Maier, Ilko L.

[["dc.bibliographiccitation.firstpage","372"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","International Journal of Stroke"],["dc.bibliographiccitation.lastpage","380"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Alegiani, Anna C"],["dc.contributor.author","Dorn, Franziska"],["dc.contributor.author","Herzberg, Moriz"],["dc.contributor.author","Wollenweber, Frank A"],["dc.contributor.author","Kellert, Lars"],["dc.contributor.author","Siebert, Eberhard"],["dc.contributor.author","Nolte, Christian H"],["dc.contributor.author","von Rennenberg, Regina"],["dc.contributor.author","Hattingen, Elke"],["dc.contributor.author","Petzold, Gabor C"],["dc.contributor.author","Bode, Felix J"],["dc.contributor.author","Pfeilschifter, Waltraud"],["dc.contributor.author","Schäfer, Jan H"],["dc.contributor.author","Wagner, Marlies"],["dc.contributor.author","Röther, Joachim"],["dc.contributor.author","Eckert, Bernd"],["dc.contributor.author","Kraft, Peter"],["dc.contributor.author","Pham, Mirko"],["dc.contributor.author","Boeckh-Behrens, Tobias"],["dc.contributor.author","Wunderlich, Silke"],["dc.contributor.author","Bernkopf, Kathleen"],["dc.contributor.author","Reich, Arno"],["dc.contributor.author","Wiesmann, Martin"],["dc.contributor.author","Mpotsaris, Anastasios"],["dc.contributor.author","Psychogios, Marios"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Maier, Ilko"],["dc.contributor.author","Berrouschot, Jörg"],["dc.contributor.author","Bormann, Albrecht"],["dc.contributor.author","Limmroth, Volker"],["dc.contributor.author","Spreer, Joachim"],["dc.contributor.author","Petersen, Martina"],["dc.contributor.author","Krause, Lars"],["dc.contributor.author","Lowens, Stephan"],["dc.contributor.author","Kraemer, Christoffer"],["dc.contributor.author","Zweynert, Sarah"],["dc.contributor.author","Lange, Kristin S"],["dc.contributor.author","Thonke, Sven"],["dc.contributor.author","Kastrup, Andreas"],["dc.contributor.author","Papanagiotou, Panagiotis"],["dc.contributor.author","Alber, Burkhard"],["dc.contributor.author","Braun, Michael"],["dc.contributor.author","Fiehler, Jens"],["dc.contributor.author","Gerloff, Christian"],["dc.contributor.author","Dichgans, Martin"],["dc.contributor.author","Thomalla, Götz"],["dc.date.accessioned","2020-12-10T18:38:36Z"],["dc.date.available","2020-12-10T18:38:36Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1177/1747493018806199"],["dc.identifier.eissn","1747-4949"],["dc.identifier.issn","1747-4930"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77382"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Systematic evaluation of stroke thrombectomy in clinical practice: The German Stroke Registry Endovascular Treatment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","362"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Stroke"],["dc.bibliographiccitation.lastpage","372"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Peter, Carolin"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Schnieder, Marlena"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.date.accessioned","2021-06-01T10:48:59Z"],["dc.date.available","2021-06-01T10:48:59Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.5853/jos.2018.00605"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86121"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","2287-6405"],["dc.relation.issn","2287-6391"],["dc.title","Outcome Prediction Using Perfusion Parameters and Collateral Scores of Multi-Phase and Single-Phase CT Angiography in Acute Stroke: Need for One, Two, Three, or Thirty Scans?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Neurology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Hofer, Sabine"],["dc.contributor.author","Eggert, Eva"],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Liman, Jan"],["dc.date.accessioned","2021-04-14T08:31:11Z"],["dc.date.available","2021-04-14T08:31:11Z"],["dc.date.issued","2020"],["dc.description.abstract","Age-related degeneration of the cervical spinal column is the most common cause of spinal cord lesions. T1 mapping has been shown to indicate the grade and site of spinal cord compression in low grade spinal canal stenosis (SCS). Aim of our study was to further investigate the diagnostic potential of a novel T1 mapping method at 0.75 mm resolution and 4 s acquisition time in 31 patients with various grades of degenerative cervical SCS. T1 mapping