molecular Psychiatry, University Medical Center, Georg-August University, 37075 Goettingen, Germany"],["dc.contributor.author","Schleicher, Eva Maria"],["dc.contributor.author","Bayer, Thomas A."],["dc.contributor.author","Iseni, Trendelina"],["dc.contributor.author","Ott, Frederik Wilhelm"],["dc.contributor.author","Wagner, Jannek Moritz"],["dc.contributor.author","Viotti, Julio S."],["dc.contributor.author","Dresbach, Thomas"],["dc.contributor.author","Bouter, Yvonne"],["dc.contributor.editor","Dal Maschio, Marco"],["dc.contributor.editor","Miletto Petrazzini, Maria Elena"],["dc.date.accessioned","2022-11-01T10:17:26Z"],["dc.date.available","2022-11-01T10:17:26Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-11T13:13:02Z"],["dc.description.abstract","The presynaptic protein Mover/TPRGL/SVAP30 is absent in Drosophila and C. elegans and differentially expressed in synapses in the rodent brain, suggesting that it confers specific functions to subtypes of presynaptic terminals. In order to investigate how the absence of this protein affects behavior and learning, Mover knockout mice (KO) were subjected to a series of established learning tests. To determine possible behavioral and cognitive alterations, male and female 8-week-old KO and C57Bl/6J wildtype (WT) control mice were tested in a battery of memory and anxiety tests. Testing included the cross maze, novel object recognition test (NOR), the Morris water maze (MWM), the elevated plus maze (EPM), and the open field test (OF). Mover KO mice showed impaired recognition memory in the NOR test, and decreased anxiety behavior in the OF and the EPM. Mover KO did not lead to changes in working memory in the cross maze or spatial reference memory in the MWM. However, a detailed analysis of the swimming strategies demonstrated allocentric-specific memory deficits in male KO mice. Our data indicate that Mover appears to control synaptic properties associated with specific forms of memory formation and behavior, suggesting that it has a modulatory role in synaptic transmission."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3390/ijms231911159"],["dc.identifier.pii","ijms231911159"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/116810"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-605"],["dc.publisher","MDPI"],["dc.relation.eissn","1422-0067"],["dc.rights","CC BY 4.0"],["dc.title","Ablation of the Presynaptic Protein Mover Impairs Learning Performance and Decreases Anxiety Behavior in Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]