Abd El Wahed, Ahmed

[["dc.bibliographiccitation.firstpage","7074"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences of the United States of America"],["dc.bibliographiccitation.lastpage","7078"],["dc.bibliographiccitation.volume","77"],["dc.contributor.author","Hasilik, A."],["dc.contributor.author","Klein, U."],["dc.contributor.author","Strecker, G."],["dc.contributor.author","Figura, Kurt von"],["dc.contributor.author","Abd El Wahed, Ahmed"],["dc.date.accessioned","2019-07-10T08:12:41Z"],["dc.date.available","2019-07-10T08:12:41Z"],["dc.date.issued","1980"],["dc.description.abstract","In human fibroblasts, the recognition of lysosomal enzymes by cell surface receptors is mediated by mannose 6-phosphate residues located on oligosaccharides that can be cleaved by endo-β-N-acetylglucosaminidase H. About half of these oligosaccharides, as isolated from β-hexosaminidase and cathepsin D secreted by human skin fibroblasts, are anionic. Most of these are resistant to alkaline phosphatase. The resistance is due to α-N-acetylglucosamine residues linked to mannose 6phosphate by a phosphodiester bond. The major phosphorylated oligosaccharides contain one and two and possibly three phosphate groups blocked by N-acetylglucosamine. Besides the blocked phosphate groups these oligosaccharides contain a common inner core consisting of Manα1,6- (Manαl,3)Manαl,6(Manαl,3)ManβαGlcNAc and either one or two αl,2-linked mannose residues."],["dc.format.mimetype","application/pdf"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3282"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61005"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.publisher","NAS"],["dc.rights","Goescholar"],["dc.rights.access","openAccess"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject","identification; α-N-acetylglucosamine (1) phospho(6)mannose; diester groups"],["dc.subject.ddc","610"],["dc.title","Phosphorylated oligosaccharides in lysosomal enzymes: identification of α-N-acetylglucosamine (1) phospho(6)mannose diester groups"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]