was performed in axial sections of the stenosis as well as above and below. Included subjects received standard T2-weighted MRI of the cervical spine (including SCS-grading 0-III), electrophysiological, and clinical examination. We found that patients with cervical SCS showed a significant difference in T1 relaxation times within the stenosis (727 ± 66 ms, mean ± standard deviation) in comparison to non-stenotic segments above (854 ± 104 ms, p \\u0026lt; 0.001) and below (893 ± 137 ms, p \\u0026lt; 0.001). There was no difference in mean T1 in non-stenotic segments in patients (p = 0.232) or between segments in controls (p = 0.272). Mean difference of the T1 relaxation times was significantly higher in grade III stenosis (234 ± 45) vs. in grade II stenosis (176 ± 45, p = 0.037) vs. in grade I stenosis (90 ± 87 ms, p = 0.010). A higher difference in T1 relaxation time was associated with a central efferent conduction deficit. In conclusion, T1 mapping may be useful as a tool for SCS quantification in all grades of SCS, including high-grade stenosis with myelopathy signal in conventional T2-weighted imaging."],["dc.identifier.doi","10.3389/fneur.2020.574604"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83508"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-2295"],["dc.rights","http://creativecommons.org/licenses/by/4.0/"],["dc.title","T1 Mapping Quantifies Spinal Cord Compression in Patients With Various Degrees of Cervical Spinal Canal Stenosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","18"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Cerebrovascular Diseases"],["dc.bibliographiccitation.lastpage","25"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Liman, Jan"],["dc.date.accessioned","2018-04-23T11:48:23Z"],["dc.date.available","2018-04-23T11:48:23Z"],["dc.date.issued","2017"],["dc.description.abstract","Background: Endovascular treatment (EVT) has been shown to significantly improve functional outcome in patients with acute large cerebral vessel occlusions. To date, no evidence-based recommendations on blood pressure management after successful EVT exist. Previous studies showed an association between high pre-EVT systolic blood pressure (SBP) and functional outcome, but do not answer the question on how to manage blood pressure after successful recanalization. The purpose of this study was to determine the role of blood pressure measurements as a predictor for early functional outcome in patients with successful EVT. Methods: Prospectively derived data from patients with acute large vessel occlusion within the anterior circulation and EVT was analyzed in this monocentric study. Mean systolic- and maximum SBP as well as SBP-peaks have been obtained for the first 24 h after successful EVT. Predictive value of SBP for discharge modified Rankin Scale (mRS) ≤2 has been investigated using logistic regression models. Results: From 168 patients with successful EVT, 74 (44%) had a favorable outcome with an mRS ≤2. Mean- (127 vs. 131 mm Hg, p = 0.035) and maximum SBP (157 vs. 169 mm Hg, p < 0.001) as well as the number of SBP-peaks (0 vs. 1.5, p = 0.004) were lower in patients with favorable outcomes. Multivariable logistic regression showed high mean- and maximum SBP to predict unfavorable outcomes. Cutoff mean SBP was 141 mm Hg and maximum SBP 159 mm Hg. Conclusions: High SBP in the first 24 h after recanalization of acute anterior cerebral vessel occlusions is associated with unfavorable functional outcome. Interventional studies are needed to determine the role of SBP management as a modifiable parameter in the early phase after successful EVT."],["dc.identifier.doi","10.1159/000484720"],["dc.identifier.gro","3142065"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13499"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.relation.issn","1015-9770"],["dc.title","High Systolic Blood Pressure after Successful Endovascular Treatment Affects Early Functional Outcome in Acute Ischemic Stroke"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","932"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Journal of NeuroInterventional Surgery"],["dc.bibliographiccitation.lastpage","936"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Anadani, Mohammad"],["dc.contributor.author","Arthur, Adam S."],["dc.contributor.author","Alawieh, Ali"],["dc.contributor.author","Orabi, Yser"],["dc.contributor.author","Alexandrov, Andrei"],["dc.contributor.author","Goyal, Nitin"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Maier, Ilko"],["dc.contributor.author","Kim, Joon-tae"],["dc.contributor.author","Keyrouz, Saleh G."],["dc.contributor.author","de Havenon, Adam"],["dc.contributor.author","Petersen, Nils H."],["dc.contributor.author","Pandhi, Abhi"],["dc.contributor.author","Swisher, Christa B."],["dc.contributor.author","Inamullah, Ovais"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Kodali, Sreeja"],["dc.contributor.author","Giles, James A."],["dc.contributor.author","Allen, Michelle"],["dc.contributor.author","Wolfe, Stacey Q."],["dc.contributor.author","Tsivgoulis, Georgios"],["dc.contributor.author","Cagle, Bradley A."],["dc.contributor.author","Oravec, Chesney S."],["dc.contributor.author","Gory, Benjamin"],["dc.contributor.author","De Marini, Pierre"],["dc.contributor.author","Kan, Peter"],["dc.contributor.author","Rahman, Shareena"],["dc.contributor.author","Richard, Sébastien"],["dc.contributor.author","Nascimento, Fábio A."],["dc.contributor.author","Spiotta, Alejandro"],["dc.date.accessioned","2021-04-14T08:32:51Z"],["dc.date.available","2021-04-14T08:32:51Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1136/neurintsurg-2019-015561"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84037"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1759-8486"],["dc.relation.issn","1759-8478"],["dc.title","Blood pressure reduction and outcome after endovascular therapy with successful reperfusion: a multicenter study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","PloS one"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Schnieder, Marlena"],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.date.accessioned","2018-01-08T17:09:39Z"],["dc.date.available","2018-01-08T17:09:39Z"],["dc.date.issued","2017"],["dc.description.abstract","Identification of patients requiring decompressive hemicraniectomy (DH) after endovascular therapy (EVT) is crucial as clinical signs are not reliable and early DH has been shown to improve clinical outcome. The aim of our study was to identify imaging-based scores to predict the risk for space occupying ischemic stroke and DH."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2017"],["dc.identifier.doi","10.1371/journal.pone.0173737"],["dc.identifier.pmid","28282456"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14394"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/11572"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Early computed tomography-based scores to predict decompressive hemicraniectomy after endovascular therapy in acute ischemic stroke"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1391843"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Stroke Research and Treatment"],["dc.bibliographiccitation.lastpage","6"],["dc.bibliographiccitation.volume","2017"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Karch, André"],["dc.contributor.author","Weber-Krueger, Mark"],["dc.contributor.author","Mikolajczyk, Rafael T."],["dc.contributor.author","Stahrenberg, Raoul"],["dc.contributor.author","Gröschel, Klaus"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Liman, Jan"],["dc.date.accessioned","2018-04-23T11:47:07Z"],["dc.date.available","2018-04-23T11:47:07Z"],["dc.date.issued","2017"],["dc.description.abstract","Background. Atrial fibrillation (AF) is an important cause of embolic stroke of undetermined source (ESUS). Imaging-patterns like multiple infarcts, simultaneous involvement of different circulations, infarcts of different ages, and isolated cortical infarcts are likely to indicate cardioembolic stroke. The aim of our study was to evaluate the association between embolic stroke patterns, ESUS, and the new diagnosis of AF. Methods. Stroke etiology and imaging characteristics from patients included in the Find-AF study were obtained. Embolic stroke patterns in CT- or MR-imaging were correlated with the diagnosis of ESUS as well as the short- (on baseline ECG and during 7-day Holter) and long-term (12-month follow-up) diagnosis of AF. Results. From 281 patients included in the Find-AF study, 127 (45.2%) patients with ischemic lesions detected in CT or MRI were included. 26 (20.5%) of these patients had ESUS. At least one embolic stroke pattern was detected in 67 (52.7%) patients. Embolic stroke patterns were not associated with ESUS (OR 1.57, 0.65–3.79, ), the short-term (OR 0.64, 0.26–1.58, ) or long-term diagnosis of AF (OR 0.72, 0.31–1.68, ). Conclusions. This secondary data analysis of the Find-AF study could not provide evidence for an association between embolic stroke patterns, ESUS, and the new diagnosis of AF."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2017"],["dc.identifier.doi","10.1155/2017/1391843"],["dc.identifier.gro","3142074"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14531"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13300"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.issn","2090-8105"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Association between Embolic Stroke Patterns, ESUS Etiology, and New Diagnosis of Atrial Fibrillation: A Secondary Data Analysis of the Find-AF Trial"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","525"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of NeuroInterventional Surgery"],["dc.bibliographiccitation.lastpage","529"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Hesse, Amélie Carolina"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Kemmling, André"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Hokamp, Nils Große"],["dc.contributor.author","Frischmuth, Isabelle"],["dc.contributor.author","Maier, Ilko"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Tran, Julia"],["dc.contributor.author","Fiehler, Jens"],["dc.contributor.author","Mpotsaris, Anastasios"],["dc.contributor.author","Schramm, Peter"],["dc.contributor.author","Berlis, Ansgar"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.date.accessioned","2020-12-10T18:37:18Z"],["dc.date.available","2020-12-10T18:37:18Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1136/neurintsurg-2017-013394"],["dc.identifier.eissn","1759-8486"],["dc.identifier.issn","1759-8478"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76905"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Comparing different thrombectomy techniques in five large-volume centers: a ‘real world’ observational study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","300"],["dc.bibliographiccitation.journal","Journal of the neurological sciences"],["dc.bibliographiccitation.lastpage","304"],["dc.bibliographiccitation.volume","372"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Schnieder, Marlena"],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Kleinknecht, Alexander"],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Psychogios, Marios"],["dc.contributor.author","Liman, Jan"],["dc.date.accessioned","2018-01-09T10:18:58Z"],["dc.date.available","2018-01-09T10:18:58Z"],["dc.date.issued","2017"],["dc.description.abstract","Although endovascular treatment for proximal cerebral vessel occlusion is very effective, it remains controversial if intravenous thrombolysis (IVT) prior to endovascular treatment is superior compared to endovascular treatment alone. In this study we compared functional outcomes and recanalization rates of endovascularly treated stroke patients with and without bridging IVT."],["dc.identifier.doi","10.1016/j.jns.2016.12.001"],["dc.identifier.pmid","28017233"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/11576"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1878-5883"],["dc.title","Bridging-therapy with intravenous recombinant tissue plasminogen activator improves functional outcome in patients with endovascular treatment in acute stroke"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Neurology"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Schramm, Katarina"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Liman, Jan"],["dc.date.accessioned","2022-01-11T14:06:14Z"],["dc.date.available","2022-01-11T14:06:14Z"],["dc.date.issued","2021"],["dc.description.abstract","Background: Patients with large vessel occlusion stroke (LVOS) eligible for mechanical thrombectomy (MT) are at risk for stroke- and non-stroke-related complications resulting in the need for tracheostomy (TS). Risk factors for TS have not yet been systematically investigated in this subgroup of stroke patients. Methods: Prospectively derived data from patients with LVOS and MT being treated in a large, academic neurological ICU (neuro-ICU) between 2014 and 2019 were analyzed in this single-center study. Predictive value of peri- and post-interventional factors, stroke imaging, and pre-stroke medical history were investigated for their potential to predict tracheostomy during ICU stay using logistic regression models. Results: From 635 LVOS-patients treated with MT, 40 (6.3%) underwent tracheostomy during their neuro-ICU stay. Patients receiving tracheostomy were younger [71 (62–75) vs. 77 (66–83), p < 0.001], had a higher National Institute of Health Stroke Scale (NIHSS) at baseline [18 (15–20) vs. 15 (10–19), p = 0.009] as well as higher rates of hospital acquired pneumonia (HAP) [39 (97.5%) vs. 224 (37.6%), p < 0.001], failed extubation [15 (37.5%) vs. 19 (3.2%), p < 0.001], sepsis [11 (27.5%) vs. 16 (2.7%), p < 0.001], symptomatic intracerebral hemorrhage [5 (12.5%) vs. 22 (3.9%), p = 0.026] and decompressive hemicraniectomy (DH) [19 (51.4%) vs. 21 (3.8%), p < 0.001]. In multivariate logistic regression analysis, HAP (OR 21.26 (CI 2.76–163.56), p = 0.003], Sepsis [OR 5.39 (1.71–16.91), p = 0.004], failed extubation [OR 8.41 (3.09–22.93), p < 0.001] and DH [OR 9.94 (3.92–25.21), p < 0.001] remained as strongest predictors for TS. Patients with longer periods from admission to TS had longer ICU length of stay ( r = 0.384, p = 0.03). There was no association between the time from admission to TS and clinical outcome (NIHSS at discharge: r = 0.125, p = 0.461; mRS at 90 days: r = −0.179, p = 0.403). Conclusions: Patients with LVOS undergoing MT are at high risk to require TS if extubation after the intervention fails, DH is needed, and severe infectious complications occur in the acute phase after ischemic stroke. These factors are likely to be useful for the indication and timing of TS to reduce overall sedation and shorten ICU length of stay."],["dc.description.abstract","Background: Patients with large vessel occlusion stroke (LVOS) eligible for mechanical thrombectomy (MT) are at risk for stroke- and non-stroke-related complications resulting in the need for tracheostomy (TS). Risk factors for TS have not yet been systematically investigated in this subgroup of stroke patients. Methods: Prospectively derived data from patients with LVOS and MT being treated in a large, academic neurological ICU (neuro-ICU) between 2014 and 2019 were analyzed in this single-center study. Predictive value of peri- and post-interventional factors, stroke imaging, and pre-stroke medical history were investigated for their potential to predict tracheostomy during ICU stay using logistic regression models. Results: From 635 LVOS-patients treated with MT, 40 (6.3%) underwent tracheostomy during their neuro-ICU stay. Patients receiving tracheostomy were younger [71 (62–75) vs. 77 (66–83), p < 0.001], had a higher National Institute of Health Stroke Scale (NIHSS) at baseline [18 (15–20) vs. 15 (10–19), p = 0.009] as well as higher rates of hospital acquired pneumonia (HAP) [39 (97.5%) vs. 224 (37.6%), p < 0.001], failed extubation [15 (37.5%) vs. 19 (3.2%), p < 0.001], sepsis [11 (27.5%) vs. 16 (2.7%), p < 0.001], symptomatic intracerebral hemorrhage [5 (12.5%) vs. 22 (3.9%), p = 0.026] and decompressive hemicraniectomy (DH) [19 (51.4%) vs. 21 (3.8%), p < 0.001]. In multivariate logistic regression analysis, HAP (OR 21.26 (CI 2.76–163.56), p = 0.003], Sepsis [OR 5.39 (1.71–16.91), p = 0.004], failed extubation [OR 8.41 (3.09–22.93), p < 0.001] and DH [OR 9.94 (3.92–25.21), p < 0.001] remained as strongest predictors for TS. Patients with longer periods from admission to TS had longer ICU length of stay ( r = 0.384, p = 0.03). There was no association between the time from admission to TS and clinical outcome (NIHSS at discharge: r = 0.125, p = 0.461; mRS at 90 days: r = −0.179, p = 0.403). Conclusions: Patients with LVOS undergoing MT are at high risk to require TS if extubation after the intervention fails, DH is needed, and severe infectious complications occur in the acute phase after ischemic stroke. These factors are likely to be useful for the indication and timing of TS to reduce overall sedation and shorten ICU length of stay."],["dc.identifier.doi","10.3389/fneur.2021.728624"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97862"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-507"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-2295"],["dc.rights","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Predictive Factors for the Need of Tracheostomy in Patients With Large Vessel Occlusion Stroke Being Treated With Mechanical Thrombectomy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]